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2020

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The Hunger Report: An In-Depth Look At Food Insecurity In Singapore, Tania Nagpaul, Dalvin Sidhu, Jinwen Chen Aug 2020

The Hunger Report: An In-Depth Look At Food Insecurity In Singapore, Tania Nagpaul, Dalvin Sidhu, Jinwen Chen

Lien Centre for Social Innovation: Research

This report provides a detailed account of the first nationally representative study on the largely hidden problem of food insecurity in Singapore.


2020 Fall - Schedule Of Classes, Office Of The Registrar, East Tennessee State University Aug 2020

2020 Fall - Schedule Of Classes, Office Of The Registrar, East Tennessee State University

Registration Resources

No abstract provided.


Clemson Commencement Program, August 2020, Clemson University Aug 2020

Clemson Commencement Program, August 2020, Clemson University

Clemson Commencement Programs

No abstract provided.


Data Management Report August 2020, Tennessee. Department Of Intellectual And Developmental Disabilities Aug 2020

Data Management Report August 2020, Tennessee. Department Of Intellectual And Developmental Disabilities

Compliance & System Data/Reports

This monthly report provides data on various aspects of the department's activities and programs.


Utah State Magazine, Fall 2020, Utah State University Aug 2020

Utah State Magazine, Fall 2020, Utah State University

Utah State Magazine

The quarterly magazine for friends and alumni of Utah State University.


A Systematic Review Of Interventions For Family Caregivers Who Care For Patients With Advanced Cancer At Home., Soojung Ahn, Rafael D. Romo, Cathy L. Campbell Aug 2020

A Systematic Review Of Interventions For Family Caregivers Who Care For Patients With Advanced Cancer At Home., Soojung Ahn, Rafael D. Romo, Cathy L. Campbell

Nursing | Faculty Scholarship

OBJECTIVE: To examine the characteristics of interventions to support family caregivers of patients with advanced cancer.

METHODS: Five databases (CINAHL, Medline, PsycINFO, Web of Science, and the Cochrane Library) were searched for English language articles of intervention studies utilizing randomized controlled trials or quasi-experimental designs, reporting caregiver-related outcomes of interventions for family caregivers caring for patients with advanced cancer at home.

RESULTS: A total of 11 studies met the inclusion criteria. Based on these studies, the types of interventions were categorized into psychosocial, educational, or both. The characteristics of interventions varied. Most interventions demonstrated statistically significant results of reducing psychological …


Consensus Guidelines For Management Of Hyperammonaemia In Paediatric Patients Receiving Continuous Kidney Replacement Therapy., Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon Mcculloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady Aug 2020

Consensus Guidelines For Management Of Hyperammonaemia In Paediatric Patients Receiving Continuous Kidney Replacement Therapy., Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon Mcculloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady

Paediatrics Publications

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the …


Hyperammonemic Encephalopathy As A Manifestation Of Reye Syndrome In A Previously-Healthy 14-Year-Old Girl: A Case Report, Dara Petel, Chitra Prasad, Tony Rupar, Simon Levin, Andréanne N. Zizzo, Ajay P. Sharma, Janice A. Tijssen Aug 2020

Hyperammonemic Encephalopathy As A Manifestation Of Reye Syndrome In A Previously-Healthy 14-Year-Old Girl: A Case Report, Dara Petel, Chitra Prasad, Tony Rupar, Simon Levin, Andréanne N. Zizzo, Ajay P. Sharma, Janice A. Tijssen

Paediatrics Publications

Reye syndrome is seldom considered in the older child presenting with acute encephalopathy. The paucity of literature on Reye syndrome in the past 30 years highlights the importance of sharing new observations of this less-commonly considered disease. This case details an atypical presentation of Reye syndrome in an adolescent girl whose course was unexpectedly complicated by dialysis disequilibrium syndrome, occurring as a result of rapid metabolic shifts in the setting of urgent hemodialysis. A 14-year-old, previously healthy girl born to non-consanguineous Pakistani parents presented with acute-onset encephalopathy characterized by aggressive behaviour and altered level of consciousness. This was preceded by …


Contemporary Strategies To Prevent Infection In Hip And Knee Arthroplasty, Lachlan M. Batty, Brent Lanting Aug 2020

Contemporary Strategies To Prevent Infection In Hip And Knee Arthroplasty, Lachlan M. Batty, Brent Lanting

