Digital Commons Network^™

Positionality Of Paraeducators: A Phenomenological Study In A Public School District In The Pacific Northwest, Ann Rene' Flynn

Antioch University Dissertations & Theses

Paraeducators play an important role in the classroom supporting students and certificated teachers. However, literature on the actual roles of paraeducators has revealed that paraeducators are rarely included in the teaching team (Patterson, 2006). Paraeducators are frequently asked to perform difficult or unpleasant jobs and may not be recognized as important professionals who support the educational system (Giangreco, Suter, & Doyle, 2010; Lucero, 2010). Surveys and interviews have shown that paraeducators view themselves differently from how coworkers view them (Chopra, Sandoval-Lucero, Aragon, Bernal, De Balderas, & Carroll, 2004; Patterson, 2006). The purpose of this phenomenological study was to gain a …

Understanding The Context And Social Processes That Shape Person- And Family-Centered Culture In Long-Term Care: The Pivotal Role Of Personal Support Workers, Ellen Helena Melis

Antioch University Dissertations & Theses

This single, exemplar case study explored the context and social processes that shape person-and family-centered culture in a long-term care (LTC) home, using grounded theory and situational analysis for the data collection and analysis. Findings revealed one core dimension: needing to be heard, valued, and understood, and five key roles: personal support workers (PSWs), executive director (ED), senior leadership, nurse managers, and residents and families, which informed five dimensions, each focused on enhancing care for residents: (a) attending to residents’ daily care needs (PSWs), (b) advocating strategically (ED), (c) translating vision into programs and policies (senior leadership), (d) ensuring quality …

Arising: Hurricane (Superstorm) Sandy’S Impact On Design/Planning Professionals, Maxinne R. Leighton

Antioch University Dissertations & Theses

Standing by my bedroom window, looking out at the ocean, a huge wave comes and swallows up my building. Everything around me is gone, including me. I wake up. I am 13 years old and living in the Coney Island Houses on Surf Avenue, Brooklyn, New York. With ongoing anthropogenic changes to the natural environment such as sea level rise and intensifying storms, coastal communities, especially ones segregated by class and culture, are particularly vulnerable in this context that challenges a way of life, and in some instances, threatens that life's survival. This dissertation focuses specifically on what one massive …

Bioactive Indanes: Development And Validation Of An Lc-Ms/Ms Bioanalytical Method For The Determination Of Ph46a, A New Potential Anti-Inflammatory Agent, In Dog And Rat Plasma And Its Application To A Pharmacokinetic Study In Dog, Gaia Scalabrino, Tao Zhang, Neil Frankish, Helen Sheridan

Articles

A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical development, in in vivo pre-clinical studies PH46A showed potent anti-inflammatory properties, which can be targeted at a range of diseases, including inflammatory bowel disease (IBD). To support the pre-clinical development of this drug candidate, we developed a LC MS/MS method for determining PH46 (the acid form of PH46A salt) in both dog and rat plasma using Compound 1 as internal standard (IS). Those species …

Bioactive Indanes: Insight Into The Bioactivity Of Iindane Dimers Related To The Lead Anti‐Inflammatory Molecule Ph46a, Kit Chan, Neil Frankish, Tao Zhang, Abdulilah Ece, Aoife Cannon, Jacintha O’Sullivan, Helen Sheridan

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Objectives PH46A (1) demonstrates significant anti-inflammatory activity in phenotypic models but its mechanism and site of action have been elusive. Current study focused on the bioactivity of PH46 (2) and related novel indane dimers (6-10) to investigate the impact of changes in substitution and stereochemistry at the C-1 and C-2 positions of the PH46 (2) scaffold.

Methods Cytotoxicity profiles of compounds were established using THP-1 macrophages and SW480 cells. Effects of the compounds were then evaluated at 10 μM using 5-lipoxygenase (LOX) and 15-LOX enzymes, and 5-LOX binding was evaluated in silico against NDGA, nitric oxide (NO) released from LPS-induced …

From Nature To Medicinal Chemistry: Anti-Cancer Activity Of Novel Indane Scaffolds, Tao Zhang, Vilmar Bandero-Filho, Kit Chan, Lorraine O’Driscoll, Neil Frankish, Helen Sheridan

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No abstract provided.

