Digital Commons Network^™

High Fat Diet Significantly Changed The Global Gene Expression Profile Involved In Hepatic Drug Metabolism And Pharmacokinetic System In Mice., Yuqi He, Tao Yang, Yimei Du, Lin Qin, Feifei Ma, Zunping Wu, Hua Ling, Li Yang, Zhengtao Wang, Qingdi Zhou, Guangbo Ge, Yanliu Lu

PCOM Scholarly Works

Background: High fat diet impact transcription of hepatic genes responsible for drug metabolism and pharmacokinetics. Until now, researches just focused on a couple specific genes without a global profile showing. Age-dependent manner was also not noted well. This study aims to investigate the high fat diet effect on transcriptome of drug metabolism and pharmacokinetic system in mouse livers and show the age-dependent evidence.

Methods: C57BL/6 male mice were used in this experiment. High fat diet was used to treat mice for 16 and 38 weeks. Serum total cholesterol, low density lipoprotein cholesterol, aspartate transaminase, and alanine transaminaselevels were measured. Meanwhile, …

Myo/Nog Cells Are Nonprofessional Phagocytes, Jacquelyn Gerhart, Lindsay Gugerty, Paul Lecker, Fathma Abdalla, Mark Martin, Olivia Gerhart, Colby Gerhart, Karanveer Johal, Jake Bernstein, John Spikes, Keith Mathers, Arturo Bravo Nuevo, Mindy George-Weinstein

PCOM Scholarly Works

Myo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to wounding in the skin and eyes. In this report, we present evidence suggesting that Myo/Nog cells phagocytose tattoo ink in tissue sections of human skin and engulf cell corpses in cultures of anterior human lens tissue and magnetic beads injected into the anterior chamber of mice in vivo. Myo/Nog cells are distinct from macrophages in the skin …

Revision Of The Eocene 'Platyrhina' Species From The Bolca Lagerstätte (Italy) Reveals The First Panray (Batomorphii: Zanobatidae) In The Fossil Record, Giuseppe Marramà, Giorgio Carnevale, Kerin M. Claeson, Gavin J P Naylor, Jürgen Kriwet

PCOM Scholarly Works

The fossil-Lagerstätte of Bolca (Italy) is well known for the diversity and exquisite preservation of its bony and cartilaginous fishes documenting tropical shallow-water marine environments associated with coral reefs in the western Tethys during the early Eocene. In this study, the taxonomic, systematic and phylogenetic position of two batoid species traditionally assigned to the living thornback ray genus Platyrhina is re-evaluated. †Platyrhina bolcensis Heckel, 1851 is recognized as a separate species of the Platyrhinidae because of its plate-like antorbital cartilage with an irregular outline and a small horn on the nasal capsules. Also, the rostral cartilage does not reach …

Barriers To Care Among Uninsured Patients With Chronic Disease In A Free Clinic: A Quantitative Study, Stephanie Jinright

DNP Research Projects

No abstract provided.

Reducing Hypertension Through Faith Community Nursing, Michelle White

DNP Research Projects

Hypertension affects approximately 31.1% of adults (1.39 million) worldwide. It continues to be a significant risk factor for cardiovascular disease and strokes, the leading causes of death in the United States (Mills, Stefanescu, & He, 2020). Hypertension is expected to increase due to the aging population and unhealthy lifestyle choices of the American people (American Heart Association [AHA], 2018a). Therefore, effective strategies are required to manage hypertension in order to decrease stroke and cardiovascular events that can save the lives of many Americans. National programs such as Healthy People 2020 are working to achieve blood pressure control within the United …

Molecular Genetic Cancer Screening: Role Of Prediction Of Colorectal Disease In The Clinic Setting, Samantha Spinks

