Digital Commons Network^™

Ancestral Roles Of Atypical Cadherins In Planar Cell Polarity, Maria Brooun, Alexander Klimovich, Mikhail Bashkurov, Bret J. Pearson, Robert E. Steele, Helen Mcneill

Open Access Publications

No abstract provided.

Risks Of Requiring A Dedicated Molecular Specimen For Hiv Diagnosis And A Potential Strategy For Mitigation, Adam L. Bailey, Neil Anderson

Open Access Publications

BACKGROUND: HIV screening (i.e. antigen/antibody) tests are followed by a supplemental (i.e. antibody-only) if the screen is positive. Discrepant results can result from two scenarios: a false-positive screening test or acute HIV infection. These scenarios can be distinguished by a molecular HIV test, but due to contamination concerns, our laboratory recently implemented a policy requiring a second specimen dedicated for molecular HIV testing. Our objective was to (1) characterize the effect of this policy on the time-to-diagnosis for patients with discrepant screening and supplemental test results, and (2) explore "strength of positivity" as an interim predictor of screening test accuracy …

Alpha-Crystallin Mutations Alter Lens Metabolites In Mouse Models Of Human Cataracts, Cheryl Frankfater, Stephanie L. Bozeman, Fong-Fu Hsu, Usha P. Andley

Open Access Publications

Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have important roles maintaining protein solubility to prevent cataract formation. Mutations in the CRYAA and CRYAB crystallin genes are associated with autosomal dominant early onset human cataracts. Although studies about the proteomic and genomic changes that occur in cataracts have been reported, metabolomics studies are very limited. Here, we directly investigated cataract metabolism using gas-chromatography-mass spectrometry (GC-MS) to analyze the metabolites in …

Exposure To Covid-19 Patients Increases Physician Trainee Stress And Burnout, Thomas G. Kannampallil, Charles W. Goss, Bradley A. Evanoff, Jaime R. Strickland, Rebecca P. Mcalister, Jennifer Duncan

Open Access Publications

The coronavirus disease 2019 (COVID-19) pandemic has put considerable physical and emotional strain on frontline healthcare workers. Among frontline healthcare workers, physician trainees represent a unique group-functioning simultaneously as both learners and caregivers and experiencing considerable challenges during the pandemic. However, we have a limited understanding regarding the emotional effects and vulnerability experienced by trainees during the pandemic. We investigated the effects of trainee exposure to patients being tested for COVID-19 on their depression, anxiety, stress, burnout and professional fulfillment. All physician trainees at an academic medical center (n = 1375) were invited to participate in an online survey. We …

Time-Series Cardiovascular Risk Factors And Receipt Of Screening For Breast, Cervical, And Colon Cancer: The Guideline Advantage, Aixia Guo, Bettina F. Drake, Yosef M. Khan, James R. Langabeer Ii, Randi E. Foraker

Open Access Publications

BACKGROUND: Cancer is the second leading cause of death in the United States. Cancer screenings can detect precancerous cells and allow for earlier diagnosis and treatment. Our purpose was to better understand risk factors for cancer screenings and assess the effect of cancer screenings on changes of Cardiovascular health (CVH) measures before and after cancer screenings among patients.

METHODS: We used The Guideline Advantage (TGA)-American Heart Association ambulatory quality clinical data registry of electronic health record data (n = 362,533 patients) to investigate associations between time-series CVH measures and receipt of breast, cervical, and colon cancer screenings. Long short-term memory …

Enteric Viral Co-Infections: Pathogenesis And Perspective, Heyde Makimaa, Harshad Ingle, Megan T Baldridge

Open Access Publications

Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and immunocompromised individuals of all ages globally. Despite virus-virus co-infection events in the intestine being increasingly detected, little is known about their impact on disease outcomes or human health. Here, we review what is currently known about the clinical prevalence of virus-virus co-infections and how co-infections may influence vaccine responses. While experimental investigations into enteric virus co-infections have been limited, we …

Ischemia Reperfusion Injury Provokes Adverse Left Ventricular Remodeling In Dysferlin‑Deficient Hearts Through A Pathway That Involves Tirap Dependent Signaling, Sarah Evans, Carla J. Weinheimer, Attila Kovacs, Jesse W. Williams, Gwendalyn J. Randolph, Wenlong Jiang, Philip M. Barger, Douglas L. Mann

Open Access Publications

No abstract provided.

