Digital Commons Network^™

Reversal Of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease, Chao-Hsien Chen

Dissertations and Theses (Open Access)

The health challenges posed by Alzheimer’s disease (AD) continue to grow as societies age worldwide. Accumulation of Tau-associated pathology correlates with clinical cognitive deterioration in AD. Resident myeloid cells within the central nervous system (CNS) have a limited capacity to uptake and degrade Tau; however, the resulting secretion of proinflammatory cytokines only acts to accelerate neurodegeneration. Therapeutic antibodies can reduce the neurotoxic oligomeric form of Tau (o-Tau), but in doing so they also aggravate inflammation. Attenuating mutation of the antibody Fc region can silence inflammation but also eliminates its capacity to mediate o-Tau clearance by CNS myeloid cells. Thus, there …

Influence Of Genetic Counselor Personal Or Family Medical History On Genetic Counseling Specialization And Practice, Kaitlyn K. Amos Ms

Dissertations and Theses (Open Access)

A personal or family medical history inherently becomes part of a genetic counselor’s life story. Yet the degree to which a counselor’s experience influences his or her specialty choice and their psychosocial practice is unexplored. A medical diagnosis may foster a counselor’s capacity for greater empathy, understanding and rapport-building self-disclosure. Conversely, it could lead to interruptive countertransference, compassion fatigue, and eventually burnout. However, research has not specifically investigated this intersection. Therefore, the aim of this study was to explore the impact of a genetic counselor’s personal or family medical history on his or her choice of practice area, as well …

Splendid Isolation: Va’S Failure To Provide Due Process Protections And Access To Justice To Veterans And Their Caregivers, Yelena Duterte

Journal of Law and Policy

Imagine you are a spouse and caregiver of a severely injured post-9/11 veteran. Your spouse served in the Marine Corps, with several deployments to Iraq. During their last deployment, your spouse sustained a severe traumatic brain injury and suffers from post-traumatic stress disorder. Due to these injuries, they need consistent care throughout the day. Thankfully, upon their return, the VA provided a caregiver program that allowed you to step away from your job and focus on caring for your spouse full time. As part of this program, you received a caregiver stipend of $2,400 per month, healthcare, and support from …

The Hunt For Loot: Proposed Solutions To More Effectively Regulate Addictive Gambling Mechanics In Video Games, Andrew Brewer

Journal of Law and Policy

Over the past decade, more and more video game developers have embraced “loot boxes” as a lucrative source of revenue. But recent concerns over the potential harms of loot boxes, particularly to children, have raised questions about their use and prompted attempts to regulate them throughout the world. This Note explores recent attempts—both foreign and domestic—to regulate loot boxes and proposes new solutions based on those strategies’ shortcomings. By carefully and competently defining terms and exceptions, and providing for more aggressive oversight of agency regulatory efforts, federally-crafted loot box legislation can more effectively protect children from predatory gambling mechanics in …

Decriminalizing Prostitution: Embracing The Swedish Model By Removing The Mistake-Of-Age Defense From New York’S Stop Violence In The Sex Trade Act, Carley Cooke

Journal of Law and Policy

In recent years, New York has re-focused on the widely debated topic of how to best manage and regulate prostitution in the United States. As a state-level issue, the debate presents an invaluable opportunity to re-examine how New York as a society views sex work. The answer in New York focuses on the idea that sex work is real work, where workers should be able to carry out their profession without stigma or fear of arrest. As it stands, the proposed reform largely focuses on decriminalizing both the purchase and sale of sex. This approach contrasts with the legal structure …

“A Climate Of Lawlessness”: Upholding A Government’S Affirmative Duty To Protect The Environment Using Deshaney’S Special Relationship Exception, Katherine G. Horner

Journal of Law and Policy

The Industrial Revolution introduced an era of exceptional technological advances. However, it also led to rampant environmental pollution and degradation. The proliferation of toxic pollutants in the air, water and soil has led us to the precipice of an unimaginable future; a future defined by climate change. This Note argues for the use of the special relationship exception, affirmed by the Supreme Court in DeShaney v. Winnebago, in environmental litigation in order to uphold governments’ affirmative duty to protect the environment. As federal and state governments have the sole power to regulate environmental pollution and enforce environmental protections, individuals are …

Detecting Mens Rea In The Brain, Owen D. Jones, Read Montague, Gideon Yaffe

Vanderbilt Law School Faculty Publications

What if the widely used Model Penal Code (MPC) assumes a distinction between mental states that doesn’t actually exist? The MPC assumes, for instance, that there is a real distinction in real people between the mental states it defines as “knowing” and “reckless.” But is there?

