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2020

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Unlocking Maize Crop Productivity Through Improved Management Practices In Northern Tanzania, Kihara J, Kizito F, Jumbo M, Kinyua M, M. Bekunda Jan 2020

Unlocking Maize Crop Productivity Through Improved Management Practices In Northern Tanzania, Kihara J, Kizito F, Jumbo M, Kinyua M, M. Bekunda

All Peer-Reviewed Publications

Addressing the problem of low crop productivity and food insecurity can be accelerated through community-centered implementation of good agricultural management practices. This study was conducted in Babati, Northern Tanzania. The objective of the study was to determine nitrogen (N) and phosphorus (P) application requirements for maize, and demonstrate economically viable best bet yield-improving management technologies under three ecozones namely; ‘low elevation low rainfall', ‘medium elevation high rainfall' and ‘medium elevation low rainfall' ecozone. Two sets of trials were conducted: N (0, 45, 90, 120 and 150 kg ha-1) and P (0, 15, 30, 40 kg ha-1) response trials in 16 …

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Mineral Fertilizer Use In Land-Scarce Conditions: Case Of Rwanda, Josaphat Rusisiro Mugabo, Eric Tollens, Jonas Nwankwo Chianu, Bernard Vanlauwe Jan 2020

Mineral Fertilizer Use In Land-Scarce Conditions: Case Of Rwanda, Josaphat Rusisiro Mugabo, Eric Tollens, Jonas Nwankwo Chianu, Bernard Vanlauwe

All Peer-Reviewed Publications

This study was undertaken to investigate the use of mineral fertilizer by smallholder farmers in order to understand the set of factors influencing the decisions of smallholder farmers to use fertilizers in land-scarce conditions. Using descriptive analysis and the Cragg's double-hurdle model, the study identified and analyzed factors that determine smallholder farmer adoption of mineral fertilizers and those that affect the intensity of household mineral fertilizer use. From factors that only influence the decision of smallholder farmers to use mineral fertilizers, distance to fertilizer market and livestock affects it negatively; while farmer association membership, landholding per capita, access to extension …

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Gendered Analysis Of The Demand For Poultry Feed In Kenya, John Njenga Macharia, Gracious Malton Diiro, John Rono Busienei, Kimpei Munei, Hippolyte D. Affognon, Sunday Ekesi, Beatrice Muriithi, Dorothy Nakimbugwe, Chrysantus Mbi Tanga, Komi K.M. Fiaboe Jan 2020

Gendered Analysis Of The Demand For Poultry Feed In Kenya, John Njenga Macharia, Gracious Malton Diiro, John Rono Busienei, Kimpei Munei, Hippolyte D. Affognon, Sunday Ekesi, Beatrice Muriithi, Dorothy Nakimbugwe, Chrysantus Mbi Tanga, Komi K.M. Fiaboe

All Peer-Reviewed Publications

This paper uses a translog cost function approach to study the farm-level demand for poultry feed in Kenya. The study estimates the demand elasticities of the three common types of poultry feed; mixed feed, grain, and leafy vegetables. The estimated model was used to obtain estimates of Marshallian demand elasticities for poultry feed in Kenya for male-headed and female-headed households. The elasticities reported can be used by researchers and policy analysts to evaluate policy effects of changes in feed demand quantities within the livestock economy in Kenya. Moreover, these parameters can provide more reliable estimates of the total change in …

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Smallholder Farmers' Knowledge And Willingness To Pay For Insect-Based Feeds In Kenya, Shaphan Y. Chia, John Macharia, Gracious M. Diiro, Menale Kassie, Sunday Ekesi, Joop J.A. Van Loon, Marcel Dicke, Chrysantus M. Tanga Jan 2020

Smallholder Farmers' Knowledge And Willingness To Pay For Insect-Based Feeds In Kenya, Shaphan Y. Chia, John Macharia, Gracious M. Diiro, Menale Kassie, Sunday Ekesi, Joop J.A. Van Loon, Marcel Dicke, Chrysantus M. Tanga

