Digital Commons Network^™

Exploring Health Literacy In The Acute Care Setting In A Rural Border Region, Shiloh Williams

Walden Dissertations and Doctoral Studies

Health literacy is important to ensuring patients have the necessary knowledge and skills needed to actively participate as a member of their own healthcare team. Patients with low health literacy are at increased risk for poor outcomes and limited participation in decisions affecting their health or treatment plan. Using the Social Ecological Model (SEM) as a framework, the purpose of this study was to determine the relationship between medical-surgical registered nurses, medical-surgical patients and the registered nurse’s (RN) assessment of their patient’s health literacy of those who live in a rural-border region. The study’s sample consisted of 84 pairs of …

Leidenfrost Droplet Microfluidics, Sidy Ndao, George Gogos, Dennis Alexander, Troy Anderson, Craig Zuhlke

Department of Mechanical and Materials Engineering: Faculty Publications

Systems and methods are described for propelling a liquid droplet in a Leidenforst state. A microfluidic device embodiment includes, but is not limited to, a solid structure having a patterned surface, the patterned surface including at least a first patterned region having a first Leidenfrost temperature with respect to a fluid, the first patterned region adjacent to the second patterned region, the first patterned region defining a path over which a droplet of the fluid is configured to travel in a Leidenfrost state.

Proper Conjugation Of Bodies: Chastity, Age, And Care Work In Sri Lankan Migrants’ Families, Michele Ruth Gamburd

Anthropology Faculty Publications and Presentations

Physical and symbolic aspects of bodies limit the migration trajectories of female domestic workers from a Buddhist community in coastal Sri Lanka. Government regulations and family decisions regarding women’s overseas labour draw upon and in turn influence discourses about gender, sexuality, age, health, and class. This ethnographic analysis illustrates that local norms task women with nurturing the brains of babies, preserving the chastity of teenage daughters, caring for frail elders, and preventing their working-class husbands from overindulging in liquor or having sex with other women. Successful social reproduction depends on the proper conjunctions of bodies in the extended family. Corporeal …

Transgender Protection And Best Practices In The Prison Setting, Jessica Renee Byrd

Walden Dissertations and Doctoral Studies

While the importance of equal protection for all offenders has been established, prison officials often do not provide adequate protection for or effectively address the unique needs of transgender inmates. In this qualitative action research study, prison officials' perceptions regarding their responsibility to provide protection and equal treatment to transgender offenders were evaluated as well as to what extent they are congruent with those stated in policies and procedures. The expectation was that linkages could be drawn between prison officials' level of knowledge regarding their responsibilities and the various types of maltreatment that transgender offenders experience as well as the …

Measuring Knowledge Of Chronic Kidney Disease (Ckd) Among Community College Students, Jacquelyn Caldwell Moore

Walden Dissertations and Doctoral Studies

Chronic Kidney Disease (CKD) once detected is easily treated; however, it has become a major health problem associated with increased morbidity and mortality rates, creating an economic burden worldwide. While approximately 24 million Americans over the age of 20 suffer from CKD, there is a lack of awareness among the general population. Using a pre/post assessment, this quantitative study measured the impact of a 75-minute workshop on 126 community college students' knowledge of kidney disease, perception of its severity, and perceived susceptibility. The theoretical framework for the study was the health belief model, which suggests that individuals will make positive …

The Impact Of Peer Victimization On Psychosocial Functioning And Adjustment Of African-Born Adolescents, Oluyemi Abimbola Adejinmi

Walden Dissertations and Doctoral Studies

AbstractPeer victimization is aggressive behavior, a school stressor, and a social problem that could have significant adverse outcomes on adolescents’ psychological, social, and physical well-being. Some of the adverse outcomes of peer victimization in the adolescent population include externalizing and internalizing problems. More insight is needed on the impact of peer victimization on the well-being of adolescents, especially those who belong to minority groups. The purpose of this study was to examine the impact of peer victimization on the psychosocial functioning and adjustment of African-born adolescents in the United States by using Lazarus and Folkman’s transactional theory of stress and …

Advanced Cancer Patient Preferences For Receiving Molecular Profiling Results, Megan Best, Phyllis Butow, Chris Jacobs, Ilona Juraskova, Jacqueline Savard, Bettina Meiser, David Goldstein, Mandy Ballinger, Nicci Bartley, Christine Napier, Grace Davies, David Thomas, Kathy Tucker, Timothy Schlub, Ainsley J. Newson

IES Papers and Journal Articles

Objective: This study aimed to discern preferences for receiving somatic molecular profiling (MP) results in cancer patients who have given consent to undergo testing.