If there are such psychological differences, there must also be brain differences. Consequently, the moral legitimacy of the Model Penal Code’s taxonomy of culpable mental states – which punishes those in defined mental states differently – depends on whether those mental states actually correspond to different brain states in the way the MPC categorization …

Novice Second-Career Teachers: Experiences And Meaning-Making Of The Transition Process, Paula Dennisse Núñez Del Rosario

Dissertations

The world we live in is in constant change. During change, people focus on the observable part of what is not there anymore and what has come in its place, not being conscious of the adaptation process that underlies the change: the transition. The transition is a process that has different phases and the development of the process is differentiated depending on the individual. Transition is also directly related to the type of experience. Although circumstances differ among individuals, it is possible to say that there are some common aspects in terms of challenges faced by all novice teachers, both …

Providing Head Start Services Amid A Global Pandemic: A Mixed Methods Explanatory Study Of Capacity, Resources, And Support, Kelly L. Vigants

Dissertations

The COVID-19 pandemic altered education in dramatic ways including immediate building closures and the implementation of virtual instruction. In March of 2020, Michigan faced a statewide shutdown on all non-essential travel as Michiganders were ordered to “Stay Home. Stay Safe.” Head Start began to provide remote services to families and students. Head Start lead teachers were charged with using virtual methods to teach their students. With little direction in the beginning and many unknowns, Head Start lead teachers used innovative methods to promote family engagement.

This study used a mixed method, explanatory sequential design to evaluate the most effective methods …

Beyond Wickedness: Managing Complex Systems And Climate Change, Michael P. Vandenbergh, Jonathan M. Gilligan

Vanderbilt Law School Faculty Publications

This Article examines the argument that climate change is a "super wicked" problem. It concludes that the wicked problem concept is best viewed as a rhetorical device that served a valuable function in arguing against technocratic hubris in the early 1970s but is unhelpful and possibly counterproductive as a tool for modern climate policy analysis. Richard Lazarus improved on this analysis by emphasizing the urgency of a climate response in his characterization of the climate problem as "super wicked." We suggest another approach based on Charles Lindblom's "science of muddling through." The muddling through approach supports the rhetorical points for …

The Wicked Problem Of Zoning, Christopher Serkin

Vanderbilt Law School Faculty Publications

Zoning is the quintessential wicked problem. Professors Rittel and Webber, writing in the 1970s, identified as “wicked” those problems that technocratic expertise cannot necessarily solve. Wicked problems arise when the very definition of the problem is contested and outcomes are not measured by “right and wrong” but rather by messier contests between winners and losers. This accurately characterizes the state of zoning and land use today.

Zoning is under vigorous and sustained attack from all sides. Conservatives have long decried regulatory interference with private development rights. More recently, progressive housing advocates have begun to criticize zoning for making thriving cities …

Feeling Shame And Guilt When Observing Workplace Incivility: Elicitors And Behavioral Responses, Gerardo A. Miranda, Jennifer L. Welbourne, Ana M. Sariol

Management Faculty Publications

This research investigates the elicitors and behavioral responses associated with feeling guilt and shame in response to observed workplace incivility. We draw from the appraisal model of selfconscious emotions to hypothesize that perceiving personal responsibility for acts of incivility conducted by others in the organization is associated with feelings of guilt and shame, and that these relationships are differentially moderated by perceived controllability over the incident. We further propose that shame is associated with avoidance and withdrawal behaviors, whereas guilt is associated with retaliatory and supportive behaviors in response to the observed incivility. We tested these hypotheses with a sample …

