Digital Commons Network^™

On Coupled Reaction Diffusion Equations And Their Applications, Juan J. Huerta

Theses and Dissertations

Reaction-diffusion equations are nonlinear partial differential equations that have been used extensively in mathematical modeling. An interesting case in this type of equation is the Fisher-Kolmogorov system, which has been used to study a low-grade glioma, a group of primary brain tumors. In the first part of this thesis, a stochastic version of the Fisher-Kolmogorov system will be studied, and exact and numerical solutions will be presented.

The second part of this thesis will show how the speed of information propagation affects disease spread and vaccination uptake through networks in epidemics. In this model, the information reaches different people at …

Incorporation Of Native Plants For Biodiversity Conservation In South Texas Agroecosystems, Kaitlynn M. Lavallee

Theses and Dissertations

I address the concerning disconnect between food production and regenerative ecological principles. First, understanding the foundational processes of seed-dormancy and germination are essential for successful restoration efforts using native species. We examine four common seed treatments (aerated hydroprime, acid scarification, cold stratification, sand scarification) on twelve commercially available species native to south Texas. Pappophorum bicolor Fourn. (pink pappusgrass) was sown in the field with the aerated hydroprime treatment, D. virgatus (Willd.) B.L. Turner (prostrate bundleflower) was planted after sand scarification treatment, and Ratibida columnifera (Nutt.) Woot. & Standl. (Mexican hat) was seeded without treatment. Small-scale field trials were conducted to …

Examining The Indoctrination Of Mexican American Criminal Justice Students, Noe Leal Jr.

Theses and Dissertations

Mexican American Criminal Justice students (MACJS) sometimes select a career in Department of Homeland Security, which has a history of systemic racism and oppression. The purpose of this thesis is to examine MACJS conformity to U.S. ideological hegemony and examine the differences in their understanding of human rights/ethics. A questionnaire was administered to MACJS (n = 156) wishing to pursue a career in DHS. The survey instrument used is based on the concepts of Social Identification: Mexican versus U.S. American; Support for Nationalist Racist Policies, Internal Colonialism, Followership by engaging in policies/orders by the government; and Human Rights: Knowledge of …

A Darker Shade Of Gray: An Empirical Examination Of Gray Swans In The Supply Chain, Tony N.K. Lynch

Theses and Dissertations

The complexity and interconnectedness of markets creates risks in the global supply chain and may lead to various types of disruptions. Prior research in the supply chain management literature has focused on some aspect of disruption and firm performance. However, the effect of Gray Swans on various aspects of firms’ operational or financial performance is an under-research area. Understanding why managers often underestimate and overlook Gray Swans contributes to ongoing conversation of risk in the global supply chain. Gray Swans are defined as low probability risk events that if/when they occur can have a severe or catastrophic impact on a …

Electromagnetic Interference Shielding Effectiveness Of Interlayered Systems Containing Metal-Oxide, Conducting Polymer And Carbon Nanotube Reinforced Polymeric Composites, Shaik Merkatur Hakim Marjuban

Theses and Dissertations

The Electromagnetic Interference (EMI) Shielding Effectiveness (SE) has become one of the important requirements for the devices associated with telecommunication systems consisting of large frequency bands. The degradation of the quality of transmitting signal influenced by frequencies emitting from external sources can be reduced by covering the circuits of the devices by EMI Shielding materials like polymer composites, metal-based nanofiber mats, the metal of oxide films, etc. The investigation strives for the attenuation of EMI by introducing two composite mats from conducting polymer-based, multiwalled carbon nanotubes (MWCNTs) coated Nylon 6 nanofiber composites. Two other composite mats are also developed by …

Association Study: Apoe Alleles Association With Neurodegenerative Disorders In The Hispanic Population, Kimberly Moreno

Theses and Dissertations

The purpose of this study was to assess the impact of phenotypic variables and Apolipoprotein E (APOE) alleles and its effect on cognitive statues. APOE is a gene found vastly in the Hispanic community, speculated to be linked to neurodegenerative disorders such as Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). Compared demographic, clinical, and genetic features among Hispanics who were diagnosed with Alzheimer's Disease, Mild Cognitive Impairment, and psychiatric disorders (e.g., anxiety and depression) in the efforts to assess the role of APOE. In past research, APOE has been considered a pathological hallmark for neurological diseases.