Bone and Joint Institute

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of Review: Prosthetic joint infection (PJI) remains a serious concern in lower limb arthroplasty. Despite the significant consequences of PJI, the assessment of the safety and efficacy of preventative measures is challenging due to a low event rate. Notwithstanding, enormous efforts have been made in this arena, and prevention strategies continue to evolve. This review provides an update on contemporary literature (published within the last 5 years) pertaining to infection prevention in primary hip and knee arthroplasty. Recent Findings: Patient optimization has been highlighted as a critical preoperative factor …


Frailty In Chronic Obstructive Pulmonary Disease And Risk Of Exacerbations And Hospitalizations, Nathan Yee, Emily R. Locke, Kenneth C. Pike, Zijing Chen, Jungeun Lee, Joe C. Huang, Huong Q. Nguyen, Vincent S. Fan Aug 2020

Frailty In Chronic Obstructive Pulmonary Disease And Risk Of Exacerbations And Hospitalizations, Nathan Yee, Emily R. Locke, Kenneth C. Pike, Zijing Chen, Jungeun Lee, Joe C. Huang, Huong Q. Nguyen, Vincent S. Fan

College of Nursing Faculty Publications

Background: Frailty is a complex clinical syndrome associated with vulnerability to adverse health outcomes. While frailty is thought to be common in chronic obstructive pulmonary disease (COPD), the relationship between frailty and COPD-related outcomes such as risk of acute exacerbations of COPD (AE-COPD) and hospitalizations is unclear.
Purpose: To examine the association between physical frailty and risk of acute exacerbations, hospitalizations, and mortality in patients with COPD.
Methods: A longitudinal analysis of data from a cohort of 280 participants was performed. Baseline frailty measures included exhaustion, weakness, low activity, slowness, and undernutrition. Outcome measures included AE-COPD, hospitalizations, and mortality over …


Multiomic Immune Clockworks Of Pregnancy, Laura S. Peterson, Ina A. Stelzer, Amy S. Tsai, Mohammad S. Ghaemi, Xiaoyuan Han, Kazuo Ando, Virginia D. Winn, Nadine R. Martinez, Kevin Contrepois, Mira N. Moufarrej, Stephen Quake, David A. Relman, Michael P. Snyder, Gary M. Shaw, David K. Stevenson, Ronald J. Wong, Petra Arck, Martin S. Angst, Nima Aghaeepour, Brice Gaudilliere Aug 2020

Multiomic Immune Clockworks Of Pregnancy, Laura S. Peterson, Ina A. Stelzer, Amy S. Tsai, Mohammad S. Ghaemi, Xiaoyuan Han, Kazuo Ando, Virginia D. Winn, Nadine R. Martinez, Kevin Contrepois, Mira N. Moufarrej, Stephen Quake, David A. Relman, Michael P. Snyder, Gary M. Shaw, David K. Stevenson, Ronald J. Wong, Petra Arck, Martin S. Angst, Nima Aghaeepour, Brice Gaudilliere

All Dugoni School of Dentistry Faculty Articles

Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, …


Peer Mentor Text Message Intervention To Mitigate Summer Melt In Lower Socioeconomic Rural High Schools, Jason Stelly Aug 2020

Peer Mentor Text Message Intervention To Mitigate Summer Melt In Lower Socioeconomic Rural High Schools, Jason Stelly

Doctoral Dissertations

Summer melt is the phenomenon where students complete the requirements and get accepted into a higher education institution but fail to matriculate following high school graduation. Lower socioeconomic status students are affected the most, and summer melt rates range from 22% to 50% in school districts (Arnold, K., Fleming, S., DeAnda, M., Castleman, B., & Wartman, K., 2009; Castleman & Page, 2014a; Naranjo, Pang, & Alvarado, 2016). After high school graduation, students are left on their own to navigate through the difficulties of matriculating. The purpose of the study is to create and implement a peer mentor text message campaign …


Health Impacts Of Global Climate Change With A Focus On Women’S Health, Mikhaila Samz Aug 2020

Health Impacts Of Global Climate Change With A Focus On Women’S Health, Mikhaila Samz

Theses and Graduate Projects

Background: Global climate change has been occurring at an unprecedented rate and is damaging to human health. With women having specific health care needs, this literature review examines the relationship between women’s health (including maternal health) and global climate change through subtopics including global temperature and heat waves, carbon dioxide emissions and air pollution, natural disasters and extreme weather events, malnutrition and food insecurity, water supply and resource scarcity, and changing infectious disease patterns.

