Digital Commons Network^™

Expression, Purification, And Characterization Of Recombinant Human Npas2, Brenda Moreno

Open Access Theses & Dissertations

Many living organisms have biological clocks known as circadian rhythms that control various physiological and behavioral processes, tailored with the day and night. At the cellular level, the circadian clock drives daily rhythms with a transcriptional-translational feedback loop (TTFL) established by multiple transcription factors and genes under their regulation. Circadian Locomotor Output Cycles Kaput (CLOCK) and Brain and Muscle ARNT-like protein 1 (BMAL1) are two of those transcription factors, initiating the TTFL by forming a heterodimeric complex that bind to DNA promoters. Neuronal PAS domain protein 2 (NPAS2) is a functional analog to CLOCK. Less knowledge about NPAS2, in contrast …

Discovery Of Glycan-Based Biomarkers For Cutaneous Leishmaniasis And Chagas Disease By Reversed Immunoglycomics, Alba Lucia Montoya

Open Access Theses & Dissertations

Protozoa are the causative agents of a number of diseases that affect humans and mammalian animals. Several forms of leishmaniasis are caused by different Leishmania species (Leishmania spp.), while Chagas disease (CD) is caused by the parasite Trypanosoma cruzi (T. cruzi). These members of the Trypanosomatidae family have characteristic glycoconjugates broadly distributed on their cell surfaces, which can be useful for diagnosis and follow-up of chemotherapy for the diseases.

Leishmania spp. expresses an “exotic” surface glycocalyx mainly composed of a number of glycosyl-phosphatidylinositol (GPI)-anchored proteins, a complex lipophosphoglycan (LPG) and a family of low-molecular mass glycoinositol-phospholipids (GIPLs), some of them …

The Framing Of Recycling Information Toward Behavioral Intention, Perla Celeste Perez

Open Access Theses & Dissertations

Most studies have measured the relationship between self-reported recycling behavior and attitudes. Very little research has focused on how the framing of recycling information moderates this relationship. Moreover, even less research has examined how communication messages directly impacts self-efficacy of recycling. Thus, the aim of this study is to further understand factors that influence self-reported recycling behavioral intention and information framing. We predicted that pro-environmental behavior would be positively associated with climate change beliefs and recycling efficacy. We also predicted that individuals that read a positive recycling article would be more likely to intend to recycle than individuals who read …

Design Of Experiments Analysis Of Powder Removal Methods For Ebm Manufactured Ti-6al-4v Parts, Luis Cesar Ramos Castañeda

Open Access Theses & Dissertations

Additive Manufacturing is a technology that allows the on-demand manufacturing of complex geometries that cannot be fabricated through traditional subtractive manufacturing methods. Powder Bed Fusion is one of the seven categories of Additive Manufacturing with two subcategories, the Laser Beam Melting and the Electron Beam Melting. Freedom of design, rapid prototyping, and customization are some of the benefits that this technology provides. Like any technology, there are limitations for each category and subcategory. The Electron Beam Melting uses the electron beam to pre-heat the powder bed, reducing the temperature difference between the build part and powder bed, causing the surrounding …

A Full Collegiate Volleyball Season Does Not Influence Jumping Or Landing Performance In Freshmen And Sophomore Players, Christian Noel Sanchez

Open Access Theses & Dissertations

Knee injuries are devastating and typically experienced by athletes when performing jumping and landing tasks throughout a complete collegiate volleyball season. The purpose of this study was to examine changes in lower extremity strength, frontal plane knee angles and moments, jump performance during a countermovement and approach jump before and after a complete Division I collegiate volleyball season in female volleyball freshman and sophomores. Eight freshman/sophomore female collegiate volleyball players participated in the study. Lower extremity strength was assessed using an isokinetic dynamometer, kinematic and kinetic data were obtained through three-dimensional motion capture system and force platforms, respectively. Participants performed …

Performane Characterization Of Stabilized Materials In Pavement Foundations, Mohammad Rashidi

Open Access Theses & Dissertations

Cementitious Stabilization has been widely used to improve the strength and durability of granular materials for the construction and rehabilitation of pavement structures. Improved mechanical properties and durability of the stabilized materials combined with relatively low cost makes it an attractive method for design engineers. Although this technique appears simple and straight forward, engineering properties of individual soils and aggregates may alter widely due to heterogeneity in soil composition, difference in micro structure among soils, heterogeneity of geologic deposits and differences in chemical interactions of water with soil particles. These differences necessitate the comprehensive study in order to provide the …

Testing The Reliability And Flexibility Of Digitizers Adapting The Rf/If Signals Over Ip Applications Using A Testbed Platform, Jose Carlos Sandoval