Methods: We conducted a mixed‐methods study to explore patients’ views on which MP results they would like to receive and why. Advanced cancer patients (n=1299) completed questionnaires after giving consent to participate in a parent genomics study and undergoing MP. A subset of patients (n=20) participated in qualitative interviews.

Results: Almost all (96%) participants were interested in receiving results which would direct cancer treatment (i.e. were actionable). A smaller majority wanted to access results which were …

The Lived Experience Of Work Stress And Coping In Eldercare Hospice Nurses, Yvette Abraham

Walden Dissertations and Doctoral Studies

The number of elderly people living with terminal diagnoses has increased, along with the need for hospice nurses with specialized training to provide high-quality personal care that addresses their unique, critical needs. Research on nurses and other professionals who function in a demanding environment has demonstrated the experience of work stress, and negative physical and psychological consequences. However, little is known about the unique work stress and challenges of hospice nurses who care for the dying elderly. This study explored the meaning of hospice nurses’ experience of work stress and coping. Giorgi’s empirical phenomenological approach guided the development of the …

Adult Attachment Functioning Of Former Foster Youth Initially Placed In Early Adolescence, Adrienne Miller

Walden Dissertations and Doctoral Studies

Child attachment has been an area of study among scholars for several decades; however, early adolescent attachment is a specific age period that few scholars have examined, especially pertaining to child welfare where placement is a necessary but forced attachment disruption. The purpose of this nonexperimental study was to examine the likelihood of early adolescent attachment during initial placement and to explore the frequencies of this population securely attaching postplacement based on the added variables of placement setting (foster home/kinship home/group home/institution) and sibling accessibility. Attachment theory was the lens through which to analyze the 83 results received via anonymous …

Black Students' Online Networking And Social Capital Development Behaviors In Varied University Settings, Tarita Bateman

Walden Dissertations and Doctoral Studies

Sustained high unemployment among educated Black jobseekers as well as disparate salaries between educated Blacks and non-Blacks continues to persist. Social capital as a major source for job attainment and career progression is recognized as a potential factor contributing to this situation. This quantitative study examined the social networking site usage intensity and external social capital development behavior among 130 graduate Black university students at predominantly White, historically Black, and diverse online universities. The theoretical foundation of social capital development was analyzed from perspectives of bridging and bonding social capital. Educational setting, sex, and socioeconomic status were used to predict …

Evaluating The Hospitals General Service Readiness Index In Guinea For Enhancing Their Performances, Mohamed Elmahady Camara

Walden Dissertations and Doctoral Studies

The healthcare system of Guinea has reported low scores on service availability and readiness assessment (SARA); the scores indicated the low availability of quality drugs, vaccines, medical equipment, and other technologies and involves a continuous history of poor quality-performance metrics. Thus the operational health problems in Guinea could be summarized as health problems (high rate of maternal, neonatal, and infant mortality, high prevalence of communicable and non-communicable diseases) and health system problems (lack of appropriate governance). Therefore, amelioration of the quality of health care and patient safety is needed. The objective of this study was to consider Guinea hospital performance …

Nurses’ Social Distancing Behaviors Toward Patients With Borderline Personality Disorder, Nicole York

Walden Dissertations and Doctoral Studies

Nurses often fear interacting with patients diagnosed with borderline personality disorder (BPD) and use self-preservation distancing strategies that can exacerbate the BPD patient’s fear of abandonment, paranoia, self-harm, and relational conflict. Prior research identified individual predictors of nurses’ social distancing. This study used multivariable and multivariate correlational profiles of fear of violence and BPD bias that influence distance, reassessing, and constructive coping. Guided by social cognitive and appraisal transaction theories, data were collected from 113 nurses in a northwestern U.S. state on measures of interpersonal stress coping, attitudinal dispositions, perceived prevention of violence, perceived likelihood of future violence, and perceived …

