Entire DC Network | Open Access Articles | Digital Commons Network™

Effectiveness And Safety Of Opicapone In Parkinson’S Disease Patients With Motor Fluctuations: The Optipark Open-Label Study, Heinz Reichmann, Andrew Lees, José Francisco Rocha, Diogo Magalhães, Patrício Soares-Da-Silva, Camille Carroll

Peninsula Medical School

No abstract provided.

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Off-Label Drug Risks: Toward A New Fda Regulatory Approach, George Horvath

Faculty Scholarship

No abstract provided.

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Sentenced To Surveillance: Fourth Amendment Limits On Electronic Monitoring, Kate Weisburd

Faculty Scholarship

As courts and legislatures increasingly recognize that “digital is different” and attempt to limit government surveillance of private data, one group is conspicuously excluded from this new privacy-protective discourse: the five million people in the United States on probation, parole, or other forms of community supervision. This Article is the first to explore how warrantless electronic surveillance is dramatically transforming community supervision and, as a result, amplifying a growing privacy-protection disparity: those in the criminal legal system are increasingly losing privacy protections even while those not in the system are increasingly gaining privacy protections. The quickly expanding use of GPS-equipped …

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The Legal Reconstruction Of Walls: N.D. & N.T. V. Spain, 2017, 2020, Moria Paz

Faculty Scholarship

Recently, Western democracies have turned to building border walls as a strategy of immigration control. This Article makes two claims. First, human rights courts and quasi-judicial bodies are deeply implicated in this move. In the past decade or so, these institutions have been successful in both enforcing and creating new rights for asylum seekers and irregular migrants. They have used variants of access to guarantee hyper-protection to individual non-nationals who have either entered a host state or come under its effective control. This legal success has resulted in the unintended consequence of rendering wall-building a logical move for state prevention …

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Unstructured Data For Cybersecurity And Internal Control, Jesus Canelón, Esperanza Huerta, Normal Leal, Terry Ryan

Faculty Research, Scholarly, and Creative Activity

This paper proposes a research framework for studying the connections-realized and potential-between unstructured data (UD) and cybersecurity and internal controls. In the framework, cybersecurity and internal control goals determine the tasks to be conducted. The task influences the types of UD to be accessed and the types of analysis to be done, which in turn influences the outcomes that can be achieved. Patterns in UD are relevant for cybersecurity and internal control, but UD poses unique challenges for its analysis and management. This paper discusses some of these challenges including veracity, structuralizing, bias, and explainability.

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Reforming Medical Regulation: A Qualitative Study Of The Implementation Of Medical Revalidation In England, Using Normalization Process Theory, Abigail Tazzyman, Jane Ferguson, Alan Boyd, Marie Bryce, John Tredinnick-Rowe, Tristan Price, Kieran Walshe

Peninsula Medical School

Objectives The introduction of medical revalidation in 2012 has been a controversial and radical change to medical regulation in the UK. It involved changes to the way organizations manage medical performance, and to the relationships between doctors, their employers and the professional regulatory body. In this paper, we explore the implementation of medical revalidation, analysing the change process and its consequences for doctors and organizations. Methods We conducted a qualitative investigation of the implementation of revalidation in 15 case study organizations in 2016–2017, collecting documents and undertaking a total of 80 interviews with medical and non-medical staff. We used Normalization …

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British Obesity And Metabolic Surgery Society Guidelines On Perioperative And Postoperative Biochemical Monitoring And Micronutrient Replacement For Patients Undergoing Bariatric Surgery—2020 Update, Mary O'Kane, Helen M. Parretti, Jonathan Pinkney, Richard Welbourn, Carly A. Hughes, Jessica Mok, Nerissa Walker, Denise Thomas, Jennifer Devin, Karen D. Coulman, Gail Pinnock, Rachel L. Batterham, Kamal K. Mahawar, Manisha Sharma, Alex I. Blakemore, Iris Mcmillan, Julian H. Barth

Peninsula Medical School

No abstract provided.

