Digital Commons Network^™

Sentenced To Child Welfare: How States Seeking Placement And Services For Justice-Involved Youth Fail To Protect The Rights Of Parents And Create "Reverse" Crossover Youth, Christina Cullen

Children's Legal Rights Journal

No abstract provided.

Reassessment Of The Triassic Archosauriform Scleromochlus Taylori: Neither Runner Nor Biped, But Hopper, S. Christopher Bennett Ph.D.

Biological Sciences Faculty Publications

The six known specimens of Scleromochlus taylori and casts made from their negative impressions were examined to reassess the osteological evidence that has been used to interpret Scleromochlus’s locomotion and phylogenetic relationships. It was found that the trunk was dorsoventrally compressed. The upper temporal fenestra was on the lateral surface of skull and two-thirds the size of the lower, the jaw joint posteriorly placed with short retroarticular process, and teeth short and subconical, but no evidence of external nares or antorbital fossae was found. The posterior trunk was covered with ~20 rows of closely spaced transversely elongate dorsal osteoderms. The …

How Cellular Metabolic State And The Chaperone Protein Hsp104 Interact To Affect The Spontaneous Formation Of The Yeast Prion [Ure3], Demyia Graham

Merge

No abstract provided.

Beyond Culture: Reimagining The Adjudication Of Indigenous Peoples' Rights In International Law, Beatriz Garcia, Lucas Lixinski

Intercultural Human Rights Law Review

This article argues that the current model of Indigenous rights adjudication foregrounds essentialized notions of culture, backgrounding interests of Indigenous peoples (IPs) that are not necessarily related to culture. Culture imposes a burden that limits the possibilities of human rights for Indigenous peoples, which is at least in part attributable to the current model's lack of precision. We show that the jurisprudence on IP rights by international adjudicatory bodies focuses on culture without meaningful attempts to explain and define it, is imprecise on how culture affects the reading of the human right for which it serves as the basis, as …

Investigating The Effects Of Cyppa On Small-Conductance Calcium-Activated Potassium Channels In Sod1g93a Transgenic Mouse Model, Matthew M. Murphy

Browse all Theses and Dissertations

Amyotrophic Lateral Sclerosis is a fatal, progressive, neurodegenerative disease. There currently is no cure for the disease and limited treatment options have modest effects. A hallmark of the disease is motoneuron degeneration. Within the membrane of motoneurons are small-conductance calcium-activated potassium channels. SK Channels function to mediate medium afterhyperpolarization period of an action potential and have substantial influence on the firing rate of motoneurons. SK channels, specifically SK2 and SK3 isoforms, have been shown through immunohistochemistry to be affected in the SOD1G93A mouse model. The goal of this study was to investigate whether neonatal administration of CyPPA, a potent SK2 …

Genetic Analysis Of Snow Leopard Population Employing Next Generation Sequencing For Its Improved Conservation And Management, Safia Janjua

Browse all Theses and Dissertations

Snow leopards (Panthera uncia) are an enigmatic, high-altitude species whose challenging habitat, low population densities and patchy distribution have presented challenges for scientists studying its biology, population structure, and genetics. To address these important ecological, conservation, and evolutionary questions, scientists are tailoring laboratory and computational methods to better extract the information from non-invasive samples, only available source of DNA for this species. These samples with very low quantity and quality of DNA, present unique methodological challenges. ddRAD-seq, one of next generation sequencing method is used here to develop reference sequence library for snow leopard using five blood samples from Mongolian …

Achievable Toilet Sanitation, Benjamin Goulart

Master of Public Health Program Student Publications

Human feces contains ten million viruses, one million bacteria, and 1,000 parasitic cysts, contributing to cholera, diarrhea, dysentery, hepatitis A, typhoid, polio, and various neglected tropical diseases (The Economist, 2019). Unimproved sanitation includes open defecation, shared latrines that lack privacy, or other sanitation methods with insufficient pathogen reduction of fecal material. The most affected regions are sub-Saharan Africa, Southern and Eastern Asia, Afghanistan, and Iraq (CDC, 2016). Without private toilets, girls reaching puberty are also less likely to continue school. Improved sanitation can contribute to increased human potential, human rights, and gross domestic product.

