Digital Commons Network^™

Collagen Xii Is A Regulator Of Corneal Stroma Structure And Function, Mei Sun, Nabeel Zafrullah, Floriane Devaux, Chinda Hemmavanh, Sheila Adams, Noel M. Ziebarth, Manuel Koch, David E. Birk, Edgar M. Espana

Molecular Pharmacology & Physiology Faculty Publications

Purpose: The aim of this study was to determine the roles of collagen XII in the regulation of stromal hierarchical organization, keratocyte organization, and corneal mechanics.

Methods: The temporal and spatial expression of collagen XII at postnatal days 4, 10, 30, 90, and 150 were evaluated in wild-type (WT) mice. The role of collagen XII in hierarchical organization was analyzed by measuring fibril diameter and density, as well as stromal lamellar structure, within ultrastructural micrographs obtained from WT and collagen XII-deficient mice (Col12a1–/–). Keratocyte morphology and networks were assessed using actin staining with phalloidin and in vivo confocal …

Observations Of Water Transparency In China’S Lakes From Space, Dong Liu, Hongtao Duan, Steven Loiselle, Chuanmin Hu, Guoqing Zhang, Junli Li, Hong Yang, Julian R. Thompson, Zhigang Cao, Ming Shen, Ronghua Ma, Min Zhang, Weixiao Han

Marine Science Faculty Publications

Water transparency, usually denoted by Secchi disk depth (SSD), represents the first-order description of water quality and has important implications for the diversity and productivity of aquatic life. In China, lakes supply freshwater and ecosystem services to nearly a billion people. Therefore, real time monitoring of lake transparency is of great significance. Moreover, understanding how and why transparency varies in space and time in response to different driving forces is needed to understand, manage, and predict lake water quality. Based on the time-saving and low-cost Google Earth Engine cloud platform, this study developed a new algorithm for quickly mapping SDDs …

West Florida Shelf Pipeline Serves As Sea Turtle Benthic Habitat Based On In Situ Towed Camera Observations, Heather A. Broadbent, Sarah E. Grasty, Robert F. Hardy, Margaret M. Lamont, Kristen M. Hart, Chad Lembke, Jennifer L. Brizzolara, Steven Murawski

Marine Science Faculty Publications

The use of marine offshore benthic habitats by sea turtles is poorly characterized due to the difficulty of obtaining in situ data. Understanding benthic habitat use that is important to the species’ reproduction, foraging, and migrations is critical for guiding management decisions. A towed camera-based assessment survey system (C-BASS) equipped with environmental sensors was used to characterize and assess benthic habitats on the West Florida Shelf (WFS) from 2014 to 2018. During these cruises, sea turtles were opportunistically observed during the surveys, and critical in situ data such as spatiotemporal information, species identification, habitat use, behavior, and environmental data were …

Influence Of Cigarettes And Alcohol On The Severity And Death Of Covid-19: A Multicenter Retrospective Study In Wuhan, China, Mengyuan Dai, Liyuan Tao, Zhen Chen, Zhi Tian, Xiaofang Guo, Diane S Allen-Gipson, Ruirong Tan, Rui Li, Li Chai, Fen Ai, Miao Liu

All publications

Background: The recent emergence and rapid global spread of coronavirus disease 2019 (COVID-19) is leading to public health crises worldwide. Alcohol consumption and cigarette smoking (CS) are two known risk factors in many diseases including respiratory infections.

Methods: We performed a multi-center study in the four largest hospitals designated for COVID-19 patients in Wuhan. There are totally 1547 patients diagnosed with COVID-19 enrolled in the study, alcohol consumption and CS history were evaluated among these patients. The epidemiology, laboratory findings and outcomes of patients contracted COVID-19 were further studied.

Results: Our findings indicated that COVID-19 patients with a history of …

Comparative Analysis Of Covid-19 Guidelines From Six Countries: A Qualitative Study On The Us, China, South Korea, The Uk, Brazil, And Haiti, Ji Youn Yoo, Samia Valeria Ozorio Dutra, Dany Fanfan, Sarah Sniffen, Hao Wang, Jamile Siddiqui, Hyo-Suk Song, Sung Hwan Bang, Dong Eun Kim, Shihoon Kim, Maureen Groer

All publications

Background: In late January, a worldwide crisis known as COVID-19 was declared a Public Health Emergency of International Concern by the WHO. Within only a few weeks, the outbreak took on pandemic proportions, affecting over 100 countries. It was a significant issue to prevent and control COVID-19 on both national and global scales due to the dramatic increase in confirmed cases worldwide. Government guidelines provide a fundamental resource for communities, as they guide citizens on how to protect themselves against COVID-19, however, they also provide critical guidance for policy makers and healthcare professionals on how to take action to decrease …