Drug Discovery: Novel Indane Scaffolds With Anticancer Activity, Vilmar Bandero, Tao Zhang, Kit Chan, Lorraine O’Driscoll, Claire Corcoran, Neil Frankish, Helen Sheridan

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No abstract provided.

Novel Mast Cell-Stabilising Amine Derivatives Of 3,4 Dihydronaphthalen-1(2h)-One And 6,7,8,9-Tetrahydro-5h-Benzo[7]Annulen-5-One, James W. Barlow, Tao Zhang, Orla Woods, Adam J. Byrne, John J. Walsh

Articles

In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone of series 20 and 21 exhibited interesting activity both in vitro and in vivo.

Mast Cell Stabilisers, Tao Zhang, Deirdre Frances Finn, James William Barlow, John Jarlath Walsh

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Mast cells play a critical role in type 1 hypersensitivity reactions. Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many different cancers. Thus, there is intense interest in the development of agents which prevent mast cell mediator release or which inhibit the actions of such mediators once released into the environment of the cell. Much progress into the design of new agents has been made since the initial discovery of the mast cell stabilising properties of khellin from Ammi visnaga and the clinical approval of cromolyn sodium. …

Antidiabetic Activities Of An Lc/Ms Fingerprinted Aqueous Extract Of Fagonia Cretica L. In Preclinical Models, Imran Nazir, Nisar Ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan

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Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. Fagonia cretica is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study, the traditional medicine was prepared as a tea, and the profile of the main metabolites present in the traditional medicine was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glycoside, kaempferol-3(6′-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6″-malonylglucoside) in addition to two unidentified …

Assessing The Biological Safety Of Atmospheric Cold Plasmatreated Wheat Using Cell And Insect Models, Agata Los, Dana Ziuzina, Daniela Boehn, Paula Bourke

Articles

Atmospheric cold plasma (ACP) is under investigation for an extensive range of biocontrol applications in food biosystems. However, the development of a novel intervention technology requires a thorough evaluation of the potential for negative effects and the implications for the human and animal food chains’ safety. The evaluations were performed using a contained, high-voltage, dielectric barrier discharge plasma system. The cytotoxicity of two types of food models—a liquid model (wheat model medium (WMM)) vs. a solid model (wheat grain extract (WGE)) was compared in vitro using the mammalian cell line CHO-K1. The residual toxicity of ACP treatment of grains for …

Characterization Of Antimicrobial Effects Of Plasma-Treated Water (Ptw) Produced By Microwave-Induced Plasma (Midiplexc) On Pseudomonas Fluorescens Biofilms, Oliver Handorf, Viktoria Isabella Pauker, Thomas Weihe, Eric Freund, Sander Bekeschus, Katharina Riedel, Uta Schnabel, Jörg Ehlbeck

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stract: For the decontamination of surfaces in the food production industry, plasma generated compounds (PGCs) such as plasma-treated water (PTW) or plasma processed air (PPA) offer many promising possibilities for future applications. Therefore, the antimicrobial effect of water treated with microwave-induced plasma (MidiPLexc) on Pseudomonas fluorescensbiofilms was investigated. 10 ml deionized water was treated with the MidiPLexc plasma source for 100 s, 300 s and 900 s (pre-treatment time) and the bacterial biofilms were exposed to the PTW for 1 min, 3 min and 5 min (post treatment time). To investigate the influence of PTW on P. fluorescensbiofilms, microbiological assays …

Cold Atmospheric Plasma Induces Silver Nanoparticle Uptake, Oxidative Dissolution And Enhanced Cytotoxicity In Glioblastoma Multiforme Cells, Eline Manaloto, Aoife Gowen, Anna Lesniak, Zhonglei He, Alan Casey, Patrick J. Cullen, James Curtin