All Peer-Reviewed Publications

Edible insects are increasingly being considered as sustainable alternatives to fish and soybean meals in animal feed because of their high nutritional quality and environmental benefits. However, successful introduction of a new product to the market depends on the target user's acceptance. Thus, evaluating the potential demand of insect-based feeds would provide relevant information for policy development. The present study assessed farmers' knowledge on edible insects as feed, their acceptance of integrating insect meals in animal feeds and willingness to pay (WTP) for insect-based feed (IBF) using a contingent valuation method. A household survey was conducted among 957 randomly selected …

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Occurrence Of Plant-Parasitic Nematodes On Enset (Ensete Ventricosum) In Ethiopia With Focus On Pratylenchus Goodeyi As A Key Species Of The Crop, Selamawit A. Kidane, Beira H. Meressa, Solveig Haukeland, Trine Hvoslef-Eide, Christer Magnusson, Marjolein Couvreur, Wim Bert, Danny L. Coyne Jan 2020

Occurrence Of Plant-Parasitic Nematodes On Enset (Ensete Ventricosum) In Ethiopia With Focus On Pratylenchus Goodeyi As A Key Species Of The Crop, Selamawit A. Kidane, Beira H. Meressa, Solveig Haukeland, Trine Hvoslef-Eide, Christer Magnusson, Marjolein Couvreur, Wim Bert, Danny L. Coyne

All Peer-Reviewed Publications

Summary - Enset (Ensete ventricosum) is an important starch staple crop, cultivated primarily in south and southwestern Ethiopia. Enset is the main crop of a sustainable indigenous African system that ensures food security in a country that is food deficient. Related to the banana family, enset is similarly affected by plant-parasitic nematodes. Plant-parasitic nematodes impose a huge constraint on agriculture. The distribution, population density and incidence of plant-parasitic nematodes of enset was determined during August 2018. A total of 308 fields were sampled from major enset-growing zones of Ethiopia. Eleven plant-parasitic nematode taxa were identified, with Pratylenchus (lesion nematode) being …

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The Kids Are Airight: Teen Sexting, Child Pornography Charges, And The Criminalization Of Adolescent Sexuality, Blaire Bayliss Jan 2020

The Kids Are Airight: Teen Sexting, Child Pornography Charges, And The Criminalization Of Adolescent Sexuality, Blaire Bayliss

University of Colorado Law Review

"Sexting" is a term that refers to the exchange of sexually explicit or sexually suggestive messages or images between individuals using electronic messaging. Teenage sexting is a controversial legal topic because the act of taking nude or semi-nude pictures of a minor technically constitutes child pornography under federal law, even when those pictures were self-portraits taken by the minor in question. This Comment argues that the prosecution of sexting under federal child pornography law constitutes the criminalization of adolescent exploration of sexuality and that states should adopt their own sexting-specific laws to address teenage sexting in a manner that respects …

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The Greater Yellowstone Ecosystem Revisited: Law, Science, And The Pursuit Of Ecosystem Management In An Iconic Landscape, Robert B. Keiter Jan 2020

The Greater Yellowstone Ecosystem Revisited: Law, Science, And The Pursuit Of Ecosystem Management In An Iconic Landscape, Robert B. Keiter

University of Colorado Law Review

Thirty years ago, the Greater Yellowstone Ecosystem (GYE) concept and ecosystem management surfaced as key to preserving this legally fragmented region's public lands and wildlife in the face of mounting development pressures. Yellowstone's grizzly bears were in sharp decline and wolves were absent from the landscape, while bison and elk management issues festered. The GYE's national forest lands were subject to extensive logging, energy leasing, and other commercial activities that cumulatively threatened the region's ecological integrity. In the face of extreme jurisdictional complexity and a strong commitment to agency discretion, a high-profile federal "Vision" effort to improve and better coordinate …

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Cercla: It's Time To Prioritize Climate Threats, Lyndsie Dundas Jan 2020

