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Cancer-Associated Fibroblast Density, Prognostic Characteristics, And Recurrence In Head And Neck Squamous Cell Carcinoma: A Meta-Analysis., Alexander M Knops, Andrew South, Ulrich Rodeck, Ubaldo Martinez-Outschoorn, Larry A Harshyne, Jennifer Johnson, Adam J Luginbuhl, Joseph M Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Introduction: The progression and clinical course of head and neck squamous cell carcinoma (HNSCC) relies on complex interactions between cancer and stromal cells in the tumor microenvironment (TME). Among the most abundant of these stromal cells are cancer-associated fibroblasts (CAFs). While their contribution to tumor progression is widely acknowledged, and various CAF-targeted treatments are under development, the relationship between CAF density and the clinicopathologic course of HNSCC has not been clearly defined. Here we examine the published evidence investigating the relationship of cancer-associated fibroblasts to local recurrence and indicators of prognostic significance in HNSCC.

Methods: We conducted a meta-analysis of …

Cancer-Associated Fibroblast Density, Prognostic Characteristics, And Recurrence In Head And Neck Squamous Cell Carcinoma: A Meta-Analysis., Alexander M Knops, Andrew South, Ulrich Rodeck, Ubaldo Martinez-Outschoorn, Larry Harshyne, Phd, Jennifer Johnson, Md, Adam J Luginbuhl, Joseph M Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Introduction: The progression and clinical course of head and neck squamous cell carcinoma (HNSCC) relies on complex interactions between cancer and stromal cells in the tumor microenvironment (TME). Among the most abundant of these stromal cells are cancer-associated fibroblasts (CAFs). While their contribution to tumor progression is widely acknowledged, and various CAF-targeted treatments are under development, the relationship between CAF density and the clinicopathologic course of HNSCC has not been clearly defined. Here we examine the published evidence investigating the relationship of cancer-associated fibroblasts to local recurrence and indicators of prognostic significance in HNSCC.

Methods: We conducted a meta-analysis of …

Editorial: Investigating The Impact Of Current Issues On Leisure, Tourism, And Hospitality In Psychological Science, Anestis K. Fotiadis, Chris A. Vasilliadis, Tzung-Cheng Huan

All Works

No abstract provided.

Preventing Injuries While Training For An Endurance Event, Stephanie Culver

Instructional Design Capstones Collection

Team FX is a team that trains for endurance events. Coach Gary Walker launched the team in 2005was started by in response to his own experiences training with other endurance event teams. The training regimens of these teams scaled too quickly and were too intense for most athletes, resulting in the fact that he and many athletes on the teams were consistently sustaining injuries. Coach Gary researched and worked with many professionals to develop coaching materials for his own team, Team FX, in order to make endurance event training more accessible and less injury ridden. However, each season, there are …

Interactive Sonification To Assist Children With Autism During Motor Therapeutic Interventions, Franceli L. Cibrian, Judith Ley-Flores, Joseph W. Newbold, Aneesha Singh, Nadia Bianchi-Berthouze, Monica Tentori

Engineering Faculty Articles and Research

Interactive sonification is an effective tool used to guide individuals when practicing movements. Little research has shown the use of interactive sonification in supporting motor therapeutic interventions for children with autism who exhibit motor impairments. The goal of this research is to study if children with autism understand the use of interactive sonification during motor therapeutic interventions, its potential impact of interactive sonification in the development of motor skills in children with autism, and the feasibility of using it in specialized schools for children with autism. We conducted two deployment studies in Mexico using Go-with-the-Flow, a framework to sonify movements …

Biosynthetic Gene Clusters, Microbiomes, And Secondary Metabolites In Cold Water Marine Organisms, Nicole Elizabeth Avalon

USF Tampa Graduate Theses and Dissertations

Microorganisms and invertebrate animals from cold water marine environments, such as in Antarctica and in Ireland’s deep sea, are a rich source of secondary metabolites. In this dissertation, research was centered around secondary metabolism and natural product biosynthesis. The projects include the delineation of biosynthetic gene clusters hypothesized to be responsible for the biosynthesis of the palmerolides, stratification of the microbiome of the Antarctic ascidian Synoicum adareanum, genomic and peptidomic analysis of a host-associated Antarctic Pseudovibrio sp., and isolation and characterization of secondary metabolites from the Irish deep-sea coral Drifa sp.