Open Access Theses & Dissertations

As physical constraints can be challenging for Radio Frequency (RF) telemetry, a new solution has been exploited to support the demand for RF transmissions. As frequency spectrum gets crowded with more technologies, a solution to a reliable transmission is needed. Digitizers can mitigate many of the physical constraints in order to achieve a successful RF transmission. The method includes the conversion of the RF signals to be sent over IP networks, transmit and de-convert the signal. IP networks will mitigate many disadvantages over a regular signal transmission. The authority in charge to allocate frequency bands is the Federal Communications Commission …

Sex Differences In The Mechanisms That Modulate The Neurochemical Effects Of Nicotine, Kevin Uribe

Open Access Theses & Dissertations

Prior behavioral studies in our laboratory revealed that overexpression of the stress peptide, corticotrophin-releasing factor (CRF), in the mesocorticolimbic reward pathway enhanced the reinforcing effects of nicotine. The latter effect was greater in female versus male rats, suggesting that females are uniquely susceptible to the effects of stress on nicotine reinforcement. The goal of this dissertation was to examine the neurochemical mechanisms by which overexpression of CRF in the nucleus accumbens (NAc), a terminal region of the mesocorticolimbic pathway, modulates the behavioral effects of nicotine. Specifically, we examined whether nicotine-induced dopamine levels are altered by CRF overexpression via excitatory (glutamate) …

Brian Valdez - Dynamics And Control Of A 3-Dof Manipulator With Deep Learning Feedback, Brian Orlando Valdez

Open Access Theses & Dissertations

With the ever-increasing demands in the space domain and accessibility to low-cost small satellite platforms for educational and scientific projects, efforts are being made in various technology capacities including robotics and artificial intelligence in microgravity. The MIRO Center for Space Exploration and Technology Research (cSETR) prepares the development of their second nanosatellite to launch to space and it is with that opportunity that a 3-DOF robotic arm is in development to be one of the payloads in the nanosatellite. Analyses, hardware implementation, and testing demonstrate a potential positive outcome from including the payload in the nanosatellite and a deep learning …

A Comprehensive And Modular Robotic Control Framework For Model-Less Control Law Development Using Reinforcement Learning For Soft Robotics, Charles Sullivan

Open Access Theses & Dissertations

Soft robotics is a growing field in robotics research. Heavily inspired by biological systems, these robots are made of softer, non-linear, materials such as elastomers and are actuated using several novel methods, from fluidic actuation channels to shape changing materials such as electro-active polymers. Highly non-linear materials make modeling difficult, and sensors are still an area of active research. These issues have rendered typical control and modeling techniques often inadequate for soft robotics. Reinforcement learning is a branch of machine learning that focuses on model-less control by mapping states to actions that maximize a specific reward signal. Reinforcement learning has …

Spatially Adaptive Estimation Of Spectrum, Yi None Xie

Open Access Theses & Dissertations

When analyzing a stationary time series, one of the questions we are often interested in is how to estimate its spectrum. Many approaches have been proposed to this end. Most are focused on smoothing the periodogram using a single smoothing parameter across all Fourier frequencies. In this paper, we smooth the log periodogram by placing a spatially adaptive prior called the dynamic shrinkage prior, so that varying degrees of smoothing may be applied to different intervals of Fourier frequencies, resulting in less biased estimates of the spectrum. Further research will extend this approach to spectral estimation for nonstationary time series.

Antioxidant Intervention In Radical-Induced Protein Damage, Emmanuel Zubia

Open Access Theses & Dissertations

Many environmental toxicants are known to increase free-radical production, which can create cellular havoc and lead to a myriad of ailments. Antioxidants can be used to ameliorate the prevalence of free radicals, potentially serving as prophylactics against radical-induced disorders. Many exogenous antioxidants are phytochemicals in origin, such as ascorbic acid, gallic acid, and ellagic acid. Some of these antioxidants can be found in traditional medicine, like tanshinone and brazilin, which have been studied and are known to have low cytotoxicity. Here we test the radical rescue capacity of a selected group of phytochemical antioxidants on protein rescue models. Specifically, our …

Using Visual Prompts In Research, Maura A. Smale, Mariana Regalado

Publications and Research

No abstract provided.

Panpsychism As An Observational Science, Gregory Matloff

Publications and Research

The metaphysical concept of panpsychism defines a field of proto-consciousness that is present at all levels in the universe. An observational indication that this concept might be correct is self-organization on all levels from the molecular to the galactic. In 2011, an investigation into the validity of author Olaf Stapledon’s concept that a portion of stellar motion is volitional led to a consideration of an observational stellar kinematics anomaly dubbed Parenago’s Discontinuity. Data available at the time indicated that cooler, less massive stars (such as the Sun) revolve a bit faster around the center of the Milky Way galaxy than …

Relationships Between Dress And Gender In A Context Of Cultural Change, Alyssa Dana Adomaitis, Diana Saiki, Kim K. P. Johnson

Publications and Research

No abstract provided.

