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2020

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Longitudinal Analysis Reveals Transition Barriers Between Dominant Ecological States In The Gut Microbiome., Roie Levy, Andrew T Magis, John C Earls, Ohad Manor, Tomasz Wilmanski, Jennifer Lovejoy, Sean M Gibbons, Gilbert S Omenn, Leroy Hood, Nathan D Price Jun 2020

Longitudinal Analysis Reveals Transition Barriers Between Dominant Ecological States In The Gut Microbiome., Roie Levy, Andrew T Magis, John C Earls, Ohad Manor, Tomasz Wilmanski, Jennifer Lovejoy, Sean M Gibbons, Gilbert S Omenn, Leroy Hood, Nathan D Price

Articles, Abstracts, and Reports

The Pioneer 100 Wellness Project involved quantitatively profiling 108 participants' molecular physiology over time, including genomes, gut microbiomes, blood metabolomes, blood proteomes, clinical chemistries, and data from wearable devices. Here, we present a longitudinal analysis focused specifically around the Pioneer 100 gut microbiomes. We distinguished a subpopulation of individuals with reduced gut diversity, elevated relative abundance of the genus Prevotella, and reduced levels of the genus Bacteroides We found that the relative abundances of Bacteroides and Prevotella were significantly correlated with certain serum metabolites, including omega-6 fatty acids. Primary dimensions in distance-based redundancy analysis of clinical chemistries explained 18.5% …

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Complex Oncological Decision-Making Utilizing Fast-And-Frugal Trees In A Community Setting-Role Of Academic And Hybrid Modeling., Ravi Salgia, Isa Mambetsariev, Tingting Tan, Amanda Schwer, Daryl Pearlstein, Hazem Chehabi, Angel Baroz, Jeremy Fricke, Rebecca Pharaon, Hannah Romo, Thomas Waddington, Razmig Babikian, Linda Buck, Prakash Kulkarni, Mary Cianfrocca, Benjamin Djulbegovic, Sumanta K Pal Jun 2020

Complex Oncological Decision-Making Utilizing Fast-And-Frugal Trees In A Community Setting-Role Of Academic And Hybrid Modeling., Ravi Salgia, Isa Mambetsariev, Tingting Tan, Amanda Schwer, Daryl Pearlstein, Hazem Chehabi, Angel Baroz, Jeremy Fricke, Rebecca Pharaon, Hannah Romo, Thomas Waddington, Razmig Babikian, Linda Buck, Prakash Kulkarni, Mary Cianfrocca, Benjamin Djulbegovic, Sumanta K Pal

Articles, Abstracts, and Reports

Non-small cell lung cancer is a devastating disease and with the advent of targeted therapies and molecular testing, the decision-making process has become complex. While established guidelines and pathways offer some guidance, they are difficult to utilize in a busy community practice and are not always implemented in the community. The rationale of the study was to identify a cohort of patients with lung adenocarcinoma at a City of Hope community site (n = 11) and utilize their case studies to develop a decision-making framework utilizing fast-and-frugal tree (FFT) heuristics. Most patients had stage IV (N = 9, 81.8%) disease …

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In Vivo Biosynthesis Of Inorganic Nanomaterials Using Eukaryotes - A Review, Ashiqur Rahman, Julia Lin, Francisco E. Jaramillo, Dennis A. Bazylinski, Clayton Jeffryes, Si Amar Dahoumane Jun 2020

In Vivo Biosynthesis Of Inorganic Nanomaterials Using Eukaryotes - A Review, Ashiqur Rahman, Julia Lin, Francisco E. Jaramillo, Dennis A. Bazylinski, Clayton Jeffryes, Si Amar Dahoumane