Predicting Personality Type From Writing Style, Tanay Gottigundala

Master's Theses

The study of personality types gained traction in the early 20th century, when Carl Jung's theory of psychological types attempted to categorize individual differences into the first modern personality typology. Iterating on Jung's theories, the Myers-Briggs Type Indicator (MBTI) tried to categorize each individual into one of sixteen types, with the theory that an individual's personality type manifests in virtually all aspects of their life. This study explores the relationship between an individual's MBTI type and various aspects of their writing style. Using a MBTI-labeled dataset of user posts on a personality forum, three ensemble classifiers were created to predict …

Nanocrystal Based Orally Disintegrating Tablets As A Tool To Improve Dissolution Rate Of Vortioxetine, Eknath Ahire, Shreya Thakkar, Yogeshwari Borade, Manju Misra

Bulletin of Faculty of Pharmacy Cairo University

Major depressive disorder (MDD) or depression is a heterogeneous mental illness which have direct effect on patient’s behavior and cognition; causing constant feeling of unhappiness and loss of concern in earlier enjoyed events. Vortioxetine (VOR) is a new atypical serotonergic antidepressant reported for the treatment of major MDD and has its use in various psychological disorders. Despite its therapeutic potential, it has poor water solubility which creates problem in delivery. Nanocrystal based orally disintegrating tablets (ODTs) are proposed to enhance water solubility and dissolution rate of VOR. Nanosuspension was prepared by nanoprecipitation method after optimizing various parameters. The formulated nanosuspension …

A Bayesian Approach To Computer Model Calibration And Model-Assisted Design, Carl Ehrett

All Dissertations

Computer models of phenomena that are difficult or impossible to study directly are critical for enabling research and assisting design in many areas. In order to be effective, computer models must be calibrated so that they accurately represent the modeled phenomena. There exists a rich variety of methods for computer model calibration that have been developed in recent decades. Among the desiderata of such methods is a means of quantifying remaining uncertainty after calibration regarding both the values of the calibrated model inputs and the model outputs. Bayesian approaches to calibration have met this need in recent decades. However, limitations …

The Appraisal Of Stressors As An Outcome: Novel Directions On The Conceptualization And Measurement Of Work Stress, Zachary Klinefelter

All Dissertations

Though work stress research has come a long way since the early unidimensional models of stressor-outcome relationships, there continues to be a lack of consensus on how stressors influence employees, and on how individual employee characteristics influence the stressor appraisal process. This study utilized a 3-wave longitudinal design to investigate the relationships between the appraisals of challenge and hindrance stressors at work, perceived resilience, stress mindset, and psychological strain. Split into two separate models, the present study sought to extend previous research on the mediating effects of perceived resilience on the relationship between stressors and strain, and to investigate potential …

Zoning Cyberspace: Protecting Privacy In The Digital Upside Down, Raymond H. Brescia

Utah Law Review

Over fifty years ago, Charles Reich posited that we should extend property protections to what he would call “government largess”: that array of interests—from licenses to welfare benefits—that often form the bases for one’s economic existence in the modern world. Reich considered such protections essential to the preservation of individual autonomy, the independence that is critical to a functioning democracy. Today, our most personal information and even our thoughts, as reflected in our online activities and digital existence, are subject to “private largess.” Private entities possess information central to the identity of those individuals who utilize their services. This information …

Markovian Approach To Stock Price Modelling In The Nigerian Oil And Gas Sector, Ayo Adekunle S., Uwabor Eboigbe S.

CBN Journal of Applied Statistics (JAS)

The study investigates the stock price movement of quoted Nigerian oil and gas firms using the Markovian model. Specifically, the study estimates the change in likelihoods and steady-state distribution of the share prices of the firms to determine the average time spent by the share price to move to another state and the turnover rate of the selected stocks. Markov chain-based stochastic modelling approach was employed by using the daily closing share prices of all the seven oil and gas firms quoted on the Nigerian Stock Exchange from April 2017 to January 2020. The study finds that the transition probabilities …

Agent-Relative Consequentialism And Collective Self-Defeat, Matthew Hammerton

Research Collection School of Social Sciences

Andrew Forcehimes and Luke Semrau argue that agent-relative consequentialism is implausible because in some circumstances it classes an act as impermissible yet holds that the outcome of all agents performing that impermissible act is preferable. I argue that their problem is closely related to Derek Parfit's problem of ‘direct collective self-defeat’ and show how Parfit's plausible solution to his problem can be adapted to solve their problem.