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Cognition And Its Relation To Brain Health In Patients With Ms: Response To Letter, Jeremy Hobart, Gavin Giovannoni

Peninsula Medical School

No abstract provided.

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Contrasting Impact Of Androgens On Male And Female Adiposity, Fat Distribution And Insulin Resistance In Childhood And Adolescence (Earlybird 75), Jade Chynoweth, Joanne Hosking, Alison Jeffery, Jonathan Pinkney

Peninsula Medical School

Objectives: To investigate associations between androgens (testosterone, dehydroepiandrosterone sulphate [DHEAS] and androstenedione), adiposity, fat distribution and insulin resistance (IR) during childhood and adolescence. Methods: Three hundred and seven children (170 [55.4%] boys; 137 [44.6%] girls)recruited at age 5 and studied annually until age 16: androgens (liquid chromatography tandem-mass spectrometry), anthropometry, body composition (dual-energy x-ray absorptiometry) and IR (homeostasis model assessment). Results: Early adiposity was associated with earlier detection of androstenedione in both sexes, and DHEAS in boys. At puberty, higher androgen levels were associated with favourable metabolic changes in boys, but adverse metabolic effects in girls. In boys, higher free …

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Assessment Of Patients With Lower Urinary Tract Symptoms Where An Undiagnosed Neurological Disease Is Suspected: A Report From An International Continence Society Consensus Working Group, Holly A. Roy, Jeremy Nettleton, Camilla Blain, Catherine Dalton, Bilal Farhan, Ailton Fernandes, Petros Georgopoulos, Sabine Klepsch, John Lavelle, Evangelista Martinelli, Jalesh N. Panicker, Ivan Radoja, Christina Anastasia Rapidi, E Silva R Pereira, Katarina Tudor, Adrian S. Wagg, Marcus J. Drake

Peninsula Medical School

AimLower urinary tract symptoms (LUTS) are a common urological referral, which sometimes can have a neurological basis in a patient with no formally diagnosed neurological disease (“occult neurology”). Early identification and specialist input is needed to avoid bad LUTS outcomes, and to initiate suitable neurological management.MethodsThe International Continence Society established a neurological working group to consider: Which neurological conditions may include LUTS as an early feature? What diagnostic evaluations should be undertaken in the LUTS clinic? A shortlist of conditions was drawn up by expert consensus and discussed at the annual congress of the International Neurourology Society. A multidisciplinary working …

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Making Litigating Citizenship More Fair, Ming Hsu Chen

Faculty Scholarship

No abstract provided.

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How Much Procedure Is Needed For Agencies To Change Novel Regulatory Policies?, Ming Hsu Chen

Faculty Scholarship

The use of guidance documents in administrative law has long been controversial and considered to be one of the most challenging aspects of administrative law. When an agency uses a guidance document to change or make policy, it need not provide notice to the public or allow comment on the new rule; this makes changes easier, faster, and less subject to judicial review. Under the Obama Administration, guidance documents were used to implement policy shifts in many areas of administrative law, including civil rights issues such as transgender inclusion and campus sexual harassment, and immigration law issues such as deferred …

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Slicing Defamation, Yonathan A. Arbel

Articles

No abstract provided.

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The Dangers Of Disclosure: How Hiv Laws Harm Domestic Violence Survivors, Courtney K. Cross

Articles

No abstract provided.

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Lumpy Work, Deepa Das Acevedo

Articles

No abstract provided.