Life Sciences Faculty Research

Bionanotechnology, the use of biological resources to produce novel, valuable nanomaterials, has witnessed tremendous developments over the past two decades. This eco-friendly and sustainable approach enables the synthesis of numerous, diverse types of useful nanomaterials for many medical, commercial, and scientific applications. Countless reviews describing the biosynthesis of nanomaterials have been published. However, to the best of our knowledge, no review has been exclusively focused on the in vivo biosynthesis of inorganic nanomaterials. Therefore, the present review is dedicated to filling this gap by describing the many different facets of the in vivo biosynthesis of nanoparticles (NPs) using living eukaryotic …

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American Heart Association Epi|Lifestyle Scientific Sessions: 2020 Meeting Highlights, Alexander C. Razavi, Véronique Gingras, Erin D. Michos, Ann Marie Navar, Sherry Ann Brown, Erin Delker, Kathryn Foti, Stéphanie Harrison, Yifei Lu, Jovia L. Nierenberg, Jewel Scott Phd, Rn, Fnp-C, Olive Tang, Alvin G. Thomas, Ruth Alma Turkson-Ocran, Amelia Wallace, Mingyu Zhang, Kristie J. Lancaster, Pamela L. Lutsey, Elizabeth Selvin Jun 2020

American Heart Association Epi|Lifestyle Scientific Sessions: 2020 Meeting Highlights, Alexander C. Razavi, Véronique Gingras, Erin D. Michos, Ann Marie Navar, Sherry Ann Brown, Erin Delker, Kathryn Foti, Stéphanie Harrison, Yifei Lu, Jovia L. Nierenberg, Jewel Scott Phd, Rn, Fnp-C, Olive Tang, Alvin G. Thomas, Ruth Alma Turkson-Ocran, Amelia Wallace, Mingyu Zhang, Kristie J. Lancaster, Pamela L. Lutsey, Elizabeth Selvin

Faculty Publications

No abstract provided.

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American Heart Association Epi|Lifestyle Scientific Sessions: 2020 Meeting Highlights, Alexander C. Razavi, Véronique Gingras, Erin D. Michos, Ann Marie Navar, Sherry Ann Brown, Erin Delker, Kathryn Foti, Stéphanie Harrison, Yifei Lu, Jovia L. Nierenberg, Jewel Scott Phd, Rn, Fnp-C, Olive Tang, Alvin G. Thomas, Ruth Alma Turkson-Ocran, Amelia Wallace, Mingyu Zhang, Kristie J. Lancaster, Pamela L. Lutsey, Elizabeth Selvin Jun 2020

American Heart Association Epi|Lifestyle Scientific Sessions: 2020 Meeting Highlights, Alexander C. Razavi, Véronique Gingras, Erin D. Michos, Ann Marie Navar, Sherry Ann Brown, Erin Delker, Kathryn Foti, Stéphanie Harrison, Yifei Lu, Jovia L. Nierenberg, Jewel Scott Phd, Rn, Fnp-C, Olive Tang, Alvin G. Thomas, Ruth Alma Turkson-Ocran, Amelia Wallace, Mingyu Zhang, Kristie J. Lancaster, Pamela L. Lutsey, Elizabeth Selvin

Faculty Publications

No abstract provided.

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Vertebrates On The Brink As Indicators Of Biological Annihilation And The Sixth Mass Extinction, Gerardo Ceballos, Paul R. Ehrlich, Peter H. Raven Jun 2020

Vertebrates On The Brink As Indicators Of Biological Annihilation And The Sixth Mass Extinction, Gerardo Ceballos, Paul R. Ehrlich, Peter H. Raven

Harold W. Manter Laboratory of Parasitology: Library Materials

The ongoing sixth mass species extinction is the result of the destruction of component populations leading to eventual extirpation of entire species. Populations and species extinctions have severe implications for society through the degradation of ecosystem services. Here we assess the extinction crisis from a different perspective. We examine 29,400 species of terrestrial vertebrates, and determine which are on the brink of extinction because they have fewer than 1,000 individuals. There are 515 species on the brink (1.7% of the evaluated vertebrates). Around 94% of the populations of 77 mammal and bird species on the brink have been lost in …