Quantifying The Impact Of Covid-19 Control Measures Using A Bayesian Model Of Physical Distancing, Sean C. Anderson, Andrew M. Edwards, Madi Yerlanov, Nicola Mulberry, Jessica E. Stockdale, Sarafa A. Iyaniwura, Rebeca C. Falcao, Michael C. Otterstatter, Michael A. Irvine, Naveed Z. Janjua, Daniel Coombs, Caroline Colijn

All publications

Extensive non-pharmaceutical and physical distancing measures are currently the primary interventions against coronavirus disease 2019 (COVID-19) worldwide. It is therefore urgent to estimate the impact such measures are having. We introduce a Bayesian epidemiological model in which a proportion of individuals are willing and able to participate in distancing, with the timing of distancing measures informed by survey data on attitudes to distancing and COVID-19. We fit our model to reported COVID-19 cases in British Columbia (BC), Canada, and five other jurisdictions, using an observation model that accounts for both underestimation and the delay between symptom onset and reporting. We …

Development And Validation Of A Model For Individualized Prediction Of Hospitalization Risk In 4,536 Patients With Covid-19, Lara Jehi, Xinge Ji, Alex Milinovich, Serpil Erzurum, Amy Merlino, Steve Gordon, James B. Young, Michael W. Kattan

All publications

Background: Coronavirus Disease 2019 is a pandemic that is straining healthcare resources, mainly hospital beds. Multiple risk factors of disease progression requiring hospitalization have been identified, but medical decision-making remains complex.

Objective: To characterize a large cohort of patients hospitalized with COVID-19, their outcomes, develop and validate a statistical model that allows individualized prediction of future hospitalization risk for a patient newly diagnosed with COVID-19.

Design: Retrospective cohort study of patients with COVID-19 applying a least absolute shrinkage and selection operator (LASSO) logistic regression algorithm to retain the most predictive features for hospitalization risk, followed by validation in a temporally …

Modeling The Role Of Asymptomatics In Infection Spread With Application To Sars-Cov-2, Hana M. Dobrovolny

All publications

SARS-CoV-2 started causing infections in humans in late 2019 and has spread rapidly around the world. While the number of symptomatically infected and severely ill people is high and has overwhelmed the medical systems of many countries, there is mounting evidence that some of the rapid spread of this virus has been driven by asymptomatic infections. In this study, we use a compartmental mathematical model of a viral epidemic that includes asymptomatic infection to examine the role of asymptomatic individuals in the spread of the infection. We apply the model to epidemics in California, Florida, New York, and Texas, finding …

Implementation Of A Medical Student-Run Telemedicine Program For Medications For Opioid Use Disorder During The Covid-19 Pandemic, Marcus Castillo, Brianna Conte, Sam Hinkes, Megan Mathew, C J Na, Ainhoa Norindr, David P. Serota, David W. Forrest, Amar R. Deshpande, Tyler S. Bartholomew, Hansel E. Tookes

All publications

Objectives: The COVID-19 pandemic led to the closure of the IDEA syringe services program medical student-run free clinic in Miami, Florida. In an effort to continue to serve the community of people who inject drugs and practice compassionate and non-judgmental care, the students transitioned the clinic to a model of TeleMOUD (medications for opioid use disorder). We describe development and implementation of a medical student-run telemedicine clinic through an academic medical center-operated syringe services program.

Methods: Students advertised TeleMOUD services at the syringe service program on social media and created an online sign-up form. They coordinated appointments and interviewed patients …

Guidelines For Tms/Tes Clinical Services And Research Through The Covid-19 Pandemic, Marom Bikson, Colleen A. Hanlon, Adam J. Woods, Bernadette T. Gillick, Leigh Charvet

All publications

The COVID-19 pandemic has broadly disrupted biomedical treatment and research including non-invasive brain stimulation (NIBS). Moreover, the rapid onset of societal disruption and evolving regulatory restrictions may not have allowed for systematic planning of how clinical and research work may continue throughout the pandemic or be restarted as restrictions are abated. The urgency to provide and develop NIBS as an intervention for diverse neurological and mental health indications, and as a catalyst of fundamental brain research, is not dampened by the parallel efforts to address the most life-threatening aspects of COVID-19; rather in many cases the need for NIBS is …

