Digital Commons Network^™

Investigating The Community-Level Variation In Hookworm Prevalence In The Kpandai District, Ghana: A Mixed-Methods Study, Harry Hyunteh Hyunteh Kim

Public Health Theses

Soil-transmitted helminths are a major cause of disability and morbidity in resource-poor settings: over 1.5 billion are estimated to be at risk of infection. Human behaviors and household socioeconomic conditions that facilitate contact with contaminated soil may increase exposure to parasites. The primary objective of the study was to investigate the community-level variation in hookworm prevalence in the Kpandai district of Ghana.

We used a mixed-methods approach to investigate behavioral, societal and environmental risk factors to hookworm exposure. 264 individuals from three neighboring villages (Jagbigbingdo [JG], Takumdo [TK], Wiae Chabor [WC]) were recruited using a convenience sampling strategy. Household questionnaires …

Prevalence, Awareness And Control Of Hypertension And Diabetes Among Hiv Positive And Negative Patients At The Military Hospital Of Douala, Cameroon, Duane Killian Madziva

Public Health Theses

Background: With anti-retroviral therapy (ART) prolonging the survival of people of living with HIV/ AIDS, other chronic co-morbidities such as hypertension, and diabetes are becoming an increasing problem. Studies on hypertension and diabetes in Sub-Saharan Africa are still limited, even with the growing concern of Africa’s dual burden of chronic and infectious diseases. As such, we aimed to determine the prevalence, awareness and control of hypertension and diabetes among people living with and without HIV/ AIDS in Cameroon. Methods: This was a hospital-based cross-sectional study conducted at the Military Hospital of Douala, Cameroon. Participants aged 21 – 65 years were …

Assessing The Functional Impact Of Pfrh5 Genetic Diversity On Erythrocyte Invasion Pathway Utilization In Plasmodium Falciparum, Adam Joseph Moore

Public Health Theses

Malaria is still responsible for over 405,000 deaths and 228 million cases of disease globally each year, with the large majority of these cases being caused by the Plasmodium falciparum parasite subspecies1. The RTS,S P. falciparum malaria vaccine, the only malaria vaccine ever licensed, is currently being rolled out in three African countries as part of a pilot implementation program and targets a major circumsporozoite protein (PfCSP). After three doses and a seven-year follow up, the vaccine showed a 7% efficacy on average with a -56.8% efficacy for patients in regions with above average exposure to P. falciparum2. While the …

Drug Use And Severe Outcomes Among Patients Hospitalized With Influenza Over Three Seasons, Christina Elizabeth Parisi

Public Health Theses

Influenza is a significant public health problem in the United States and around the world, causing considerable morbidity and mortality annually. Drug use is also a significant issue that is associated with numerous health complications and conditions. However, the relationship between severe influenza outcomes and drug use is not well understood. The objectives of this investigation are to compare the prevalence of demographic and behavioral factors associated with severe influenza outcomes between persons who use drugs (PWUDs) and non-PWUDs hospitalized with influenza and, by controlling for those factors we find are significant, determine if there is an association between severe …

Geospatial Analysis Of Drug-Resistant Tuberculosis In Santiago De Cali, Colombia, Oscar Norberto Perales

Public Health Theses

Infectious diseases like tuberculosis are undergoing an epidemiological transformation in developing countries such as Colombia and throughout Latin America. Recent economic and social developments may drive heterogeneous burdens of disease in the region, especially in urban settings. Geographic Information Systems (GIS) may allow us to better appreciate the geospatial distributions of TB in these contexts. In this study, we aimed to identify regions in Santiago de Cali facing disproportionate TB burdens and sought to determine whether the distribution of drug resistant TB differed. Additionally, we aimed to identify patient risk factors that could lead to differential drug resistance testing. This …

Evidence-Based Interventions For Antimicrobial Resistance In Conflict-Afflicted Lmics, Noora M. Reffat

Public Health Theses

Introduction: Although control strategies for antimicrobial resistance (AMR) have been described in high-income settings, interventions to curb the emergence and spread of AMR in conflict-afflicted low- and middle-income countries (LMICs) have not been systematically explored.

Objective: The objective of this review was to identify and assess the effectiveness of various control strategies in curbing the emergence and spread of AMR in conflict-afflicted LMICs.

