Digital Commons Network^™

Incidence And Prediction Of Intraoperative And Postoperative Cardiac Arrest Requiring Cardiopulmonary Resuscitation And 30-Day Mortality In Non-Cardiac Surgical Patients, Heiko A. Kaiser, Nahel N. Saied, Andreas S. Kokoefer, Lina Saffour, Jonathan K. Zoller, Mohammad A. Helwani

Open Access Publications

BACKGROUND: The incidence, prediction and mortality outcomes of intraoperative and postoperative cardiac arrest requiring cardiopulmonary resuscitation (CPR) in surgical patients are under investigated and have not been studied concurrently in a single study.

METHODS: A retrospective cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program data between 2008 and 2012. Firth's penalized logistic regression was used to study the incidence and identify risk factors for intra- and postoperative CPR and 30-day mortality. simplified prediction model was constructed and internally validated to predict the studied outcomes.

RESULTS: Among about 1.86 million non-cardiac operations, the incidence …

Redox Systems Biology: Harnessing The Sentinels Of The Cysteine Redoxome, Jason M. Held

Open Access Publications

No abstract provided.

Ancestry Specific Associations Of Fto Gene Variant And Metabolic Syndrome: A Longitudinal Aric Study, Dale S. Hardy, Jane T. Garvin, Tesfaye B. Mersha, Susan B. Racette

Open Access Publications

No abstract provided.

Insulin Resistance Drives Hepatic De Novo Lipogenesis In Nonalcoholic Fatty Liver Disease, Gordon I Smith, Mahalakshmi Shankaran, Mihoko Yoshino, George G Schweitzer, Maria Chondronikola, Joseph W Beals, Adewole L Okunade, Bruce W Patterson, Edna Nyangau, Tyler Field, Claude B Sirlin, Saswata Talukdar, Marc K Hellerstein, Samuel Klein

Open Access Publications

BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The physiological factors that stimulate hepatic DNL and the effect of weight loss on hepatic DNL are not clear.METHODSHepatic DNL, 24-hour integrated plasma insulin and glucose concentrations, and both liver and whole-body insulin sensitivity were determined in individuals who were lean (n = 14), obese with normal IHTG content (n = 26), or obese with NAFLD (n = 27). Hepatic DNL was assessed using the deuterated …

Inducible Expression Of Wnt7b Promotes Bone Formation In Aged Mice And Enhances Fracture Healing, Deye Song, Guangxu He, Fangfang Song, Zhepeng Wang, Xiaochen Liu, Lele Liao, Jiangdong Ni, Matthew J. Silva, Fanxin Long

Open Access Publications

No abstract provided.

Movement Pattern Training Compared With Standard Strengthening And Flexibility Among Patients With Hip-Related Groin Pain: Results Of A Pilot Multicentre Randomised Clinical Trial, Marcie Harris-Hayes, Karen Steger-May, Allyn M. Bove, Stefanie N. Foster, Michael J. Mueller, John C. Clohisy, G. Kelley Fitzgerald

Open Access Publications

No abstract provided.

Dietary Glycaemic Index, Glycaemic Load And Head And Neck Cancer Risk: A Pooled Analysis In An International Consortium, Chun-Pin Chang, Jose P Zevallos, Et Al

Open Access Publications

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR

Mouse Genetics Identifies Unique And Overlapping Functions Of Fibroblast Growth Factor Receptors In Keratinocytes, Michael Meyer, Maya Ben-Yehuda Greenwald, Theresa Rauschendorfer, Catharina Sänger, Marko Jukic, Haruka Iizuka, Fumimasa Kubo, Lin Chen, David M Ornitz, Sabine Werner

Open Access Publications

Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases. In human and murine epidermis, FGF receptor 3 (FGFR3) activation causes benign skin tumours, but the consequences of FGFR3 deficiency in this tissue have not been determined. Here, we show that FGFR3 in keratinocytes is dispensable for mouse skin development, homeostasis and wound repair. However, the defect in the epidermal barrier and the resulting inflammatory skin disease that develops in mice lacking FGFR1 and FGFR2 in keratinocytes were further aggravated upon additional loss of FGFR3. This caused …

Heavy Metals Contaminating The Environment Of A Progressive Supranuclear Palsy Cluster Induce Tau Accumulation And Cell Death In Cultured Neurons, Carolina Alquezar, Jessica B. Felix, Elizabeth Mccandlish, Brian T. Buckley, Dominique Caparros-Lefebvre, Celeste M. Karch, Lawrence I. Golbe, Aimee W. Kao

Open Access Publications

No abstract provided.