"'In A Distant Unknown Country': A New Historicist Look At James Joyce’S “Eveline,” Argentina, And The Zwi Migdal In The Early 1900s.", M Laura Barberan Reinares

Publications and Research

This article analyzes James Joyce’s story “Eveline” (1904) looking at the moral panic about “white slavery” in Europe and the new continent, especially focusing on Argentina, the foremost recipient of trafficked women between 1880 and 1930 (and, of course, Joyce’s destination of choice for Eveline). It was precisely at the turn of the twentieth century that, along with the popularity of transatlantic migration, sex trafficking went fully global and news about international “dangers” for single white women reached the general public, provoking all kinds of repressive reactions through what became known as the “social purity” movement.

Annual Report Of The Registrar 2019/2020, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

Contents:

--- Definitions
--- Some Comparisons
--- Annual Report Data
--- Summary of Attendance
--- Attendance by Session
--- Degrees Granted 2019/20
--- Degree Summary 2019/20
--- Program Certificates 2019/20
--- Miscellaneous Enrollment Information
--- Degrees Granted by College, Degree and Racial/Ethnic Classification

Plasma Jet Flow Characterization Via Computational Modeling, Declan Brick

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Exploring The Potential Of Commensal Lactobacilli To Inhibit Growth Of Uropathogens, Lydia Delaney

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

The Flipped Classroom In Esl Teacher Education: An Example From Call, Yuyen Lee, Katherine I. Martin

Articles

The flipped classroom is one of many technology-enhanced teaching strategies. In this approach, students are responsible for initial learning at home (often via instructional videos) and class time is used for problem-solving and activities to deepen understanding. Although research on and use of the flipped classroom in language education is growing, little work has examined its use in teacher education, particularly for language teachers. To address this gap, this study examined the flipped classroom through the eyes of pre-service language teachers to reveal what hinders them from or encourages them to adopt this approach. Data were collected from students in …

Interferon Beta Activity Is Modulated Via Binding Of Specific S100 Proteins, Alexei S. Kazakov, Alexander D. Sofin, Nadezhda V. Avkhacheva, Alexander I. Denesyuk, Eugenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Molecular Medicine Faculty Publications

Interferon-β (IFN-β) is a pleiotropic cytokine used for therapy of multiple sclerosis, which is also effective in suppression of viral and bacterial infections and cancer. Recently, we reported a highly specific interaction between IFN-β and S100P lowering IFN-β cytotoxicity to cancer cells (Int J Biol Macromol. 2020; 143: 633–639). S100P is a member of large family of multifunctional Ca2+-binding proteins with cytokine-like activities. To probe selectivity of IFN-β—S100 interaction with respect to S100 proteins, we used surface plasmon resonance spectroscopy, chemical crosslinking, and crystal violet assay. Among the thirteen S100 proteins studied S100A1, S100A4, and S100A6 proteins exhibit strictly Ca2+-dependent …

Liquid–Liquid Phase Separation By Intrinsically Disordered Protein Regions Of Viruses: Roles In Viral Life Cycle And Control Of Virus–Host Interactions, Stefania Brocca, Rita Grandori, Sonia Longhi, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Intrinsically disordered proteins (IDPs) are unable to adopt a unique 3D structure under physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs are ubiquitous and widely spread in the protein realm. In the last decade, compelling experimental evidence has been gathered, pointing to the ability of IDPs and intrinsically disordered regions (IDRs) to undergo liquid–liquid phase separation (LLPS), a phenomenon driving the formation of membrane-less organelles (MLOs). These biological condensates play a critical role in the spatio-temporal organization of the cell, where they exert a multitude of key biological functions, ranging from transcriptional regulation and silencing to control …

Intrinsic Disorder In Tetratricopeptide Repeat Proteins, Nathan W. Bibber, Cornelia Haerle, Roy Khalifa, Bin Xue, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Among the realm of repeat containing proteins that commonly serve as “scaffolds” promoting protein-protein interactions, there is a family of proteins containing between 2 and 20 tetratricopeptide repeats (TPRs), which are functional motifs consisting of 34 amino acids. The most distinguishing feature of TPR domains is their ability to stack continuously one upon the other, with these stacked repeats being able to affect interaction with binding partners either sequentially or in combination. It is known that many repeat-containing proteins are characterized by high levels of intrinsic disorder, and that many protein tandem repeats can be intrinsically disordered. Furthermore, it seems …

