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2020

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Comparing Performance Of Mcgrath Mac Videolaryngoscope In Morbidly Obese Andnonobese Patients, Ying Gao, Liu-Jia-Zi Shao, Fushan Xue Jan 2020

Comparing Performance Of Mcgrath Mac Videolaryngoscope In Morbidly Obese Andnonobese Patients, Ying Gao, Liu-Jia-Zi Shao, Fushan Xue

Turkish Journal of Medical Sciences

No abstract provided.

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Antioxidative Effects Of Uridine In A Neonatal Rat Model Of Hyperoxic Brain Injury, Nevi̇n Al, Ayşen Çakir, Cansu Sevi̇nç, Mehmet Cansev, Tüli̇n Alkan Jan 2020

Antioxidative Effects Of Uridine In A Neonatal Rat Model Of Hyperoxic Brain Injury, Nevi̇n Al, Ayşen Çakir, Cansu Sevi̇nç, Mehmet Cansev, Tüli̇n Alkan

Turkish Journal of Medical Sciences

Background/aim: Premature birth is a major problem that results in an increased risk of mortality and morbidity. The management of such infants consists of supraphysiological oxygen therapy, which affects brain development due, in part, to the deterioration caused by reactive oxygen species (ROS). We showed previously that exogenously administered uridine provides neuroprotection in a neonatal rat model of hyperoxic brain injury. Hence, the aim of the present study was to investigate the effects of uridine on ROS in the same setting. Materials and methods: Hyperoxic brain injury was induced by subjecting a total of 53 six-day-old rat pups to 80% …

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Comment On: ?Treatment Of Idiopathic Granulomatous Mastitis And Factors Related Withdisease Recurrence?, Ahmet Sami̇ Akbulut, Tevfi̇k Tolga Şahi̇n Jan 2020

Comment On: ?Treatment Of Idiopathic Granulomatous Mastitis And Factors Related Withdisease Recurrence?, Ahmet Sami̇ Akbulut, Tevfi̇k Tolga Şahi̇n

Turkish Journal of Medical Sciences

No abstract provided.

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The Role And Importance Of Auxiliary Tests In Differential Diagnosis In Patients Withmildly High Basal 17-Oh-Progesterone Levels In The Evaluation Of Hirsutism, Taner Demi̇rci̇, Hasret Cengi̇z, Ceyhun Varim, Sedat Çeti̇n Jan 2020

The Role And Importance Of Auxiliary Tests In Differential Diagnosis In Patients Withmildly High Basal 17-Oh-Progesterone Levels In The Evaluation Of Hirsutism, Taner Demi̇rci̇, Hasret Cengi̇z, Ceyhun Varim, Sedat Çeti̇n

Turkish Journal of Medical Sciences

Background/aim: In the differential diagnosis of hirsutism, early follicular basal 17-OH-progesterone levels sometimes overlap with the diagnosis of late onset congenital adrenal hyperplasia (LOCAH) and other causes of hyperandrogenism. This study aims to investigate the role of some common tests and clinical findings in differential diagnosis in such cases. Materials and methods: One hundred seventy-five female patients with hirsutism and mildly high initial 17-OH-progesterone levels (2-10 ng/mL) were included in the study. The cases were divided into three groups according to their diagnosis: LOCAH (n = 16, mean age = 26.1 ± 6.9), polycystic ovary syndrome (PCOS) (n = 122, …

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Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu Jan 2020

Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu

Turkish Journal of Medical Sciences

Background/aim: This study aims to investigate peripheral nerve excitability in patients with subacute stroke. Materials and methods: The study was performed in 29 stroke patients within the subacute period and 29 healthy controls using QTRAC software and TRONDNF protocol. The threshold electrotonus, recovery cycle, stimulus-response, strength-duration, and current-threshold relationships were recorded. Results: The membrane was more hyperpolarized, and excitability was decreased in the hemiplegic side. The impairment of inward rectifying channel function, degree of hyperpolarization, and decrease of excitability were directly related to the Brunnstrom stages, which were more pronounced in lower stages. Conclusion: The lower motor neurons were affected …

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The Effect Of Long-Term Systemic Immunosuppressive Drug Use On Druse Formation: A Newperspective To Age-Related Macular Degeneration, Özkan Sever, Ridvan Mercan Jan 2020