Past research has …

Thermal And Spectroscopic Investigations On Polymer-Based Nanofibers, Omosola Oriretan

Theses and Dissertations

Nanofibers of Poly (ethylene oxide), PEO, Poly (vinylpyrrolidone) PVP, Co-nanofiber of PEO-PVP and PEO nanocomposite of various Fullerene compositions were prepared by dissolving PEO, PVP and Fullerene in water. The Fullerene nanoparticles were added to the PEO solutions, the mixtures were homogenized under high power sonication. The PEO solutions, PVP solutions, the co-polymer solutions of PEO-PVP and the PEO -Fullerene solutions were centrifugally spun using Force spinning™ machine. The obtained nanofibers and the nanocomposites were subjected to FTIR analysis, Raman analysis and various heating and cooling cycles with heating and cooling rates ranging from 10C/min to 600C/min using differential scanning …

Infection And Persistence Of Zika Virus In Female Immune-Competent Gray Short-Tailed Opossums (Monodelphis Domestica), Oscar Quintanilla

Theses and Dissertations

Zika virus (ZIKV) is a class IV RNA virus transmitted by Aedes species of mosquitoes. It produces flu-like symptoms, but recent studies have associated additional, more severe pathologies with ZIKV like microcephaly. Currently, no effective treatment options or vaccines exist. This is partly due to limitations of current animal models. Monodelphis domestica (the gray short-tail opossum) may serve as a proper model for ZIKV research. Here we test the susceptibility of M. domestica to ZIKV infection. Female, immune-competent subjects were injected with live ZIKV and analyzed serologically and histologically for evidence of ZIKV replication. ELISAs performed on sera confirmed that …

Chemical Modification And In Silico Validation Of Medicinally Privileged Molecular Scaffolds As Kras And Sars-Cov-2 Protease Inhibitors, Precious M. Okwuchukwu

Theses and Dissertations

Coronavirus disease was declared a global pandemic by WHO in March 2020, cancer is the second leading cause of death by a disease. Several scientists around the world are working relentlessly to discover an effective remedy to eradicate these deadly diseases. A natural polyphenol (magnolol) has been isolated from a tree Magnolia grandiflora (family Magnoliaceae) found on UTRGV campuses. This research is focused on design of a series of chemically modified sulfonyl derivatives based on the isolated magnolol framework and other medicinally privileged molecular scaffolds framework that can effectively bind to the COVID-19 main protease, SARS- CoV-2 3CL protease …

Effects Of Elevated Temperature On 8-Hydroxy-2'-Deoxyguanosine Expression, Dna Damage And Cellular Apoptosis In The American Oyster (Crassostrea Virginica), Md Faizur Rahman

Theses and Dissertations

Global temperature increases due to anthropogenic activities. The effects of rising temperature are well documented in aquatic organisms. The American oyster is an ideal shellfish species to study on global warming and oxidative DNA damage. In this study, We observed the effects of high temperature on heat shock protein-70 (HSP70), 8-hydroxy-2’-deoxyguanosine (8-OHdG), ssDNA, dsDNA, caspase-3 (CASP3), BAX and γH2AX, a molecular marker of DNA damage, protein expressions in gills of oysters. Immunohistochemical results showed that elevated temperatures (28 and 32°C) significantly increased HSP70, 8-OHdG, dsDNA, γH2AX, BAX and CASP3 protein expressions in gills of oysters compare to control (24°C). In …

Fabrication And Flow Dynamics Analysis Of Micromixer For Lab-On-A-Chip Devices, Md Fazlay Rubby

Theses and Dissertations

The miniaturized systems designed for lab-on-a-chip (LOC) technologies are generally implemented with a micro-scale mixer to provide intimate contact between the reagent molecules for interactions and chemical reactions. The exponential increase of research in microfabrication and microfluidic applications highlights the importance of understanding the theory and mechanism that governs mixing at the microscale level. In this study, the fabrication of an active and passive micromixer was discussed. The optimized state of art soft lithography and 3D printing was used as a microfabrication technique. The challenges at different fabrication steps were presented along with the modifications. Microelectrodes were integrated with the …

Role Of Glycolytic Metabolism In Glioblastoma Multiforme, Shreya Udawant

Theses and Dissertations

PI3K/AKT/mTOR signaling pathway is activated in 90% of all Glioblastoma Multiforme (GBM) tumors. We used a dual targeting approach to interfere with the phosphoinositide 3-kinase- mammalian target of rapamycin (PI3K-mTOR) pathway by treating U87MG GBM cells with NVP-BEZ235 (PI3K and mTOR a dual inhibitor) and, their downstream effects on molecular regulation on glycolytic genes were investigated using RNA-sequencing and gene set enrichment analysis (GSEA). RNA-seq identified 7803 differentially regulated genes in response to NVP-BEZ235. GSEA identified two glycolysis-related gene sets had significant differences (P < 0.05) in gene expression between control and NVP-BEZ235 treated samples. The GSEA core enrichment reported 17 and 35 genes were significantly downregulated (P adj < 0.05) in response to NVP-BEZ235 treatment in two different glycolysis related gene sets. We validated the expression of genes using qRT-PCR in U87MG cells as well as other GBM cell lines. Our results suggest novel insights on hallmark metabolic reprogramming associated with the PI3K-mTOR inhibition and provides advances in developing molecular targeted therapies.