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Silver nanoparticles (AgNP) emerged as a promising reagent for cancer therapy with oxidative stress implicated in the toxicity. Meanwhile, studies reported cold atmospheric plasma (CAP) generation of reactive oxygen and nitrogen species has selectivity towards cancer cells. Gold nanoparticles display synergistic cytotoxicity when combined with CAP against cancer cells but there is a paucity of information using AgNP, prompting to investigate the combined effects of CAP using dielectric barrier discharge system (voltage of 75 kV, current is 62.5 mA, duty cycle of 7.5kVA and input frequency of 50–60Hz) and 10 nm PVA-coated AgNP using U373MG Glioblastoma Multiforme cells. Cytotoxicity in …

Computational Modelling Approach For The Optimization Of Apple Juice Clarification Using Immobilized Pectinase And Xylanase Enzymes, Shady Hassan, Gwilym Williams, Amit Jaiswal

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Apple juice is typically marketed as a clear juice, and hence enzymatic treatments are common practices in juice industry. However, enzymatic treatments have been shown to face some challenges when process efficiency, and cost effectiveness are concerned. Therefore, it is necessary to optimize the enzymatic treatment process to maximize efficiency, and reuse enzymes to minimize the overall cost via immobilization. In this context, the present work features the immobilization of pectinase and xylanase from M. hiemalis on genipin-activated alginate beads, with subsequent evaluation of its efficacy in apple juice clarification. A central composite rotatable design (CCRD), coupled with artificial neural …

Effect Of Atmospheric Cold Plasma On The Functional Properties Of Whole Wheat (Triticum Aestivum L.) Grain And Wheat Flour, Sonal Chaple, Chaitanya Sarangapani, John B. Jones, Ed Carey, Lucie Causeret, Annaik Genson, Brendan Duffy, Paula Bourke

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Atmospheric cold plasma (ACP) has emerged as a novel processing technology, with demonstrated efficiencies in microbial inactivation. However, studies on the effects of ACP and potential to modify the functional properties of foods are sparse. The objective of this study is to determine the effect of ACP on physico-chemical and functional properties of wheat flour. In this study, both whole wheat grains and wheat flour were subjected to a dielectric barrier discharge (DBD) contained plasma reactor for a range of treatment times (5–30 min) at 80 kV. Plasma treatment increased the flour hydration properties of wheat flour. Rapid visco-analyser results …

Food Security And Diet Quality In Native Hawaiian, Pacific Islander, And Filipino Infants 3 To 12 Months Of Age, Sally Campbell, John J. Chen, Carol J. Boushey, Heather Eicher-Miller, Fengqing Zhu, Marie K. Fialkowski

Articles

Food insecurity and other nutritional risks in infancy pose a lifelong risk to wellbeing; however, their effect on diet quality in Native Hawaiian, Pacific Islander, and Filipino (NHPIF) infants in Hawai‘i is unknown. In this cross-sectional analysis, the association between various indicators of food security and NHPIF infant diet quality were investigated in 70 NHPIF infants aged 3–12 months residing on O‘ahu, Hawai‘i. The dietary assessments of the infants were collected using a mobile food record^TM. Foods consumed across four days were categorized into seven food groups. Indicators for food security were examined through an adapted infant food …

Cultural Differences, Social Support, And Therapy Outcomes: A Comparative Study Between Individualist And Collectivist Cultures, Veronica Felstad

Antioch University Dissertations & Theses

Social support plays an integral role in our lives, and recent research demonstrates that the presence or lack of social support has a potential impact on factors of interest to psychologists, such as therapeutic progress and therapeutic alliance. There is a lack of research demonstrating the relationship between social support and treatment outcomes and the role culture plays. This quantitative international study aimed to explore cultural variances in perceptions, utilizations, and functions of social support, particularly between individualist and collectivist cultures, and the potential effect these variances had on the relationship between social support and therapeutic outcomes. Sixty clients and …

Beyond Dissociation And Appropriation: Evaluating The Politics Of U.S. Psychology Via Hermeneutic Interpretation Of Culturally Embedded Presentations Of Yoga, Genelle N. Benker

Antioch University Dissertations & Theses

Psychology in the United States (U.S.) is partially constituted by a cultural history of intellectual imperialism that undermines its altruistic intent and prevents disciplinary reflexivity. The scholarship and clinical application of Yoga exemplifies the way U.S. psychology continues to give lived authority to imperialism as part of the neoliberal agenda. Through a hermeneutic literature analysis of two source Yogic texts and peer-reviewed articles that exemplify the dominant discourse on Yoga in U.S. psychology, this dissertation identified themes that describe culturally embedded presentations of Yoga and their sociopolitical implications. Through interpretation, Yoga was conceptualized as: (a) a 5,000 year-old tradition that …