The Effect Of Long-Term Systemic Immunosuppressive Drug Use On Druse Formation: A Newperspective To Age-Related Macular Degeneration, Özkan Sever, Ridvan Mercan

Turkish Journal of Medical Sciences

Background/aim: To evaluate the effect of the long-term use of systemic immunosuppressive drugs on druse formation in patients aged over 50 years. Materials and methods: The current retrospective cohort study includes 420 eyes of 420 patients. 210 eyes of 210 patients who used immunosuppressive drugs (Group 1) at least for the last 5 years and 210 eyes of 210 control patients (Group 2) who did not use any drugs were compared. All patients were older than 50 years and selected among patients who were followed by rheumatology and ophthalmology clinic at a tertiary university hospital. All patients had complete ophthalmic …

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Proteomic Analysis Of The Anticancer Effect Of Various Extracts Of Endemicthermopsis Turcica In Human Cervical Cancer Cells, Mustafa Yildiz, Hakan Terzi̇, Sali̇ha Handan Yildiz, Nuray Varol, Müjgan Özdemi̇r Erdoğan, Murat Kasap, Nermi̇n Akçali, Mustafa Solak Jan 2020

Proteomic Analysis Of The Anticancer Effect Of Various Extracts Of Endemicthermopsis Turcica In Human Cervical Cancer Cells, Mustafa Yildiz, Hakan Terzi̇, Sali̇ha Handan Yildiz, Nuray Varol, Müjgan Özdemi̇r Erdoğan, Murat Kasap, Nermi̇n Akçali, Mustafa Solak

Turkish Journal of Medical Sciences

Background/aim: Thermopsis turcica is a perennial species endemic to Turkey and different extracts of T. turcica have an antiproliferative effect on cancer cells, but there has not been any report on HeLa (human cervical cancer) cells. Materials and methods: To get a better understanding of the molecular mechanism of anticancer activity of methanolic extracts of leaves (LE) and flowers (FE) of T. turcica, we employed 2-DE-based proteomics to explore the proteins involved in anticancer activity in HeLa cells. Results: T. turcica extracts showed a potent cytotoxic effect on HeLa cells with the IC50 values of 1.75 mg/mL for LE and …

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Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan Jan 2020

Research On The Protective Effect Of Caffeic Acid Phenethyl Ester On Testicular Damagecaused By Cisplatin, Tayfun Ceylan, Emi̇n Kaymak, Fazi̇le Cantürk Tan, Bi̇rkan Yakan

Turkish Journal of Medical Sciences

Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage. Materials and methods: Group 1 (control group) was given physiological saline solution intraperitoneally (IP) throughout the experiment. Group 2 (CP group) was given a single dose of CP (7 mg/kg) IP on the day 7. Group 3 (CP + CAPE group), was given CAPE (10 μmol/kg/day) IP for 12 days and a single dose …

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Comparison Of The Sensititre Yeastone Antifungal Method With The Clsi M27-A3reference Method To Determine The Activity Of Antifungal Agents Against Clinical Isolatesof Candida Spp., Rabi̇ye Altinbaş, Ayşe Bariş, Sümeyye Şen, Recep Öztürk, Nuri̇ Ki̇raz Jan 2020

Comparison Of The Sensititre Yeastone Antifungal Method With The Clsi M27-A3reference Method To Determine The Activity Of Antifungal Agents Against Clinical Isolatesof Candida Spp., Rabi̇ye Altinbaş, Ayşe Bariş, Sümeyye Şen, Recep Öztürk, Nuri̇ Ki̇raz

Turkish Journal of Medical Sciences

Background and aim: Infections caused by Candida species are significantly increasing today, and invasive Candida infections are generally associated with high mortality. Early diagnosis and identification of Candida spp. is important for the determination of antifungal agents that will be used for treatment. The aim of the present study was to provide a better regimen for Candida infections in the future. Materials and methods: The Sensititre YeastOne (SYO) method was compared with The Clinical Laboratory Standards Institute (CLSI) reference broth microdilution (BMD) testing method. Endpoints of minimal inhibitory concentrations (MICs) were determined for both methods. Results: By using both methods, …

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In Reply: Comparing Performance Of Mcgrath Mac Videolaryngoscope In Morbidlyobese And Nonobese, Zehra İpek Arslan Aydin Jan 2020

In Reply: Comparing Performance Of Mcgrath Mac Videolaryngoscope In Morbidlyobese And Nonobese, Zehra İpek Arslan Aydin

Turkish Journal of Medical Sciences

No abstract provided.