Methods: A literature search was conducted across several online databases, predominantly PubMed, for articles related to global climate change and its role in women’s health. The …


Does Urbanization Or Industrialization Have More Impact On The Increasing Prevalence Of Diabetes In Developing Countries?, Simon Mazza Aug 2020

Does Urbanization Or Industrialization Have More Impact On The Increasing Prevalence Of Diabetes In Developing Countries?, Simon Mazza

Theses and Graduate Projects

Regardless of how developed a nation is, diabetes mellitus II and other noncommunicable diseases are becoming an increasing problem throughout the globe. However, as more developing countries are introduced to the advancements of industrialized technologies, as well as the shift from rural living to an urban environment they are experiencing a more marked increase in diabetes than anywhere else in the world. In this article we break down the categories of industrialization and urbanization into several key underlying factors that contribute to their proliferation of diabetes in the developing world.

For industrialization we assess the influence of food processing, agriculture …


Factors That Impact Glycemic Control In Adolescents With Type 1 Diabetes, Kelsey Mcfarling Aug 2020

Factors That Impact Glycemic Control In Adolescents With Type 1 Diabetes, Kelsey Mcfarling

Theses and Graduate Projects

The incidence of Type 1 Diabetes (T1D) is increasing worldwide and is diagnosed disproportionately in adolescent populations. Additionally, studies show that adolescents with T1D experience worse glycemic control during this developmental period. Maintaining glycemic control in patients with T1D decreases the risk of developing future diabetic-related complications. Factors such as race, ethnicity, gender identity, sexual orientation, socioeconomic status, and medical comorbidities influence disparities in maintaining glycemic control in adolescents. The recognition of these factors on the management of T1D through an integrative team approach leads to increased glycemic control and decreased diabetic- related complications. This paper explores the effects of …


Idiopathic Gastroparesis: Lifestyle Modifications Versus Pharmacotherapy, Rebecca K. Schieffer Aug 2020

Idiopathic Gastroparesis: Lifestyle Modifications Versus Pharmacotherapy, Rebecca K. Schieffer

Theses and Graduate Projects

Idiopathic gastroparesis is a chronic symptomatic motility disorder of the stomach of unknown cause characterized by delayed gastric emptying in the absence of mechanical obstruction, with the majority of gastroparesis cases being classified as idiopathic. Idiopathic gastroparesis continues to be a challenging diagnosis to manage and difficulty remains in treating associated symptoms that result in decreased quality of life. Current non-invasive recommendations for the treatment of idiopathic gastroparesis are lifestyle modifications, including dietary adjustments to follow a gastroparesis diet, and pharmacotherapy prescribed for symptomatic relief. Metoclopramide is currently the only medication approved by the Food and Drug Administration (FDA) in …


The Great Debate At 'Immunotherapy Bridge', Naples, December 5, 2019., Paolo A Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N Khleif, Jennifer Mcquade, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H Butterfield, Igor Puzanov Aug 2020

The Great Debate At 'Immunotherapy Bridge', Naples, December 5, 2019., Paolo A Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N Khleif, Jennifer Mcquade, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H Butterfield, Igor Puzanov

Articles, Abstracts, and Reports

As part of the 2019 Immunotherapy Bridge congress (December 4-5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion …


Novel Vibrational Energy Harvesters Utilizing Piezoelectric Li-Doped Zno Nanowires And The Triboelectric Effect, H M Ashfiqul Hamid Aug 2020

Novel Vibrational Energy Harvesters Utilizing Piezoelectric Li-Doped Zno Nanowires And The Triboelectric Effect, H M Ashfiqul Hamid

Electrical Engineering Dissertations - Archive

Vibration sources are omnipresent everywhere in our regular lives including the automobiles, aircraft, human body motion, wind flow, and water waves. Vibrational energy harvesters are electromechanical systems that can convert the ambient vibrations into electrical energy which can be stored to power up small scale electronic devices, essentially converting them into self-powered systems. The electronics industry has always propelled towards the scaling of electronic devices for improved flexibility and reduced production cost. This scaling, combined with the power-efficient designs, is widening the scope of applications for the energy harvesters. For instance, the vibrational energy harvesters have substantial applications in small …


The Biomechanics Of Cardiac Elastin And Its Role In Bioengineering, Sara R. Mcmahan Aug 2020

The Biomechanics Of Cardiac Elastin And Its Role In Bioengineering, Sara R. Mcmahan

Bioengineering Dissertations - Archive

Elastin is an essential structural protein responsible for the elasticity of many tissues, including skin, lungs, blood vessels, and other highly dynamic tissues and organs in the body. In the heart, cardiac elastin has been largely ignored as one of the key players in heart health and functionality. In this study, we will fill the knowledge gap with novel experiments and biomechanical investigations that will allow us to understand the roles of elastin in cardiac biomechanics, as well as explore the bioengineering applications of elastin-rich cardiac tissues. For Aim 1, we performed a biomechanical and ultrastructural comparison of the elastin-rich …