Medulloblastoma Has A Global Impact On Health Related Quality Of Life: Findings From An International Cohort, Cynthia B De Medeiros, Josh Rubin, Et Al

Open Access Publications

BACKGROUND: Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.

METHODS: Seventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables …

A Meta-Analysis Of Genome-Wide Association Studies Of Multiple Myeloma Among Men And Women Of African Ancestry, Zhaohui Du, Graham A. Colditz, Mark A. Fiala, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Uncovering Tumour Heterogeneity Through Pkr And Nc886 Analysis In Metastatic Colon Cancer Patients Treated With 5-Fu-Based Chemotherapy, María Belén Ortega-García, Igor Zwir, Et Al

Open Access Publications

Colorectal cancer treatment has advanced over the past decade. The drug 5-fluorouracil is still used with a wide percentage of patients who do not respond. Therefore, a challenge is the identification of predictive biomarkers. The protein kinase R (PKR also called EIF2AK2) and its regulator, the non-coding pre-mir-nc886, have multiple effects on cells in response to numerous types of stress, including chemotherapy. In this work, we performed an ambispective study with 197 metastatic colon cancer patients with unresectable metastases to determine the relative expression levels of both nc886 and PKR by qPCR, as well as the location of PKR by …

Polycystin 2 Is Increased In Disease To Protect Against Stress-Induced Cell Death, Allison L. Brill, Tom T. Fischer, Jennifer M. Walters, Arnaud Marlier, Lorenzo R. Sewanan, Parker C. Wilson, Eric K. Johnson, Gilbert Moeckel, Lloyd G. Cantley, Stuart G. Campbell, Jeanne M. Nerbonne, Hee Jung Chung, Marie E. Robert, Barbara E. Ehrlich

Open Access Publications

No abstract provided.

Frequency And Clinical Significance Of Localized Adverse Events Following Mass Drug Administration For Lymphatic Filariasis In An Endemic Area In South India, Vijesh Sreedhar Kuttiatt, Roopali K Somani, Subramanian Swaminathan, Kaliannagounder Krishnamoorthy, Gary J Weil, Jambulingam Purushothaman

Open Access Publications

Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue reactions might be due to the death of adult worms following therapy. Most AEs are mild and self-limited. However, localized AEs are sometimes more significant and of concern to participants. Here, we describe localized AEs that were noted during a large community study that evaluated the safety of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the treatment of LF in India. We have also discussed …

A Novel Histological Index For Evaluation Of Environmental Enteric Dysfunction Identifies Geographic-Specific Features Of Enteropathy Among Children With Suboptimal Growth, Ta-Chiang Liu, Kelley Vanbuskirk, Lori R. Holtz, I. Malick Ndao, Michael H. Isaacs, John D. Pfeifer, Phillip I. Tarr, Et Al.

Open Access Publications

BACKGROUND: A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is the lack of a comprehensive, reproducible histologic framework for characterizing the small bowel lesions. We hypothesized that the development of such a system will identify unique histology features for EED, and that some features might correlate with clinical severity.

METHODS: Duodenal endoscopic biopsies from two cohorts where EED is prevalent (Pakistan, Zambia) and North American children with and without gluten sensitive enteropathy (GSE) were processed for routine hematoxylin & eosin (H&E) staining, and scanned to produce whole slide images (WSIs) which we shared among study pathologists …

A Wnt-Mediated Transformation Of The Bone Marrow Stromal Cell Identity Orchestrates Skeletal Regeneration, Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono

Open Access Publications

No abstract provided.

Clinical And Functional Significance Of Circular Rnas In Cytogenetically Normal Aml, Dimitrios Papaioannou, Geoffrey L. Uy, Et Al.

Open Access Publications

No abstract provided.

Five-Year Outcomes Of Transcatheter Or Surgical Aortic-Valve Replacement, Raj R. Makkar, Alan Zajarias, Et Al.

Open Access Publications

No abstract provided.

Algorithm For Management Of Mandibular Condylar Base Fractures, Erin C. Peterson, Dennis C. Nguyen, Ethan J. Baughman, Gary B. Skolnick, John J. Chi, Kamlesh B. Patel

Open Access Publications

No abstract provided.

Safety And Pharmacokinetics Of Cxcr4 Peptide Antagonist, Ly2510924, In Combination With Durvalumab In Advanced Refractory Solid Tumors, Mark H. O'Hara, Wells Messersmith, Hedy Kindler, Wei Zhang, Celine Pitou, Anna M. Szpurka, Dan Wang, Sheng-Bin Peng, Burkhard Vangerow, Anis A. Khan, Mythili Koneru, Andrea Wang-Gillam

Open Access Publications

No abstract provided.