Methods: A systematic scoping review of the literature was conducted using Embase, PubMed, and Scopus to identify primary literature reporting on AMR in Pakistan, Lebanon, Jordan, or Turkey published in the last decade (Jan. 2010 – Jan. …

Are Food Baskets Helpful For Refugees With Chronic Illnesses In Sub-Saharan Africa?, Anthony Russell

Public Health Theses

ABSTRACT

Refugees are among some of the most vulnerable populations in our world today. Food insecurity appears to be a consistent state among many refugee populations regardless of length of refugee status and setting. The primary study aims were to: a) identify factors influencing refugees’ ability to manage their chronic illnesses; b) describe food insecurity and dietary intake among refugees with chronic illnesses; c) understand the role food baskets play for this population.

A cross-sectional mixed methods study was conducted in two phases. Phase 1 consisted of 10 in-depth interviews with older adult refugees to identify factors influencing their management …

Nitrous Oxide: Use In Labor & Delivery And Steps Toward Healthcare Sustainability, Bethany Sanchez

Public Health Theses

Objective: This study explores trends in procurement for 3 hospitals in Connecticut over a four-year period to better understand how much N2O is released. N2O use and frequency of conversion to epidural after N2O, as well as emergency cesarean section after N2O use is also examined. A plan for N2O destruction technology testing is outlined.

Background: Nitrous Oxide (N2O) is a well-documented greenhouse gas (GHG) and ozone-depleting agent. N2O use continues to be unregulated, and concurrently it has also become more widely adopted for use in labor and delivery in the US, though it has been popular in Europe and …

Meteorological Determinants Of Mosquito Populations In Connecticut, Melpomene Vasiliou

Public Health Theses

As climate change continues at an alarming rate, it is important to quantify and characterize its wide-ranging impacts at both the global and more localized scales. This study aims to build on this body of evidence that details the local impacts of climate change that have already begun to and will increasingly harm human health. The study explores time trends in Connecticut’s mosquito abundance, as well as potential meteorological determinants of abundance for one key species. Secondary analysis using computational techniques was performed on mosquito abundance data provided by the Connecticut Agricultural Experiment Station (CAES). Simple linear regression was performed …

Evaluating The Appropriateness Of Oral Antibiotic Therapy Following Discharge For Patients With Urinary Tract Infection, Sera Yoo

Public Health Theses

Introduction: Inappropriate use of antibiotics is common in healthcare settings, with urinary tract infections (UTI) being one of the most common indications for antibiotic prescriptions. This study evaluated the appropriateness of oral antibiotic therapy among adult patients with suspected UTI who were admitted to Yale New Haven Hospital during January 2018. We hypothesized that 60% of antibiotics were inappropriate, and that inappropriate therapy was associated with Clostridioides difficile infection, hospital readmission and/or mortality.

Methods: We conducted a retrospective cohort study of adult patients who were admitted to Yale New Haven Hospital from January 1, 2018 to January 31, 2018. Data …

Hiv Testing During Antenatal Care In Eastern & Southern Africa: How Do Adolescents And Young Women Fare?, Claire Young

Public Health Theses

Background

To validate Elimination of Mother to Child HIV Transmission (eMTCT), pregnant women must receive antenatal care (ANC) HIV testing. Given challenges for adolescent girls in ANC, we hypothesized that adolescents were less likely to receive ANC HIV testing in Eastern and Southern Africa (ESA).

Methods

For 10 ESA countries, we use 2015-2018 Demographic and Health Surveys (DHS) to study 46,056 women attending ANC and giving birth in the last three years. We used age-stratified (15-19, 20-24, and 25-49 years of age at time of delivery) crude and adjusted logistic regressions to assess predictive factors for ANC HIV testing, both …

Stopping The Resurgence Of Vaccine-Preventable Childhood Diseases: Policy, Politics, And Law, Hillel Y. Levin, Stacie Patrice Kershner, Timothy D. Lytton, Daniel Salmon, Saad B. Omer