Intrinsic Disorder-Based Design Of Stable Globular Proteins, Galina S. Nagibina, Bogdan S. Melnik, Vladimir N. Uversky, Tatiana N. Melnik, Bogdan S. Melnik

Molecular Medicine Faculty Publications

Directed stabilization of globular proteins via substitution of a minimal number of amino acid residues is one of the most complicated experimental tasks. This work summarizes our research on the effect of amino acid substitutions on the protein stability utilizing the outputs of the analysis of intrinsic disorder predisposition of target proteins. This allowed us to formulate the basis of one of the possible approaches to the stabilization of globular proteins. The idea is quite simple. To stabilize a protein as a whole, one needs to find its "weakest spot" and stabilize it, but the question is how this weak …

Hsp22 With An N-Terminal Domain Truncation Mediates A Reduction In Tau Protein Levels, Jack M. Webster, April L. Darling, Taylor A. Sanders, Danielle M. Blazier, Yamile Vidal-Aguiar, David Beaulieu-Abdelahad, Drew G. Plemmons, Shannon E. Hill, Vladimir N. Uversky, Paula C. Bickford, Chad Anthony Dickey, Laura J. Blair

Molecular Medicine Faculty Publications

Misfolding, aggregation and accumulation of proteins are toxic elements in the progression of a broad range of neurodegenerative diseases. Molecular chaperones enable a cellular defense by reducing or compartmentalizing these insults. Small heat shock proteins (sHsps) engage proteins early in the process of misfolding and can facilitate their proper folding or refolding, sequestration, or clearance. Here, we evaluate the effects of the sHsp Hsp22, as well as a pseudophosphorylated mutant and an N-terminal domain deletion (NTDΔ) variant on tau aggregation in vitro and tau accumulation and aggregation in cultured cells. Hsp22 wild-type (WT) protein had a significant inhibitory effect on …

Rigidity Of The Outer Shell Predicted By A Protein Intrinsic Disorder Model Sheds Light On The Covid-19 (Wuhan-2019-Ncov) Infectivity, Gerard Kian-Meng Goh, A. Keith Dunker, James A. Foster, Vladimir N. Uversky

Molecular Medicine Faculty Publications

The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, …

Why Covid-19 Transmission Is More Efficient And Aggressive Than Viral Transmission In Previous Coronavirus Epidemics?, Fatma Elrashdy, Elrashdy M. Redwan, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a pandemic of coronavirus disease 2019 (COVID-19). The worldwide transmission of COVID-19 from human to human is spreading like wildfire, affecting almost every country in the world. In the past 100 years, the globe did not face a microbial pandemic similar in scale to COVID-19. Taken together, both previous outbreaks of other members of the coronavirus family (severe acute respiratory syndrome (SARS-CoV) and middle east respiratory syndrome (MERS-CoV)) did not produce even 1% of the global harm already inflicted by COVID-19. There are also four other CoVs capable of infecting humans …

Why Covid-19 Transmission Is More Efficient And Aggressive Than Viral Transmission In Previous Coronavirus Epidemics?, Fatma Elrashdy, Elrashdy M. Redwan, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a pandemic of coronavirus disease 2019 (COVID-19). The worldwide transmission of COVID-19 from human to human is spreading like wildfire, affecting almost every country in the world. In the past 100 years, the globe did not face a microbial pandemic similar in scale to COVID-19. Taken together, both previous outbreaks of other members of the coronavirus family (severe acute respiratory syndrome (SARS-CoV) and middle east respiratory syndrome (MERS-CoV)) did not produce even 1% of the global harm already inflicted by COVID-19. There are also four other CoVs capable of infecting humans …

Granulins Modulate Liquid–Liquid Phase Separation And Aggregation Of The Prion-Like C-Terminal Domain Of The Neurodegeneration-Associated Protein Tdp-43, Anukool A. Bhopatkar, Vladimir N. Uversky, Vijayaraghavan Rangachari