Predictors Of Organizational Decoupling In The Context Of Corporate Sustainability, Ajith Venugopal Aug 2020

Predictors Of Organizational Decoupling In The Context Of Corporate Sustainability, Ajith Venugopal

Management Dissertations - Archive

The gap between what firms say and what they do is referred to as organizational decoupling. Despite the fact that decoupling is a widespread phenomenon, there is a paucity of empirical studies that have examined individual level predictors of organizational decoupling, especially in the context of corporate sustainability. In this dissertation, utilizing upper echelon theory, I examine how CEO psychological charactersitics predict policy-practice decoupling in the environmental and social dimensions of corporate sustainability. Using a sample of U.S.manufacturing companies from S&P 1500 during the period 2009-2018, I test the relationship between CEO personality (FFM traits), CEO value (self-transcendence), and CEO …


The Potential Impacts Of Soy Protein On Fish Gut Health, Vikas Kumar, Sakhawat Hossain, Janice A. Ragaza, Marina Rubio Benito Aug 2020

The Potential Impacts Of Soy Protein On Fish Gut Health, Vikas Kumar, Sakhawat Hossain, Janice A. Ragaza, Marina Rubio Benito

Biology Faculty Publications

Soy protein is the major source of protein as fishmeal replacement in fish feed because of its worldwide availability and low price. However, the presence of high carbohydrate content along with saponins, lectins, and phytates can have a negative impact on fish gut health. Based on the literature and our lab studies, dietary soybean meal can cause a dose-dependent type of distal intestine inflammation called enteritis in commercial fish species including salmonids. This leads to reduced absorptive capacity, increased mucus secretion, hyperpermeability, and leucocyte infiltration in the lamina propria and submucosa, also inducing the pro-inflammatory cytokine genes expression, including Il-1β, …


Gaining Momentum: A Systematic Review Of Interventions To Promote Mental Health & Wellness For Mothers Postpartum, Amanda Marcinko, Ots, Lauren Opdyke, Ots, Jessica Sinotte, Ots, Emily Van’T Slot, Ots, E. Adel Herge, Otd, Otr/L, Faota Aug 2020

Gaining Momentum: A Systematic Review Of Interventions To Promote Mental Health & Wellness For Mothers Postpartum, Amanda Marcinko, Ots, Lauren Opdyke, Ots, Jessica Sinotte, Ots, Emily Van’T Slot, Ots, E. Adel Herge, Otd, Otr/L, Faota

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Outcomes:

  • Define participation challenges of mothers in the postpartum period.
  • Discuss qualities of effective interventions within maternal mental healthcare.
  • Apply effective interventions in occupational therapy practice to promote mental health and wellness of postpartum mothers.

PICO Question:

What interventions within the scope of occupational therapy practice promote mental health and wellness for women in the postpartum period?


Secondary Traumatic Stress In Teachers And School Communities Impacted By The Opioid Epidemic, Anne Steketee Aug 2020

Secondary Traumatic Stress In Teachers And School Communities Impacted By The Opioid Epidemic, Anne Steketee

Education (PhD) Dissertations

People who support others who have experienced trauma, like nurses, doctors, social workers, or first responders can sometimes be affected by a type of stress called secondary traumatic stress (STS). Although the effect of STS has been studied in helpers like social workers and medical professionals, the prevalence and characteristics of STS in teachers have not been studied extensively and are less understood. Schools in our communities impacted by the opioid epidemic also report additional stressors from issues like addiction, overdose, crime, neglect, rise in foster care, increased medical care, and death. This dissertation investigates STS in K-12 public school …


Elucidating The Relation Between Human Milk Fatty Acids, Extracellular Vesicles, And Infant Developmental Outcomes In The First Year Of Life, Diana Bickmore Aug 2020

Elucidating The Relation Between Human Milk Fatty Acids, Extracellular Vesicles, And Infant Developmental Outcomes In The First Year Of Life, Diana Bickmore

Food Science (MS) Theses

For most infants, human milk is the recommended source of nutrition. Improved developmental outcomes have been reported in infants that consume human milk compared to infant formula. Essential fatty acids (EFAs) confer health benefits. However, EFAs cannot be synthesized by the body, and therefore must be consumed in diet. Extracellular vesicles (EVs) are nanoparticles containing a lipid bilayer membrane and are present in human milk. Methods of EV isolation such as ultracentrifugation (UC) may not be feasible for the study of EVs in human milk due to the need for large sample volume, which may not be available. The objectives …