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Healthcare Licensing And Liability, Benjamin J. Mcmichael

Articles

The United States' affordable care crisis and chronic physician shortage have required advanced practice registered nurses "APRNs" and physician assistants "PAs" to assume increasingly important roles in the healthcare system The increased use of these nonphysician providers has improved access to healthcare and lowered the price of care However restrictive occupational licensing laws"”specifically scopeofpractice laws"”have limited their ability to care for patients While these laws by themselves have important implications for the healthcare system they also interact with other legal regimes to impact the provision of care Restrictive scopeofpractice laws can increase the malpractice liability risk of physicians and decrease …

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Dynamic Expression Of Slit1-3 And Robo1-2 In The Mouse Peripheral Nervous System After Injury, Bing Chen, Lauren Carr, Xin-Peng Dun

Peninsula Medical School

The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors. Although we previously reported that Slit1-3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system, how this expression changes after injury has not been well studied. Herein, we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve. At 14 days after injury, quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1-3 and Robo1-2 in L4-5 spinal cord …

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What Approaches To Social Prescribing Work, For Whom, And In What Circumstances? A Realist Review, Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Iain Lang, Richard Byng, Ruth Garside

Peninsula Medical School

No abstract provided.

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The Effect Of A Dementia Awareness Class On Changing Dementia Attitudes In Adolescents, Nicolas Farina, Laura J. Hughes, Ellen Jones, Sahdia Parveen, Alys W. Griffiths, Kathleen Galvin, Sube Banerjee

Peninsula Medical School

Background Current evidence suggests that negative and stigmatising attitudes towards dementia may develop at a young age. There are a number of dementia education and awareness initiatives aimed at reducing stigma, though they have not been robustly evaluated to establish the impact on dementia attitudes or suitability in adolescent populations. This study explored the efficacy and satisfaction of one such initiative (Dementia Friends) in a British adolescent sample. Methods 301 adolescents (M = 12.6 years old, SD = 0.73) were assigned to either receive Dementia Friends (a 60-min interactive class that teaches about dementia and its effects on people’s lives) …

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A Large Population-Based Study Of The Mental Health And Wellbeing Of Children And Young People In The North Of England, Barry Wright, Megan Garside, Victoria Allgar, Rachel Hodkinson, Helen Thorpe

Peninsula Medical School

Background: There has been a recent reported rise in prevalence of mental health problems among children in the United Kingdom, alongside increased referrals into specialist services. There is a need for up-to-date information regarding changing trends of young people’s mental health to allow for improved understanding and service planning. Objectives: This article aims to provide an overview of the current mental health and well-being of years 8, 9 and 11 secondary school–aged pupils from two large regions in the North of England. Method: This was a cohort cross-sectional study. Measures including the Strengths and Difficulties questionnaire, the EQ-5D-Y, social media …

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Ensuring That Covid-19 Research Is Inclusive - Guidance From The Nihr Include Project, Miles D. Witham, Eleanor Anderson, Camille B. Carroll, Paul M. Dark, Kim Down, Alistair S. Hall, Joanna Knee, Eamonn R. Maher, Rebecca H. Maier, Gail A. Mountain, Gary Nestor, Jt O’Brien, Laurie Oliva, James Wason, Lynn Rochester

Peninsula Medical School

No abstract provided.

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Art In Medicine: A Powerful Aid To Modern Medical Education, Fenyu Wang

Student Works

Advances in modern technologies reform medical education in various aspects, and physicians undergo progressively more rigorous and specialized technical training to meet the needs of a modern society that demands cure and longer life-expectancy. However, as we celebrate these advances in modern medicine and medical education, we should not neglect the human aspect of this doctoring profession. Physicians and prevalent medical pedagogies are not impeccable. Many studies discovered mitigated physical exam and observational ability in contemporary physicians. Since 2001, medical schools and residency programs experimented with using art to teach physical examination and observational skills. Participants embraced such programs enthusiastically. …

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The Evidence For Switching Dibenzazepines In People With Epilepsy, Lance Watkins, Marie O'Dwyer, Katy Oak, Charlotte Lawthom, Melissa Maguire, Rhys Thomas, Rohit Shankar