The Resilience Of Female Survivors Of Intimate Partner Violence In Southwest Nigeria: An Interdisciplinary Analysis, Tobi F. Oloyede

Electronic Theses and Dissertations

Female survivors of intimate partner violence (IPV) in Nigeria endure harsh and traumatic experiences that affect their rights as women and their well-being. As the phenomenon of IPV persists in Nigeria, it is not only a family problem but a critical social and psychological problem. This study examined Nigerian female survivors’ hidden strength, agency, and resilience, rather than their powerlessness and vulnerability. Analysis of survey questionnaires, interviews, and secondary scholarship reveals that some Nigerian female survivors of IPV are able to cope whilst navigating stressful and traumatic experiences. The results also show that survivors’ ability to thrive and cope under …

It Must Have Been Your Eyes, Christian Vasquez

Theses and Dissertations

This fiction book entails the story of a Mexican orphan girl, Mariana, who is propelled on to a journey to the U.S. along with her mysterious ability to see the future in people’s eyes. Her plight lands her on a shelter for unaccompanied immigrant children in Texas where she is forced to confront her fears and grow. In this surreal story that is based on true events, our times are reflected and even our future

Effect Of A Mobile Phone Intervention For Female Sex Workers On Unintended Pregnancy In Kenya (Whisper Or Shout): A Cluster-Randomised Controlled Trial, Frances H. Ampt, Megan S. C. Lim, Paul A. Agius, Kelly L'Engle, Griffins Manguro, Caroline Gichuki, Peter Gichangi, Walter Jaoko, Marleen Temmerman, Stanley Luchters

Obstetrics and Gynaecology, East Africa

Background: Female sex workers in low-income and middle-income countries face high risks of unintended pregnancy. We developed a 12-month, multifaceted short messaging service intervention (WHISPER) for female sex workers in Kenya who had the potential to become pregnant, to improve their contraceptive knowledge and behaviours. The aim of this study was to assess the effectiveness of the intervention to reduce the incidence of unintended pregnancy among sex workers in Kenya compared with an equal-attention control group receiving nutrition-focused messages (SHOUT).

Methods: Our two-arm, cluster-randomised controlled trial was done in sex-work venues in two subcounties of Mombasa, Kenya (Kisauni and Changamwe). …

Watching Androids Dream Of Electric Sheep: Immersive Technology, Biometric Psychography, And The Law, Brittan Heller

Vanderbilt Journal of Entertainment & Technology Law

Virtual reality and augmented reality present exceedingly complex privacy issues because of the enhanced user experience and reality-based models. Unlike the issues presented by traditional gaming and social media, immersive technology poses inherent risks, which our legal understanding of biometrics and online harassment is simply not prepared to address. This Article offers five important contributions to this emerging space. It begins by introducing a new area of legal and policy inquiry raised by immersive technology called “biometric psychography.” Second, it explains how immersive technology works to a legal audience and defines concepts that are essential to understanding the risks that …

Hitting The Trail: An Exploration Of An Outdoor Educational Experience At Intermountain West Junior High School, David N. Joy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Outdoor educational experiences are one of the ways that young people learn about and experience the benefits that are found in the outdoors. However, despite the benefits that outdoor educational experiences have to offer, many young people do not participate for one reason or another. These reasons are often rooted in issues of social injustice. This study adds to about how outdoor educational experiences effect the perceptions of and attitudes toward the outdoors and learning in the outdoors, as well as what may be keeping so many people from participating in these experiences. One junior high school in the intermountain …

Teacher Retention In Secure Residential Settings, Daniel Froemel

Electronic Theses and Dissertations

A phenomenological study was conducted to identify the factors associated with job retention among teachers in secure residential treatment centers in Tennessee. Central to this investigation was the exploration of how residential teachers perceive they are supported in their position, how teachers in residential settings perceive the culture of the facility, and what factors are associated with teacher retention in secure residential settings. Through a series of fifteen interviews, common themes emerged from the coding that provided insight into these questions.