Protocol Development And Optimization For Rnls Mouse Characteristic Assessment, Hasan Farid

Browse all Theses and Dissertations

Protocol development and optimization are vital in the scientific method process. By having accurate protocols, one can properly assess the characteristics of their animal model for any given experiment. One animal newly adopted in our lab was the novel regulatable nuclear localization sequence (rNLS) mouse model. This novel mouse model displays symptoms of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD), after the accumulation of the hTDP-43 (TAR DNA-binding protein 43) aggregate in the central nervous system. The expression of this protein occurs after the removal of deoxycycline from the mouse’s food source. Once the removal of the drug, this …

Low Dose Uv-B Induced Keratinocyte Exosomes Protect Schwann Cells Against High Glucose Injury, Kartheek Pothana

Browse all Theses and Dissertations

In this study, we tested the protective effect of UV-B treated HG-HaCaT-Exos on Schwann cells (SCs) injured by HG (high glucose) model. At first, we determined the dose of UV-B radiation and the time for the release of HaCaT-Exos. Furthermore, the Schwann cells were injured through the HG model, isolated by ultracentrifugation from the HaCaT cell culture supernatant were co-incubated within the injured cells. It was found that UV-B treated HaCaT-Exos decrease apoptosis and increase the viability of injured SC by transferring miR-222 from HaCaT cells to them via exosomes, hence protecting them.

The Pulse: College Of Health Sciences E-Newsletter, Irvin B. Harrell (Editor)

Ellmer College of Health Sciences Newsletters

January 2020 issue of Old Dominion University's College of Health Sciences Newsletter.

Topography And Disturbance Influence Trait‐Based Composition And Productivity Of Adjacent Habitats In A Coastal System, Joseph K. Brown, Julie C. Zinnert

Biology Publications

Coastal systems experience frequent disturbance and multiple environmental stressors over short spatial and temporal scales. Investigating functional traits in coastal systems has the potential to inform how variation in disturbance frequency and environmental variables influence differences in trait‐based community composition and ecosystem function. Our goals were to (1) quantify trait‐based communities on two barrier islands divergent in topography and long‐term disturbance response and (2) determine relationships between community trait‐based composition and ecosystem productivity. We hypothesized that locations documented with high disturbance would have habitats with similar environmental conditions and trait‐based communities, with the opposite relationship in low‐disturbance locations. Furthermore, we …

Gut Microbiome And Opioid-Induced Analgesic Tolerance, Sach D. Thakker, Karan H. Muchhala

Biology Publications

The gut microbiome plays an important role in maintaining health and homeostasis. Chronic usage of opioids leads to microbial dysbiosis in the gut. This dysbiosis leads to several severe diseases such as irritable bowel syndrome (IBS), diabetes, cancer, and obesity. Here, we discuss the literature on how opioids affect the gut-microbiome axis and how these changes alter the ability of morphine to produce analgesic tolerance. Chronic morphine exposure leads to increases in gut permeability due to disruption of tight junction proteins and increases in inflammation due to release of proinflammatory cytokines, both of which promote tolerance to morphine. Additionally, it …

Icipe Annual Report 2020, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Insects For Life – A Brief History Of Icipe@50, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Do We Need More Productive Theorizing? A Commentary, David Reinking, David B. Yaden Jr.

Publications

In this commentary, we argue that literacy research would be more produc- tive if researchers had a clearer, more nuanced understanding of theory. Specifically, we argue that theory in a practice-oriented field is most fun- damentally productive when it provides instrumental guidance for literacy beyond academic understanding about literacy. Premises for that argument are presented, as well as how productivity connects to an instrumental view of theory within the philosophy of science. We provide examples from au- thoritative sources and relevant studies suggesting that conceptions and uses of theory in literacy research are ambiguous, diffuse, and incoherent. We argue that …

Is Hyperbaric Oxygen Therapy Effective For Treating Autism?, Malky Meyer

The Science Journal of the Lander College of Arts and Sciences

Autism spectrum disorder (ASD) is characterized as a developmental disability caused by abnormalities in brain function. Studies link ASD with various physiological abnormalities, such as cerebral hypoperfusion, oxidative stress, inflammation, and mitochondrial dysfunction. Studies show that diminished blood flow to the brain demonstrates a connection between several core autistic behaviors, and the hypoperfusion generally worsen with age, growing more prevalent in older children. Although hyperbaric oxygen therapy (“HBOT”) is not yet approved by the United States Food and Drug Administration ) (“FDA”), several studies performed internationally have proven its efficacy in treating people with autism. Even so, the FDA does …