The Impact Of Covid-19 On Hiv Treatment And Research: A Call To Action., Tiffany Chenneville, Kemesha Gabbidon, Patricia Hanson, Cashea Holyfield

All publications

The impact of the COVID-19 pandemic is far reaching, with devastating effects on individuals, communities, and societies across the world. People with chronic health conditions may be at greater risk of contracting or experiencing complications from COVID-19. In addition to illness or death for those who contract the virus, the physical distancing required to flatten the curve of new cases is having a negative impact on the economy, the effects of which intersect with mental health and other existing health concerns, thus affecting marginalized communities. Given that HIV also has a disproportionate impact on marginalized communities, COVID-19 is affecting people …

The Importance Of Research On The Origin Of Sars-Cov-2, Kenneth Lundstrom, Murat Seyran, Damiano Pizzol, Parise Adadi, Tarek Mohamed Abd El-Aziz, Sk. Sarif Hassan, Antonio Soares, Ramesh Kandimalla, Murtaza M. Tambuwala, Alaa A. A. Aljabali, Gajendra Kumar Azad, Pabitra Pal Choudhury, Vladimir N. Uversky, Samendra P. Sherchan, Bruce D. Uhal, Nima Rezaei, Adam M Brufsky

All publications

The origin of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus causing the COVID-19 pandemic has not yet been fully determined. Despite the consensus about the SARS-CoV-2 origin from bat CoV RaTG13, discrepancy to host tropism to other human Coronaviruses exist. SARS-CoV-2 also possesses some differences in its S protein receptor-binding domain, glycan-binding N-terminal domain and the surface of the sialic acid-binding domain. Despite similarities based on cryo-EM and biochemical studies, the SARS-CoV-2 shows higher stability and binding affinity to the ACE2 receptor. The SARS-CoV-2 does not appear to present a mutational “hot spot” as only the D614G mutation has …

Ångström- And Nano-Scale Pore-Based Nucleic Acid Sequencing Of Current And Emergent Pathogens, Britney A. Shepherd, Md Rubayat-E Tanjil, Yunjo Jeong, Bilgenur Baloğlu, Jingqiu Liao, Michael Cai Wang

All publications

State-of-the-art nanopore sequencing enables rapid and real-time identification of novel pathogens, which has wide application in various research areas and is an emerging diagnostic tool for infectious diseases including COVID-19. Nanopore translocation enables de novo sequencing with long reads (> 10 kb) of novel genomes, which has advantages over existing short-read sequencing technologies. Biological nanopore sequencing has already achieved success as a technology platform but it is sensitive to empirical factors such as pH and temperature. Alternatively, ångström- and nano-scale solid-state nanopores, especially those based on two-dimensional (2D) membranes, are promising next-generation technologies as they can surpass biological nanopores in …

Education Reforms For Inclusion? Interrogating Policy-Practice Disjunctions In Early Childhood Education In Bulgaria, Veselina Lambrev, Anna Kirova, Larry Prochner

Teaching and Learning Faculty Publications

This article examines how early childhood educators, as policy implementers, perceive reforms in Bulgaria’s education system that occurred between 2008 and 2018. Both Roma and non-Roma educators participated in this project that compares perceptions of Bulgarian teachers in public schools and Roma educators in informal educational settings operated by NGOs and religious institutions. Applying intersectionality as a framework, the study draws from anti-Romaism as a particular form of racism that militates against the inclusion of Roma to examine whether and to what extent discourses of minoritized and racialised children are evident in the views held by the Bulgarian educators, resulting, …

Broadening The Engineering Canon: How Culturally Responsive Pedagogies Can Help Educate The Engineers Of The Future, Bertrand Momo, Gordon D. Hoople, Diana A. Chen, Joel Alejandro Mejia, Susan M. Lord

School of Engineering: Faculty Scholarship

Point of view: We are a diverse group. Three of us are pre-tenure faculty members in a newly founded Integrated Engineering department that seeks to develop a more holistic and inclusive engineering pedagogy with SML as the only tenured (full) professor. The fifth member of our team, and lead au- thor, joined us in this endeavor while pursuing a Master’s in Peace Studies. BM is a Black male born in Cameroon with a background in the social sciences. GDH is a White male born in the USA who seeks to use this unearned privilege to help change the culture of …

Exploring Faculty And Student Frameworks For Engineering Knowledge Using An Online Card Sorting Platform, Diana A. Chen, Gordon D. Hoople, Nico Ledwith, Eric Burlingame, Seth D. Bush, Gregory E. Scott