DNP Research Projects

Colorectal Cancer is the third most common cancer in men and women and the second leading cause of cancer related deaths (ACS, 2019). Colonoscopy screening can prevent colon cancer by early detection and removal of adenomatous colon polyps. The ACS has been lowered from age 50 to 45 due to an increase in the prevalence of colon cancer in people below the age of 50 years of age. Molecular genetic screening is a tool that providers can use to identify patients who are at risk for premature adenomas. People who have a genetic variant are more likely to develop adenomas …

Breastfeeding Issues Leading To Early Cessation, Brandy Kirstein

DNP Research Projects

Breastfeeding has come to the forefront in modern research as a necessary and important phenomenon to understand and address due to the vast amount of evidence revealing its health benefits for both Mom and baby. Disparities exist related to socioeconomic status, education level, poverty, young age, obesity, alcohol use, smoking, and living in rural areas. This project aims to discover the areas that need the most awareness and change specific to the state of Tennessee to increase the prevalence of exclusive breastfeeding for six months (EBF6) creating healthier future generations and society. This project was a non-experimental, retrospective, correlational design, …

Art Making To Inform Dialogue Across Spiritual Otherness In The Therapeutic Space, Caitlin Brosious, Emma Burgin, Andrea Dyer, Maggie Knobbe

LMU Theses and Dissertations

This research was a preliminary pilot study meant to encourage further exploration on the intersection of art therapy, art making, spirituality, and dialogue. This study topic is an important area of investigation due to the long-standing challenges of interfaith dialogue, both historically and currently. An abundance of reviewed literature linking interfaith dialogue and dialogue through art making guided the research hypothesis, which states that the act of viewing and being viewed by the spiritual other through art making could deepen one’s own spiritual practice, increase empathy, foster dialogue, and inform clinical work as psychotherapists. To explore this, the researchers held …

Gale Presents: Udemy, Rob Tench

Libraries Faculty & Staff Publications

No abstract provided.

Enhancing The Self-Efficacy Of Nurses In The Reduction Of Potentially Avoidable Nursing Home To Hospital Transfers, Marjorie Elena Tapia

Yale School of Nursing Digital Theses

Nursing home hospitalizations are classified as potentially avoidable when they do not improve quality of life or change the course of illness. These hospitalizations are costly, disruptive and detrimental to the quality of nursing home care. Nurses maintain the interconnection amongst the key stakeholders involved in the decision to hospitalize and are integral to the efforts employed in reducing potentially avoidable transfers. The purpose of this project is to enhance the self-efficacy of long-term care nurses with respect to reducing potentially avoidable nursing home hospitalizations, utilizing an expert validated educational module. A review of the literature on potentially avoidable nursing …

Training Pre-Licensure Nursing Students As First Responders In Clinical Emergencies, Poy Yamada

Yale School of Nursing Digital Theses

The Joint Commission requires formal education for healthcare providers who are first responders giving care to patients whose conditions are deteriorating. However, most nursing programs do not include education about the role of first responders during clinical emergencies in the pre-licensure curricula. A literature search shows positive outcomes of increased knowledge, skills competences, and confidence, and that additional education training of the role of the first responder was needed. While there are positive outcomes from the current literature, additional research is needed to further the argument that first responders training is essential in the pre-licensure nursing programs.

This Doctor of …

Factors Affecting The Microbiome Of Ixodes Scapularis And Amblyomma Americanum, R. Jory Brinkerhoff, Chris Clark, Kelly Ocasio, David T. Gauthier, Wayne L. Hynes

Biological Sciences Faculty Publications

The microbial community composition of disease vectors can impact pathogen establishment and transmission as well as on vector behavior and fitness. While data on vector microbiota are accumulating quickly, determinants of the variation in disease vector microbial communities are incompletely understood. We explored the microbiome of two human-biting tick species abundant in eastern North America (Amblyomma americanum and Ixodes scapularis) to identify the relative contribution of tick species, tick life stage, tick sex, environmental context and vertical transmission to the richness, diversity, and species composition of the tick microbiome. We sampled 89 adult and nymphal Ixodes scapularis (N …

