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2020

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Learning From The Past: Distributed Cognition And Crisis Management Capabilities For Tackling Covid-19, Seulki Lee, Jungwon Yeo, Chongmin Na Aug 2020

Learning From The Past: Distributed Cognition And Crisis Management Capabilities For Tackling Covid-19, Seulki Lee, Jungwon Yeo, Chongmin Na

Research Collection School of Social Sciences

The outbreak of coronavirus disease 2019 (COVID-19) has presented an unprecedented public health crisis across the globe. Governments have developed different approaches to tackle the complex and intractable challenge, showing variations in their effectiveness and results. South Korea has achieved exceptional performance thus far: It has flattened the curve of new infections and brought the outbreak under control without imposing forceful measures such as lockdowns and travel ban. This commentary addresses the South Korean government’s response to COVID-19 and highlights distributed cognition and crisis management capabilities as critical factors. The authors discuss how the South Korean government has cultivated distributed …


How Do Intercrisis Learning Outcomes Affect Intracrisis Learning? “Learning In The Making” In The Case Of South Korea’S Covid-19 Response, Chongmin Na, Seulki Lee, Jungwon Yeo Aug 2020

How Do Intercrisis Learning Outcomes Affect Intracrisis Learning? “Learning In The Making” In The Case Of South Korea’S Covid-19 Response, Chongmin Na, Seulki Lee, Jungwon Yeo

Research Collection School of Social Sciences

This study explores the processes of intercrisis and intracrisis learning and the link between them, drawing on South Korea’s responses to the COVID-19 pandemic as an example. The crisis management literature suggests that intracrisis learning is less likely to occur than intercrisis learning due to inherent barriers that hinder learning and adaptation in the heat of crisis. Based on the conceptual framework of problem-oriented governance and crisis learning, we unpack how prominent outcomes of intercrisis learning facilitate intracrisis learning during the acute phase of an emerging crisis. We postulate that learning after 2015 MERS crisis developed the core capabilities for …


Prostitution During The Pandemic: Findings Show Need For Nordic Model, Debra K. Boyer Aug 2020

Prostitution During The Pandemic: Findings Show Need For Nordic Model, Debra K. Boyer

Dignity: A Journal of Analysis of Exploitation and Violence

The impact of COVID-19 on sexually exploited individuals provides an opportunity to advance the Nordic Model approach and create lasting change. Although subject to gender-based violence and denied safety net services, commercially sexually exploited women are seldom seen as a “vulnerable” group in the pandemic. Interviews from social service agencies in Seattle, Washington show women are experiencing more physical and sexual violence from sex buyers and women who have exited prostitution are finding their stability and security in jeopardy. Advocates can make the case to address disparities with safety net guarantees and structural change with the adoption of the Nordic …


Utility Of Molecular Tools For The Identification And Characterization Of Infectious Agents, Shih Keng Loong Aug 2020

Utility Of Molecular Tools For The Identification And Characterization Of Infectious Agents, Shih Keng Loong

Student Works (2020-2029)

Molecular tools involving nucleic acid sequence-based detection offer rapid, sensitive and specific identification of bacterial infections, all together instrumental in timely patient management and infection control. Analyses of DNA sequences played a pivotal role in the discovery of novel or uncommon bacterial pathogens. This method can be applied to detect and identify rare and potentially pathogenic bacterial infectious diseases emerging from the interactions between human, animal and the environment. In this study, the 16S rDNA sequencing demonstrated superior utility against the conventional phenotypic identification systems for the identification of rare pathogenic bacteria. Its inability to differentiate between certain bacterial species …


A Tale Of Two Crises: The Compounded Effect Of Covid-19 And Anti-Immigration Policy In The United States, Luz M. Garcini, Melanie M. Domenech Rodriguez, Alfonso Mercado, Manuel Paris Aug 2020

A Tale Of Two Crises: The Compounded Effect Of Covid-19 And Anti-Immigration Policy In The United States, Luz M. Garcini, Melanie M. Domenech Rodriguez, Alfonso Mercado, Manuel Paris

Psychological Science Faculty Publications

The COVID-19 pandemic is highlighting some important sources of health disparities that assail our society’s most vulnerable people, particularly undocumented immigrants and asylum seekers. The focus of this commentary is on uncovering those sources of health disparities and making a call for action.