Palmerolide A, the principle secondary metabolite associated with S. …

Vestibular Rehabilitation In Multiple Sclerosis: Study Protocol For A Randomised Controlled Trial And Cost-Effectiveness Analysis Comparing Customised With Booklet Based Vestibular Rehabilitation For Vestibulopathy And A 12 Month Observational Cohort Study Of The Symptom Reduction And Recurrence Rate Following Treatment For Benign Paroxysmal Positional Vertigo, J. Marsden, M. Pavlou, R. Dennett, A. Gibbon, R. Knight-Lozano, L. Jeu, C. Flavell, J. Freeman, D. E. Bamiou, C. Harris, A. Hawton, E. Goodwin, B. Jones, S. Creanor

School of Health Professions

Abstract Background Symptoms arising from vestibular system dysfunction are observed in 49–59% of people with Multiple Sclerosis (MS). Symptoms may include vertigo, dizziness and/or imbalance. These impact on functional ability, contribute to falls and significant health and social care costs. In people with MS, vestibular dysfunction can be due to peripheral pathology that may include Benign Paroxysmal Positional Vertigo (BPPV), as well as central or combined pathology. Vestibular symptoms may be treated with vestibular rehabilitation (VR), and with repositioning manoeuvres in the case of BPPV. However, there is a paucity of evidence about the rate and degree of symptom recovery …

Eosinophil Micrornas Play A Regulatory Role In Allergic Diseases Included In The Atopic March., Émile Bélanger, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Marie-Michelle Simon, Tony Kwan, Tomi Pastinen, Catherine Laprise

Manuscripts, Articles, Book Chapters and Other Papers

(1) Background: The atopic march is defined by the increased prevalence of allergic diseases after atopic dermatitis onset. In fact, atopic dermatitis is believed to play an important role in allergen sensitization via the damaged skin barrier, leading to allergic diseases such as allergic asthma and allergic rhinitis. The eosinophil, a pro-inflammatory cell that contributes to epithelial damage, is one of the various cells recruited in the inflammatory reactions characterizing these diseases. Few studies were conducted on the transcriptome of this cell type and even less on their specific microRNA (miRNA) profile, which could modulate pathogenesis of allergic diseases and …

Environmental Factors Influencing Urban Homicide Clearance Rates: A Spatial Analysis Of New York City, Leslie W. Kennedy, Joel M. Caoplan, Eric L. Piza, Amanda L. Thomas

Publications and Research

In this paper, we explore the conditions under which clearance rates improve by looking at the experience across New York City. Using one agency provides a control on the administrative differences that appear across other jurisdictions that have been studied, usually through cross-national analysis. Our analysis uses Risk Terrain Modeling (RTM) to identify environmental features that relate to closed versus open homicide cases using two years of New York City Police Department (NYPD) data. This analysis is supplemented with an investigation of precinct-wide social structure variables to examine how context matters in influencing closure rates.

Decentralization, Local Government Fiscal Independence, And Poverty: Evidence From Philippine Provinces, Tristan A. Canare

Economics Department Faculty Publications

Decentralization has become a popular development program among middle- and low-income economies worldwide. The rationale behind decentralization is the local government’s proximity to consumers gives it an information advantage over the central government on needs and preferences. However, the central government has economies of scale and has access to more resources. Using data from Philippine provinces, this paper studies the relationship between decentralization – as represented by local government fiscal independence and as measured by locally sourced revenues expressed as share of total revenue – and poverty incidence. It finds evidence that fiscal independence is associated with lower poverty, but …

Randomised Controlled Trial Of An Augmented Exercise Referral Scheme Using Web-Based Behavioural Support For Inactive Adults With Chronic Health Conditions: The E-Coacher Trial., A Taylor, Rs Taylor, W Ingram, Sg Dean, K Jolly, N Mutrie, J Lambert, L Yardley, A Streeter, C Greaves, C Mcadam, L Price, Nk Anokye, J Campbell