Patterns Of Genetic Diversity In Highly Invasive Species: Cogongrass (Imperata Cylindrica) Expansion In The Invaded Range Of The Southern United States (Us), Rima D. Lucardi, Lisa E. Wallace, Gary N. Ervin

Biological Sciences Faculty Publications

The spatial expansions of invasive organisms in the novel range are generally expected to follow an isolation-by-distance relationship (IBD) if the invasion is biologically driven; however, many invasions are facilitated anthropogenically. This research focused on the extant expansion patterns of cogongrass (Imperata cylindrica). Cogongrass is a widespread invasive species throughout the southern United States (US). Patterns of infestation vary among US states. Cogongrass is pyrogenic, and its invasion threatens softwood (Pinus spp.) plantations, a substantial economic market for this US region. Over 600 individuals were sampled from seven invaded US states, using amplified fragment length polymorphisms (AFLPs) …

Phenotypic Variation Of Partridge Pea (Chamaecrista Fasciculata) From Mississippi Persists In A Common Garden, Lisa E. Wallace, Mahboubeh Hosseinalizadeh-Nobarinezhad, Robert Coltharp

Biological Sciences Faculty Publications

Intraspecific phenotypic variation occurs for many different reasons and understanding its basis has applications in taxonomy, ecology, and evolution. Chamaecrista fasciculata (partridge pea) is a widely distributed species with much phenotypic variation and varied interactions with other species in communities where it grows. Botanists have often noted that phenotypic variation in some traits of this species increases from north to south in the eastern United States. In this study, we grew seeds collected from five Mississippi populations in a common greenhouse environment to determine if the observed variation in leaf and stem traits is maintained in this environment. Interpopulation variation …

Tick-Borne Flavivirus Inhibits Sphingomyelinase (Issmase), A Venomous Spider Ortholog To Increase Sphingomyelin Lipid Levels For Its Survival In Ixodes Scapularis Ticks, Pravesh Regmi, Supreet Khanal, Girish Neelakanta, Hameda Sultana

Biological Sciences Faculty Publications

Our previous study showed that cells from medically important arthropods, such as ticks, secrete extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Understanding the molecular determinants and mechanism(s) of arthropod-borne flavivirus transmission via exosome biogenesis is very important. In this current study, we showed that in the presence of tick-borne Langat Virus (LGTV; a member of tick-borne encephalitis virus complex), the expression of arthropod IsSMase, a sphingomyelinase D (SMase D) that catalyzes the hydrolytic cleavage of substrates like sphingomyelin (SM) lipids, was significantly reduced in both Ixodes scapularis ticks (in vivo) …

Discovery Of Exosomes From Tick Saliva And Salivary Glands Reveals Therapeutic Roles For Cxcl12 And Il-8 In Wound Healing At The Tick-Human Skin Interface, Wenshuo Zhou, Faizan Tahir, Joseph Che-Yen Wang, Michael Woodson, Michael B. Sherman, Shahid Karim, Girish Neelakanta, Hameeda Sultana

Biological Sciences Faculty Publications

Ticks secrete various anti-coagulatory, anti-vasoconstrictory, anti-inflammatory, and anti-platelet aggregation factors in their saliva at the bite site during feeding to evade host immunological surveillance and responses. For the first time, we report successful isolation of exosomes (small membrane-bound extracellular signaling vesicles) from saliva and salivary glands of partially fed or unfed ixodid ticks. Our data showed a novel role of these in vivo exosomes in the inhibition of wound healing via downregulation of C-X-C motif chemokine ligand 12 (CXCL12) and upregulation of interleukin-8 (IL-8). Cryo-electron microscopy (cryo-EM) analysis revealed that tick saliva and salivary glands are composed of heterogeneous populations …

College Of Psychology Doctoral Program Practicum Brochure 2020-2021, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Nsu College Of Psychology Graduate Student Catalog 2020–2021, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.

Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn

Theses and Dissertations (Comprehensive)

Downslope walking (DSW) has been proposed as a rehabilitation tool for people with Multiple Sclerosis (PwMS) although there are mixed findings in young adults (YA) regarding the balance control changes, despite both populations experiencing depressed spinal motor neuron (MN) pool excitability. Our aim was to determine whether YAs could demonstrate improved balance control in conjunction with SOL H reflex depression (estimate of spinal MN excitability) following DSW. We also aimed to determine whether reciprocal inhibition was a potential mechanism for H reflex depression via conditioned SOL H reflexes. Thirty young adults (23±1.4y, 6 males) were assigned to 30-minutes of DSW …

Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze

Theses and Dissertations (Comprehensive)

Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …

(Subjective) Time Heals All Wounds: The Competing Roles Of Objective And Subjective Time In Reactions To Past Events, Sarah L. Williams

Theses and Dissertations (Comprehensive)

Although folk wisdom states that “time heals all wounds,” the truth of this claim is questionable and may be contingent on the nature of time in question. People think about and represent time in different ways: they consider how far away events (objectively) are, as well as how close or far away they (subjectively) feel. How close or distant a temporal event feels from the present is quite malleable and can be affected by a host of psychological factors independent of chronological time. However, little research has explicitly investigated the extent to which objective, calendar time, and one’s subjective sense …

Fanm Pa Chita: Mobilities, Intimate Labour, And Political Subjectivities Among Haitian Women On The Move, Masaya Llavaneras Blanco

Theses and Dissertations (Comprehensive)

This dissertation asks: how does intimate labour interact with the mobility and political subjectivities of Haitian migrant women and women of Haitian descent in the Dominican Republic (DR)? It answers this question in three specific ways. First, it explains the relationship between intimate labour and the spatial trajectories of women of Haitian ancestry who work as domestic workers. Second, it examines how the interaction between intimate labour and human mobility plays out in the Dominican border regime. Third, it explains how these subaltern women act politically in the midst of the intersections between borders, mobilities, and intimacy.

The dissertation proposes …

Exploring Young Acb Women’S Experiences Of Navigating Sexual Health In The Greater Toronto Area., Natasha Afua Darko

Theses and Dissertations (Comprehensive)

This thesis explores the experiences of young African, Caribbean, and Black (ACB) women in the Greater Toronto Area (GTA) regarding how they navigate sexual health. Young ACB women face challenges that put them at increased risk for HIV and other sexually transmitted infections. Despite this, few studies have focused on the social contexts that affect sexual health for ACB women in Canada. This Community Based Participatory Research ( CBPR) study (N = 24) utilized focus groups to examine young ACB women's experiences navigating sexual health. In the following thesis document, I present two manuscripts where I share a) a reflection …

Seeking A Path To Wellness And Flourishing: Exploring Ecological Citizenship, Systems Thinking, And Environmental Governance In Southwest Yukon, Amanda Solmes

Theses and Dissertations (Comprehensive)

While efforts toward environmental management (EM) have been increasing, the state of our natural world is getting worse. Numerous reports have outlined that today’s environmental problems are predominantly human-induced, yet approaches to EM often only address “environmental” rather than “human” issues. More holistic approaches are required. This thesis explores “ecological citizenship” (EC) as an alternative framework that may have the potential to address elements too often left out of top-down and reductionist approaches. Academic and case-based notions of this concept are explored, and a new definition for the term is developed. A case study, drawn from the rich results of …

“There’S No Manual For This”
: A Multi-Case Study Exploring Familial Experiences Of Maternal Incarceration, Lauren Hawthorne

Theses and Dissertations (Comprehensive)

Women are the fastest growing prison population in the world (ICPR, 2017). This holds true in the Canadian context, where 70% of federally incarcerated women are mothers to children under 18 (Sapers, 2015). Inevitably, the carceral experience is inherently familial: the experiences of criminalized women cannot be extricated from that of their families, and the experiences of children and caregivers cannot be extricated from that of the criminalized mother and other family members. Yet, there is a great deal that we do not know about incarceration and family life—particularly from the perspectives of caregivers, mothers, and children themselves. This multi-case …