Teachers’ Experiences Of School-Wide Positive Behavior Interventions And Supports: A Qualitative Study, Eric Walter

Antioch University Dissertations & Theses

The purpose of this study was to describe the unique personal experiences of teachers implementing School-Wide Positive Behavior Interventions and Supports (SWPBIS) in their classroom and identify themes within their experiences that impacted their desire or ability to implement SWPBIS. Phenomenological analysis was utilized to analyze data to develop a greater understanding of how teachers view and experience SWPBIS, and identify factors that aid and hinder acceptance and implementation. Four participants involved in implementing Tier 1 of SWPBIS were interviewed and asked about their experiences implementing SWPBIS. Participants described a number of experiences that negatively impacted their belief in, attitude …

Assessing Benefits And Barriers To Deployment Of Solar Mini Grids In Ghanaian Rural Island Communities, Jude T. Nuru

Antioch University Dissertations & Theses

Researchers, policy makers, and development partners are increasingly concerned about the challenges of climate change and lack of energy access facing countries in sub-Saharan Africa. While the majority of people in sub-Saharan African countries lack livelihood diversification skills and are vulnerable to climate change, energy poverty is also widespread, particularly in the rural areas where it is difficult and expensive to extend grid electricity. In the face of these two challenges, it has been envisaged that since sub-Saharan Africa is endowed with variety of renewable energy resources such as solar, wind, and biomass, their deployment could help address both climate …

Using Environmental Identity To Promote Environmental Concern And Willingness To Participate In Endangered Species Conservation, Christina M. Wesolek

Antioch University Dissertations & Theses

Environmental identity (EID), a concept from the social sciences specifically conservation psychology, refers to how we orient ourselves to the natural world, and thereby take action based on our personality, values, and sense of self. The realization that conservation is a human endeavor has prompted the inclusion of the social sciences in conservation research. Research on environmental identity has been conducted in such places as zoos, higher education institutions, and with farmers, and has demonstrated that EID is a good predictor of environmental concern and proenvironmental behaviors. There is a gap in the literature regarding whether environmental identity can be …

Coercive And Compulsive Treatment Of Eating Disorders: Surveying Treatment Providers’ Attitudes And Behavior., Jessica Cowan

Antioch University Dissertations & Theses

Stigma toward individuals with eating disorders is common and well-documented. Individuals with eating disorders regularly report experiencing stigma associated with perceptions that they are to blame for their illness, that their illness is trivial compared to other conditions, or that they are engaging in disordered behavior to gain attention. These stigmatizing attitudes toward eating disorders are also reported by the general public and healthcare professionals, including those who treat eating disorders. Treatment of these illnesses at all levels of care often include paternalistic approaches such as coercion and compulsion that can have both adverse and advantageous consequences. While there are …

Wildland Fire Disturbance - Recovery Dynamics In Upland Forests At Acadia National Park, Maine, Jessica E. Charpentier

Antioch University Dissertations & Theses

The overall goal of this study was to evaluate whether coastal Maine (USA) forests are resilient to changing climate and fire regimes. The occurrence of a catastrophic wildfire at Acadia National Park (ANP) in 1947 provided a unique opportunity to examine the impacts of wildfire on forest dynamics in upland communities of coastal spruce-fir and northern hardwood forests of the Maine coast. This study, conducted 68 years after the stand-replacing 1947 Bar Harbor Fire, builds on studies by W.A. Patterson conducted in 1980 and 1992-1994, 33 and 45-47 years after the fire. There were two lines of investigation in this …

To Empathize Or Iempathize: Social Networking And Adolescent Female Friendships, Jennifer A. Schonberg

Antioch University Dissertations & Theses

Through qualitative methodology, this dissertation aimed to explore adolescent girls’ use of social networking sites (SNS) and the impact these sites could be having on girls’ development of empathy and their ability to address conflict in their friendships. The topic is introduced by outlining the relevant statistics and through highlighting some of the negative and positive influences of SNS use on adolescent female life. Carol Gilligan’s theory of moral development is explained and used to frame the research questions for this phenomenological research study. Section One of this dissertation reviews the current literature on this topic, including how social media …