Parkinson’S Disease: Causes, Symptoms, Research, And Interventions, Alexander Labkowsky

The Science Journal of the Lander College of Arts and Sciences

This paper covers several pathogenic theories of Parkinson’s disease (PD); the physiology and biological pathways involved. This includes a mitochondrial DNA (mtDNA) route, a nuclear DNA route, and other hypotheses about idiopathic PD. The subsequent discussion of PD symptoms utilizes a neurological perspective, analyzing the neuroanatomical systems involved, and how they are treated. This includes medications and surgical techniques that are employed in an effort to manage symptomatology and increase health-related quality of life.

Maximizing Effectiveness Of Palliative Radiotherapy In Terminal Cancer Patients, Sarah Bifano

Student Research Poster Presentations 2020

Radiation therapy is utilized to treat tumor cells with high-dose radiation. When the severity of the cancer progresses, the goal of radiation therapy becomes relief of symptoms. This is referred to as palliative radiotherapy. Palliative radiotherapy can be futile if not administered efficiently. There is a recurring question of how to achieve optimal palliative radiotherapy for patients. This research evaluates the most effective factors to optimize treatment, such as proper patient selection and effective timing. A guideline for treatment selection based upon patient performance status, severity of symptoms, progression of cancer, and metastasis of cancer is formed. The sooner a …

Floods, Fires And A Pandemic...Oh My!, Melanie Dowling

Student Research Poster Presentations 2020

No abstract provided.

Supine Vs. Prone Positioning For Breast Radiation, Jennifer Curtin

Student Research Poster Presentations 2020

When treating breast cancer patients with radiation therapy, it is important to find treatment techniques that reduce the dose to organs at risk without compromising the target tumor volume. Due to advances in cancer diagnosis, patients are diagnosed and treated earlier causing them to live longer. However, these patients are at greater risk for developing long-term complications from treatment, specifically cardiac toxicity and cardiac diseases. Research was evaluated regarding the best treatment position for breast cancer patients to reduce the dose to organs at risk, focusing on the dose to the heart. Every breast cancer patient varies in breast anatomy, …

The Effects Of Rolipram, A Selective Phosphodiesterase Inhibitor, On Immortalized Schwann Cell Proliferation, Kyle Kenney, Amanda Bohn, Angela Asirvatham

Student Research Poster Presentations 2020

The regulation of Schwann cell growth in vitro is facilitated by heregulin, a neuron-secreted growth factor, and an unknown mitogen that activates the cyclic adenosine monophosphate (cAMP) pathway. The quantity of cAMP available to Schwann cells can determine if they become a myelinating or proliferating phenotype. The abundance of intracellular cAMP available to the cell is widely regulated by a family of enzymes called phosphodiesterases (PDEs). PDE inhibitors such as rolipram have therapeutic potential in various disorders and function by increasing the levels of cAMP in the cell. This study was undertaken to determine the concentration of rolipram that would …

Chemistry In Medicine, Olivia Visaggio, Alyssa Bondi, Matthew Gillingham, Hailey Loughlin

Student Research Poster Presentations 2020

The chemistry behind medicine is important and necessary to study many different drugs and their effects. In this project, we focused on the chemical composition and mechanisms of various drugs. The drugs we focused on include Opioids, NSAIDs, and other medications, such as Benzodiazepines and antibiotics. For each drug, we provided its structure as well as the functional groups, which include a part of a molecule that is recognized based on its arrangement of atoms. Organic Chemistry provides individuals with an understanding of various organic compounds, and this field of study is important as it explains the ways in which …

Advancement Of Predictive Modeling Of Zeta Potentials (Ζ) In Metal Oxide Nanoparticles With Correlation Intensity Index (Cii), Andrey A. Toropov, Natalia Sizochenko, Alla P. Toropova, Danuta Leszczynska, Jerzy Leszczynski