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Mango Ginger (Curcuma Amada) Inhibits Collagen-Induced Arthritis By Modulatinginflammatory Cytokine Levels In Rats, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahi̇n, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca, Vijaya Juturu, Kazi̇m Şahi̇n Jan 2020

Mango Ginger (Curcuma Amada) Inhibits Collagen-Induced Arthritis By Modulatinginflammatory Cytokine Levels In Rats, Ahmet Karataş, Cemal Orhan, Mehmet Tuzcu, Nurhan Şahi̇n, İbrahi̇m Hani̇fi̇ Özercan, Süleyman Serdar Koca, Vijaya Juturu, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Mango ginger (MG: curcuma amada) has antioxidant and antiinflammatory activities. The aim was to evaluate the antiarthritic potential efficacy of MG on collagen-induced arthritis. Materials and methods: Twenty-one female Wistar-albino rats were divided into three groups. Arthritis was induced by intradermal injections of type II collagen and Freund's adjuvant. MG extract was orally administered starting from the first collagen injection. TNF-α, IL-6, IL-17, obestatin, sclerostin, and DKK-1 serum levels were determined, and perisynovial inflammation and cartilage-bone destruction in the paws were histologically evaluated. Moreover, joint tissue TNF-α, IL-17, NF-κB, and COX-2 levels were analyzed. Results: TNF-α, IL-17, IL-6, and …

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Comment On `Treatment Of Idiopathic Granulomatous Mastitis And Factors Related Withdisease Recurrence?, Emre Tekgöz, Seda Çolak, Muhammet Çinar, Sedat Yilmaz Jan 2020

Comment On `Treatment Of Idiopathic Granulomatous Mastitis And Factors Related Withdisease Recurrence?, Emre Tekgöz, Seda Çolak, Muhammet Çinar, Sedat Yilmaz

Turkish Journal of Medical Sciences

No abstract provided.

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Preemptive Action Saves Lives In A Pandemic: Closing The Grand Bazaar Before Thecovid-19 Infection Starts, Abdullah Emre Güner, Kemal Memi̇şoğlu, Şuayip Bi̇ri̇nci̇ Jan 2020

Preemptive Action Saves Lives In A Pandemic: Closing The Grand Bazaar Before Thecovid-19 Infection Starts, Abdullah Emre Güner, Kemal Memi̇şoğlu, Şuayip Bi̇ri̇nci̇

Turkish Journal of Medical Sciences

No abstract provided.

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Cover And Contents Jan 2020

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal Jan 2020

Mobilizing The Research Ecosystem For Scientific Advances Towards Positive Impact In Thecontext Of The Covid-19 Pandemic, Hasan Mandal

Turkish Journal of Medical Sciences

This special issue of the Turkish Journal of Medical Sciences is dedicated to providing scientific advances in the process of better understanding the SARS-CoV-2 virus that causes the COVID-19 infection. The special issue is published in a special time in which science-based approaches, cocreation-based collaboration, and the effective utilization and integration of competences have a crucial role during the race against time while combating the COVID-19 pandemic. In this process, the Scientific and Technological Research Council of Turkey (TÜBİTAK), which publishes academic journals including the Turkish Journal of Medical Sciences, has taken rapid action to mobilize the research community. This …

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Global Threat Of Covid 19 And Evacuation Of The Citizens Of Different Countries, İrfan Şencan, Semanur Kuzi̇ Jan 2020

Global Threat Of Covid 19 And Evacuation Of The Citizens Of Different Countries, İrfan Şencan, Semanur Kuzi̇

Turkish Journal of Medical Sciences

Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and has been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected regions and combined the evacuation with quarantine process. Some examples of these countries who evacuated their citizens are Germany, Italy, Spain, and USA. In further times, during the course of pandemic, according to spread, other countries evacuated their citizens from these countries too. Despite being the origin …

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Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe Jan 2020

Covid-19 Outbreak Control, Example Of Ministry Of Health Of Turkey, Yasemi̇n Demi̇rbi̇lek, Gülen Pehli̇vantürk, Zeynep Özge Özgüler, Emi̇ne Alp Meşe

