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Scientometric Analysis: Identification Of Research Trends For Covid-19, Mohamed Idhris, Jps Kumaravel, Associate Professor (Retd)

Library Philosophy and Practice (e-journal)

Coronaviruses in the electron micrographs are medium-sized RNA viruses with a very distinctive profile. Coronaviruses infect many species of animals, including humans. Coronaviruses have been described for more than 50 years. Human coronaviruses started its existence in 1965, when Tyrrell and Bynoe (1966) found that a virus called B814 could transfer. It was found in human embryonic tracheal organ cultures from an adult with a common cold respiratory tract. Inoculation of human volunteers of the medium of these cultures showed the presence of an infectious agent. Two new human coronaviruses associated with respiratory diseases have been reported since identification of …

2020-11-28_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-11-27_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Desirability Of Outcome Ranking For The Management Of Antimicrobial Therapy (Door Mat): A Framework For Assessing Antibiotic Selection Strategies In The Presence Of Drug Resistance, Brigid M. Wilson, Robin L.P. Jump, Federico Perez, Robert A. Bonomo

Faculty Scholarship

The complexities of antibiotic resistance mean that successful stewardship must consider both the effectiveness of a given antibiotic and the spectrum of that therapy to minimize imposing further selective pressure. To meet this challenge, we propose the Desirability of Outcome Ranking approach for the Management of Antimicrobial Therapy (DOOR MAT), a flexible quantitative framework that evaluates the desirability of antibiotic selection. Herein, we describe the steps required to implement DOOR MAT and present examples to illustrate how the desirability of treatment selection can be evaluated using resistance information. While treatments and the scoring of treatment selections must be adapted to …

Mycobacterium Fortuitum And Mycobacterium Abscessus Infections In The Foot And Ankle In Two Immunocompetent Patients, Khai Phang Wong, Zhi Hao Tang, Gek Meng Tan

BioMedicine

Nontuberculous mycobacteria (NTM) infections of the musculoskeletal system are commonly missed due to its rarity and the absence of systemic symptoms. A high clinical index of suspicion is required to recognize such infections as they may occur in immunocompetent hosts. We present two cases of foot and ankle NTM infections involving Mycobacterium fortuitum and Mycobacterium abscessus in two such patients. The first case involves an 83-year old lady who presented with a two-month history of multiple foot abscesses initially treated at a rural hospital. She underwent drainage and debridement of her foot, with eventual cultures growing Pseudomonas aeruginosa and Mycobacterium …

2020-11-26_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of the date of the collection of a sample for diagnostic testing …

Development Of Novel Methodology For The Molecular Differentiation Of Cryptosporidium Parvum Gp60 Subtypes Via High Resolution Melting Analysis, Jennifer K. O'Leary, Liam Blake, Gerard D. Corcoran, Roy D. Sleator, Brigid Lucey

Department of Biological Sciences Publications

Cryptosporidium species subtypes are generally identified via DNA sequencing of the gp60 gene tandem repeat motif region. Due to the immunogenic nature of its glycoprotein products, gp60 is subject to host selective pressures, genetic recombination and evolutionary processes that drive extensive polymorphism at this locus. The elucidation of the polymorphic nature of this gene has led to the current mainstay in Cryptosporidium subtyping nomenclature.

This study aimed to develop a real-time polymerase chain reaction based method utilising a post-PCR application, high resolution melting (HRM) analysis, in conjunction with the abovementioned gp60 nomenclature system, in order to differentiate between Cryptosporidium parvum …

Validating A Common Tick Survey Method: Cloth‑Dragging And Line Transects, Pia L. Kjellander, Malin Aronsson, Ulrika A. Bergvall, Josep L. Carrasco, Madeleine Christensson, Per-Eric Lindgren, Mikael Åkesson, Petter Kjellander