Scholarly Works

Mandatory vaccination programs in the United States are generally successful, but their continued success is under threat. The ever-increasing number of parents who opt their children out of vaccination recommendations has caused severe outbreaks of vaccine-preventable diseases. Public health advocates have pushed for changes to state laws, but their efforts have generally been unsuccessful. We suggest that their lack of success is due to public health advocates’ failures to contend with the features of the political system that impede change and to propose reforms that are ethically defensible, efficacious, and politically feasible. Based on our earlier public health studies, ethical …

Lps, A Tlr-4 Agonist And Viper A Tlr-4 Inhibitor Upregulate Phagocytosis Of Zymosan In Bv2 Cells, Sherouk Alzeory

Dissertations and Theses

Microglia cells are the first line of innate immunity defense in the central nervous system (CNS). They play a critical role in maintaining CNS homeostasis by having an active but yet balanced phagocytic activity. However, in various CNS related diseases, microglia cells have been shown to malfunction. In Alzheimer's Disease (AD), hyperactive microglia with impaired phagocytic activity is the main hallmark of this disease, along with the accumulation of amyloid-beta aggregates. Additionally, emerging new studies have suggested a fungal infection etiology to AD, specifically in relation to Candida albicans (C.albicans). Thus, understanding the mechanism of fungal clearance in the …

Dynamics And Phase Behavior Of Mixed Antibody-Excipient Adsorption At An Air/Water Interface, Ankit D. Kanthe

Dissertations and Theses

Monoclonal antibodies (mAbs) have become a leading candidate for oncological therapeutics due to their unparalleled selectivity. Monoclonal antibodies are amphiphilic, containing polar and nonpolar amino acid residues on their biomolecular surfaces. Their amphiphilic nature drives mAbs to strongly adsorb to air/water interfaces. Interfacial adsorption presents a central problem to the production and use of antibody-based pharmaceuticals. Air/water interfaces are frequently generated during the manufacture (filtration and chromatography) and production (freezing, thawing, filtration and filling) of the drug product. Moreover, air/water interfaces are present during the storage, transportation and administration of the therapeutics. When an air/water interface is created, the antibodies …

Disparities In The Prevalence And Risk Factors Of Anaemia Among Children Aged 6–24 Months And 25–59 Months In Ethiopia, Tafere Gebreegziabher Belay, Nigatu Regassa, Micaela Wakefield, Kelly Pritchett, Susan Hawk

All Faculty Scholarship for the College of Education and Professional Studies

Despite global efforts made to address anaemia, the prevalence remains high in most Sub-Saharan African countries. In Ethiopia, anaemia poses a very strong public health concern. The purpose of the present study was to examine the key risk factors related to anaemia among children aged 6–24 months (younger age group) and 25–59 months (older age group). We used the 2016 Ethiopian Demographic and Health Survey data, collected from 11 023 mothers with under five children. Ordered logistic regression modelling was used for assessing risk factors of childhood anaemia. The results suggest that the prevalence of anaemia was 72 % in …

Exploring The Impact Of A Nutrition Support Workshop For Ghanaian Nutrition Professionals, Sarah D. Zeola

UNF Graduate Theses and Dissertations

Ghana, a middle-income country in West Africa, has long experienced high rates of malnutrition and is increasingly struggling with nutritional challenges from non-communicable diseases including overweight, obesity, hypertension and stroke. There is an inadequate number of trained Ghanaian nutrition professionals to meet the demands of providing nutrition care for the citizens of Ghana and those professionals providing nutrition care have limited opportunities for continuing education. This quasi-experimental prospective, single cohort pre-test/post-test research was conducted in Accra, Ghana in September 2019 to determine if providing a nutrition support workshop to Ghanaian nutrition professionals (dietitians, dietetic interns, dietetic students and nutritionists) would …

Pregnancy: A Window Into Future Cardiovascular Risk: What Do We Know And What Can We Do At Lvhn?, Lillian Tung, Lekha Racharla Do, Kailyn Mann Do, Joanne Quiñones Md, Msce, Amy M. Ahnert Md

USF-LVHN SELECT

No abstract provided.

Humans, Wildlife, And Our Environment: One Health Is The Common Link, Terry A. Messmer

Human–Wildlife Interactions

One Health has become more important in recent years because interactions between people, animals, plants, and our environment have dramatically changed. This Back Page article discusses One Health during the COVID-19 pandemic.