Surgical Site Infection Prevention - Timing Of Preoperative Vancomycin Administration: Summary, Children's Mercy Kansas City Aug 2020

Surgical Site Infection Prevention - Timing Of Preoperative Vancomycin Administration: Summary, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.


The Aids Virus And The Galvanization Of The Lgbtq Movement For Equality, Michael Ernest Wachowski Aug 2020

The Aids Virus And The Galvanization Of The Lgbtq Movement For Equality, Michael Ernest Wachowski

Graduate Theses

The LGBTQ community was greatly altered by the AIDS crisis and the organizations that were founded in the 1980s. AIDS would become associated with those of the gay community during the early years of the crisis. The government and leading health officials perpetuated the public’s ignorance about the relativity new disease leading to more misunderstandings and mishandlings of the HIV/AIDS crisis. The disease did not discriminate among people, however, and quickly spread throughout many of the communities in the U.S. Organizations with roots in the LGBTQ community established themselves during the 1980s to deal with not only the AIDS crisis, …


Research Focal Areas, Asli Aslan, Brenda Blackwell, Tracy Linderholm Aug 2020

Research Focal Areas, Asli Aslan, Brenda Blackwell, Tracy Linderholm

Research & Economic Development

Executive Summary

Georgia Southern University is well-positioned to serve the local region and global community by engaging in public impact research. Public impact research matches community (broadly defined) needs with University resources to help solve the most pressing societal problems. Positioning Georgia Southern University as a public impact research institution aligns well with its recently established Strategic Plan (2019-2024), which calls for building research infrastructure to support interdisciplinary collaborations, better engage within our local, regional, and global communities, and build mutually beneficial partnerships. To move the University in this direction, the Vice Provost for Research, Dr. Chris Curtis, initiated the …


In Ovo Administration Of Defined Lactic Acid Bacteria Previously Isolated From Adult Hens Induced Variations In The Cecae Microbiota Structure And Enterobacteriaceae Colonization On A Virulent Escherichia Coli Horizontal Infection Model In Broiler Chickens, Margarita A. Arreguin-Nava, Brittany D. Graham, Bishnu Adhikari, Melissa Agnello, Callie M. Selby, Xochitl Hernandez-Velasco, Christine N. Vuong, Bruno Solis-Cruz, Daniel Hernandez-Patlan, Juan David Latorre, Guillermo Tellez Jr., Billy M. Hargis, Guillermo Tellez-Isaias Aug 2020

In Ovo Administration Of Defined Lactic Acid Bacteria Previously Isolated From Adult Hens Induced Variations In The Cecae Microbiota Structure And Enterobacteriaceae Colonization On A Virulent Escherichia Coli Horizontal Infection Model In Broiler Chickens, Margarita A. Arreguin-Nava, Brittany D. Graham, Bishnu Adhikari, Melissa Agnello, Callie M. Selby, Xochitl Hernandez-Velasco, Christine N. Vuong, Bruno Solis-Cruz, Daniel Hernandez-Patlan, Juan David Latorre, Guillermo Tellez Jr., Billy M. Hargis, Guillermo Tellez-Isaias

Poultry Science Faculty Publications and Presentations

The effects of in ovo administration of a defined lactic acid microbiota (LAM), previously isolated from adult hens, in the cecae microbiota structure and Enterobacteriaceae colonization after exposure to virulent Escherichia coli during the hatching phase of broiler chickens were evaluated. Embryos inoculated with LAM showed a significant (P < 0.05) reduction of Enterobacteriaceae colonization at day-of-hatch (DOH) and day (d) 7. Furthermore, there was a significant increase in total lactic acid bacteria on DOH, body weight (BW) DOH, BW d7, and d0–d7 BW gain and reduced mortality d0–d7 was observed in the LAM group compared with that in phosphate-buffered saline (PBS) control. …