Coronavirus Proteins As Ion Channels: Current And Potential Research, Conor Mcclenaghan, Alex Hanson, Sun-Joo Lee, Colin G Nichols

Open Access Publications

Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Respiratory Syndrome (SARS) CoV-1 in 2003 and Middle East Respiratory Syndrome (MERS) CoV in 2012, with the current SARS-CoV-2 pandemic we are now in the midst of the third deadly international CoV outbreak in less than 20 years. Coronavirus outbreaks present a critical threat to global public health and an urgent necessity for therapeutic options. …

Relationship Of Amyloid Beta And Neurofibrillary Tau Deposition In Neurodegeneration In Aging Down Syndrome (Niad) Study At Baseline, D L Tudorascu, C M Laymon, M Zammit, D S Minhas, S J Anderson, P A Ellison, S Zaman, B M Ances, M Sabbagh, S C Johnson, C A Mathis, W E Klunk, B L Handen, B T Christian, A D Cohen

Open Access Publications

Importance: Adults with Down syndrome (DS) are at high-risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21 encoding the amyloid precursor protein. Adults with DS are uniformly affected by AD pathology by their 30's and have a 70% to 80% chance of clinical dementia by their 60's. Our previous studies have assessed longitudinal changes in amyloid beta (Aβ) accumulation in DS.

Objective: The goal of the present study was to assess the presence of brain tau using [

Design: Cohort study.

Setting: Multi-center study.

Participants: Participants consisted of a sample of individuals with …

Development Of Aplastic Anemia During Treatment Of Anaplastic Astrocytoma With Temozolomide, Karam Khaddour, Nigel Harrison, Ashwin Govindan, Jian L. Campian

Open Access Publications

No abstract provided.

Robust Deep Learning Classification Of Adamantinomatous Craniopharyngioma From Limited Preoperative Radiographic Images, Eric W. Prince, David D. Limbrick Jr., Et Al.

Open Access Publications

No abstract provided.

Chikungunya Virus Strains From Each Genetic Clade Bind Sulfated Glycosaminoglycans As Attachment Factors, Nicole Mcallister, Michael S. Diamond, Et Al

Open Access Publications

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes debilitating musculoskeletal disease. CHIKV displays broad cell, tissue, and species tropism, which may correlate with the attachment factors and entry receptors used by the virus. Cell surface glycosaminoglycans (GAGs) have been identified as CHIKV attachment factors. However, the specific types of GAGs and potentially other glycans to which CHIKV binds and whether there are strain-specific differences in GAG binding are not fully understood. To identify the types of glycans bound by CHIKV, we conducted glycan microarray analyses and discovered that CHIKV preferentially binds GAGs. Microarray results also indicate that sulfate groups …

Financial Evaluation Of Kidney Transplant With Hepatitis C Viremic Donors To Uninfected Recipients, David A. Axelrod, Krista L. Lentine, Ramji Balakrishnan, Su-Hsin Chang, Terek Alhamad, Huiling Xiao, Bertran L. Kasiske, Roy D. Bloom, Mark A. Schnitzler

Open Access Publications

No abstract provided.

Pif1, Rpa, And Fen1 Modulate The Ability Of Dna Polymerase Δ To Overcome Protein Barriers During Dna Synthesis, Melanie A. Sparks, Peter M. Burgers, Roberto Galletto

Open Access Publications

No abstract provided.

Characterization Of The Complete Mitochondrial Genomes Of Two Sibling Species Of Parasitic Roundworms, Haemonchus Contortus And Teladorsagia Circumcincta, Nikola Palevich, Paul H Maclean, Young-Jun Choi, Makedonka Mitreva

Open Access Publications

No abstract provided.

Validation Of A Parkinson Disease Predictive Model In A Population-Based Study, Irene M. Faust, Brad A. Racette, Susan Searles Nielsen

Open Access Publications

No abstract provided.

Antibodies Targeting Epitopes On The Cell-Surface Form Of Ns1 Protect Against Zika Virus Infection During Pregnancy, Alex W. Wessel, Nurgun Kose, Robin G. Bombardi, Vicky Roy, Warangkana Chantima, Juthathip Mongkolsapaya, Melissa A. Edeling, Christopher A. Nelson, Irene Bosch, Galit Alter, Gavin R. Screaton, David H. Fremont, James E. Crowe Jr, Michael S. Diamond

Open Access Publications

No abstract provided.