Cercla: It's Time To Prioritize Climate Threats, Lyndsie Dundas

University of Colorado Law Review

Climate change will bring more extreme weather, including increased flooding and wind damage, to all stretches of the United States. These effects of climate change will cause profound consequences for communities living near sites with a legacy of toxic waste. With 1,883 Superfund sites on the National Priorities List and countless other U.S. properties with some degree of contamination, climate change will result in increased risk of exposure for surrounding local populations and environments. Currently, the Hazard Ranking System does not consider effects of climate change when calculating the risk a site poses to the public. Without considering associated climate …

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Uber's Efficiencies: A Modest Proposal For Limiting Use Of Antitrust's Per Se Rule, Kathleen Guilfoyle Jan 2020

Uber's Efficiencies: A Modest Proposal For Limiting Use Of Antitrust's Per Se Rule, Kathleen Guilfoyle

University of Colorado Law Review

In antitrust law, the per se rule against horizontal price-fixing seems set in stone. Over time, however, antitrust enforcers and courts have declined to use this rule and instead have used the rule of reason. This change stems directly from the recognition that the per se rule's blunt application may end up harming consumers in some contexts. Using Uber as an example of a consumer-friendly, efficiencyenhancing business model, this Comment argues that using the per se rule to analyze horizontal arrangements like Uber's sacrifices consumer welfare. Instead, courts should use the rule of reason and engage in cost-benefit analysis where …

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Toward Sustainable Recreation On Colorado's Fourteeners, Rebecca Sokol Jan 2020

Toward Sustainable Recreation On Colorado's Fourteeners, Rebecca Sokol

University of Colorado Law Review

Colorado's fourteen-thousand-foot mountains, commonly known as fourteeners, are attracting visitors in unprecedented numbers. As people flock to the state's most popular peaks, hikers degrade the environment and create safety problems. This Comment addresses potential approaches to recreation management on fourteeners and argues that traditional use-limit management methods, like visitor quotas, do not align with sustainability objectives. The Forest Service, the primary land management agency for most fourteeners, has a duty to promote sustainable recreation by incorporating environmental, social, and economic factors into its decision-making processes. However, the Forest Service tends to rely on use limits even though these methods would …

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Reference Dependent Prices In Bargaining: An Experimental Examination Of Precise First Offers, Erik O. Kimbrough, David Porter, Mark Schneider Jan 2020

Reference Dependent Prices In Bargaining: An Experimental Examination Of Precise First Offers, Erik O. Kimbrough, David Porter, Mark Schneider

ESI Working Papers

Evidence from psychology and marketing suggests that those who make a "precise" first offer in bargaining get a better deal than those who make a "round" first offer. We report on a series of experiments designed to test for and improve our understanding of the "precise first offer" (PFO) effect in bargaining and whether it likely reflects rational optimizing or equilibrium behavior. Our experimental treatments vary whether decisions are incentivized and whether the PFO effect can emerge as an equilibrium of a cheap-talk signaling game. We find evidence of a PFO effect when subjects read a vignette and make unincentivized …

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Visual Analog Pain Scores Reported To A Nurse And A Physician In A Postoperative Setting, Trevor Mcbride, Bs, Aaron Wilke, Jamie Chisholm, Mba, Kevin D. Martin Jan 2020

Visual Analog Pain Scores Reported To A Nurse And A Physician In A Postoperative Setting, Trevor Mcbride, Bs, Aaron Wilke, Jamie Chisholm, Mba, Kevin D. Martin

Student Papers, Posters & Projects

Background: The purpose of this study was to compare postoperative foot and ankle patient-reported visual analog pain scores (VAS) to nursing staff and the treating surgeon during a single encounter. Prior literature established preoperative patients reported higher pain scores to a surgeon as compared to nursing staff. We hypothesized that there will be no differences in postoperative patients’ pain scores when reporting to nursing staff vs a surgeon. Methods: This study was a retrospective cohort of 201 consecutive postoperative foot and ankle patients with 3 follow-up encounters treated by a single surgeon. The patients were asked to rate their pain …

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Seed Quality And Mycoflora Associated With Chickpea (Cicer Arientinum L.) Seed In Ethiopia, G. Getaneh, T. Tefera, F. Lemmessa, S. Ahmed, A. Zewudie Jan 2020