Structural And Functional Insights Into Alphavirus-Host Interactions, Arthur S. Kim Aug 2020

Structural And Functional Insights Into Alphavirus-Host Interactions, Arthur S. Kim

Arts & Sciences Graduate Student Theses and Dissertations

Alphaviruses are arthropod-transmitted positive sense, single-stranded RNA viruses of the Togaviridae family that cause explosive, global outbreaks with significant morbidity. These viruses are classified into two groups based on genetic relatedness and clinical manifestations. Arthritogenic alphaviruses include chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), O’nyong’nyong (ONNV) and generally cause acute and chronic musculoskeletal disease. To date, CHIKV has caused >1.8 million cases in over 40 countries. Encephalitic alphaviruses, including Eastern (EEEV), Venezuelan (VEEV), and Western (WEEV) equine encephalitis viruses, infect the central nervous system and result in encephalitic sequelae. In 2019, outbreaks of EEEV in the United States have resulted …


Is Solitary Confinement A Punishment?, John F. Stinneford Aug 2020

Is Solitary Confinement A Punishment?, John F. Stinneford

Northwestern University Law Review

The United States Constitution imposes a variety of constraints on the imposition of punishment, including the requirements that the punishment be authorized by a preexisting penal statute and ordered by a lawful judicial sentence. Today, prison administrators impose solitary confinement on thousands of prisoners despite the fact that neither of these requirements has been met. Is this imposition a “punishment without law,” or is it a mere exercise of administrative discretion? In an 1890 case called In re Medley, the Supreme Court held that solitary confinement is a separate punishment subject to constitutional restraints, but it has ignored this …


Sexually Transmitted Infection Prevalence Among Women At Risk For Hiv Exposure Initiating Safer Conception Care In Rural, Southwestern Uganda, Pooja Chitneni, Mwebesa Bosco Bwana, Moran Owembabazi, Kasey O'Neil, Paul Kato Kalyebara, Winnie Muyindike, Nicholas Musinguzi, David R. Bangsberg, Jeanne M. Marrazzo, Jessica E. Haberer, Angela Kaida, Lynn T. Matthews Aug 2020

Sexually Transmitted Infection Prevalence Among Women At Risk For Hiv Exposure Initiating Safer Conception Care In Rural, Southwestern Uganda, Pooja Chitneni, Mwebesa Bosco Bwana, Moran Owembabazi, Kasey O'Neil, Paul Kato Kalyebara, Winnie Muyindike, Nicholas Musinguzi, David R. Bangsberg, Jeanne M. Marrazzo, Jessica E. Haberer, Angela Kaida, Lynn T. Matthews

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background Knowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda. Methods We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to …


Combating Covid On College Campuses: The Impact Of Structural Changes On Viral Transmissions, Jared Knofczynski, Aria Killebrew Bruehl, Ben Warner, Ryne Shelton Aug 2020

Combating Covid On College Campuses: The Impact Of Structural Changes On Viral Transmissions, Jared Knofczynski, Aria Killebrew Bruehl, Ben Warner, Ryne Shelton

altREU Projects

One of the most significant issues in the COVID-19 pandemic is the reopening of schools while minimizing the transmission of coronavirus. Opportunities for evaluating the effectiveness of policies that might be utilized at such institutions are limited, as the necessary empirical data has not been gathered yet. Agent-based modeling, where various entities within an environment are simulated as agents, offers an opportunity to examine the effectiveness of various policies in a way that drastically minimizes the health and economic risks involved. Agent-based modeling is common within biology, ecology and other fields; and has seen some use within the coronavirus literature. …