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Proteomic Identification Reveals The Role Of Ciliary Extracellular‐Like Vesicle In Cardiovascular Function, Ashraf M. Mohieldin, Rajasekharreddy Pala, Rinzhin T. Sherpa, Madhawi Alanazi, Ashwaq Alanazi, Kiumars Shamloo, Amir Ahsan, Wissam A. Aboualaiwi, James J. Moresco, John R. Yates Iii, Surya M. Nauli Jun 2020

Proteomic Identification Reveals The Role Of Ciliary Extracellular‐Like Vesicle In Cardiovascular Function, Ashraf M. Mohieldin, Rajasekharreddy Pala, Rinzhin T. Sherpa, Madhawi Alanazi, Ashwaq Alanazi, Kiumars Shamloo, Amir Ahsan, Wissam A. Aboualaiwi, James J. Moresco, John R. Yates Iii, Surya M. Nauli

Pharmacy Faculty Articles and Research

Primary cilia are shown to have membrane swelling, also known as ciliary bulbs. However, the role of these structures and their physiological relevance remains unknown. Here, it is reported that a ciliary bulb has extracellular vesicle (EV)‐like characteristics. The ciliary extracellular‐like vesicle (cELV) has a unique dynamic movement and can be released by mechanical fluid force. To better identify the cELV, differential multidimensional proteomic analyses are performed on the cELV. A database of 172 cELV proteins is generated, and all that examined are confirmed to be in the cELV. Repressing the expression of these proteins in vitro and in vivo …

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We Are Not Alone In Trying To Be Alone, Patricia C. Lopes Jun 2020

We Are Not Alone In Trying To Be Alone, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Certain diseases, like colds, tend not to stop us. A paracetamol here, an ibuprofen there, and we are on the go. That is, until we, as a species, are faced with a virus that not only spreads through social contact, but has an estimated reproductive number of 2 to 2.5 and potentially kills 3–4% of those infected (WHO, 2020). To reduce transmission probability of COVID-19, governmental agencies around the world have recommended or enforced measures to decrease social contact; early evidence suggests these measures produce the intended effect (Kucharski et al., 2020).

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Hplc-Pda Method And Uses Thereof In Phytoestrogen Measurement, Maria Teresa Aguirre Jun 2020

Hplc-Pda Method And Uses Thereof In Phytoestrogen Measurement, Maria Teresa Aguirre

Patents

Presented are improved and more sensitive methods for measuring levels of phytoestrogens in a biological sample, and specifically in a human urine sample, employing a High Pressure Liquid Chromatography method, coupled with a photodiode array analysis detection system. Calibration curve preparation for each of a panel of phytoestrogen analytes, including daidzein, equol and genistein, are provided employing techniques that demonstrate greater accuracy and sensitivity of sample level measurement. Clinically applicable techniques suitable for large population scale screening, diet and gut microflora characterization and disease analysis and correlation in human populations, such as in at risk breast cancer populations, through monitoring …

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Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin Jun 2020

Rapid Identification Of Nicotine In Electronic Cigarette Liquids Based On Surface-Enhanced Raman Scattering, Jun-Yi Chien, Yong-Chun Gu, Hsin-Mei Tsai, Chun-Hao Liu, Chia-Yuan Yen, Yuh-Lin Wang, Juen-Kai Wang, Chi-Hung Lin

Journal of Food and Drug Analysis

Nicotine-containing electronic cigarette liquid (e-liquid) is prohibited in many countries, creating requirements for rapid detection approaches for on-site inspection or screening for large amounts of samples. Here, we demonstrate a simple way to identify nicotine using surface-enhanced Raman scattering (SERS) with substrates made of silver nanoparticle arrays imbedded in anodic aluminum oxide nanochannels (Ag/AAO). Compared with the reported colloidal nanoparticle-based SERS, that required serial dilutions to enable colloid aggregation in the viscous e-liquid, a small amount of undiluted e-liquid sample can be directly added onto our solid-phase Ag/AAO substrate without any pre-treatment. The sensitivity of our SERS measurements is 2e3 …