Peninsula Medical School

The dibenzazepines particularly carbamazepine are associated with known adverse effects (AEs) and drug to drug interactions. Eslicarbazepine acetate (ESL) is structurally distinct from other members of the dibenzazepine family and has the advantage of once daily dosing. Observational and trial data report successful switching from older dibenzazepines to ESL. The evidence base for doing so is unclear and not standardized. This is a literature review following the PRISMA scoping guidelines identifying the evidence of switching dibenzazepines. Transition methods, ratios, tolerance to change, adverse effects and retention post-change were evaluated. Study quality was assessed using the Oxford Centre for Evidence Based …

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Evaluating Enhanced Recovery After Surgery: Time To Cover New Ground And Discover The Missing Patient Voice, M Nunns, Jb John, Js Mcgrath, L Shaw, S Briscoe, Coon J Thompson, A Hemsley, Cj Lovegrove, D Thomas, Mg Mythen, R Anderson

School of Health Professions

AbstractMulticomponent peri-operative interventions offer to accelerate patient recovery and improve cost-effectiveness. The recent National Institute of Health Research-commissioned evidence synthesis review by Nunns et al. considers the effectiveness and cost-effectiveness of all types of multicomponent interventions for older adults undergoing elective inpatient surgery. Enhanced recovery programmes (ERPs) were the most commonly evaluated intervention. An association between ERPs and decreased length of stay was observed, whilst complication rates and time to recovery were static or sometimes reduced. Important areas which lack research in the context of ERPs are patient-reported outcome measures, patients with complex needs and assessment of factors pertaining to …

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The Unequal Variance Signal-Detection Model Of Recognition Memory: Investigating The Encoding Variability Hypothesis, Rory W. Spanton, Christopher J. Berry

School of Psychology

Despite the unequal variance signal-detection (UVSD) model’s prominence as a model of recognition memory, a psychological explanation for the unequal variance assumption has yet to be verified. According to the encoding variability hypothesis, old item memory strength variance (σo) is greater than that of new items because items are incremented by variable, rather than fixed, amounts of strength at encoding. Conditions that increase encoding variability should therefore result in greater estimates of σo. We conducted three experiments to test this prediction. In Experiment 1, encoding variability was manipulated by presenting items for a fixed or variable (normally distributed) duration at …

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Coronavirus (Covid-19) In The Uk: A Personality-Based Perspective On Concerns And Intention To Self-Isolate, Alison M. Bacon, Philip J. Corr

School of Psychology

No abstract provided.

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Aging Predicts Decline In Explicit And Implicit Memory: A Life-Span Study, Emma V. Ward, Christopher J. Berry, David R. Shanks, Petter L. Moller, Enida Czsiser

School of Psychology

Explicit memory declines with age, but age effects on implicit memory are debated. This issue is important because if implicit memory is age invariant, it may support effective interventions in individuals experiencing memory decline. In this study, we overcame several methodological issues in past research to clarify age effects on implicit memory (priming) and their relationship to explicit memory (recognition, source memory). We (a) recruited a large life-span sample of participants ( N = 1,072) during a residency at the Science Museum in London, (b) employed an implicit task that was unaffected by explicit contamination, and (c) systematically manipulated attention …