Trajectories Of Initiation For The Heroin-Based Drug Whoonga – Qualitative Evidence From South Africa, Griffin A. Tyree, Nzwakie Mosery, Elizabeth F. Closson, Zonke Mabude, Carol Du Toit, David Bangsberg, Steven A. Safren, Kenneth H. Mayer, Jennifer A. Smit, Matthew J. Mimiaga, David J. Grelotti Aug 2020

Trajectories Of Initiation For The Heroin-Based Drug Whoonga – Qualitative Evidence From South Africa, Griffin A. Tyree, Nzwakie Mosery, Elizabeth F. Closson, Zonke Mabude, Carol Du Toit, David Bangsberg, Steven A. Safren, Kenneth H. Mayer, Jennifer A. Smit, Matthew J. Mimiaga, David J. Grelotti

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: Whoonga is a smoked heroin-based street drug that first emerged in South Africa a decade ago. While previous scientific reports suggest that use is growing and youth are particularly vulnerable, trajectories of initiation are not well characterized. Methods: In 2015, 30 men undergoing residential addiction treatment for this smoked heroin drug in KwaZulu-Natal, South Africa participated in semi-structured interviews about their experiences using the drug. Interview data were coded using qualitative content analysis. Results: Participant trajectories to initiating smoked heroin were “vertical” in the context of marijuana use or “horizontal” in the context of other hard drug use. Participants …


Correlates Of Access To Hand Hygiene Resources In Ghanaian Households: An Exploratory Analysis Of The 2014 Demographic And Health Survey, Paul Lawer Kenney, Herman Nuake Kofi Agboh, Florence Akosua Agyemang, Seth Sylvester Dadzie, Henry Ofori Duah, Pascal Agbadi Aug 2020

Correlates Of Access To Hand Hygiene Resources In Ghanaian Households: An Exploratory Analysis Of The 2014 Demographic And Health Survey, Paul Lawer Kenney, Herman Nuake Kofi Agboh, Florence Akosua Agyemang, Seth Sylvester Dadzie, Henry Ofori Duah, Pascal Agbadi

College of Nursing Faculty Research and Publications

Objectives

Handwashing with soap and water remains the most effective public health measure to reduce the risk of infectious diseases, which kill over 2.5 million people annually, mostly children in developing countries. The absence of hand hygiene resources in homes put many at risk of these infectious diseases. In the wake of the outbreak of the COVID-19 pandemic, the World Health Organization (WHO) and governments around the world have stressed the importance of regular handwashing to prevent the spread of the virus. This suggests that research on water, sanitation, and hygiene issues deserve continuous scholarly attention. In Ghana, studies on …


Impact Of The Societal Response To Covid-19 On Access To Healthcare For Non-Covid-19 Health Issues In Slum Communities Of Bangladesh, Kenya, Nigeria And Pakistan: Results Of Pre-Covid And Covid-19 Lockdown Stakeholder Engagements, Syed A K Shifat Ahmed, Motunrayo Ajisola, Kehkashan Azeem, Pauline Bakibinga, Yen-Fu Chen, Narjis Rizvi, Syed Iqbal Azam, Romaina Iqbal, Ahsana Nazish, Komal Tabani Aug 2020

Impact Of The Societal Response To Covid-19 On Access To Healthcare For Non-Covid-19 Health Issues In Slum Communities Of Bangladesh, Kenya, Nigeria And Pakistan: Results Of Pre-Covid And Covid-19 Lockdown Stakeholder Engagements, Syed A K Shifat Ahmed, Motunrayo Ajisola, Kehkashan Azeem, Pauline Bakibinga, Yen-Fu Chen, Narjis Rizvi, Syed Iqbal Azam, Romaina Iqbal, Ahsana Nazish, Komal Tabani