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A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang Jun 2020

A Multi-Analyte Lc-Ms/Ms Method For Screening And Quantification Of Nitrosamines In Sartans, Shu-Han Chang, Ching-Chia Chang, Li-Jing Wang, Wei-Ching Chen, Shu-Yu Fan, Chi-Zong Zang, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

An incident of sartan medicine contamination was notified by Europe in June 2018. The contaminant was identified as a probable carcinogenic nitrosamine and the recalls of sartan medicines were soon made. Since then, more nitrosamine contaminants in sartan medicines were reported. To broaden the applicability and variety in nitrosamine determination, a multi-analyte method is required. In this study, a feasible and sensitive multi-analyte LC-MS/MS method for determination of 12 nitrosamines in sartans was established, where the active pharmaceutical ingredients and final products merchandised in Taiwan were also examined. Chromatographic separation was achieved on an Xselect® HSS T3 column (15 cm …

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Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee Jun 2020

Anti-Inflammatory Effects Of Peptides From A Marine Algicolous Fungus Acremonium Sp. Ntu492 In Bv-2 Microglial Cells, George Hsiao, Shih-Wei Wang, Yin-Ru Chiang, Wei-Chiung Chi, Yueh-Hsiung Kuo, Do Anh Phong, Chia-Yu Chen, Tzong-Huei Lee

Journal of Food and Drug Analysis

Located in tropical and subtropical region, Taiwan is an island with high algal species diversity. In this study, a number of fungal strains were isolated from marine macroalgae collected from northeastern intertidal zone of Taiwan. Preliminary anti-inflammatory screening has shown that the methanolic extracts of solid fermented products of the red alga Mastophora rosea-derived fungal strain Acremonium sp. NTU492 exhibited significant bioactivity. In an attempt to disclose the active principles from this fungal strain, a series of separation and purification was thus undertaken, which has led to the isolation and characterization of seven compounds including four new peptides, namely acrepeptins …

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A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu Jun 2020

A Rapid Strategy For Screening High-Efficiency Pcsk9 Inhibitors From Ginkgo Biloba Leaves By Ligand Fishing, Hplc-Q-Tof-Ms And Interdisciplinary Assay, Li Li, Meng-Lin Fan, Ya-Nan Li, Ya-Xuan Huang, Xiu-Feng Liu, Ji-Hua Liu

Journal of Food and Drug Analysis

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an attractive target for new cholesterol-lowering drug development. Here, we developed a method integrating ligand fishing, HPLC-Q-TOF-MS and interdisciplinary assay, aiming to explore potential PCSK9 inhibitors from mixtures rapidly and accurately. PCSK9 was expressed and purified firstly, and then the recombined PCSK9 was coated on the surface of magnetic beads (MBs). The PCSK9-immobilized MBs (PCSK9-MBs) were used for ligand fishing combined with HPLC and Q-TOF-MS/MS. Ginkgo biloba leaves (GBL), an herbal medicine widely used in Asia and Europe with good efficacy in treatment of hypercholesterolemia, were chosen as an illustration for ligand fishing. …

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Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee Jun 2020

Food Preservative Sorbic Acid Deregulates Hepatic Fatty Acid Metabolism, Chia-Hui Chen, Sin-Ni Ho, Po-An Hu, Yu Ru Kou, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Sorbic acid (SA) is one of the most commonly used food preservatives worldwide. Despite SA having no hepatotoxicity at legal dosages, its effect on hepatic lipid metabolism is still unclear. We investigated the effect of SA on hepatic lipid metabolism and its mechanism of action in C57BL/6 mice. Daily treatment with SA (1 g/kg in diet) for 4 weeks did not alter the body weight, organ weight, and blood lipids in mice. However, hepatic lipid accumulation, particularly that of triglycerides, fatty acids, and glycerol, but not cholesteryl ester and free cholesterol, was increased with SA treatment. Mechanistically, SA decreased the …