Seed Quality And Mycoflora Associated With Chickpea (Cicer Arientinum L.) Seed In Ethiopia, G. Getaneh, T. Tefera, F. Lemmessa, S. Ahmed, A. Zewudie

All Peer-Reviewed Publications

The study was conducted at Ethiopian Institute of Agricultural Research, Haramaya University and Jimma University, Ethiopia. Crop yield is directly associated with the physical and biological quality of planting material or seed. Ninety-nine (99) chickpea seed lot samples were collected for physical purity, seed health and germination tests from major chickpea growing areas in Ethiopia in the 2016/17 cropping season to assess the status of chickpea seed health and quality among subsistence farmers, research stations and seed growers. The seed lots were grouped as researcher saved, farmers saved and seed growers’ saved seed. The maximum physical purity of 97.5% was …

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Metrics For Identifying Food Security Status, Nicholas Ogot Jan 2020

Metrics For Identifying Food Security Status, Nicholas Ogot

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This chapter introduces food security as “a state when at all the time, all people can access adequate, safe and efficient nutritive food that meet their dietary needs and food preferences for a healthy and active healthy life.” While metrics refer to the measure of quantitative elements assessed in a research, a wide variety of data content obtained from the field is guided by a process of numerous methods that aim at efficiency. Food security metrics focus basically on the four domains of food security: availability, accessibility, utilization, and stability. The need for new metrics is essential for improving the …

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Impact Of Integrated Fruit Fly Management Strategy On Food Security Among Smallholder Mango Farmers In Kenya, P. N. Nyang'au, B. W. Muriithi, J. M. Nzuma, P. Irungu, H. M. Gichungi, G. Diiro Jan 2020

Impact Of Integrated Fruit Fly Management Strategy On Food Security Among Smallholder Mango Farmers In Kenya, P. N. Nyang'au, B. W. Muriithi, J. M. Nzuma, P. Irungu, H. M. Gichungi, G. Diiro

All Peer-Reviewed Publications

Adoption of agricultural innovations is perceived as a key avenue for poverty reduction and improved food and nutritional security in developing countries. The International Centre for Insect Physiology and Ecology (icipe) has developed and implemented a set of Integrated Pest Management (IPM) strategies in several sub-Saharan African countries aimed at controlling mango infesting fruit flies (Bactrocera dorsalis). Although positive returns from the use of fruit fly IPM have already been documented, the impact of these technologies on food security is not well understood. This study evaluated the impact of the IPM strategy on food security with the help of a …

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Population Genetics Of The Mediterranean Corn Borer (Sesamia Nonagrioides) Differs Between Wild And Cultivated Plants, Abdel Kader Naino Jika, B. Le Ru, C. Capdevielle-Dulac, F. Chardonnet, J. F. Silvain, L. Kaiser, S. Dupas Jan 2020

Population Genetics Of The Mediterranean Corn Borer (Sesamia Nonagrioides) Differs Between Wild And Cultivated Plants, Abdel Kader Naino Jika, B. Le Ru, C. Capdevielle-Dulac, F. Chardonnet, J. F. Silvain, L. Kaiser, S. Dupas

All Peer-Reviewed Publications

The population genetic structure of crop pest populations gives information about their spatial ecology, which helps in designing management strategies. In this paper, we investigated the genetic structure of the Mediterranean Corn Borer (MCB), Sesamia nonagrioides Lefèbvre (Lepidoptera: Noctuidae), one of the most important maize pests in the Mediterranean countries, using microsatellite markers for the first time in this species. Insects were collected in twenty-five locations in southwest and southeast France from cultivated and wild host plants (Zea mays, Sorghum halepense and Typha domingensis). Contrary to what has been reported so far in France, we found that MCB populations could …

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Role Of Egg-Laying Behavior, Virulence And Local Adaptation In A Parasitoid's Chances Of Reproducing In A New Host, R. Benoist, S. Paquet, F. Decourcelle, J. Guez, R. Jeannette, P. A. Calatayud, B. Le Ru, F. Mougel, L. Kaiser Jan 2020