Community Health Sciences

Introduction: With COVID-19, there is urgency for policymakers to understand and respond to the health needs of slum communities. Lockdowns for pandemic control have health, social and economic consequences. We consider access to healthcare before and during COVID-19 with those working and living in slum communities.
Methods: In seven slums in Bangladesh, Kenya, Nigeria and Pakistan, we explored stakeholder perspectives and experiences of healthcare access for non-COVID-19 conditions in two periods: pre-COVID-19 and during COVID-19 lockdowns.
Results: Between March 2018 and May 2020, we engaged with 860 community leaders, residents, health workers and local authority representatives. Perceived common illnesses in …


Evaluation Of Red Blood Cell Count As An Ancillary Index To Hemoglobin Level In Defining The Severe Falciparum Malarial Anemia Among Ghanaian Children In Low-Resource Communities, Kwabena Nsiah, Bernard Bahaah, Bright Oppong Afranie, Emmanuel Acheampong Aug 2020

Evaluation Of Red Blood Cell Count As An Ancillary Index To Hemoglobin Level In Defining The Severe Falciparum Malarial Anemia Among Ghanaian Children In Low-Resource Communities, Kwabena Nsiah, Bernard Bahaah, Bright Oppong Afranie, Emmanuel Acheampong

Research outputs 2014 to 2021

© 2020 The Author(s) Our study evaluated red blood cell count as supporting hematological index to hematocrit level in predicting severe malarial anemia instead of the hemoglobin levels among malaria-infected children in Ghana. This case-control study was conducted at the Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. The study recruited 139 children, of which 45 were Controls (C), 43 with severe malaria (SM), and 51 with mild malaria (MM). Validated questionnaires were administered to obtain the socio-demographic data from each respondent. Venous blood was obtained for parasitemia count and to determine the hematological profile of each participant. With point …


Modulation Of Hedgehog Signaling By Kappa Opioids To Attenuate Osteoarthritis, Alexander E Weber, Omid Jalali, Sean Limfat, Ruzanna Shkhyan, Robert Van Der Horst, Siyoung Lee, Yucheng Lin, Liangliang Li, Erik N Mayer, Liming Wang, Nancy Q Liu, Frank A Petrigliano, Jay R Lieberman, Denis Evseenko Aug 2020

Modulation Of Hedgehog Signaling By Kappa Opioids To Attenuate Osteoarthritis, Alexander E Weber, Omid Jalali, Sean Limfat, Ruzanna Shkhyan, Robert Van Der Horst, Siyoung Lee, Yucheng Lin, Liangliang Li, Erik N Mayer, Liming Wang, Nancy Q Liu, Frank A Petrigliano, Jay R Lieberman, Denis Evseenko

Faculty, Staff and Students Publications

OBJECTIVE: Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease-modifying activity in OA.

METHODS: Primary human articular cartilage and synovial tissue samples from patients with knee OA undergoing total joint replacement and from healthy human subjects were obtained from the National Disease Research Interchange. For in vivo animal studies, a partial medial meniscectomy (PMM) model of knee …


“Tomorrow Never Dies”: Recent Advances In Diagnosis, Treatment, And Prevention Modalities Against Coronavirus (Covid-19) Amid Controversies, Partha Laskar, Murali M. Yallapu, Subhash C. Chauhan Aug 2020

“Tomorrow Never Dies”: Recent Advances In Diagnosis, Treatment, And Prevention Modalities Against Coronavirus (Covid-19) Amid Controversies, Partha Laskar, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to be responsible for COVID-19. The World Health Organization has declared the ongoing global public health emergency as a pandemic. The whole world fights against this invincible enemy in various capacities to restore economy, lifestyle, and safe life. Enormous amount of scientific research work(s), administrative strategies, and economic measurements are in place to create a successful step against COVID-19. Furthermore, differences in opinion, facts, and implementation methods laid additional layers …


Increasing New Orienting Emergency Department Nurses' Awareness Of Mass Casualty Incident Emergency Preparedness And Disaster Response Core Competencies To Improve Mass Casualty Incident Response, Christopher C. Deramo Ii Aug 2020