2019 Pediatric Initiative Network: Progress, Proceedings, And Plans, Leena Nahata, Veronica Gomez-Lobo, Lillian Meacham, Leslie Appiah, Krista Childress, Holly Hoefgen, Maggie Dwiggins, Stacy Whiteside, Kari Bjornard, Julie Rios, Antoinette Anazodo, Courtney Finlayson, Olivia Frias, Teresa Woodruff, Molly Moravek

Open Access Publications

No abstract provided.

A Functional Role For Eicosanoid-Lysophospholipids In Activating Monocyte Signaling, Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Harold F. Sims, Shaoping Guan, Richard W. Gross

Open Access Publications

No abstract provided.

Knowledge Base And Perceptions Of Inpatient Providers And Parents About Influenza Vaccination In Hospitalized Children, Shakila Mathew, Mythili Srinivasan

Open Access Publications

No abstract provided.

Race- And Gender-Based Differences In Descriptions Of Applicants In The Letters Of Recommendation For Orthopaedic Surgery Residency, Alexa Powers, Katherine M. Gerull, Rachel Rothman, Sandra A. Klein, Rick W. Wright, Christopher J. Dy

Open Access Publications

No abstract provided.

Surgical Technique For Below-Knee Amputation With Concurrent Targeted Muscle Reinnervation, Timothy H.F. Daugherty, Rajiv Parikh, Brian A. Mailey, John M. Felder, Reuben A. Bueno Jr.

Open Access Publications

No abstract provided.

The Genetic Architecture Of Human Brainstem Structures And Their Involvement In Common Brain Disorders, Torbjørn Elvsåshagen, Deanna M. Barch, Et Al.

Open Access Publications

No abstract provided.

Reconstruction Of Severe Palm Injury With Sensate Medial Plantar Artery Flap And Nerve Grafting, William M. Padovano, Elspeth J.R. Hill, John M. Felder Iii

Open Access Publications

No abstract provided.

Platelet Α-Granules Are Required For Occlusive High-Shear-Rate Thrombosis, Dongjune A. Kim, Katrina J. Ashworth, Jorge Di Paola, David N. Ku

Open Access Publications

No abstract provided.

Neighborhood Socioeconomic Deprivation Associated With Fat Mass And Weight Status In Youth, Morgan Clennin, Asia Brown, Min Lian, Marsha Dowda, Natalie Colabianchi, Russell R Pate

Open Access Publications

(1) Background: Few studies have examined the relationship between neighborhood socioeconomic deprivation (SED) and weight-related outcomes in youth, controlling for weight-related behaviors. Hence, the purpose of this study was to examine the association between neighborhood SED, weight status, and fat mass in a diverse sample of youth, before and after controlling for physical activity and diet. (2) Methods: The sample included 828 youth from the Transitions and Activity Changes in Kids study. Neighborhood SED was expressed as an index score at the census tract of residence. Height, weight, and body composition were measured and used to calculate fat mass index …

Case Report: Dsm-5 Misses An Edge Case In Tic Disorders Nosology, Kevin J. Black

Open Access Publications

A boy with multiple phonic tics, one lifetime motor tic, and no impairment or marked distress does not meet criteria for any DSM-5 tic disorder diagnosis. The next version of the Diagnostic and Statistical Manual should adjust the criteria for Tourette's Disorder and/or for "other specified tic disorder" and "unspecified tic disorder."