Turkish Journal of Medical Sciences

Our first COVID-19 case in Turkey was a 44-year-old male who referred to the hospital on March 9, 2020. The first related death occurred on March 17, 2020. Preparedness for the pandemic has been ongoing before the first case was detected. The National Pandemic Plan was published in 2006. The Pandemic Influenza National Preparedness Plan was available after being updated in light of experiences gained during the 2009 Influenza A pandemic. Accordingly, Pandemic Coordination Boards and Operation Centers have been established on the national and provincial levels. This was an adaptable plan to the Novel Coronavirus Disease (COVID-19). We formed …

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Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n Jan 2020

Protective Measures For Covid-19 For Healthcare Providers And Laboratory Personnel, Canan Ağalar, Derya Öztürk Engi̇n

Turkish Journal of Medical Sciences

In the COVID-19 pandemic, which affects the whole world, healthcare professionals (HCP) are at high risk of transmission due to their direct contact with patients with COVID-19. Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. During the care of these patients, HCP should wear their personal protective equipment (PPE) in accordance with the procedure and should not neglect hand hygiene. The samples of the patient …

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Critically Ill Covid-19 Patient, Burçi̇n Halaçli, Akin Kaya, Arzu Topeli̇ İski̇t Jan 2020

Critically Ill Covid-19 Patient, Burçi̇n Halaçli, Akin Kaya, Arzu Topeli̇ İski̇t

Turkish Journal of Medical Sciences

Coronavirus disease 2019 (COVID-19) stands out as the major pandemic that we have experienced in the last century. As it affects every social structure, it brought the importance of intensive care support once again to the agenda of healthcare system after causing severe acute respiratory syndrome. The precautions to be taken against this virus, where our knowledge is extremely small, intensive care units take an indispensable place in pandemic planning. In this review, we aimed to emphasize the crucial points regarding intensive care management of COVID-19 patients, which we have written not only for intensivists but also for all healthcare …

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Understanding Dynamics Of Pandemics, Levent Akin, Mustafa Gökhan Gözel Jan 2020

Understanding Dynamics Of Pandemics, Levent Akin, Mustafa Gökhan Gözel

Turkish Journal of Medical Sciences

Along the centuries, novel strain of virus such as influenza produces pandemics which increase illness, death and disruption in the countries. Spanish flu in 1918, Asian flu in 1957, Hong Kong flu in 1968 and swine flu in 2009 were known pandemic which had various characteristics in terms of morbidity and mortality. A current pandemic is caused by novel corona virus originated from China. COVID-19 pandemic is very similar to Spanish, Hong Kong, Asian and swine influenza pandemics in terms of spreading to world by the mobilized people. Burden of pandemic is considered in terms of disease transmissibility and the …

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Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n Jan 2020

Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: Coronavirus Infectious Disease 2019 (COVID-19) is now a pandemic spreading in most countries including Turkey. Materials and methods: The current knowledge of COVID-19 and the virus causing it, SARS-CoV-2, was reviewed. The epidemiology and control in different countries was compared and the differences discussed. Results: The population attack rates and case fatality rates vary from country to country with Lombardy in northern Italy reporting an attack rate in the general population of 0.37% compared to 0.004% in Hong Kong. The differences are caused by different testing strategies and reporting systems. Conclusion: Turkey is early in the outbreak. Different control …

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Medical Mask Or N95 Respirator: When And How To Use?, Alpay Azap, Fatma Şebnem Erdi̇nç Jan 2020

Medical Mask Or N95 Respirator: When And How To Use?, Alpay Azap, Fatma Şebnem Erdi̇nç

Turkish Journal of Medical Sciences

COVID-19 pandemic is now a global threat to human health reaching up to 2 million infected people all around the world. Since its first recognition in Wuhan, many topics were discussed intensively about COVID-19, both in the public and scientific community. Personal protective equipment, especially masks, has been among the hottest topics during this pandemic. Regardless of which mask is used, performing hand hygiene frequently with an alcohol-based hand rub or with soap and water if hands are dirty is the most effective preventive measure for COVID-19. The type of mask used when caring for COVID-19 patients will vary according …

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The Early Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay Jan 2020

The Early Impact Of The Covid-19 Pandemic On The Global And Turkish Economy, Ömer Açikgöz, Asli Günay