Determination Of Samarium And Dysprosium Solubility, Seana Brennan

Theses and Dissertations (Comprehensive)

In recent years, the use of Rare Earth Elements (REE) has rapidly increased, resulting in numerous potential anthropogenic inputs to the environment. As a result, these metals are emerging as microcontaminants and pose a potential threat to aquatic life. However, the toxicity of REE are largely unknown due, in part, to the limited information on their chemical speciation. The purpose of this project was to gain an understanding of REE precipitate formation and solubility as the foundation for the development of the chemical equilibrium component of toxicity prediction models. Solubility experiments were conducted with Samarium, (Sm), a light REE, and …

A Qualitative Investigation Into The Influence Of A Mental Health Physical Activity Intervention On University Students, Heather M. Tunks

Theses and Dissertations (Comprehensive)

Objective

Among the university student population, mental illnesses are highly prevalent. Adults aged 20-30 years have the highest rates of mood and anxiety disorders than any other age group, with approximately 12.0% diagnosed with an anxiety disorder and 7.0 to 9.0% experiencing clinical depression (Nunes et al., 2014; Pedrelli, Nyer, Yeung, Zulauf, & Wilens, 2015). Reducing or preventing the effects of mental illness among this population may have lifelong implications including improvements in coping and management of mental illness throughout the lifespan(Jaworska, DeSomma, Fonseka, Heck, & MacQueen, 2016). This research examines the lived experiences of volunteers and participants in a …

Abiotic Conditions, Algal Biomass & Fish Growth Rates Affect Fish Mercury Concentrations In Two Subarctic Lakes, Ari Yamaguchi

Theses and Dissertations (Comprehensive)

Kakisa Lake and Tathlina Lake, located in the Dehcho Region of the Northwest Territories, support important fisheries for the local Ka’a’gee Tu First Nation (KTFN). Recently, Walleye (Sander vitreus) of typical catch size in Tathlina Lake were found to have mercury concentrations above Health Canada’s commercial sale guideline of 0.5 ppm. Wild foods with elevated mercury concentrations can pose health risks to the humans who consume them, depending on consumption amounts and vulnerability factors such as age and pregnancy. Because wild fish can accumulate relatively high mercury levels and subsistence fishing contributes greatly to food security in northern …

Structural And Functional Characterization Of Cazyme And Cazyme-Related Proteins From: Bacteroides Thetaiotaomicron And Porphyromonas Gingivalis: Two Abundant Colonizers Of The Human Microbiome, James Stevenson

Theses and Dissertations (Comprehensive)

The human body consists of approximately 30 trillion cells, while non-human microbes that reside on and within the body outnumber human somatic cells by a factor of 1.3 – 2.3. The interplay between our cells and those of the colonizing microorganisms affect physiology in a multitude of ways, both beneficial and detrimental. Microbes found in the oral cavity, such as the Red Complex member Porphyromonas gingivalis, are associated with pathology, namely periodontal diseases including gum deterioration, tooth decay, and loss of underlying alveolar bone. At the other end of the gastrointestinal tract, microbes such as Bacteroides thetaiotaomicron are found …

“This Is My Little World…”: Navigating The Group Exercise Experience Of Stay-Fit Members, Olivia Jones

Theses and Dissertations (Comprehensive)

Objective

Cancer is the leading cause of death in Canada, with one in two Canadians expected to develop cancer over their lifetime (Canadian Cancer Society, 2019). Exercise is reportedly a safe therapy to help ease the common side effects of cancer and its treatments (Schmitz et al., 2010). Past research has shown the benefits of group exercise while in treatment for cancer, but there is a dearth of research regarding the impact of long-term group exercise programming for cancer survivors. This phenomenological study explored the lived experiences of group exercise participation for individuals who previously had cancer and were enrolled …