A Phase Ii Study Of Glembatumumab Vedotin For Metastatic Uveal Melanoma, Merve Hasanov, Matthew J Rioth, Kari Kendra, Leonel Hernandez-Aya, Richard W Joseph, Stephen Williamson, Sunandana Chandra, Keisuke Shirai, Christopher D Turner, Karl Lewis, Elizabeth Crowley, Jeffrey Moscow, Brett Carter, Sapna Patel

Open Access Publications

Glembatumumab vedotin (CDX-011, GV) is a fully human Immunoglobulin G2 monoclonal antibody directed against glycoprotein NMB coupled via a peptide linker to monomethyl auristatin E (MMAE), a potent cytotoxic microtubule inhibitor. This phase II study evaluated the overall response rate and safety of GV, glycoprotein NMB (GPNMB) expression, and survival in patients with metastatic uveal melanoma. Eligible patients with metastatic uveal melanoma who had not previously been treated with chemotherapy received GV 1.9 mg/kg every three weeks. The primary endpoint was the objective response rate (ORR). Secondary endpoints included GPNMB expression, progression-free survival (PFS), overall survival (OS), and toxicity analysis. …

Bioinspired Thermosensitive Hydrogel As A Vitreous Substitute: Synthesis, Properties, And Progress Of Animal Studies, Amine Laradji, Ying-Bo Shui, Bedia Begum Karakocak, Lynn Evans, Paul Hamilton, Nathan Ravi

Open Access Publications

In many vitreal diseases, the surgeon removes the natural vitreous and replaces it with silicone oils, gases, or balanced salt solutions to fill the eyeball and hold the retina in position. However, these materials are often associated with complications and have properties that differ from natural vitreous. Herein, we report an extension of our previous work on the synthesis of a biomimetic hydrogel that is composed of thiolated gellan as an analogue of type II collagen and poly(methacrylamide-co-methacrylate-co-bis(methacryloyl)cystamine), a polyelectrolyte, as an analogue of hyaluronic acid. This thermosensitive hydrogel can be injected into the eye as a viscous solution at …

Cancer In Youth Living With Hiv (Ylwhiv): A Narrative Review Of The Access To Oncological Services Among Ylwhiv And The Role Of Economic Strengthening In Child Health, Ruth G N Katumba, Ozge Sensoy Bahar, Kimberly J Johnson, Fred M Ssewamala

Open Access Publications

Youth Living with HIV/AIDS (YLWHIV) have a higher risk of developing immunodeficiency related illnesses including certain cancers than their general population counterparts of the same age. This narrative review of current available literature describes factors associated with pediatric access to oncological services, and the role economic strengthening could play in improving health outcomes for this vulnerable population. Findings suggest that both HIV-infected and -uninfected children living in low and middle-income countries struggle with access and adherence to cancer treatment and care. Cost of treatment is a major barrier to access and adherence. Asset-building savings programs may increase financial security and …

The Baby Bridge Program: A Sustainable Program That Can Improve Therapy Service Delivery For Preterm Infants Following Nicu Discharge, Roberta Pineda, Elizabeth Heiny, Patricia Nellis, Joan Smith, Jaqueline M. Mcgrath, Margaux Collins, Abigail Barker

Open Access Publications

OBJECTIVE: The aim of this project was to determine revenues and costs over time to assess the sustainability of the Baby Bridge program.

METHODS: The Baby Bridge program was developed to promote timely, consistent and high quality early therapy services for high-risk infants following neonatal intensive care unit (NICU) discharge. Key features of the Baby Bridge program were defined as: 1) having the therapist establish rapport with the family while in the NICU, 2) scheduling the first home visit within one week of discharge and continuing weekly visits until other services commence, 3) conducting comprehensive assessments to inform targeted interventions …

Focused Ultrasound For Safe And Effective Release Of Brain Tumor Biomarkers Into The Peripheral Circulation, Lifei Zhu, Arash Nazeri, Christopher Pham Pacia, Yimei Yue, Hong Chen