Harold W. Manter Laboratory of Parasitology: Library Materials

Cloth-dragging is the most widely-used method for collecting and counting ticks, but there are few studies of its reliability. By using cloth-dragging, we applied a replicated line transects survey method, in two areas in Sweden with different Ixodes ricinus tick-densities (low at Grimsö and high at Bogesund) to evaluate developmental stage specific repeatability, agreement and precision in estimates of tick abundance. ‘Repeatability’ was expressed as the Intraclass Correlation Coefficient (ICC), ‘agreement’ with the Total Deviation Index (TDI) and ‘precision’ by the coefficient of variation (CV) for a given dragging distance. Repeatability (ICC) and agreement (TDI) were higher for the most …

Behavioural Immune System Responses To Coronavirus: A Reinforcement Sensitivity Theory Explanation Of Conformity, Warmth Towards Others And Attitudes Towards Lockdown, Alison M. Bacon, Philip J. Corr

School of Psychology

Behavioural immune system (BIS) describes psychological mechanisms that detect cues to infectious pathogens in the immediate environment, trigger disease-relevant responses and facilitate behavioural avoidance/escape. BIS activation elicits a perceived vulnerability to disease (PVD) which can result in conformity with social norms. However, a response to superficial cues can result in aversive responses to people that pose no actual threat, leading to an aversion to unfamiliar others, and likelihood of prejudice. Pathogen-neutralizing behaviours, therefore, have implications for social interaction as well as illness behaviours and responses to health communications. In this study, we investigate how PVD influences conformity, attitudes to other …

Global Burden Of Acute Lower Respiratory Infection Associated With Human Metapneumovirus In Children Under 5 Years In 2018: A Systematic Review And Modelling Study, Xin Wang, You Li, Maria Deloria-Knoll, Shabir A. Madhi, Cheryl Cohen, Syed Asad Ali, Sudha Basne, Quique Bassat, W Abdullah Brooks, Malinee Chittaganpitch

Department of Paediatrics and Child Health

Background: Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed vaccines or drugs exist for human metapneumovirus infections. We aimed to estimate the age-stratified human metapneumovirus-associated ALRI global incidence, hospital admissions, and mortality burden in children younger than 5 years.
Methods: We estimated the global burden of human metapneumovirus-associated ALRIs in children younger than 5 years from a systematic review of 119 studies published between Jan 1, 2001, and Dec 31, 2019, and a further 40 high …

2020-11-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Applications Of Non-Invasive Neuromodulation For The Management Of Disorders Related To Covid-19, Abrahão Fontes Baptista, Adriana Baltar, Alexandre Hideki Okano, Alexandre Moreira, Ana Carolina Pinheiro Campos, Ana Mércia Fernandes, André Russowsky Brunoni, Bashar W. Badran, Clarice Tanaka, Daniel Ciampi De Andrade, Daniel Gomes Da Silva Machado, Edgard Morya, Eduardo Trujillo, Jaiti K. Swami, Joan A. Camprodon, Katia Monte-Silva, Katia Nunes Sá, Isadora Nunes, Juliana Barbosa Goulardins, Marom Bikson, Pedro Sudbrack-Oliveira, Priscila De Carvalho, Rafael Jardim Duarte-Moreira, Rosana Lima Pagano, Samuel Katsuyuki Shinjo, Yossi Zana

Publications and Research

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19.

Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders.

Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders.

Results: …

Asthma And Its Relationship To Mitochondrial Copy Number: Results From The Asthma Translational Genomics Collaborative (Atgc) Of The Trans-Omics For Precision Medicine (Topmed) Program, Maxwell P. Cocco, Evan White, Shujie Xiao, Donglei Hu, Angel Mak, Patrick Sleiman, Mao Yang, Kevin R. Bobbit, Hongsheng Gui, Albert M. Levin, Samantha Hochstadt, Kyle Whitehouse, Dean Rynkowski, Andrea J. Barczak, Gonçalo Abecasis, Thomas W. Blackwell, Hyun Min Kang, Deborah A. Nickerson, Soren Germer, Jun Ding, David E. Lanfear, Frank Gilliland, W. James Gauderman, Rajesh Kumar, David J. Erle, Fernando Martinez, Hakon Hakonarson, Esteban G. Burchard, Keoki L. Williams

Center for Individualized and Genomic Medicine Research Articles

BACKGROUND: Mitochondria support critical cellular functions, such as energy production through oxidative phosphorylation, regulation of reactive oxygen species, apoptosis, and calcium homeostasis.