Serum Chemistry Values In Wild Black Vultures In Mississippi, Usa, Fred L. Cunningham, Sherman W. Jack, Amanda R. Deese, Eric R. Wengert, Kyle Van Why, Carla L. Huston, Scott Lemmons, Richard B. Minnis

Human–Wildlife Interactions

Vultures (Cathartidae and Accipitridae) play an important role in ecosystem balance by rapidly disposing animal carcasses and thus preventing the potential spread of pathogens. Blood chemistry values provide a means of assessing the health of wildlife and wild animal populations; however, there are significant differences in chemistries among species and when comparing captive and free-living New and Old World vultures. In 2007, we collected blood serum from 30 female and 14 male wild, healthy black vultures (Coragyps atratus) live-trapped by the U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services from a power substation in …

Shift Work: Gut Health And Metabolic Disease, Hailey Lane

Senior Honors Theses

The number of people engaged in shift work continues to rise, and with it the research linking shift work to various diseases and conditions. Shift work changes the body’s sleeping patterns and circadian rhythms which has an effect on all parts of the body including the heart, immunity, cancer development, and inflammatory processes. Altered sleeping patterns and circadian rhythms change the composition and anatomy of the gut and microbiome, which in turn affects the development of metabolic diseases. Shift work also changes one’s eating patterns and habits. Altered eating habits similarly changes the composition and anatomy of the gut and …

Covid-19: Prevention And Control Measures In Community, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fi̇rdevs Aktaş

Turkish Journal of Medical Sciences

On January 30, 2020, the WHO declared the COVID-19 outbreak a public health emergency of international concern and, in March 2020, began to characterize it as a pandemic in order to emphasize the gravity of the situation and urge all countries to take action in detecting infection and preventing spread. Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. Although there are cures for illnesses and developments made by leaps and bounds in our day, the strongest and most effective weapon that …

Buck V. Bell, American Eugenics, And The Bad Man Test: Putting Limits On Newgenics In The 21st Century, Alessandra Suuberg

Minnesota Journal of Law & Inequality

No abstract provided.

The Importance Of Environmental Interventions In Eliminating Trachoma Infection In Africa: The Case Of Gashoho Health District, Burundi, Desire Ndisabiye

Theses

Gashoho Health District, Burundi, has not achieved the World Health Organisation (WHO) target of elimination of the blinding infectious disease, trachoma, by 2020. The work in this thesis addresses this problem using three different approaches.

Firstly, a cross-sectional study was undertaken to establish the current trachoma prevalence in Gashoho and whether poor sanitation was a risk factor for infection. 468 individuals from 117 households across four villages were clinically examined for signs of trachoma infection, and completed a questionnaire about environmental risk factors. The current prevalence of trachoma in Gashoho was 7.9% (95 % CI 5.0 - 10.6%). Children under …

Host-Parasite Interactions: Comparative Analyses Of Population Genomics, Disease-Associated Genomic Regions, And Host Use, Sara Rose Seibert

Browse all Theses and Dissertations

Birds are major vectors and reservoir hosts of pathogens across our globe. Pathogens can be spread through the dispersal and seasonal movements of migratory and resident wild birds. Although biogeographic barriers have the potential to restrict completely or in part gene flow in wild birds, variation in ecological drivers of dispersal likely influences the effectiveness of these barriers amongst different species. This dissertation seeks to enhance our knowledge of Southern Hemisphere waterfowl species’ dispersal, population genomics, and disease ecology using population genomic techniques (double-digest restriction-site associated DNA sequencing (ddRADseq)) and multi-variate statistics. First, we investigated the roles of dispersal behavior …

Pre-Treatment Hiv-Drug Resistance Associated With Virologic Outcome Of First-Line Nnrti-Antiretroviral Therapy: A Cohort Study In Kenya, Ingrid A. Beck, Molly Levine, Christine J. Mcgrath, Steve Bii, Ross S. Milne, James M. Kingoo, Isaac So, Nina Andersen, Sandra Dross, Michael Chung

Internal Medicine, East Africa

Background: Pre-treatment HIV-drug-resistance (PDR) to WHO-recommended 1st-line non-nucleoside reverse transcriptase inhibitors (NNRTI)-based antiretroviral treatment (ART) is increasing in low-resource communities. We evaluated the risk of PDR on treatment failure if detected at single or multiple codons, at minority (2–9%) or higher (≥10%) frequencies during efavirenz- vs. nevirapine-ART.