Open Access Publications

The development of noninvasive approaches for brain tumor diagnosis and monitoring continues to be a major medical challenge. Although blood-based liquid biopsy has received considerable attention in various cancers, limited progress has been made for brain tumors, at least partly due to the hindrance of tumor biomarker release into the peripheral circulation by the blood-brain barrier. Focused ultrasound (FUS) combined with microbubbles induced BBB disruption has been established as a promising technique for noninvasive and localized brain drug delivery. Building on this established technique, we propose to develop FUS-enabled liquid biopsy technique (FUS-LBx) to enhance the release of brain tumor …

Smoking-By-Genotype Interaction In Type 2 Diabetes Risk And Fasting Glucose, Peitao Wu, Mary F. Feitosa, Yize Li, Michael M. Province, D C Rao, Et Al.

Open Access Publications

Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in …

Client Processing Is Altered By Novel Myopathy-Causing Mutations In The Hsp40 J Domain, Melanie Y. Pullen, Conrad C. Weihl, Heather L. True

Open Access Publications

The misfolding and aggregation of proteins is often implicated in the development and progression of degenerative diseases. Heat shock proteins (HSPs), such as the ubiquitously expressed Type II Hsp40 molecular chaperone, DNAJB6, assist in protein folding and disaggregation. Historically, mutations within the DNAJB6 G/F domain have been associated with Limb-Girdle Muscular Dystrophy type 1D, now referred to as LGMDD1, a dominantly inherited degenerative disease. Recently, novel mutations within the J domain of DNAJB6 have been reported in patients with LGMDD1. Since novel myopathy-causing mutations in the Hsp40 J domain have yet to be characterized and both the function of DNAJB6 …

Impact Of Cytogenetic Abnormalities On Outcomes Of Adult Philadelphia-Negative Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Study By The Acute Leukemia Working Committee Of The Center For International Blood And Marrow Transplant Research, Aleksandr Lazaryan, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Obesity Is A Risk Factor For Acute Promyelocytic Leukemia: Evidence From Population And Cross-Sectional Studies And Correlation With Flt3 Mutations And Polyunsaturated Fatty Acid Metabolism, Luca Mazzarella, Timothy J. Ley, Et Al.

Open Access Publications

No abstract provided.

Spatial Mapping Of The Collagen Distribution In Human And Mouse Tissues By Force Volume Atomic Force Microscopy, Annalisa Calò, Yevgeniy Romin, Rami Srouji, Constantinos P. Zambirinis, Ning Fan, Anthony Santella, Elvin Feng, Sho Fujisawa, Mesruh Turkekul, Sharon Huang, Amber L. Simpson, Michael D'Angelica, William R. Jarnagin, Katia Manova-Todorova

Open Access Publications

No abstract provided.

Serum Urate Lowering With Allopurinol And Kidney Function In Type 1 Diabetes, Alessandro Doria, Janet B. Mcgill, Et Al.

Open Access Publications

No abstract provided.

The Nemp Family Supports Metazoan Fertility And Nuclear Envelope Stiffness, Yonit Tsatskis, Ariz Mohammad, Karen Krchma, Jun Wu, Didier Hodzic, Daniel Potter, Tim Schedl, Kyunghee Choi, Helen Mcneill, Et Al

Open Access Publications

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in

Impact Of Preoperative Chlorhexidine Gluconate (Chg) Application Methods On Preoperative Chg Skin Concentration, Bobby G Warren, Alicia Nelson, David K Warren, Meghan A Baker, Candace Miller, Tracey Habrock, Jahnavi Bongu, Abinav Gowda, Jacob Johnson, Deverick J Anderson, Cdc Prevention Epicenters Program

Open Access Publications

Elective surgical patients routinely bathe with chlorhexidine gluconate (CHG) at home days prior to their procedures. However, the impact of home CHG bathing on surgical site CHG concentration is unclear. We examined 3 different methods of applying CHG and hypothesized that different application methods would impact resulting CHG skin concentration.