Field Of Dreams: Environmental Factors Contributing To The Academic And Professional Success Of Mexican-American Former Migrant Students From The Rio-Grande Valley Of South Texas, Jaime Villarreal

Theses and Dissertations

The purpose of this study was to identify protective factors contributing to the college graduation of seven Mexican-American Hispanic former migrant students from the Rio-Grande Valley of South Texas, the southernmost part of the United States that borders Mexico. I used a case study methodology to examine the real life context of a phenomenon with the data collected from the seven participants using interviews. The findings indicated that interrelated cultural, school and home environmental protective factors enhanced the resiliency of the seven participants as they navigated through their academic endeavors and ultimate college graduation. This study is important to the …

Stem Cell Technology For Age Related Macular Degeneration Intervention, Laura Valdez

Theses and Dissertations

The main focus of this thesis is to study RPE cell derived from IMR90 induced pluripotent stem cells in various physiological conditions mimicking RPE transplantation rejection. Retinal pigmented epithelium (RPE) cells are located between the choroid and photoreceptors in the eye and they are essential to provide nutrients from blood to rods and cones, as well retinoids of the visual cycle. Vision loss and various ocular diseases are attributable to the degeneration or dysfunction of the RPE cells, leading to blindness. One of the major ocular problem from RPE dysfunction is macular degeneration. Age-related macular degeneration (AMD) can be frequently …

Pre-Entrance Factors And Student Success In An A.A.S. Nursing Program, Connie Marshall

Electronic Theses and Dissertations

The purpose of this study was to evaluate the relationship of pre-entrance factors and the success of students in an Associate of Applied Science (A.A.S.) degree nursing program at a community college in East Tennessee. The criterion variable was success in the nursing program. Success was defined as academic success in all nursing courses and completion of the nursing program to graduation. The predictor variables of pre-entrance factors were gender, age, Health Education Systems, Incorporated (HESI) A2 scores, Pell Grant eligibility, pre-nursing GPA, and prior licensure. The data for this non-experimental secondary analysis were derived from the electronic database in …

Pre-Transplant Marital Status And Hematopoietic Cell Transplantation Outcomes., J Tay, S Beattie, C Bredeson, R Brazauskas, N He, Ibrahim A. Ahmed, M Aljurf, M Askar, Y Atsuta, S Badawy, A Barata, A M Beitinjaneh, N S Bhatt, D Buchbinder, J Cerny, S Ciurea, A D'Souza, J Dalal, N Farhadfar, C O Freytes, S Ganguly, U Gergis, S Gerull, H M Lazarus, T Hahn, S Hong, Y Inamoto, N Khera, T Kindwall-Keller, R T Kamble, J M Knight, Y N Koleva, A Kumar, J Kwok, H S Murthy, R F Olsson, M Angel Diaz-Perez, D Rizzieri, S Seo, S Chhabra, H Schoemans, H C Schouten, A Steinberg, K M Sullivan, J Szer, D Szwajcer, M L Ulrickson, L F Verdonck, B Wirk, W A Wood, J A Yared, W Saber

Manuscripts, Articles, Book Chapters and Other Papers

Background: Evidence about the impact of marital status before hematopoietic cell transplantation (hct) on outcomes after hct is conflicting.

Methods: We identified patients 40 years of age and older within the Center for International Blood and Marrow Transplant Research registry who underwent hct between January 2008 and December 2015. Marital status before hct was declared as one of: married or living with a partner, single (never married), separated or divorced, and widowed. We performed a multivariable analysis to determine the association of marital status with outcomes after hct.