OBJECTIVE: Given the heightened level of cellular activity in patients with asthma, we sought to determine whether mitochondrial DNA (mtDNA) copy number measured in peripheral blood differed between individuals with and without asthma.

METHODS: Whole genome sequence data was generated as part of the Trans-Omics for Precision Medicine (TOPMed) Program on participants from the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) and the Study of African Americans, Asthma, Genes, & Environment II (SAGE II). We …

The Effect Of Mock Code Blue Simulations And Dedicated Advanced Cardiac Life Support Didactics On Resident Perceived Competency., Dallis Q Ngo, Christina Vu, Thien Nguyen, Patricia Sotolongo, Manika Talati, Nikki Zahabi, Katrina Platt

Articles, Abstracts, and Reports

In-hospital cardiac or pulmonary arrest is associated with high mortality. In the USA, approximately 200,000 of these events occur and are associated with overall survival rates of 18%-20%. Despite advances in resuscitative methods, the probability of intact survival also remains unfavorable. Though many factors play a role, we believe a large portion of a patient's survival is dependent on the competency of the leader of the code blue or resuscitative team's efforts. Newly minted physicians who enter medical training in their respective residencies are equipped with a wide range of clinical competency in regards to hands-on experience and aptitude with …

A Longitudinal Descriptive Study On The Sleep Of Young Adults With Developmental Disabilities, Emily E. Grubbs

Theses and Dissertations

Sleep is vital for optimal physical and mental health, as well as cognitive and social functioning. Young adults with developmental disabilities (DD) are at greater risk for physical and mental health disorders and experience limitations in cognitive and social functioning in ways that can prevent participation in meaningful activities associated with young adulthood. Sleep literature has reflected that persons with DD experience worse sleep than persons without DD. Suboptimal sleep could compromise functionality and thus participation in young adulthood activities. Not much is known however of the nature of sleep problems experienced by young adults with DD. This study is …

Evolving The Narrative For Protecting A Rapidly Changing Ocean, Post‐Covid‐19, D. Laffoley, J. M. Baxter, D. J. Amon, J. Claudet, Jm Hall‐Spencer, K Grorud‐Colvert, L. A. Levin, Chris P. Reid, A. D. Rogers, M. L. Taylor, L. C. Woodall, N. F. Andersen

School of Biological and Marine Sciences

No abstract provided.

The Use Of Tlr Ligands And Phytochemicals To Better Understand Gut Immunity In Zebrafish And Channel Catfish, Ann Elizabeth Peterman

Theses and Dissertations

Toll-like receptor (TLR) ligands and phytochemical feed additives (PFAs) were evaluated in this study to determine the effects of immune stimulation on gut immunity in the zebrafish, Danio rerio, and the channel catfish, Ictalurus punctatus. Rag1-/- (MT) zebrafish were used to study how the TLR ligands β-glucan and resiquimod (R848) affect the innate immune system in the gut of MT zebrafish. Enhanced expression of marker genes (NITR9, NCCRP-1 and MPEG-1) indicated stimulation of Natural Killer (NK) cells, non-specific cytotoxic cells (NCCs) and macrophages. After challenge with Edwardsiella ictaluri, MT zebrafish stimulated with β-glucan demonstrated higher survival and the presence of …

Prevalence And Characterization Of Avian Pathogenic Escherichia Coli And Campylobacter In Mississippi Broilers, Tianmin Li