The Labour Of Austerity: Absurdity, Performative Resistance, And Cultural Transformation, Nora Almeida

Publications and Research

This essay explores the social-psychic toll of prolonged austerity on academic librarians and the range of strategies that have (or could) serve as tools of resistance. Using a combination of theoretical analysis and autoethnography, I examine the emotional impact of bottomless and invisible labour imposed by austerity and the ways institutions use emotional coercion to promote self-surveillance, meta-work, and hyper-productivity. Following this analysis, I discuss the ways that oppressive institutional cultures silence dissent and absorb common resistance tactics advocated by educators. Finally, I introduce several examples of performance-based resistance projects and explore how creative, personal, and absurd forms of protest …

Hard As Kerosene, Aaron Barlow

Publications and Research

This novel is set in West Africa during the 1980s and concerns one man's trip through Peace Corps, war and alcoholism.

Rpas: An Enhanced Finite Element Code For The Mechanistic Analysis Of Rigid Pavements, Nancy Aguirre

Open Access Theses & Dissertations

Significant amount of research has been conducted to improve the design of rigid pavements through the development of mechanistic analysis tools capable of accurately modeling the performance of such pavements. The use of the finite element (FE) method as a comprehensive tool for modeling the responses of rigid pavements has been limited in the past because of the complexity of calculations in modeling nonlinear behaviors, which are difficult to describe mathematically and computationally. Researchers from The University of Texas at El Paso developed NYSLAB, an FE modeling tool, for the analysis of rigid pavements subjected to traffic and environmental loading …

Fabrication, Development, And Characterization Of Hipco Swcnt - Alginate Hydrogel Composites For Cellular Product Applications, Fabian Armando Alvarez-Primo

Open Access Theses & Dissertations

In this study, we designed, synthesized, and characterized ultrahigh purity single-walled carbon nanotube (SWCNT)-alginate hydrogel composites. Among the parameters of importance in the formation of an alginate-based hydrogel composite with single-walled carbon nanotubes, are their varying degrees of purity, their particulate agglomeration and their dose-dependent correlation to cell viability, all of which have an impact on the resultant compositeâ??s efficiency and effectiveness towards biomedical applications. To promote their homogenous dispersion by preventing agglomeration of the SWCNT, at first, we used three different surfactants-sodium dodecyl sulfate (SDS-anionic), cetyltrimethylammonium bromide (CTAB-cationic), and Pluronic F108 (nonionic). After experimentation and corroboration through evidence obtained …

Assessment Of Hydraulic And Structural Behavior Of Inundated Pavements, Mojtaba Asadi

Open Access Theses & Dissertations

Severe flooding events have increasingly inundated the transportation infrastructure, including road networks, across the world and the Unites States. Such extreme events induce significant ingress of water into the pavement layers, which in turn leads to structural defects due to the reduction of the shear strength and resilient moduli of the soil layers, asphalt stripping in flexible pavements, pumping effect in rigid pavements, migration of fines into drainable layers, and swelling of expansive soils. Consequently, premature pavement failure may take place that can impose unforeseen maintenance/rehabilitation costs to highway agencies. Although some experimental research studies have been conducted to assess …

Abstraction Techniques In Security Games With Underlying Network Structure, Anjon Basak

Open Access Theses & Dissertations

In a multi-agent system, multiple intelligent agents interact with each other in an environment to achieve their objectives. They can do this because they know which actions are available to them and which actions they prefer to take in a particular situation. The job of game theory is to analyze the interactions of the intelligent agents by different solution techniques and provide analysis such as predicting outcomes or recommending courses of action to specific players. To do so game theory works with a model of real-world scenarios which helps us to make a better decision in our already complex daily …

Structure-Property-Performance Evaluation Of Refractory Metal Incorporated Gallium Oxide Thin Films For Extreme Environment Applications, Anil Krishna Battu

Open Access Theses & Dissertations

An approach is presented to design refractory-metal (RM) incorporated Ga2O3-based materials with controlled structural, mechanical, and optical properties. A model system based on molybdenum (Mo) doped Ga2O3 (GMO) has been considered to elucidate the combined effect of RM-doping and processing parameters on the properties and oxygen sensor performance of GWO nanomaterials. The molybdenum (Mo) content in Ga2O3 was varied from 0 to 11 at% in the sputter-deposited Ga-Mo-O films. Molybdenum was found to significantly affect the structure and optical properties. While low Mo content (≤4 at%) results in the formation of single-phase (β-Ga2O3), higher Mo content results in amorphization. Chemically …

Understanding The Digital Lives Of Transnational Students: A Case Study, Chowaing Chagra Belekeh