Results: We identified 10,226 allogeneic and 5714 autologous hct cases with, respectively, …

The Effect Of Deer Browse On Achyranthes Japonica, Nicholas R. Seaton

Theses

AN ABSTRACT OF THE THESIS OFNicholas Seaton, for the Master of Science degree in Plant Biology, presented on December 4, 2019 at Southern Illinois University Carbondale. TITLE: THE EFFECT OF DEER BROWSE ON ACHYRANTHES JAPONICAMAJOR PROFESSOR: Dr. David GibsonPlants respond in many ways to damage. These responses vary between sites depending on the severity and duration of the incident. One common form of damage in the forest understory is herbivory or browse. White tailed deer (Odocoileus virginianus) have been observed to change the dominant species of forests by selectively browsing palatable species in the understory. These changes in species dominance …

Differentiating Between Invasive And Native Populations Of Bighead And Silver Carp Using Ms-Aflp, Erika Renee Sarvela

Theses

When a species is introduced outside their native range, the genetic diversity of the introduced population is generally decreased due to the founder effect, and the fitness of individuals in the introduced population may decrease due to inbreeding depression. Invasive species are a paradox to this paradigm because while the initial population size of an invasive species may be small in their non-native range, the individuals are able to survive, eat, and reproduce so successfully, that they have deleterious effects on native species. One mechanism that invasive species use to overcome a lack of genetic diversity and adapt to their …

Identification Of Micrornas Related To Type 2 Diabetic Osteopath, Mouza Mohammed Saeed Alfashti Alaleeli

Theses

T2DM is linked to an increase in the fracture rate as compared to the non-diabetic population even with normal or raised Bone Mineral Density (BMD). Previous studies have addressed the question of how T2DM induces osteoporosis; the exact underlying mechanism is still elusive. Bones undergo continuous remodelling throughout life. Bone remodelling implicates the coupling of osteoclastic bone resorption and osteoblastic bone formation. This process is controlled by numerous genetic, hormonal, and neurogenic mechanisms. Osteoporosis is a result of bone loss that occurs by uncoupled remodelling. The existing evidence indicates that short non-coding RNAs known as microRNAs (miRNAs), are the key …

Design, Synthesis And Antibacterial Studies Of Some New Pyridopyrimidine Derivatives As Biotin Carboxylase Inhibitors, Vivek B. Panchabhai, Parag G. Ingole, S R. Butle

Bulletin of Faculty of Pharmacy Cairo University

Present study reports the development of novel pyridopyrimidine derivatives as biotin carboxylase inhibitors with potent antibacterial activity. These compounds were designed to avoid possibility of resistance development. Accordingly eighteen compounds were synthesised and characterized on the basis of spectral data. These compounds were tested for their antibacterial potential by the enzyme kinetic assay against the biotin carboxylase. The minimum inhibitory concentration (MIC) and single step resistance studies were also performed. Compound 2-((2-Phenylpyrido[2,3-d]pyrimidin-4-yl)amino)phenol (6o) showed promising activity in biotin carboxylase inhibition with low MIC. It showed molecular docking score of -7.96, this compound showed formation of hydrogen bonds with the active …

Does Socioeconomic Status Influence Students’ Postsecondary Plans?, Brian A. Young

Dissertations

The purpose of this study was to examine whether or not socioeconomic status (SES) influenced high school students’ plans for continuing their learning after high school. This study collected data via an online survey and a sample size of 343 participants from three comprehensive public high schools. A hierarchical logistic regression was conducted and found to be statistically significant. The variables of gender, race, and SES were found not to be significant predictors of having a postsecondary plan, but grade point average (GPA) was a significant predictor. The results failed to reject the null hypothesis, meaning household SES was not …

Perceived Servant Leadership Behaviors And Employee Outcomes In National Collegiate Athletic Association Division Iii, Athletics Departments The Moderating Role Of Trust-In-Leader And Organizational Tenure, Sean Fletcher Daly

Dissertations

ESPN reported that in the 2016–2017 academic year, the National Collegiate Athletic Association (NCAA) surpassed $1 billion in revenue (Rovell, 2018). Trends in revenue and business models have caused scholars, educators, and professionals to call for a reform of how collegiate sport organizations are led (Lapchick et al., 2013; Lopiano & Gurney, 2014). Some believe servant leadership (Greenleaf, 1977) is the answer (Burton & Peachey, 2013; Dodd et al., 2018). Research studies on servant leadership in the sporting context have found it has a positive impact on the development of an ethical climate (Achen et al., 2019; Burton et al., …

Systems Genetics And Systems Biology Analysis Of Paraquat Effects In Bxd Recombinant Inbred Mice, Carolina Del Valle Torres Rojas

Theses and Dissertations (ETD)

Paraquat (PQ) is a chemical herbicide that is used in many countries including the United States. It is also highly acutely toxic to humans and has been used as a means of suicide. As PQ is applied mainly in agricultural settings, it moves to soil and well water. Chronic low dose exposure via drinking water may have adverse effects on humans, including increased risk for sporadic Parkinson’s disease (sPD). The etiology of sPD is unclear and the most accepted hypothesis states it is the result of the interaction between environmental factors and genetic susceptibility. Increasing evidence led us to infer …

Early Diagnosis Of Alzheimer’S Disease In The Primary Care Setting, Raymond R. Romano