Role Of Egg-Laying Behavior, Virulence And Local Adaptation In A Parasitoid's Chances Of Reproducing In A New Host, R. Benoist, S. Paquet, F. Decourcelle, J. Guez, R. Jeannette, P. A. Calatayud, B. Le Ru, F. Mougel, L. Kaiser

All Peer-Reviewed Publications

Understanding the ability of parasitoid insects to succeed in new host populations is a relevant question for biological control and adaptive mechanisms. Cotesia typhae is an African parasitoid specialized on the moth Sesamiae nonagrioides, also called the Mediterranean corn borer. Two Kenyan strains of C. typhae differ in their virulence against a new host population from France. We explored behavioral and physiological hypotheses about this differentiation. Cotesia genus belongs to a group of Hymenoptera in which females inject a domesticated virus in their host to overcome its resistance. Since viral particles are injected along with eggs and since the strain …

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Reducing Bureaucracy In Clinical Research: A Call For Action, J Gribben, E Macintyre, P Sonneveld, J Doorduijn, Et Al Jan 2020

Reducing Bureaucracy In Clinical Research: A Call For Action, J Gribben, E Macintyre, P Sonneveld, J Doorduijn, Et Al

Peninsula Medical School

The increasing administrative burden associated with conducting clinical trials is a threat to patient safety, independent academic clinical research, and access to affordable innovation. While the Clinical Trials Regulation1 —adopted by the European Parliament in 2014 to replace the Clinical Trials Directive2 (from 2001) and finally expected to become applicable in the course of 2020—will go some way in addressing bureaucracy overload, more action is needed. This article discusses the issues resulting from the exponential growth of regulatory and administrative requirements for the conduct of clinical studies and the impact this is having on researchers and patients. It also describes …

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Maturo, A. And Moretti, V.Digital Health And The Gamification Of Life, Bingley: Emerald Publishing2017. 176 Pp (Pbk) £60.00 (Ebk) £43.19 Isbn 978‐1‐78754‐366‐9, J Tredinnick‐Rowe Jan 2020

Maturo, A. And Moretti, V.Digital Health And The Gamification Of Life, Bingley: Emerald Publishing2017. 176 Pp (Pbk) £60.00 (Ebk) £43.19 Isbn 978‐1‐78754‐366‐9, J Tredinnick‐Rowe

Peninsula Medical School

No abstract provided.

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Protocol: A Comparison Of The Effectiveness Of Cognitive Behavioural Interventions Based On Delivery Features For Elevated Symptoms Of Depression In Adolescents, Gretchen J. Bjornstad, Shreya Sonthalia, Benjamin Rouse, Luke Timmons, Laura Whybra, Nick Axford Jan 2020

Protocol: A Comparison Of The Effectiveness Of Cognitive Behavioural Interventions Based On Delivery Features For Elevated Symptoms Of Depression In Adolescents, Gretchen J. Bjornstad, Shreya Sonthalia, Benjamin Rouse, Luke Timmons, Laura Whybra, Nick Axford

Peninsula Medical School

No abstract provided.

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A Novel Lung Health Programme Addressing Awareness And Behaviour-Change Aiming To Prevent Chronic Respiratory Diseases In Rural Uganda: A Two-Year Train-The-Trainer Programme, R Jones, B Kirenga, S Buteme, S Williams, Gemert F Van Jan 2020

A Novel Lung Health Programme Addressing Awareness And Behaviour-Change Aiming To Prevent Chronic Respiratory Diseases In Rural Uganda: A Two-Year Train-The-Trainer Programme, R Jones, B Kirenga, S Buteme, S Williams, Gemert F Van

Peninsula Medical School

Chronic lung disease is a huge, growing, but under reported problem in Africa. Following a survey in rural Uganda, which found 16% of the adult population had COPD, we developed a lung health programme aiming to raise awareness in the community of the risk factors for developing chronic lung disease and how to reduce the risks. A two-year train-the-trainer programme was conducted by healthcare workers (HCWs) in Masindi District, Uganda. Strategy and preliminary education materials were co-developed in a series of meetings with stakeholders including clinicians and community members. An initial group of HCWs were trained and further refned the …