School of Engineering: Faculty Scholarship

In this study we investigate how faculty and students think about engineering us-ing a technique new to engineering education: card sorting. In card sorting partic-ipants sort stimuli (cards) into groups, in the process revealing how they catego-rize information. Here we examine how both engineering faculty (n=23) and first-year undergraduate students (n=62) categorize engineering scenarios. We found engineering faculty sort based on cross-disciplinary engineering activities rather than engineering disciplines. This is a surprising result as our educational frameworks are based around disciplines, and yet they are not the primary way in which faculty think. First-year students, on the other hand, showed …

Balancing Complex Social And Technical Aspects Of Design: Exposing Engineering Students To Homelessness Issues, Diana A. Chen, Mark A. Chapman, Joel Alejandro Mejia

School of Engineering: Faculty Scholarship

This paper describes the development and implementation of a classroom experience involving problem-based and project-based learning with community engagement in an engineering design context. While most User-Centered Design courses ask students to critically analyze and synthesize user needs, particularly of users who they see as “not like them”, our version is unique in having students wrestle with concepts of power, privilege, and oppression alongside developing prototypes that address sociotechnical aspects of engineering design that are rarely discussed in engineering courses. The course project described in this paper was developed to integrate issues of homelessness with engineering design. To achieve this …

Growing Up Puerto Rican: College Students' Reality Of Staying In Puerto Rico Post-Maria, Bianca M. Pizarro Vázquez

Honors Undergraduate Theses

Puerto Rico has been under influence and colonial rule by the United States since the Spanish-American War of 1898. This has led the island to have partial and limited control over the affairs inside it. The passing of Hurricane Maria on September 20^th of 2017 exposed problems even further. Puerto Rico remains under the control of a Financial Oversight and Management Board since the passing of the PROMESA act (The Puerto Rico Oversight, Management, and Economic Stability Act) signed by President Barack Obama in 2016. This had forced Puerto Rico to make drastic cuts to its public services. One …

Models Of Perception: Lay Theories And Stigma Towards Alcohol Use Disorder, Tori L. Jansen

Honors Undergraduate Theses

Alcohol Use Disorder (AUD) has multiple health and social consequences which negatively affect individuals’ lives. However, the decision to utilize treatment is influenced by a variety of social factors. The stigma associated with AUD may impact individuals’ willingness to seek treatment after drinking is viewed as an issue. A highly stigmatized disorder, perceptions of AUD may be influenced by medical/moral lay theories, responsibility attributions and implicit theories. Once treatment is sought, support from others during the recovery process has been associated with treatment retention rates and success. Lay recovery beliefs, such as change perceptions, influence the amount of support offered …

Concerning The Continuation Of The Regulation Of Naturopathic Doctors, And, In Connection Therewith, Implementing Recommendations Contained In The 2019 Sunset Report By The Department Of Regulatory Agencies., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Environmental Monitoring Report: For Work Performed: July 1, 2019 Through June 30, 2020, Tennessee. Department Of Environment And Conservation

Environmental Monitoring Reports

This FY2020 EMR presents results for 16 independent projects, originally defined in TDEC’s FY2020 Environmental Monitoring Plan (EMP) and completed over the course of FY2020 period of performance.

Concerning Aligning State Statutes With Federal Law On Hemp, And, In Connection Therewith, Making An Appropriation., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Analyzing Citation Metrics In Civil Engineering With Focus On Construction Engineering And Management, Islam H. El-Adaway, Gasser G. Ali, Rayan Assaad, Amr Elsayegh, Ibrahim S. Abotaleb

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

There are several metrics used to evaluate academic publications, including number of citations, h-index, and others. While these metrics are directly related to rewards in the academic community, it is debated whether they correctly reflect the true impact of research. As such, there is a need to clearly interpret and understand such metrics. The goal of this paper is to investigate the citation metrics used to assess academic publications in civil engineering (CE) with a considerable focus on construction engineering and management (CEM). The investigation of these two research fields is important since each one of them has its own …

Winter 2020 Academic Calendar, Registrar Office

Academic Calendars of the NSU Registrar

No abstract provided.

Psilocybin-Assisted Psychotherapy: Treating Depression And Anxiety With Mushrooms, Sofia Beck

Physician Assistant Studies | Student Authored Articles

Depression and anxiety are debilitating mental health conditions that affect a large portion of the United States. Current pharmacological treatments for these disorders require daily administration, are associated with a number of side effects, and can be ineffective for some. Emerging evidence in novel treatment options may necessitate a shift toward how we treat these psychiatric disorders.