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The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu Jun 2020

The Potential Role Of Phenolic Compounds On Modulating Gut Microbiota In Obesity, Gow-Chin Yen, Hsin-Lin Cheng, Li-Yu Lin, Shiuan-Chih Chen, Chin Lin Hsu

Journal of Food and Drug Analysis

Obesity is a rising public health issue and challenge which is tightly correlated with socio-economic development paralleled with increased energy intake and sedentary behavior that subsequently cause adipose tissue accumulation. Physiological and metabolic status changes during obesity development have been suggested with low grade inflammation of gastrointestinal tract. The gut microbiota plays an essential role in regulating whole body energy metabolism and also lipid accumulation, and immunity of host. However, the detail mechanism of which the gut microbiota composition influence obesity development in humans still need deeper investigation owing to the complex pathophysiology of such disease. Recently, the consumption of …

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Rehabilitation Of Grasslands Through Perennial Grass Recruitment Within Existing Swards, R. Thapa, David R. Kemp, Warwick B. Badgery, David L. Michalk Jun 2020

Rehabilitation Of Grasslands Through Perennial Grass Recruitment Within Existing Swards, R. Thapa, David R. Kemp, Warwick B. Badgery, David L. Michalk

IGC Proceedings (1977-2023)

No abstract provided.

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The State Of Forage Germplasm Resources In Yunnan Province, Zhenzhong Sun, Jun Yin, Qiao Wei Jun 2020

The State Of Forage Germplasm Resources In Yunnan Province, Zhenzhong Sun, Jun Yin, Qiao Wei

IGC Proceedings (1977-2023)

No abstract provided.

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Alien Plant Invasions Of Jinfo Mountain National Nature Reserve--Identifying And Implying, Juan Sun, Ruijun Long, Guofeng Yang, Yuqiang Gai, Di Yan, Yongqing Teng Jun 2020

Alien Plant Invasions Of Jinfo Mountain National Nature Reserve--Identifying And Implying, Juan Sun, Ruijun Long, Guofeng Yang, Yuqiang Gai, Di Yan, Yongqing Teng

IGC Proceedings (1977-2023)

No abstract provided.

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Proportional Fitness Loss And The Timing Of Defensive Investment: A Cohesive Framework Across Animals And Plants, Michael J. Sheriff, John L. Orrock, Maud Co Ferrari, Richard Karban, Evan L. Preisser, Andrew Sih, Jennifer S. Thaler Jun 2020

Proportional Fitness Loss And The Timing Of Defensive Investment: A Cohesive Framework Across Animals And Plants, Michael J. Sheriff, John L. Orrock, Maud Co Ferrari, Richard Karban, Evan L. Preisser, Andrew Sih, Jennifer S. Thaler

Biological Sciences Faculty Publications

The risk of consumption is a pervasive aspect of ecology and recent work has focused on synthesis of consumer–resource interactions (e.g., enemy–victim ecology). Despite this, theories pertaining to the timing and magnitude of defenses in animals and plants have largely developed independently. However, both animals and plants share the common dilemma of uncertainty of attack, can gather information from the environment to predict future attacks and alter their defensive investment accordingly. Here, we present a novel, unifying framework based on the way an organism’s ability to defend itself during an attack can shape their pre-attack investment in defense. This framework …

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Effects Of Socioeconomic Status And Race On Access To Healthcare In The United States, Madeline Ohlson Jun 2020

Effects Of Socioeconomic Status And Race On Access To Healthcare In The United States, Madeline Ohlson