Theses and Dissertations

Avian pathogenic Escherichia. coli (APEC) and Campylobacter are pathogenic threats to poultry and human health, respectively. In this study, the prevalence of these pathogens in Mississippi broilers and their antimicrobial resistance (AMR) properties were investigated, and a multidrug-resistant APEC strain (APEC-O2-MS1170) was further explored by whole-genome sequencing (WGS). The efficacy of in ovo injection of Lactobacillus in reducing the APEC in broilers was evaluated. Results revealed a high prevalence of APEC and Campylobacter in broilers and broiler products. A lot of isolates were resistant to antibiotics of different sorts. Moreover, the in ovo administration of Lactobacillus did not reduce the …

American Media Depiction Of Terrorism In The U.S After September 11 Attacks, Maria Thuy Trinh

Theses and Dissertations

The purpose of this dissertation was to analyze perceptions of terrorism through the analysis of two newspapers’ news coverage of terrorism after the September 11 attacks, a popular Kentucky newspaper, the Courier-Journal and the New York Times (NYT). The social construction of terrorism was reflected as a problem through moral panics or something that a society believed as wrong that needed to be eradicated. Previous research had found that newspapers have contributed to moral panics by exaggerating the scope of social problems such as school shootings. I used the theoretical framework of moral panics; Goode and Ben-Yehuda’s (2009) two criteria …

In Ovo Vaccination Of Layer Chickens With 6/85 And Ts-11 Vaccine Strains Of Mycoplasma Gallisepticum, Abdulmohsen Alqhtani

Theses and Dissertations

Mycoplasma gallisepticum (MG) is the organism that causes avian respiratory mycoplasmosis, leading to chronic respiratory disease in chickens and infectious sinusitis in turkeys (Stipkovits and Kempf, 1996; Levisohn and Kleven, 2000). It is also responsible for reductions in egg production and other economic losses in the poultry industry (Stipkovits and Kempf, 1996; Levisohn and Kleven, 2000). Commercially, layer chickens are vaccinated against MG in the pullet phase before lay. In this dissertation, the potential application of in ovo vaccination in layer embryos for the subsequent early protection of pullets against field-strain MG infections was investigated. The use of different sites …

2020-11-24_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

The Intriguing Interaction Of Escherichia Coli With The Host Environment And Innovative Strategies To Interfere With Colonization: A Summary Of The 2019 E. Coli And The Mucosal Immune System Meeting, Eric Cox, Meryem Aloulou, James M Fleckenstein, Christina Schäffer, Åsa Sjöling, Stephanie Schüller, Kurt Hanevik, Bert Devriendt, Weiping Zhang, Ann-Mari Svennerholm, Edward G Dudley

Open Access Publications

The third

Transcriptional Remodeling Patterns In Murine Dendritic Cells Infected With Paracoccidioides Brasiliensis: More Is Not Necessarily Better, Calliandra M De-Souza-Silva, Fabián Andrés Hurtado, Aldo Henrique Tavares, Getúlio P De Oliveira, Taina Raiol, Christiane Nishibe, Daniel Paiva Agustinho, Nalvo Franco Almeida, Maria Emília Machado Telles Walter, André Moraes Nicola, Anamélia Lorenzetti Bocca, Patrícia Albuquerque, Ildinete Silva-Pereira

Open Access Publications

Most people infected with the fungus

Age, Comorbidities, And Mortality Correlation In Covid-19 Patients: A Review, Vidyulata Salunkhe, Amr Aboelnasr, Parul Pahal, Nida Qadir, Simra Kiran, Balaji Sekaran, Omar Fahmy, Farah Daas, Syed Shah

The University of Louisville Journal of Respiratory Infections

Background: The risk of death due to COVID-19 among hospitalized patients is known to be higher in older adults and those with underlying health conditions. Understanding the proportion of patients who are at increased risk of death due to COVID-19 and how this varies between age groups will inform the healthcare community as to how to evaluate the risk of COVID-19 and better design healthcare and economic policies.