Increasing New Orienting Emergency Department Nurses' Awareness Of Mass Casualty Incident Emergency Preparedness And Disaster Response Core Competencies To Improve Mass Casualty Incident Response, Christopher C. Deramo Ii

Doctoral Dissertations and Projects

Mass casualty incidents (MCI) impose a substantial threat to healthcare. Despite the increasing frequency of MCIs many healthcare organizations and nursing programs do not adequately prepare nurses to be effective responders during an MCI. This evidence-based practice pilot project was purposed to increase new orienting emergency department nurses’ confidence and ability to effectively respond to an MCI. This project involved implementing an MCI educational program consisting of a disaster nursing framework to educate new orienting emergency department nurses on emergency preparedness and disaster response core competencies. The project leader utilized a quasi-experimental design to collect data pre- and post-intervention utilizing …


Saudi Society Of Maternal-Fetal Medicine Guidance On Pregnancy And Coronavirus Disease 2019, Yaser A. Faden, Nadia A. Alghilan, Samiha H. Alawami, Eman S. Alsulmi, Hythem A. Alsum, Yasir A. Katib, Yasser S. Sabr, Fadwah H. Tahir, Nabeel S. Bondagji Aug 2020

Saudi Society Of Maternal-Fetal Medicine Guidance On Pregnancy And Coronavirus Disease 2019, Yaser A. Faden, Nadia A. Alghilan, Samiha H. Alawami, Eman S. Alsulmi, Hythem A. Alsum, Yasir A. Katib, Yasser S. Sabr, Fadwah H. Tahir, Nabeel S. Bondagji

Saudi Medical Journal

No abstract provided.


Intussusception In An Infant As A Manifestation Of Covid-19, Zorays Moazzam, Areej Saleem, Alina Ashraf, Fyezah Jehan, Muhammad Arshad Aug 2020

Intussusception In An Infant As A Manifestation Of Covid-19, Zorays Moazzam, Areej Saleem, Alina Ashraf, Fyezah Jehan, Muhammad Arshad

Medical College Documents

Gastrointestinal manifestations of COVID-19 are rare and have primarily been limited to diarrhea or vomiting. Intussusception is the most common cause of bowel obstruction in infants, with up to 30% of pediatric intussusception cases having a preceding viral illness. We present the rare case of intussusception in a SARS-CoV-2 positive infant. This is the first documented case of survival in a SARS-CoV-2 positive patient presenting with intussusception as the primary manifestation. As our knowledge of this disease evolves, surgeons need to remain suspicious for possible gastrointestinal manifestations of COVID-19.


Snail Fever Of The Bladder In A Non-Endemic Area, Romana Idress, Zehra Jamil, Muhammad Areeb Ashfaq, Daniya Umer, Romana Idress, Hammad Ather Aug 2020

Snail Fever Of The Bladder In A Non-Endemic Area, Romana Idress, Zehra Jamil, Muhammad Areeb Ashfaq, Daniya Umer, Romana Idress, Hammad Ather

Department of Pathology and Laboratory Medicine

Schistosomiasis is rarely seen in Pakistan and is generally not very high on the list of differential diagnoses. However, it is an important cause of haematuria in certain endemic areas. It can affect multiple organs including the bladder, liver and lungs. We present a case of a young Pakistani male, travelling to and from Africa, who presented with complains of haematuria and suprapubic discomfort. Final pathologic diagnosis was urinary schistosomiasis (hematobium species). This case is particularly notable for the characteristic sago nodules identified on cystoscopy. It is important to consider schistosomiasis in the differential of haematuria in such scenarios as …


Reducing Overtreatment Of Urinalysis In Obstetric Triage Patients, Emelia Winston, Rachel Marteney, Erin Casey, Kevin Conway Jul 2020

Reducing Overtreatment Of Urinalysis In Obstetric Triage Patients, Emelia Winston, Rachel Marteney, Erin Casey, Kevin Conway

Marshall Journal of Medicine

Introduction

Overtreatment of asymptomatic bacteriuria (ASB) is a major issue that has been coming to the forefront in recent decades. Studies have shown that it can lead to adverse side effects, extra costs, and antimicrobial resistance. The purpose of this study was to determine the number of patients presenting to obstetric triage who were overtreated for a urinalysis (UA) and to see if an educational intervention could reduce the incidence of overtreatment for suspected ASB.