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Use Of The Patient Health Questionnaire (Phq-9) In Practice: Interactions Between Patients And Physicians, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe Jan 2020

Use Of The Patient Health Questionnaire (Phq-9) In Practice: Interactions Between Patients And Physicians, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe

Peninsula Medical School

We analyze the use of nine-item Patient Health Questionnaire (PHQ-9), an instrument that is widely used in diagnosing and determining the severity of depression. Using conversation analysis, we show how the doctor deploys the PHQ-9 in response to the patient’s doubts about whether she is depressed. Rather than relaying the PHQ-9 verbatim, the doctor deviates from the wording so that the response options are selectively offered to upgrade the severity of the patient’s symptoms. This works in favor of a positive diagnosis and is used to justify a treatment recommendation that the patient previously resisted. This contrasted with the rest …

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A Large Population-Based Study Of The Mental Health And Wellbeing Of Children And Young People In The North Of England, Barry Wright, Megan Garside, Victoria Allgar, Rachel Hodkinson, Helen Thorpe Jan 2020

A Large Population-Based Study Of The Mental Health And Wellbeing Of Children And Young People In The North Of England, Barry Wright, Megan Garside, Victoria Allgar, Rachel Hodkinson, Helen Thorpe

Peninsula Medical School

Background: There has been a recent reported rise in prevalence of mental health problems among children in the United Kingdom, alongside increased referrals into specialist services. There is a need for up-to-date information regarding changing trends of young people’s mental health to allow for improved understanding and service planning. Objectives: This article aims to provide an overview of the current mental health and well-being of years 8, 9 and 11 secondary school–aged pupils from two large regions in the North of England. Method: This was a cohort cross-sectional study. Measures including the Strengths and Difficulties questionnaire, the EQ-5D-Y, social media …

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Seizure And Sudden Unexpected Death In Epilepsy (Sudep) Characteristics In An Urban Uk Intellectual Disability Service, James J. Sun, Bhathika Perera, William Henley, Samantha Ashby, Rohit Shankar Jan 2020

Seizure And Sudden Unexpected Death In Epilepsy (Sudep) Characteristics In An Urban Uk Intellectual Disability Service, James J. Sun, Bhathika Perera, William Henley, Samantha Ashby, Rohit Shankar

Peninsula Medical School

Purpose: This study identifies epilepsy-related characteristics and SUDEP risk factors in people with epilepsy (PWE) attending an urban community ID service in the UK where managing epilepsy is not part of the service remit, to understand the care provided to this vulnerable population. Methods: An electronic database search in a north London community ID service (catchment population approx. 290,000) identified relevant ID/epilepsy characteristics in PWE to compare those with mild ID to moderate-profound ID. The SUDEP and Seizure Safety Checklist (“Checklist”), was administered to patients and families/carers. Risk management data was compared to similar data from Cornwall UK where PWE …

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Letter On “Protection By Exclusion? The (Lack Of) Inclusion Of Adults Who Lack Capacity To Consent To Research In Clinical Trials In The Uk”, Sarah Griffiths, Lorna Manger, Rebecca Chapman, Lauren Weston, Ian Sherriff, Cath Quinn, Paul Clarkson, Caroline Sutcliffe, Karen Davies, Richard Byng Jan 2020

Letter On “Protection By Exclusion? The (Lack Of) Inclusion Of Adults Who Lack Capacity To Consent To Research In Clinical Trials In The Uk”, Sarah Griffiths, Lorna Manger, Rebecca Chapman, Lauren Weston, Ian Sherriff, Cath Quinn, Paul Clarkson, Caroline Sutcliffe, Karen Davies, Richard Byng

Peninsula Medical School

Dear editors, We read with interest the recent article regarding the lack of inclusion of people who lack capacity in trials: ‘Protection by exclusion? The (lack of) inclusion of adults who lack capacity to consent in clinical trials in the UK’. As the authors so eloquently spotlight, those without capacity in many population groups are those who are likely to be most vulnerable to frailty, comorbidities and isolation. Their exclusion from research significantly limits the specific evidence base for their care. As a research team developing and evaluating a Dementia Support Worker intervention based in primary care, we appreciate the …