Turkish Journal of Medical Sciences

Background/aim: Individuals infected by the Covid-19 potentially are at risk of health and economic well-being. Today, the Covid-19 is a global issue, and the world economy can be interpreted as almost at the standstill. In this context, this study aims to discuss the potential first reactions of short and long term global economic impacts of the pandemic through sectors by assessing its costs according to the data announced for both the world and Turkey. In addition, this study tries to put forth possible economic and political scenarios for the post-pandemic world. Materials and methods: This is a review article that …

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Global Surveillance, Travel, And Trade During A Pandemic, Ceren Çeti̇n, Ateş Kara Jan 2020

Global Surveillance, Travel, And Trade During A Pandemic, Ceren Çeti̇n, Ateş Kara

Turkish Journal of Medical Sciences

Pandemics have had very important consequences in human history. Lots of people lost their lives and countries have been intensively affected in terms of socioeconomic problems. Unfortunately, avoidance of pandemics and limiting the spread are still currently not always possible. Maybe the most important factor for this is the increasing frequency of traveling. Increasing airline traveling rate also increases the rate of spread. Global organizations like the World Health Organization and United Nations are trying to play a supreme role over the countries. Pandemics do not have borders; therefore, efforts should be given globally, definition of pandemic should be established …

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Quarantine And Its Legal Dimension, Rahmi̇ Kiliç, Çi̇ğdem Ataman Hati̇poğlu, Cemi̇l Güneş Jan 2020

Quarantine And Its Legal Dimension, Rahmi̇ Kiliç, Çi̇ğdem Ataman Hati̇poğlu, Cemi̇l Güneş

Turkish Journal of Medical Sciences

Quarantine and isolation are public health measures used for centuries to prevent the spread of infectious diseases. Quarantine is separation of persons who have been exposed to an infection but asymptomatic, while isolation is separation of infected patients. Voluntary quarantine is preferred, but if necessary, it can be mandatory. These implementations can lead to restrictions on individual liberties, leading to ethical and legal problems. Isolation and quarantine enforcement are regulated by laws. Those who do not follow the quarantine rules could be punished. Isolation and quarantine practices in our country are described in General Hygiene Law. In this study the …

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Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç Jan 2020

Coronaviruses And Sars-Cov-2, Mustafa Hasöksüz, Selçuk Kiliç, Fahri̇ye Saraç

Turkish Journal of Medical Sciences

Coronaviruses (CoVs) cause a broad spectrum of diseases in domestic and wild animals, poultry, and rodents, ranging from mild to severe enteric, respiratory, and systemic disease, and also cause the common cold or pneumonia in humans. Seven coronavirus species are known to cause human infection, 4 of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. The others namely SARS-CoV (severe acute respiratory syndrome coronavirus), MERS-CoV (Middle East respiratory syndrome coronavirus) were zoonotic in origin and cause severe respiratory illness and fatalities. On 31 December 2019, the existence of patients with pneumonia …

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Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato Jan 2020

Epidemiology Of Covid-19, Cemal Bulut, Yasuyuki̇ Kato

Turkish Journal of Medical Sciences

It seems that coronaviruses take an important place in the 21th century history. Five of seven human coronavirus was isolated in this century. Unfortunately, last three of them entered our life with a fear of outbreak, pandemic or death. Last human coronavirus which emerged world from Wuhan China, SARS CoV-2 and its clinical expression, Coronavirus disease (COVID-19) recently taken a significant place in our daily practice. Initial reports showed that, its origin was bats. It transmitted human to human by droplet and contact routes, but some doubt about airborne, fecal or intrauterine transmission also should be removed. Its R0 value …

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Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu Jan 2020

Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu

Turkish Journal of Medical Sciences

Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 …

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Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ Jan 2020

Novel Coronavirus Disease (Covid-19) In Children, Hasan Tezer, Tuğba Bedi̇r Demi̇rdağ

Turkish Journal of Medical Sciences

Coronavirus disease (COVID-19) was firstly reported at the end of 2019. The disease rapidly spread all around the world in a few months and was declared a worldwide pandemic by WHO in March 2020. By April 9, there were 1,436,198 confirmed COVID-19 cases in the world, nearly with 6% mortality rate. This novel infectious disease causes respiratory tract illness that may generally occur as mild upper respiratory tract disease or pneumonia. In older patients and/or patients with underlying conditions, it may result in acute respiratory distress syndrome, multi organ failure and even death. According to the current literature, children account …

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Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic Jan 2020

Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic

Turkish Journal of Medical Sciences

In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …

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