Peninsula Medical School

OBJECTIVE: To determine whether adding web-based support (e-coachER) to an exercise referral scheme (ERS) increases objectively assessed physical activity (PA). DESIGN: Multicentre trial with participants randomised to usual ERS alone (control) or usual ERS plus e-coachER (intervention). SETTING: Primary care and ERS in three UK sites from 2015 to 2018. PARTICIPANTS: 450 inactive ERS referees with chronic health conditions. INTERVENTIONS: Participants received a pedometer, PA recording sheets and a user guide for the web-based support. e-coachER interactively encouraged the use of the ERS and other PA options. MAIN OUTCOME MEASURES: Primary and key secondary outcomes were: objective moderate-to-vigorous PA (MVPA) …

Nocturnal Surface Urban Heat Island Over Greater Cairo: Spatial Morphology, Temporal Trends And Links To Land-Atmosphere Influences, Am El Kenawy, M Hereher, Sm Robaa, Mf Mccabe, Et Al

School of Geography, Earth and Environmental Sciences

This study assesses the spatial and temporal characteristics of nighttime surface urban heat island (SUHI) effects over Greater Cairo: the largest metropolitan area in Africa. This study employed nighttime land surface temperature (LST) data at 1 km resolution from the Moderate Resolution Imaging Spectroradiometer (MODIS) Aqua sensor for the period 2003–2019. We presented a new spatial anomaly algorithm, which allowed to define SUHI using the most anomalous hotspot and cold spot of LST for each time step over Greater Cairo between 2003 and 2019. Results demonstrate that although there is a significant increase in the spatial extent of SUHI over …

Mycobacterium Fortuitum And Mycobacterium Abscessus Infections In The Foot And Ankle In Two Immunocompetent Patients, Khai Phang Wong, Zhi Hao Tang, Gek Meng Tan

BioMedicine

Nontuberculous mycobacteria (NTM) infections of the musculoskeletal system are commonly missed due to its rarity and the absence of systemic symptoms. A high clinical index of suspicion is required to recognize such infections as they may occur in immunocompetent hosts. We present two cases of foot and ankle NTM infections involving Mycobacterium fortuitum and Mycobacterium abscessus in two such patients. The first case involves an 83-year old lady who presented with a two-month history of multiple foot abscesses initially treated at a rural hospital. She underwent drainage and debridement of her foot, with eventual cultures growing Pseudomonas aeruginosa and Mycobacterium …

Persistent Palatal Hypertrophy Associated With Rapid Maxillary Expansion Procedure: Report Of A Rare Case, Mehmet Melih Omezli, Damla Torul, Tolunay Avci

BioMedicine

Maxillary transversal deficiency (MTD) is a common skeletal problem. If not treated on time, MTD evolve to a more complex malocclusion. This problem can affect facial growth and development. Rapid maxillary expansion (RME) procedure frequently used for the management. This technique is usually successful in young individuals but as the age advances and the articulations of the maxilla with surrounding facial bones get more rigid, it becomes ineffective. Undesirable side effects or results have been reported after use of RME in skeletally mature patients such as buccal tipping of posterior teeth, extrusion, periodontal tissue recession, fenestration of buccal cortex, necrosis …

Investigation The Effect Of Jujube Capsule On Sleep Quality Of Postmenopausal Women: A Double-Blind Randomized Clinical Trial, Razieh Mahmoudi, Somayeh Ansari, Mohammad Hosein Haghighizadeh, Nader Shakiba Maram, Simin Montazeri

BioMedicine

Abstract

Bakground and objective: Sleep disorder is among the most common problems in the life of postmenopausal women. Because of the complications of chemical drugs, many women prefer to use herbal supplements for relieving sleep problems. So, the main objective of this study was to determine the effect of the jujube capsule on sleep quality in postmenopausal women.

Materials and methods: This study was a double-blind clinical trial conducted on 106 postmenopausal women in Khuzestan province, southwest of Iran. All participants were selected by a simple non-probability sampling method. Data were collected through a demographic data form and the Pittsburgh …

Three-Dimensional Reconstruction Of Renal Vascular Tumor Anatomy To Facilitate Accurate Preoperative Planning Of Partial Nephrectomy, Chien-Heng Lin

BioMedicine

Objectives: To evaluate the role of three-dimensional (3D) reconstruction tumors and vessels of the kidneys in aiding the preoperative planning of partial nephrectomy.