Methods: We conducted a literature search for studies published between December 2019 and May 16, 2020 in PubMed, Embase, and Cochrane (CENTRAL). Descriptive statistics were performed.

Results: We reviewed 14 studies, of …

Time To Treatment Disruption In Children With Hiv-1 Randomized To Initial Antiretroviral Therapy With Protease Inhibitors Versus Non-Nucleoside Reverse Transcriptase Inhibitors., Dwight E. Yin, Christina Ludema, Stephen R. Cole, Carol E. Golin, William C. Miller, Meredith G. Warshaw, Ross E. Mckinney, Penpact-1 (Penta 9 / Pactg 390) Study Team

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Choice of initial antiretroviral therapy regimen may help children with HIV maintain optimal, continuous therapy. We assessed treatment-naïve children for differences in time to treatment disruption across randomly-assigned protease inhibitor versus non-nucleoside reverse transcriptase inhibitor-based initial antiretroviral therapy.

METHODS: We performed a secondary analysis of a multicenter phase 2/3, randomized, open-label trial in Europe, North and South America from 2002 to 2009. Children aged 31 days toyears, who were living with HIV-1 and treatment-naive, were randomized to antiretroviral therapy with two nucleoside reverse transcriptase inhibitors plus a protease inhibitor or non-nucleoside reverse transcriptase inhibitor. Time to first documented treatment …

Linking Mosquito Surveillance To Dengue Fever Through Bayesian Mechanistic Modeling, Clinton B. Leach, Jennifer A. Hoeting, Kim M. Pepin, Alvaro E. Eiras, Mevin B. Hooten, Colleen T. Webb

United States Department of Agriculture Wildlife Services: Staff Publications

Our ability to effectively prevent the transmission of the dengue virus through targeted control of its vector, Aedes aegypti, depends critically on our understanding of the link between mosquito abundance and human disease risk. Mosquito and clinical surveillance data are widely collected, but linking them requires a modeling framework that accounts for the complex non-linear mechanisms involved in transmission. Most critical are the bottleneck in transmission imposed by mosquito lifespan relative to the virus’ extrinsic incubation period, and the dynamics of human immunity. We developed a differential equation model of dengue transmission and embedded it in a Bayesian hierarchical …

Covid-19: Best Practices And The Way Forward, Juliana Nwauwa

Student Scholarly Projects

COVID-19 is a global health emergency that originated in Wuhan, China, in December 2019. It was declared a pandemic on March 11, 2020, and since then has affected more than 53,507,282 individuals and claimed the lives of more than 1,305,164 around the globe. It is a respiratory virus transmitted from person to person through airborne aerosols and droplets from infected individuals and direct contact with infected surfaces.

Numerous factors, such as socioeconomic status, population density, pre-existing health conditions, and lack of health insurance, have contributed to the disproportionate impact of COVID-19 among certain demographic groups. The COVID-19 impact ranges from …

Personal Impact Of Media Publicity During Covid-19 Pandemic And Awareness Among Generation Z In Jakarta, Indonesia, Elsa Roselina, Taufik Asmiyanto

Library Philosophy and Practice (e-journal)

The outbreak of coronavirus disease (COVID-19) has caused anxiety and fear worldwide. In Indonesia, the Government has implemented large-scale social restrictions during pandemic and it causes trauma to the society. In addition, the information about the coronavirus disease were rapidly published and shared on various media and social networking sites which confuses the public society. Information plays a very important role in society in responding to a pandemic situation appropriately. The aim of this study is to determine the public awareness in dealing with the personal impact of media publicity during COVID-19 pandemic and relating the behaviour and attitude of …

2020-11-22_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Happy Thanksgiving! And Hail To The Pharmaceutical And Biotech Industries – And The Scientists!, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.