Molecular Medicine Faculty Publications

TAR DNA-binding protein 43 (TDP-43) has emerged as a key player in many neurodegenerative pathologies, including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Hallmarks of both FTLD and ALS are the toxic cytoplasmic inclusions of the prion-like C-terminal fragments of TDP-43 CTD (TDP-43 C-terminal domain), formed upon proteolytic cleavage of full-length TDP-43 in the nucleus and subsequent transport to the cytoplasm. Both full-length TDP-43 and its CTD are also known to form stress granules by coacervating with RNA in the cytoplasm during stress and may be involved in these pathologies. Furthermore, mutations in the PGRN gene, leading to …

New Technologies To Analyse Protein Function: An Intrinsic Disorder Perspective, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Functions of intrinsically disordered proteins do not require structure. Such structure-independent functionality has melted away the classic rigid “lock and key” representation of structure–function relationships in proteins, opening a new page in protein science, where molten keys operate on melted locks and where conformational flexibility and intrinsic disorder, structural plasticity and extreme malleability, multifunctionality and binding promiscuity represent a new-fangled reality. Analysis and understanding of this new reality require novel tools, and some of the techniques elaborated for the examination of intrinsically disordered protein functions are outlined in this review.

Lung Cancer Cells Survive Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Exposure Through Upregulation Of Cholesterol Synthesis, Mark C. Howell, Ryan Green, Roukiah Khalil, Elspeth Foran, Waise Quarni, Rajesh Nair, Stanley Stevens, Aleksandr Grinchuk, Andrew Hanna, Shyam Mohapatra, Subhra Mohapatra

Molecular Medicine Faculty Publications

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide clinical benefits over chemotherapy for lung cancer patients with EGFR activating mutations. Despite initial clinical responses, long-term efficacy is not possible because of acquired resistance to these therapies. We have developed EGFR TKI drug-tolerant (DT) human lung cancer cell lines as a model for de novo resistance. Mass spectroscopic analysis revealed that the cytochrome P450 protein, CYP51A1 (Lanosterol 14α-demethylase), which is directly involved with cholesterol synthesis, was significantly upregulated in the DT cells. Total cellular cholesterol, and more specifically, mitochondrial cholesterol, were found to be upregulated in DT cells. We …

The Dual Pi3kδ/Ck1Ε Inhibitor Umbralisib Exhibits Unique Immunomodulatory Effects On Cll T Cells, Kamira Maharaj, John J. Powers, Alex Achille, Melanie Mediavilla-Varela, Wael Gamal, Karen L. Burger, Renee Fonseca, Kun Jiang, Hari P. Miskin, Dave Maryanski, Andrii Monastyrskyi, Derek R. Duckett, William R. Roush, John L. Cleveland, Eva Sahakian, Javier Pinilla-Ibarz

Molecular Medicine Faculty Publications

The in-clinic phosphatidylinositol 3-kinase (PI3K) inhibitors idelalisib (CAL-101) and duvelisib (IPI-145) have demonstrated high rates of response and progression-free survival in clinical trials of B-cell malignancies, such as chronic lymphocytic leukemia (CLL). However, a high incidence of adverse events has led to frequent discontinuations, limiting the clinical development of these inhibitors. By contrast, the dual PI3Kδ/casein kinase-1-ε (CK1ε) inhibitor umbralisib (TGR-1202) also shows high rates of response in clinical trials but has an improved safety profile with fewer severe adverse events. Toxicities typical of this class of PI3K inhibitors are largely thought to be immune mediated, but they are poorly …

Critical Media Literacy And Cultural Autonomy In A Mediated World, Bill Yousman, Lori Bindig Yousman

Communication, Media & The Arts Faculty Publications

We live in mediated worlds. Every waking hour of our lives finds us close, physically and mentally, to some sort of media content: Television, radio, movies, magazines, billboards, blogs, YouTube videos, websites, and social media like Facebook, Instagram, Twitter, Snapchat, TikTok, and Pinterest. Media scholars have been researching the ubiquitous role that media play in our lives for decades, but the current media environment is unlike any seen in history, as developments in digital technologies have produced a veritable onslaught of words, images, and sounds that can be accessed anywhere, at any time; all from a device that most of …