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Quantifying Sources Of Variability In Infancy Research Using The Infant-Directed-Speech Preference, Michael C. Frank, Katherine Jane Alcock, Natalia Arias-Trejo, Gisa Aschersleben, Dare Baldwin, Stéphanie Barbu, Elika Bergelson, Christina Bergmann, Alexis K. Black, Ryan Blything, Maximilian P. Böhland, Petra Bolitho, Arielle Borovsky, Shannon M. Brady, Bettina Braun, Anna Brown, Krista Byers-Heinlein, Linda E. Campbell, Cara Cashon, Mihye Choi, Joan Christodoulou, Laura K. Cirelli, Stefania Conte, Sara Cordes, Christopher Cox, Alejandrina Cristia, Rhodri Cusack, Catherine Davies, Klerk M De, Luche C Delle, Ld Ruiter, Dhanya Dinakar, Kate C. Dixon, Virginie Durier, Samantha Durrant, Christopher Fennell, Brock Ferguson, Alissa Ferry, Paula Fikkert, Teresa Flanagan, Caroline Floccia, Megan Foley, Tom Fritzsche, Rebecca L.A. Frost, Anja Gampe, Judit Gervain, Nayeli Gonzalez-Gomez, Anna Gupta, Laura E. Hahn, Hamlin J Kiley, Ee Hannon, N Havron, J Hay, M Hernik, B Höhle, Dm Houston, Lh Howard, M Ishikawa, S Itakura, I Jackson, Kv Jakobsen, M Jarto, Sp Johnson, C Junge, D Karadag, N Kartushina, Dj Kellier, T Keren-Portnoy, K Klassen, M Kline, E-S Ko, Jf Kominsky, Je Kosie, He Kragness, Aar Krieger, F Krieger, J Lany, Rj Lazo, M Lee, C Leservoisier, C Levelt, C Lew-Williams, M Lippold, U Liszkowski, L Liu, Sg Luke, Ra Lundwall, Cassia V Macchi, N Mani

School of Psychology

Psychological scientists have become increasingly concerned with issues related to methodology and replicability, and infancy researchers in particular face specific challenges related to replicability: For example, high-powered studies are difficult to conduct, testing conditions vary across labs, and different labs have access to different infant populations. Addressing these concerns, we report on a large-scale, multisite study aimed at (a) assessing the overall replicability of a single theoretically important phenomenon and (b) examining methodological, cultural, and developmental moderators. We focus on infants’ preference for infant-directed speech (IDS) over adult-directed speech (ADS). Stimuli of mothers speaking to their infants and to an …

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The Mcgill Face Database: Validation And Insights Into The Recognition Of Facial Expressions Of Complex Mental States, Gunnar Schmidtmann, Ben J. Jennings, Dasha A. Sandra, Jordan Pollock, Ian Gold

School of Health Professions

Current databases of facial expressions represent only a small subset of expressions, usually the basic emotions (fear, disgust, surprise, happiness, sadness, and anger). To overcome these limitations, we introduce a database of pictures of facial expressions reflecting the richness of mental states. A total of 93 expressions of mental states were interpreted by two professional actors, and high-quality pictures were taken under controlled conditions in front and side view. The database was validated in two experiments. First, a four-alternative forced-choice paradigm was employed to test the ability to select a term associated with each expression. Second, the task was to …

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Visual Function And Subjective Perception Of Vision Following Bilateral Implantation Of Monofocal And Multifocal Intraocular Lenses: A Randomised Controlled Trial, Elizabeth M. Law, Rajesh K. Aggarwal, H Buckhurst, Hosam E. Kasaby, Jonathan Marsden, Gary Shum, P Buckhurst

School of Health Professions

No abstract provided.

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Full-Text Articles in Entire DC Network

Effectiveness And Safety Of Opicapone In Parkinson’S Disease Patients With Motor Fluctuations: The Optipark Open-Label Study, Heinz Reichmann, Andrew Lees, José Francisco Rocha, Diogo Magalhães, Patrício Soares-Da-Silva, Camille Carroll

Peninsula Medical School

Off-Label Drug Risks: Toward A New Fda Regulatory Approach, George Horvath

Faculty Scholarship

Sentenced To Surveillance: Fourth Amendment Limits On Electronic Monitoring, Kate Weisburd

Faculty Scholarship

The Legal Reconstruction Of Walls: N.D. & N.T. V. Spain, 2017, 2020, Moria Paz

Faculty Scholarship

Unstructured Data For Cybersecurity And Internal Control, Jesus Canelón, Esperanza Huerta, Normal Leal, Terry Ryan

Faculty Research, Scholarly, and Creative Activity

Reforming Medical Regulation: A Qualitative Study Of The Implementation Of Medical Revalidation In England, Using Normalization Process Theory, Abigail Tazzyman, Jane Ferguson, Alan Boyd, Marie Bryce, John Tredinnick-Rowe, Tristan Price, Kieran Walshe