Methods

This was a retrospective chart review analyzing UA results and outcomes of OB triage patients that came through labor and delivery before and after …


Blocking Serine Protease (Tmprss2) By Bromhexine; Looking At Potential Treatment To Prevent Covid-19 Infection, Ramin Tolouian, Audrey C. Tolouian, Mohammadreza Ardalan Jul 2020

Blocking Serine Protease (Tmprss2) By Bromhexine; Looking At Potential Treatment To Prevent Covid-19 Infection, Ramin Tolouian, Audrey C. Tolouian, Mohammadreza Ardalan

Marshall Journal of Medicine

Not applicable. Manuscript is being submitted under Viewpoints category.


All The Easy Jobs Are Filled": The Enduring Promise Of A Life In Medicine, Maurice A. Mufson Jul 2020

All The Easy Jobs Are Filled": The Enduring Promise Of A Life In Medicine, Maurice A. Mufson

Marshall Journal of Medicine

N/A


Chemsex Screening And Intervention Training For Urban Primary Care Providers, Jona Tanguay Jul 2020

Chemsex Screening And Intervention Training For Urban Primary Care Providers, Jona Tanguay

Yale School of Medicine Physician Associate Program Theses

Chemsex, defined as the use of drugs before or during sex to enhance and facilitate the experience, is increasingly prevalent in urban populations of men who have sex with men. Chemsex is associated with higher risks of sexually transmitted infections including HIV, and it has negative effects on mental health and productivity. However, chemsex is under- or un-addressed in most primary care practices, and chemsex users rarely present to specialists in addiction medicine. We hypothesize that an integrative, multimodal training program for urban primary care providers in chemsex identification and harm reduction will increase the proportion of male patients screened …


A Sound Approach: Hydroxychloroquine Reduces Mortality In Severe Covid-19, Marcus Zervos, Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, Gordon Jacobsen, Dee Dee Wang, Kylie Huitsing, Indira Brar, George J. Alangaden, Mayur S. Ramesh, John E. Mckinnon, William O'Neill Jul 2020

A Sound Approach: Hydroxychloroquine Reduces Mortality In Severe Covid-19, Marcus Zervos, Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, Gordon Jacobsen, Dee Dee Wang, Kylie Huitsing, Indira Brar, George J. Alangaden, Mayur S. Ramesh, John E. Mckinnon, William O'Neill

Department of Pharmacy Practice

No abstract provided.


2020-07-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services Jul 2020

2020-07-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …


Cell Cycle Regulation In Macrophages And Susceptibility To Hiv-1, Isabella A. T. M. Ferreira, James Zachary Porterfield, Ravindra K. Gupta, Petra Mlcochova Jul 2020

Cell Cycle Regulation In Macrophages And Susceptibility To Hiv-1, Isabella A. T. M. Ferreira, James Zachary Porterfield, Ravindra K. Gupta, Petra Mlcochova

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Macrophages are the first line of defence against invading pathogens. They play a crucial role in immunity but also in regeneration and homeostasis. Their remarkable plasticity in their phenotypes and function provides them with the ability to quickly respond to environmental changes and infection. Recent work shows that macrophages undergo cell cycle transition from a G0/terminally differentiated state to a G1 state. This G0-to-G1 transition presents a window of opportunity for HIV-1 infection. Macrophages are an important target for HIV-1 but express high levels of the deoxynucleotide-triphosphate hydrolase SAMHD1, which restricts viral DNA synthesis by decreasing levels of dNTPs. While …