Articles

It was expected that index of the ideality of correlation (IIC) and correlation intensity index (CII) could be used as possible tools to improve the predictive power of the quantitative model for zeta potential of nanoparticles. In this paper, we test how the statistical quality of quantitative structure-activity models for zeta potentials (ζ, a common measurement that reflects surface charge and stability of nanomaterial) could be improved with the use of these two indexes. Our hypothesis was tested using the benchmark data set that consists of 87 measurements of zeta potentials in water. We used quasi-SMILES molecular representation to take …

Atomic Force Microscopy (Afm) As A Surface Mapping Tool In Microorganisms Resistant Toward Antimicrobials: A Mini-Review, Zuzanna Grzeszczuk, Antoinette Rosillo, Oisin Owens, Sourav Bhattacharjee

Other resources

The worldwide emergence of antimicrobial resistance (AMR) in pathogenic microorganisms, including bacteria and viruses due to a plethora of reasons, such as genetic mutation and indiscriminate use of antimicrobials, is a major challenge faced by the healthcare sector today. One of the issues at hand is to effectively screen and isolate resistant strains from sensitive ones. Utilizing the distinct nanomechanical properties (e.g., elasticity, intracellular turgor pressure, and Young’s modulus) of microbes can be an intriguing way to achieve this; while atomic force microscopy (AFM), with or without modification of the tips, presents an effective way to investigate such biophysical properties …

A Comparative Study Of Cadworx Plant 2018 And Revit 2020 With Ez-Iso Add-In, For The Production Of Piping Isometrics, Bim Tudublin, Killian Lynch

Capstone Reports

BIM software evaluation and selection is a complex process. In this paper, a comparative study of Revit 2020 with Ez-ISO add-in, and CADWorx Plant 2018, was carried out. The aim of this study was to determine if a MEP contractor could consolidate software usage into one package, thereby reducing costs for pipework modelling and isometric production. A comprehensive evaluation was developed based on a literature review. A multicriteria decision-making method was used in conjunction with the software evaluation to ensure sound choices were made. An online survey of senior BIM professionals was conducted to validate the analysis and findings. The …

Holographic Security, Vincent Toal

Books/Book Chapters

This chapter is concerned with the security applications of holographic techniques. Holograms are used in product authentication, product branding and brand protection, and personal and other documents. Serialization to ensure the uniqueness of each hologram for added security is briefly discussed. The theory of optical character recognition and joint transform correlation methods is outlined. Holographic recording using encrypted reference waves enables secure storage of information. Several methods are considered for encrypting optical data as well as holographic recording of encrypted images and their reconstruction and decryption. Millimeter and microwave holographic imaging techniques for the detection of hidden contraband, narcotics, firearms, …

Grano Restaurant Menus 2020, Grano Restaurant

Menus of the 21st Century

An Italian mother shephered this brilliant Stoneybatter restaurant into being in the depths of an Irish winter when she flew in with a suitcase of still grass stems for rolling the handmade fileja pasta. Robert Mungo's mother has gone home, but her stamp remains, and Grano has been the best addition to Stoneybatter since L Mulligan Grocer opened its door.

Temporal Mercies And Eternal Being: Using The Science Of Time To Understand God’S Nature And Our Own, Jared R. Stenson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

How does God relate to time? How do we? Modern science and revelation offer distinctive and fascinating perspectives to these questions. Specifically, the physical mechanisms underlying time have doctrinal parallels, they appear to be operative at the Fall, and they correlate with several phenomena that make God’s mercy possible.

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.

Farming With Nature: Promoting Biodiversity Across Europe Through Partridge Conservation, Jen Brewin, Francis Buner, Julie Ewald

Galliformes Specialist Group and Affiliated Societies: Reports and Other Materials

A summary of scientific evidence underlying the North Sea Region Interreg PARTRIDGE project, https://northsearegion.eu/partridge.

This publication describes how grey partridge conservation helps to address the farmland biodiversity crisis across Europe. It summarises the most relevant scientific evidence regarding grey partridge management and the biodiversity benefits associated with it. We have selected what we felt were the best and most thorough studies and papers available. We cite high-impact peer-reviewed papers wherever possible, relying on our combined experience and expertise to quote non-reviewed reports where published papers were unavailable.