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Ehealth Technologies And The Know-Do Gap: Exploring The Role Of Knowledge Mobilisation, Sheena Asthana, Rod Sheaff, Ray Jones, Arunangsu Chatterjee Jan 2020

Ehealth Technologies And The Know-Do Gap: Exploring The Role Of Knowledge Mobilisation, Sheena Asthana, Rod Sheaff, Ray Jones, Arunangsu Chatterjee

Peninsula Medical School

Background: eHealth technologies are widely believed to contribute to improving health and patients’ experience of care and reducing health system costs. While many studies explore barriers to and facilitators of eHealth innovation, we lack understanding of how this knowledge can be translated into workable, practicable and properly resourced knowledge mobilisation (KM) strategies. Aims and objectives: This paper describes the aims, methods and outputs of a large European Union funded project (eHealth Productivity and Innovation in Cornwall and the Isles of Scilly (EPIC)) to support the development of a sustainable innovation ecosystem in Cornwall and the Isles of Scilly, in order …

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Constitutive Activation Of The Egfr–Stat1 Axis Increases Proliferation Of Meningioma Tumor Cells, Sara Ferluga, Daniele Baiz, David A. Hilton, Claire L. Adams, Emanuela Ercolano, Jemma Dunn, Kayleigh Bassiri, Kathreena M. Kurian, Clemens O. Hanemann Jan 2020

Constitutive Activation Of The Egfr–Stat1 Axis Increases Proliferation Of Meningioma Tumor Cells, Sara Ferluga, Daniele Baiz, David A. Hilton, Claire L. Adams, Emanuela Ercolano, Jemma Dunn, Kayleigh Bassiri, Kathreena M. Kurian, Clemens O. Hanemann

Peninsula Medical School

Abstract Background Meningiomas are the most frequent primary brain tumors of the central nervous system. The standard of treatment is surgery and radiotherapy, but effective pharmacological options are not available yet. The well-characterized genetic background stratifies these tumors in several subgroups, thus increasing diversification. We identified epidermal growth factor receptor–signal transducer and activator of transcription 1 (EGFR–STAT1) overexpression and activation as a common identifier of these tumors. Methods We analyzed STAT1 overexpression and phosphorylation in 131 meningiomas of different grades and locations by utilizing several techniques, including Western blots, qPCR, and immunocytochemistry. We also silenced and overexpressed wild-type and mutant …

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After The Fire: Post-Pandemic Reflections, Daniel Martin Jan 2020

After The Fire: Post-Pandemic Reflections, Daniel Martin

Peninsula Medical School

Over the space of a few months virtually everything we know has been turned on its head. In Wuhan (China) during the closing months of 2019 a spillover event occurred in which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was transferred from its animal host population into humans 1, 2. Spread mainly by respiratory droplets, the virus has a basic reproduction number (R0) of between 2-6 in an unprotected population making it more contagious than influenza, but considerably less so than measles. As SARS-CoV-2 rapidly spread across the planet, aided by our love of intercontinental travel, the local market …

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Leadership In Dental Practice: A Three Stage Systematic Review And Narrative Synthesis, Sally Hanks, Lucy Spowart, Debby R.E. Cotton Jan 2020

Leadership In Dental Practice: A Three Stage Systematic Review And Narrative Synthesis, Sally Hanks, Lucy Spowart, Debby R.E. Cotton

Peninsula Medical School

No abstract provided.

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Editorial: ‘Do We Really Need Another Review On The Effects Of Physical Activity On Alcohol And Other Drug Use Disorders?’, Adrian H. Taylor, Tom P. Thompson, Jane Horrell Jan 2020

Editorial: ‘Do We Really Need Another Review On The Effects Of Physical Activity On Alcohol And Other Drug Use Disorders?’, Adrian H. Taylor, Tom P. Thompson, Jane Horrell

Peninsula Medical School

No abstract provided.

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