Peninsula Medical School

Peninsula Medical School

Cognition And Its Relation To Brain Health In Patients With Ms: Response To Letter, Jeremy Hobart, Gavin Giovannoni

Peninsula Medical School

Contrasting Impact Of Androgens On Male And Female Adiposity, Fat Distribution And Insulin Resistance In Childhood And Adolescence (Earlybird 75), Jade Chynoweth, Joanne Hosking, Alison Jeffery, Jonathan Pinkney

Peninsula Medical School

Peninsula Medical School

Making Litigating Citizenship More Fair, Ming Hsu Chen

Faculty Scholarship

How Much Procedure Is Needed For Agencies To Change Novel Regulatory Policies?, Ming Hsu Chen

Faculty Scholarship

Slicing Defamation, Yonathan A. Arbel

Articles

The Dangers Of Disclosure: How Hiv Laws Harm Domestic Violence Survivors, Courtney K. Cross

Articles

Lumpy Work, Deepa Das Acevedo

Articles

Healthcare Licensing And Liability, Benjamin J. Mcmichael

Articles

Dynamic Expression Of Slit1-3 And Robo1-2 In The Mouse Peripheral Nervous System After Injury, Bing Chen, Lauren Carr, Xin-Peng Dun

Peninsula Medical School

What Approaches To Social Prescribing Work, For Whom, And In What Circumstances? A Realist Review, Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Iain Lang, Richard Byng, Ruth Garside

Peninsula Medical School

The Effect Of A Dementia Awareness Class On Changing Dementia Attitudes In Adolescents, Nicolas Farina, Laura J. Hughes, Ellen Jones, Sahdia Parveen, Alys W. Griffiths, Kathleen Galvin, Sube Banerjee

Peninsula Medical School

A Large Population-Based Study Of The Mental Health And Wellbeing Of Children And Young People In The North Of England, Barry Wright, Megan Garside, Victoria Allgar, Rachel Hodkinson, Helen Thorpe

Peninsula Medical School

Peninsula Medical School

Art In Medicine: A Powerful Aid To Modern Medical Education, Fenyu Wang

Student Works

The Evidence For Switching Dibenzazepines In People With Epilepsy, Lance Watkins, Marie O'Dwyer, Katy Oak, Charlotte Lawthom, Melissa Maguire, Rhys Thomas, Rohit Shankar

Peninsula Medical School

Evaluating Enhanced Recovery After Surgery: Time To Cover New Ground And Discover The Missing Patient Voice, M Nunns, Jb John, Js Mcgrath, L Shaw, S Briscoe, Coon J Thompson, A Hemsley, Cj Lovegrove, D Thomas, Mg Mythen, R Anderson

School of Health Professions

The Unequal Variance Signal-Detection Model Of Recognition Memory: Investigating The Encoding Variability Hypothesis, Rory W. Spanton, Christopher J. Berry

School of Psychology

Coronavirus (Covid-19) In The Uk: A Personality-Based Perspective On Concerns And Intention To Self-Isolate, Alison M. Bacon, Philip J. Corr

School of Psychology

Aging Predicts Decline In Explicit And Implicit Memory: A Life-Span Study, Emma V. Ward, Christopher J. Berry, David R. Shanks, Petter L. Moller, Enida Czsiser

School of Psychology

School of Psychology

The Mcgill Face Database: Validation And Insights Into The Recognition Of Facial Expressions Of Complex Mental States, Gunnar Schmidtmann, Ben J. Jennings, Dasha A. Sandra, Jordan Pollock, Ian Gold

School of Health Professions

Visual Function And Subjective Perception Of Vision Following Bilateral Implantation Of Monofocal And Multifocal Intraocular Lenses: A Randomised Controlled Trial, Elizabeth M. Law, Rajesh K. Aggarwal, H Buckhurst, Hosam E. Kasaby, Jonathan Marsden, Gary Shum, P Buckhurst

School of Health Professions