Open Access Theses & Dissertations

The proliferation and the fast-paced evolution of digital information communication technologies (ICTs) in contemporary times have arguably raised concern for us to comprehend what we do with these technologies and what these technologies do for us. The experience of engaging these technologies may not necessarily be the same for everyone—especially students who come from around the world to attain post-graduate degrees in the United States. This research focused on understanding the digital lives, choices, and experiences of transnational students who navigate and negotiate geopolitical borders and boundaries (physical)– in their quest for education. Using a case study analysis and collecting …

A Comparative Study Of The Impact Of Depth In Deep Learning Architectures, Kirsten Byers

Open Access Theses & Dissertations

Machine Learning continues to evolve as applications become more complex. Neural Networks, or Deep Networks, are integral to machine learning and the entire taxonomy of Artificial Intelligence [Sze17]. Intelligent structures and algorithms continue to advance, keeping pace with the complexi-ty of data. Changes in architecture, algorithms, and parameters are necessary to keep up with com-putational complexity and data available. This study focuses on how changes in depth of the archi-tecture affect performance on three distinct datasets, including one on Heart Disease. An adaptable network is created in original code, trained, and tested on these datasets. Its performance parameters are observed …

Development Of Advanced Statistical Methods For Multivariate Classification, Mario Cardenas Jr

Open Access Theses & Dissertations

This work is on the development of an observation reduction technique based on the principal component scores, or loadings, intended for the classification of data.

Graduate School Application Accessibility For International Students, Estefania Castillo

Open Access Theses & Dissertations

The graduate school application is a time consuming, yet important, process that can often be complicated for students. However, this process is made even more complicated for international students who often face extra steps and other obstacles when applying to graduate programs in the US. Following my own experience of applying to a master's program as an international student, I set out to further explore how international students experienced and navigated this process. This research project explored the graduate school application process through the experiences of international students that were shared in testimonios through platicas, or open and friendly conversations. …

3d Printed Alginate-Based Zinc Oxide Nanoparticle Scaffolds For Wound Healing, Carol Cleetus

Open Access Theses & Dissertations

Effective treatment of chronic wounds is essential for the prevention of infection and scar tissue formation, requiring a novel approach to address the limitations of existing options. This study utilizes Calcium Chloride (CaCl2) crosslinked alginate, a common biomaterial widely used in wound dressing, and UV activated Zinc Oxide (ZnO) nanoparticles (NPs) for their potential hydroxyl radical mediated antibacterial applications. ZnO NPs were synthesized by combustion method from Zinc Nitrate Hexahydrate and Sucrose. Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) characterization were used to verify composition and NP size. Terephthalic Acid, used as a fluorescent probe, confirmed the generation of …

Association Of A Repetitive Manual Task On Inflammatory Biomarker Expression, Heart Rate Variability And Rating Of Perceived Exertion, Daniel Conde

Open Access Theses & Dissertations

The National Institute for Occupational Safety and Health (NIOSH) defines work related musculoskeletal disorders (WMSDs) as a group of disorders involving muscles, tendons, and nerves. The WMSDs symptoms are considered the most common occupational disease, causing limitations in daily activities. Even though there is an association between repetitive manual tasks involving short work cycles, force demanding tasks, and the development of WMSDs, the specific cause of the physiological changes over a long period of time is a cause of debate. The study of mechanisms underlying the physiological changes is essential for the early detection, diagnosis, and appropriate management of WMSDs.

To Or Through The Skin: A Rational Design Of Transdermal Drug Delivery, Isaac Giovanni Deaguero

Open Access Theses & Dissertations

The skin is the largest organ in the body and plays many crucial roles through diverse functions ranging from protection, temperature regulation, energy storage via fat deposits, and is used to communicate with our surroundings. Various methods have been attempted to deliver drugs to target areas of the skin in effective dosages by a variety of means with limited success. Recently, advances in transdermal drug delivery have offered avenues previously unattainable through conventional means. Some of these new delivery methods have been reviewed, explored and offer promising results with the potential to carve a new avenue in the way therapeutic …

Development And Characterization Of Perovskite Solar Cells For Tandem Device Configuration, Angel Moiseis De La Rosa

Open Access Theses & Dissertations

Photovoltaic devices based on perovskite materials are constantly progressing towards more applicability in large-area panels. In order for perovskite-based photovoltaics to reach reliable and stable commercialization, common issues with the use of perovskite still need to be resolved, including the need to identify fabrication processes that can yield optimal material parameters for better photovoltaic performance. Defining an optimal fabrication process requires that researchers and manufacturers alike come to an agreement regarding perovskite characteristics that result from device operation and material processing. This work focuses on characterizing physical, electrical, and electronic properties of a FAxCs1-xPb(IyBr1-y)3 perovskite, and how some of these …