Perspectives

This literature review discusses the effects of an individual or community’s socioeconomic status and race on their access to healthcare in the United States as important and controversial. Health issues affect all Americans, yet inequalities still exist in the healthcare system. Aspects of socioeconomic status and race are prevalent factors in many social problems, especially in their significant influence on access to, quality of, and availability of healthcare that a person receives. The reviewed studies discuss how social stratification regarding socioeconomic status and race lead to disparities in the field of healthcare when discussing the quality of care, health insurance, …

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Lactate Dehydrogenase Expression Modulates Longevity And Neurodegeneration In Drosophila Melanogaster, Dani M. Long, Ariel Frame, Patrick N. Reardon, Robert C. Cumming, David A. Hendrix, Doris Kretzschmar, Jadwiga M. Giebultowicz Jun 2020

Lactate Dehydrogenase Expression Modulates Longevity And Neurodegeneration In Drosophila Melanogaster, Dani M. Long, Ariel Frame, Patrick N. Reardon, Robert C. Cumming, David A. Hendrix, Doris Kretzschmar, Jadwiga M. Giebultowicz

Paediatrics Publications

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease patients, and it is not clear whether lactate plays protective or detrimental roles in these contexts. Here we show that Ldh transcript levels are elevated and cycle with diurnal rhythm in the heads of aged flies and this is associated with increased LDH protein, enzyme activity, and lactate concentrations. To understand the biological significance of increased Ldh gene expression, we genetically manipulated Ldh levels in …

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Clinician Approaches To Noise-Exposed, “Normal” Hearing Ears: Investigating The Need & Reliability Of A Candidate Measure Of Human Vulnerability To Noise Damage., Sarah Powell Jun 2020

Clinician Approaches To Noise-Exposed, “Normal” Hearing Ears: Investigating The Need & Reliability Of A Candidate Measure Of Human Vulnerability To Noise Damage., Sarah Powell

Doctoral Dissertations

It has been well-established that there is large variability between individuals’ vulnerability to noise-induced hearing loss (NIHL), but recent work has galvanized the auditory research and clinical communities to re-evaluate the physiologic and perceptual consequences of subclinical noise-induced damage in individuals that would traditionally be considered “normal hearing.” The auditory efferent system is one potential source of variation between individuals, and research in animal models indicates that strength of the medial olivocochlear reflex (MOCR) is predictive of vulnerability to noise damage because it suppresses cochlear gain. Therefore, it has been proposed that MOCR strength may be useful as a clinical …

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Undergraduates Get Research Experience Studying Songbird Reproduction, Ohio University College Of Arts & Sciences Jun 2020

Undergraduates Get Research Experience Studying Songbird Reproduction, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Machine-Learning Tools Find Targets Old Drugs Can Exploit Against Covid-19, Matt Windsor Jun 2020

Machine-Learning Tools Find Targets Old Drugs Can Exploit Against Covid-19, Matt Windsor

Browse All News

No abstract provided.

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Resolving Metabolic Heterogeneity In Experimental Models Of The Tumor Microenvironment From A Stable Isotope Resolved Metabolomics Perspective, Teresa W-M Fan, Richard M. Higashi, Yelena Chernayavskaya, Andrew N. Lane Jun 2020

Resolving Metabolic Heterogeneity In Experimental Models Of The Tumor Microenvironment From A Stable Isotope Resolved Metabolomics Perspective, Teresa W-M Fan, Richard M. Higashi, Yelena Chernayavskaya, Andrew N. Lane

Center for Environmental and Systems Biochemistry Faculty Publications

The tumor microenvironment (TME) comprises complex interactions of multiple cell types that determines cell behavior and metabolism such as nutrient competition and immune suppression. We discuss the various types of heterogeneity that exist in solid tumors, and the complications this invokes for studies of TME. As human subjects and in vivo model systems are complex and difficult to manipulate, simpler 3D model systems that are compatible with flexible experimental control are necessary for studying metabolic regulation in TME. Stable Isotope Resolved Metabolomics (SIRM) is a valuable tool for tracing metabolic networks in complex systems, but at present does not directly …