Methods: We conducted a pooled analysis across three cohorts of Kenyans initiating 1st-line NNRTI-ART between 2006 and 2014. Mutations K103N, Y181C, G190A, M184V and K65R were detected by an oligonucleotide ligation assay (OLA) and confirmed by Sanger and next-generation sequencing (NGS). PDR was defined as detection of any mutation by OLA when confirmed …

Effect Of Patient-Level Characteristics On Fluoroquinolone Susceptibility, Jeffrey Alan Franks

All ETDs from UAB

Antimicrobial stewardship programs are becoming more widespread to combat antibiotic resistance. This study aimed to evaluate the influence of patient-level characteristics on fluoroquinolone susceptibly among five gram-negative isolates to help better their implementation. We performed a retrospective analysis of patients over the age of 18 for five gram-negative isolates (Acinetobacter species, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa). We utilized Cox proportional hazards to determine the risk of patient-level characteristics, for both hospital and community-acquired infections, on fluoroquinolone resistance between 2016 and 2019. The population sample consisted of 8,285 patients receiving fluoroquinolones for at least one of the …

Impact Of Different Human Coronaviruses (Hcovs) On Pediatric Patients At A Tertiary Pediatric Hospital – Retrospective Study, Abdulsalam Alsulami

All ETDs from UAB

Background: Human Coronaviruses (HCoV) are important pathogens associated with respiratory disease in humans and animals. The majority of HCoVs are emerging human pathogens with 7 known types causing human disease and 5 being identified in the last 2 decades. Methods: We performed a retrospective review of all encounters with known HCoV at a tertiary pediatric hospital from January 2015 until January 2018. Electronic medical records (EMRs) were reviewed for demographic data, HCoV type, viral copathogens, time to testing, admission, need for increased intensity of care (HLC), requirement for supplemental oxygen, radiographic findings suggestive lower respiratory tract disease (LRT) when available …

Cd8 T-Cell Responses To A Diverse Virus: Adaptation And Cross-Reactivity In Hiv Vaccination, Sushma Boppana

All ETDs from UAB

In the four decades since human immunodeficiency virus (HIV) was discovered, significant progress has been made in treating HIV infection and in understanding the viral and immune dynamics underlying disease pathogenesis. However, in spite of scientific advances, HIV remains a significant global health issue, and an effective preventative vaccine has yet to be created. Many groups have demonstrated the importance of CD8 T cells in viral control during natural HIV infection and believe that CD8 T cells could contribute to vaccine efficacy by alleviating disease course in individuals who became infected despite vaccination. One major obstacle to inducing potent CD8 …

Early Childhood Quality Of Education And Late-Life Cognitive Function In A Population-Based Sample From Puerto Rico, Cheyanne Celine Barba

All ETDs from UAB

In general, greater years of education is associated with reduced risk of cognitive impairment in older adulthood, but the strength of this association has been found to differ by study population. Additionally, quality of education is understudied, despite evidence that quality of education and, in turn, literacy, may be additional indicators of cognitive reserve. This thesis examined years of education, literacy, and childhood quality of education indicators in relation to late-life cognitive outcomes in an older Puerto Rican population. We hypothesized that greater years of education, literacy, and quality of childhood education would be positively associated with each other, as …

Representations Of Africa In Us Media: A Semiotic Analysis Of Ebola: The Doctor’S Story And Body Team 12, Olubusola Akinpelu

Masters Theses

The Western media has often been criticized for biased coverage of happenings in and around Africa. The 2014 Ebola outbreak created a lot of media attention for West Africa, and by extension, the entire continent. This study examined to what extent postcolonial discourses were infused in two films from the HBO Trilogy: Ebola: The Doctor’s Story (2015) and Body Team 12 (2015). To analyze these texts, I took a semiotic approach by identifying, describing and interpreting the signs in both films, to discuss the postcolonial discourses in three broad themes. Ebola: The Doctor’s Story (2015) was analyzed in the …