Theses and Dissertations (ETD)

The burden of Alzheimer’s disease (AD) affects not just the individual but also families, providers, and society. Early recognition and diagnosis of AD may reduce cost by reducing interaction with the health care system, earlier initiation of treatment, and prolonging time to long- term care. Primary care providers, the first contact for diagnosis of patients with AD, are not fulfilling the potential of early diagnosis for a variety of reasons. Biomarkers of AD emerge on average 15 to 20 years before clinical diagnosis, yet currently established biomarkers are not easily available in the primary care setting. A growing body of …

Establishing The Public Library As An Out-Of-School Partner In Stem/Steam Education, Gwyneth Fernandez

Electronic Theses, Projects, and Dissertations

The American public library is a unique community presence that positively influences the lives of families as an out-of-school partner in education. By examining the public library through a systems lens using Bronfenbrenner’s Bioecological Theory the impact of these institutions may be seen. A key characteristic of public library service is timely, relevant adaptations that meet the needs of the community served. In this project, a recent public library pilot program is evaluated. This program was created in response to the emerging trend in Science Technology Engineering Art and Math (STEAM) within schools and informal education opportunities. It was found …

A Four-Session Workshop For Parents Of Children With Autism: Understanding And Managing Challenging Behaviors, And Supporting The Development Of Children With Asd, Vanessa Huizar

Electronic Theses, Projects, and Dissertations

Research studies continue to show that being a parent of a child with autism spectrum disorder (ASD) presents unique challenges for many families including understanding ASD deficits and behaviors, and identifying effective ways to manage these behaviors. Because ASD interventions generally take a behaviorally-based approach, parents tend to lack an understanding of child development, positive child guidance practices, ways to build strong parent-child relationships, and methods to engage in enrichment activities that will support their child’s overall development. The purpose of the current project was to create a parent workshop to help parents of children with ASD: 1) understand the …

Population Structure Of A Federally Endangered Plant (Astragalus Jaegerianus Munz, Fabaceae) With Limited Range Using Microsatellites, Sueann Neal

Electronic Theses, Projects, and Dissertations

Studies on population genetics examine the relationship and effects of population structure, migration, gene flow and demographic history, and are therefore important in the conservation of endangered species. Astragalus jaegerianus, a critically federally endangered species found in a geographically restricted range is investigated to determine population structure and genetic variation. Previous research on A. jaegerianus focused on DNA sequence data for cpDNA and nrDNA showed no variation. Further research on A. jaegerianus utilizing AFLP’s on the whole genome indicated substantial gene diversity and population structure consistent with geographically widespread species. AFLP research is a cost-effective process to identify levels …

How To Help Your Child Succeed In Elementary School A Parent Education Workshop, Lauren Rivera

Electronic Theses, Projects, and Dissertations

Over the last decade, research studies have demonstrated that academic success has a significant impact on a child’s long-term outcomes (e.g., Duncan et al., 2007). The purpose of this project was to provide parents with the information and skills to help their child succeed in elementary school. A 6-session workshop titled Helping Your Child Succeed in Elementary School was created which included the following topics: attachment, parenting style, positive discipline, and creating an enriched home environment. After attending the workshop, the four parent participants reported an increase in their knowledge of the importance of establishing a secure attachment with their …

Retirement Planning Motivation From A Reinforcement Sensitivity Theory (Rst) Perspective, Luke Poulter

Electronic Theses, Projects, and Dissertations

Retirement planning is a complex issue. There are plenty of challenges that individuals and governments confront regarding retirement planning. Understanding what motivates retirement planning is a critical element for individuals and governments to understand. Therefore, the primary goal of the current study was to extend the literature on retirement planning by expanding knowledge of what influences retirement planning by incorporating Reinforcement Sensitivity Theory (RST). RST is a neuroscientific theory of emotion, motivation, and learning, extended to personality psychology. It suggests three systems, the Behavioral Approach System (BAS), Fight–Flight–Freeze system (FFFS), and the Behavioral Inhibition System (BIS). The BAS mediates responses …

Online Strategies For Small Businesses Affected By Covid-19: A Social Media And Social Commerce Approach, Julianne Itliong

Electronic Theses, Projects, and Dissertations

The Covid-19 pandemic has altered the way many US citizens work, live, and interact with one another. Many rules and regulations have been put in place by government officials to slow the spread of the virus because of how contagious it is in social settings. Because of these rules and regulations, many small businesses were forced to temporarily close their doors to the public in order to comply with the rules of social distancing and the ban on large gatherings. For some businesses, this shift from physical sales to digital sales has always been a part of their business models, …