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10 Patient-Centered Questions For Clinical Encounters With Transgender Patients, Blossom Kim Jun 2020

10 Patient-Centered Questions For Clinical Encounters With Transgender Patients, Blossom Kim

Physician Assistant Studies | Student Authored Articles

Transgender (TG) individuals face extensive barriers to care that result in detrimental health disparities and increased prevalence of certain medical conditions such as mood disorders, HIV, and substance abuse. Existing research details multiple approaches to aid healthcare providers in reducing these disparities, but they tend to either generalize the transgender community or provide a surplus of information that may potentially overwhelm healthcare providers. This best practices review aims to provide clinicians with an approach that includes 10 patient-centered questions in hopes of improving patient-clinician rapport and addressing the main disparities and health concerns a TG patient may have.

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Adverse Effects Of Cell Phone Use During Pregnancy, Stephanie Santos Jun 2020

Adverse Effects Of Cell Phone Use During Pregnancy, Stephanie Santos

Physician Assistant Studies | Student Authored Articles

This study explored the possible adverse outcomes of cell phone use during the prenatal period. Previous literature has lacked in the analysis of all the potential adverse outcomes of cell phone use during pregnancy. This gap in literature, is needed to determine if a reduction in cell phone usage during pregnancy should be recommended in future clinical practices. For my research, I reviewed three published studies that have been done on cell phone use during pregnancy. These studies include the potential adverse effects in causing ADHD, developmental milestone delays, and low birth weights in children. Of the three studies analyzed, …

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Orda Weekly Update, 2020.06.15, Office Of Research And Development Administration Jun 2020

Orda Weekly Update, 2020.06.15, Office Of Research And Development Administration

ORDA Weekly Update

No abstract provided.

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Determination Of Volatile Organic Compounds At A Marine Terminal In United States Using In-Borehole Gas Monitoring, A. N. Nwachukwu, C. U. Uwa, K. E. Nwagu, B. E. Ephraim Jun 2020

Determination Of Volatile Organic Compounds At A Marine Terminal In United States Using In-Borehole Gas Monitoring, A. N. Nwachukwu, C. U. Uwa, K. E. Nwagu, B. E. Ephraim

Journal of Marine Science and Technology–Taiwan

A time-series study was conducted to determine both the aggregate and specific Volatile Organic Compounds (VOCs) concentrations at a Marine Terminal. An in-situ aggregate data of VOC concentrations and some environmental parameters were logged by means of an in-borehole gas monitor called Gasclam (Ion Science, UK). A Tenax TA sorbent tube incorporated into and to work in parallel with the Gasclam was used to adsorb bulk concentrations of VOCs and subsequently desorbed (for characterization) using Thermal Desorption/Gas Chromatography-Mass Spectroscopy (TD/GC-MS) technique. The result shows aggregate VOC concentrations of 31385 ppm and 17140 ppm in wells I and II respectively over …

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Small Molecules To Control Porcine Reproductive And Respiratory Syndrome Virus Infection, Chang Huang Jun 2020

Small Molecules To Control Porcine Reproductive And Respiratory Syndrome Virus Infection, Chang Huang

Doctoral Dissertations

Porcine reproductive and respiratory syndrome (PRRS) is an economically significant panzootic affecting the swine industry worldwide. CD163 is the indispensable receptor for PRRS virus (PRRSV) infection and porcine alveolar macrophages (PAMs) are the principle target for productive PRRSV infection in pigs. We validated that the interleukin 10 (IL-10) stimulated Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signaling upregulates CD163 expression in pig cells. We identified a natural compound cryptotanshinone (Cpt) that inhibits IL-10-stimulated and basal level of CD163 expression in PAMs, and thus suppresses infection of PAMs by type I and type II PRRSV in vitro. …

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