The Use Of Mobile Social Technology As Transitional Objects Impact On Personality Functioning, Peter Gleiberman

Antioch University Dissertations & Theses

The purpose of this dissertation is to examine the impact unlimited connectivity and unlimited access to voice, text, and video communication as well as multimedia content consumption through mobile social technology has on personality integration. The increased use of mobile social technology has changed how the user engages social relationships. Through mobile social technology, the user places importance in an inanimate object for engagement of social relationships. A reliance on the inanimate object as a social relationship is thought to compromise the ability to internalize integrated object relations and develop stable personality organization. This theoretical research uses hermeneutic analysis of …

Integrated Care For Older Adults And Memory: A Quality Improvement Approach, Haley E. Curt

Antioch University Dissertations & Theses

Integrated care, a combination of medical and behavioral health, is necessary to address the complex needs of the rapidly growing population of adults over the age of 65 (Karel, Gratz, & Smyer, 2012). Cognitive impairment, a common issue associated with aging, is a major concern for aging adults, their caregivers and family members. Comprehensively addressing cognition, whether there is an identified impairment or not, in a primary care setting allows the individual to take advantage of their independence, be an active member of planning care and making decisions, and begin treating their disease earlier when it is more manageable (Callahan …

Moral Reconation Therapy: Efficacy And Predictors Of Dropout, Amber Maiwald

Antioch University Dissertations & Theses

No known research has been conducted on whether Moral Reconation Therapy (MRT) actually reduces criminogenic thinking. Similarly, no known research has been conducted to identify factors associated with dropout from the MRT program (i.e., choosing to leave the group before completion/release). Therefore, the purpose of this study was twofold: (a) to discover whether MRT reduces criminogenic thinking, and (b) to determine if criminogenic thinking, ACEs, cognitive abilities, and personality traits, particularly impulsivity, psychoticism, and antisocial traits, influence dropout. If significant effects in one or more of the aforementioned areas are discovered, individuals predicted to have the same profile as past …

Stepping Outside: A Quantitative Study Exploring Nature’S Effect On Therapist Compassion, Dana N. Vitrano

Antioch University Dissertations & Theses

This dissertation explored the impact of spending time in nature on therapist levels of compassion fatigue and compassion satisfaction for office- and nature-based therapists. While the study mainly focused on office-based therapists, a sample of nature-based therapists were included for exploratory purposes as they constitute a unique niche of mental health workers who combine traditional talk therapy methods and the healing properties of nature. The literature is reviewed within an ecopsychology frame, key terms are defined, and nature’s impact on mental health and wellbeing is explored. One hundred fifty participants (124 office-based, 26 nature-based) were included in this study. They …

Adolescent Perspectives On Media Use: A Qualitative Study, April Fiacco

Antioch University Dissertations & Theses

This qualitative study looks at adolescents’ engagement with media and explores their perceptions of how media plays a role in their lives. For the purpose of this study, media includes watching television shows, watching and reading the news, and involvement in various types of social media. The influence of parents and peers is also explored to examine adolescents’ views of whether parent and peer opinions affect the types of media with which the adolescent participants choose to engage. The study used a semi structured interview to collect data with participants from a Massachusetts public high school. The data were analyzed …

A Drama-Based Group Intervention For Adolescents To Improve Mentalization, Michael S. Goddard

Antioch University Dissertations & Theses

This dissertation is an innovative intervention design to improve mentalization in preadolescents. The intervention presented is conducted in a group format and using techniques drawn from drama-based therapy. I have provided a brief literature review on mentalization, and relevant topics in group treatment and drama therapy. I have outlined key concepts from mentalization theory including: (a) the development of the self, (b) its relationship to attachment, (c) psychic equivalence and pretend mode functioning, (d) marked-affect mirroring, (e) the various facets of mentalization, and (f) mentalization treatment with children. After outlining these concepts, I discuss psychodynamic group treatment, mentalization-based group therapy, …