Cross-Sectional Analysis Of The Relationship Between Violent Crime And Mental Health Disorders In A Sample Of Homeless Adults Recently Released From Jail, Addison Ransom Aug 2020

Cross-Sectional Analysis Of The Relationship Between Violent Crime And Mental Health Disorders In A Sample Of Homeless Adults Recently Released From Jail, Addison Ransom

Dissertations and Theses (Open Access)

Adverse mental health conditions among incarcerated populations are high, and treatment for these conditions is particularly low. Additionally, there is a culture of stigma in the United States towards those with mental health conditions and violent criminal history, contributing to mass incarceration. The present cross-sectional study sought to assess the association between violent criminal history and mental health symptoms among recently incarcerated homeless adults in Dallas, Texas. This study included 230 participants, taking place at The Bridge Homeless Recovery Center, evaluating non-violent versus violent criminal history. Outcome measures of positive screens for post-traumatic stress disorder, generalized anxiety disorder, and depression …


The Role Of Notch In Adipose-Derived Stem Cell Adipogenesis, Mengcheng Liu Aug 2020

The Role Of Notch In Adipose-Derived Stem Cell Adipogenesis, Mengcheng Liu

Master's Theses

Obesity is the leading cause of chronic disease and has contributed to significant health problems and complications. In order to solve this increasingly serious social problem, it is particularly important to deepen the understanding of the biological causes of obesity. Obesity is the result of an increased mass of adipose tissue after excessive caloric intake, and adipogenesis is the main strategy through which the body increases the number of adipocytes. However, due to the lack of research, the current understanding of adipogenesis is not enough to yield results in the clinic.

The regulation of adipogenesis is complex, and the role …


Development Of Seaweed Biodegradable Nanocomposite Films Reinforced With Cellulose Nanocrystals For Food Packaging, Hansol Doh Aug 2020

Development Of Seaweed Biodegradable Nanocomposite Films Reinforced With Cellulose Nanocrystals For Food Packaging, Hansol Doh

All Dissertations

This research studied is about development of seaweed biodegradable nanocomposite films reinforced with cellulose nanocrystals (CNCs) from seaweed biomass and investigating the properties of the films. Study was conducted to isolate CNCs from seaweed biomass and these isolated CNCs are applied to developed seaweed biopolymer films. At last, degradability of these films was evaluated with a weight loss method in soil burial and lake water immersion systems.

CNCs were extracted from seaweed biomass of brown, red, and green by four steps process of depolymerization, bleaching, acid hydrolysis, and mechanical dispersion. Physicochemical and thermal properties were determined for each seaweed group …


Forage News [2020-08], Department Of Plant And Soil Sciences, University Of Kentucky Aug 2020

Forage News [2020-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.


Brain Health And Active Living: A Social Ecological Approach, Xiaoxia Zhang Aug 2020

Brain Health And Active Living: A Social Ecological Approach, Xiaoxia Zhang

Kinesiology Dissertations - Archive

Advocating active lifestyles and improving brain health across the lifespan is one of the universal and ultimate goals for Healthy People 2030. Unhealthy movement behaviors (physically inactive, excessive sedentary behavior, and insufficient sleep) and high prevalence of depression and cognitive impairment among young adults keep challenging higher education and public health systems. A comprehensive understanding of the determinants and mechanisms of movement behaviors and brain health is needed. Grounded in the social ecological model, this dissertation was to examine the behavioral and psychosocial mechanisms of brain health (depression and cognitive function) among young adults (18-45 years old). Study 1 (Chapter …


Novel Mechanisms Of Peripheral Vascular Dysfunction In Patients With Type 2 Diabetes, Ben Earl Young Aug 2020

Novel Mechanisms Of Peripheral Vascular Dysfunction In Patients With Type 2 Diabetes, Ben Earl Young

Kinesiology Dissertations - Archive

Currently, over 30 million adults in the United States have been diagnosed with Type 2 Diabetes mellitus (T2D). Importantly, T2D disproportionately augments the risk for the development of cardiovascular disease (CVD), which is currently the leading cause of morbidity and mortality in the United States. A hallmark characteristic of T2D is insulin resistance (IR), defined as a reduced tissue responsiveness to insulin stimulation, which contributes to prolonged periods of post-prandial hyperglycemia and is associated with a compensatory rise in pancreatic insulin secretion (hyperinsulinemia). Importantly, there is a well-known bi-directional association between the degree of IR/hyperinsulinemia and hypertension (HTN), with nearly …