Teachers who had worked in residential settings for more than five years seemed to have very strong internal belief …

Safety In The Educational Environment: Rural District Administrator Perceptions Of School Safety In Northeast Tennessee Public Schools, Richard A. True

Electronic Theses and Dissertations

A qualitative research study was conducted to identify, describe, and understand the perceptions of administrators of public school districts in northeast Tennessee regarding school safety. Using a semi-structured interview process, the researcher identified emerging themes regarding the factors most associated with safe school districts, the factors most associated with unsafe school districts, the items identified as needed to improve safety, and the topics identified as future safety issues at the school and district level. Through such study, the researcher was able to develop an understanding regarding the overall safety of school districts in northeast Tennessee and the specific components that …

Assimilating Through Consumption: A Rhetorical History Of The Early Years Of The Advocate, Cora Beth Butcher-Spellman

Graduate Theses and Dissertations

This thesis uses analysis of constitutive rhetoric and queer archival methods to examines how The Advocate used assimilationist rhetoric and consumerist rhetoric in fundamentally anti-democratic ways to consolidate the form of ideal gay consumer-citizenship. Focusing on the first three years of the publication, I utilize queer theory and theories of citizenship and political economy to explain how The Advocate’s rhetoric and mainstream success allowed the publication to normalize a limited and politically weak gay identity. This thesis argues The Advocate’s rhetoric of exclusion, authority, and consumerism were three central features shaping ideal gay consumer-citizenship as most available to people who …

Effect Of Sound Source Location And Spatial Hearing On The Vestibulo-Ocular Reflex (Vor), Mary Easterday

Theses and Dissertations (ETD)

Accurate measurement of the vestibulo-ocular reflex (VOR) is imperative in differential diagnosis of vestibular disorders and balance function. However, the assessment protocol faces a number of limitations, including the need to control for extra- vestibular sensory factors such as hearing. Previous research has shown that the use of an auditory stimulus can have a significant effect on functional measures of balance, and many have contributed effects to be the result of spatial hearing. However, no studies have directly assessed the effect of speaker location on the VOR nor investigated correlations of functional spatial hearing with the VOR. Therefore, the aims …

Early Diagnosis Of Alzheimer’S Disease In The Primary Care Setting, Raymond R. Romano

Theses and Dissertations (ETD)

The burden of Alzheimer’s disease (AD) affects not just the individual but also families, providers, and society. Early recognition and diagnosis of AD may reduce cost by reducing interaction with the health care system, earlier initiation of treatment, and prolonging time to long- term care. Primary care providers, the first contact for diagnosis of patients with AD, are not fulfilling the potential of early diagnosis for a variety of reasons. Biomarkers of AD emerge on average 15 to 20 years before clinical diagnosis, yet currently established biomarkers are not easily available in the primary care setting. A growing body of …

Risk Factors Contributing To The Development Of Bronchopulmonary Dysplasia Among Preterm Infants, Caitlin E. Bradley

Graduate Doctoral Dissertations

Bronchopulmonary dysplasia (BPD) is a pulmonary disease that affects infants born < 32 weeks gestational age. Despite improved survival among preterm infants, the incidence and severity of BPD has not improved, rather the features and severity of BPD have evolved (Abman et al., 2017). BPD is a disease that has significant impact on the outcomes of preterm infants, including poor pulmonary and neurodevelopmental outcomes (Abman et al., 2017). Since its identification in 1967, and many iterations to its defining criteria, healthcare practitioners are unable to accurately predict infants’ risk of developing BPD. Further, there is significant family, social, and economic impacts from BPD. This dissertation research examined risk factors for BPD, as identified in a mid-range theory developed from a systematic review of the literature. This mid-range theory is framed using the Neuman Systems Model (NSM) (2011). The research utilized a secondary analysis of data from a database including a cohort of infants born at < 32 weeks’ gestation (n=455) treated at Boston Children’s Hospital. Findings from this research demonstrated that multiple intrapersonal risk factors are associated with development of BPD and the grades of BPD severity including gestational age, birth weight, surfactant administration, necrotizing enterocolitis, infections, mechanical ventilation duration, and patent ductus arteriosus. This research adds to the current body of research by demonstrating specific risks associated with BPD. Findings of this research could be used to identify maternal infant dyads that would benefit from early therapy(s) to reduce BPD risk.