Studies involving the psychedelic serotonin agonist, psilocybin, are currently experiencing a resurgence as an alternative for patients who are unresponsive to traditional treatments. Clinical trials using psilocybin in combination with psychotherapy have demonstrated sustained reductions in depression and/or anxiety symptoms. When used in …

Anti-Hypochlorite, Antioxidant, And Catalytic Activity Of Three Polyphenol-Rich Super-Foods Investigated With The Use Of Coumarin-Based Sensors, Karolina Starzak, Tomasz Świergosz, Arkadiusz Matwijczuk, Bernadette Creaven, Janusz Podleśny, Dariusz Karcz

Articles

The anti-hypochlorite activity of açaí (Euterpe oleracea Mart.), goji (Lycium barbarum L.) and schisandra (Schisandra chinensis) fruit extracts were assessed by determining the reactive chlorine species (RCS)-scavenging ability of these three “super-food” berries. In addition, the aqueous extracts obtained were employed as both the media and the catalyst in a green chemistry approach to the synthesis of a coumarin-based fluorescence turn-off sensor, which was then used for anti-hypochlorite activity testing. The aqueous extracts were also assessed for total phenolic content (TPC), using the Folin–Ciocalteu method, and the antioxidant activity using the ABTS+• assay. Moreover, the main water-soluble polyphenolic constituents of …

Concerning The Colorado Water Conservation Board’S Authority To Use Water That A Water Right Owner Voluntarily Loans To The Board For Instream Flow Purposes., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Dicamba Retention In Commercial Sprayers Following Triple Rinse Cleanout Procedures, And Soybean Response To Contamination Concentrations, Frances B. Browne, Xiao Li, Katilyn J. Price, Jianping Wang, Yi Wang, Greg R. Kruger, Jeff Golus, Gabrielle De Castro Macedo, Bruno C. Vieira, Tyler Sandlin

Department of Agronomy and Horticulture: Faculty Publications

The commercial launch of dicamba‐tolerant (DT) crops has resulted in increased dicamba usage and a high number of dicamba off‐target movement complaints on sensitive soybeans (Glycine max L.). Dicamba is a synthetic auxin and low dosages as 0.028 g ae ha−1 can induce injury on sensitive soybean. Tank contamination has been identified as one of the sources for unintended sensitive crop exposure. The labels of new dicamba formulations require a triple rinse cleanout procedure following applications. Cleanout efficacy might vary based on the sprayer type and procedure followed. This study was performed to quantify dicamba retention in commercial sprayers and …

Improving On Modis Mcd64a1 Burned Area Estimates In Grassland Systems: A Case Study In Kansas Flint Hills Tall Grass Prairie, Rheinhardt Scholtz, Jayson Prentice, Yao Tang, Dirac Twidwell

Department of Agronomy and Horticulture: Faculty Publications

Uncertainty in satellite-derived burned area estimates are especially high in grassland systems, which are some of the most frequently burned ecosystems in the world. In this study, we compare differences in predicted burned area estimates for a region with the highest fire activity in North America, the Flint Hills of Kansas, USA, using the moderate resolution imaging spectroradiometer (MODIS) MCD64A1 burned area product and a customization of the MODIS MCD64A1 product using a major ground-truthing effort by the Kansas Department of Health and Environment (KDHE-MODIS customization). Local-scale ground-truthing and the KDHE-MODIS product suggests MODIS burned area estimates under predicted fire …

Analysis Of Student Perceptions Of Just-In-Time Teaching Pedagogy In Pharmd Microbiology And Immunology Courses, Charitha Madiraju, Eglis Tellez-Corrales, Henry Hua, Jozef Stec, Andromeda M. Nauli, Deborah M. Brown

Nebraska Center for Virology: Faculty Publications

Just-In-Time Teaching (JiTT) active learning pedagogy is utilized by various disciplines, but its value in a professional pharmacy curriculum has not yet been demonstrated. The purpose of our research study is to implement and evaluate JiTT in a Doctor of Pharmacy (PharmD) program. The impetus in implementing JiTT into a PharmD curriculum was to provide students with an out-of-classroom learning opportunity to enhance knowledge-based skills. The current study summarizes the implementation of JiTT in four distinct instances: two iterations of the required courses “Integrated Microbiology and Virology” (Fall 2016 and Fall 2017) and “Integrated Immunology” (Winter 2016–2017 and Winter 2017–2018). …