Materials and Methods: Patients with renal tumors to be treated with partial nephrectomy were included. Each patient underwent a preoperative computed tomography (CT) survey, and the reconstruction of each patient’s 3D arteriography and 3D surface-rendered tumor was performed based on the CT images for preoperative surgical planning.

Results: A total of 6 patients, three with tumors of the right kidney and three with tumors of the left kidney, were enrolled in the study. The patients’ mean age …

Evaluation Of Subacute Subarachnoid Haemorrhage Detection Using A Magnetic Resonance Imaging Sequence: Double Inversion Recovery, Zahra Mardanshahi, Maryam Tayebi, Sajad Shafiee, Maryam Barzin, Misagh Shafizad, Reza Alizadeh-Navaei, Abdolmajid Gholinataj

BioMedicine

Background and Objectives: The diagnosis of subarachnoid hemorrhage (SAH) especially at the subacute stage is still a challenging issue using the conventional imaging modalities. Here we evaluated the role of double inversion recovery (DIR) sequence of MRI compared with the conventional gradient-recalled echo (GRE)-T2*-W and susceptibility-weighted imaging (SWI) sequences in the diagnosis of subacute SAH.

Materials and Methods: This prospective study was conducted on 21 patients with SAH, which were diagnosed using CT scan at the initial step. In the third week after the injury (14-20 days), all patients underwent a brain MRI exam that included T2*-W, SWI, and …

The Effect Of Opium Addiction On Short-Term Postoperative Outcomes After Coronary Artery Bypass Graft Surgery: A Prospective Observational Cohort Study, Mohammad Reza Habibi, Abbas Alipour, Aria Soleimani, Farshad Hasanzadeh Kiabi, Ali Habibi, Amir Emami Zeydi

BioMedicine

Introduction: Opium addiction has been recently suggested as a potential risk factor for the occurrence of perioperative complications in patients undergoing coronary artery bypass graft (CABG) surgery. The aim of this study was to evaluate whether opium addiction can potentially affect patients' short-term postoperative outcomes after CABG surgery.

Material and Methods: In a prospective observational cohort study, all consecutive patients who were scheduled for first-time isolated elective on pump CABG surgery were screened during the study period for opium addiction. The study was carried out between September 2015 and November 2016 at Mazandaran Heart Center, Sari, Iran. A total …

Diagnostic Accuracy Of Resistive Index Of Capsular And Intratesticular Branches Of Testicular Arteries In Infertile Men With Oligoasthenospermia: A Case-Control Study, Mehdi Zolfaghar-Khani, Hadi Majidi Dr, Behzad Feizzadeh, Mojtaba Sabaghi

BioMedicine

Introduction: Male infertility accounts for nearly 50% of couples' infertility. Only a few studies evaluate the diagnostic accuracy of resistive index (RI) of testicular arteries using color Doppler imaging to identify male infertility. The aim of this study was to investigate the diagnostic accuracy of RI of the capsular and intratesticular branches of testicular arteries in infertile men with oligoasthenospermia and its comparison with normal men.

Material and Methods: In a case-control study, 30 patients with oligoasthenospermia (case group) and 30 healthy controls who meet the inclusion criteria, were selected. For all patients, RI was measured using color …

Astragalus Fascicolifolius Manna Abortifacient Risk And Effects On Sex Hormones In Balb/C Mice, Mehrdad Shahrani, Najmeh Asgharzadeh, Soleiman Kheiri, Roya Karimi, Arezo Sadeghimanesh, Shirin Asgharian, Zahra Lorigooini

BioMedicine

Background: Astragalus fascicolifolius manna is used to treat different diseases. Because pregnant women tend to use Astragalus. fascicolifolius and Iranian traditional medicine emphasizes the abortifacient potential of this plant, this study aimed to investigate Astragalus fascicolifolius manna abortifacient property and effects on estrogen, progesterone, LH and FSH levels in BALB/c mice.

Method: This experimental study was conducted with 70 female BALB/c mice assigned to seven groups: Nonpregnant, untreated; nonpregnant, Astragalus. fascicolifolius extract (400 mg/kg)-treated; pregnant, Astragalus. fascicolifolius extract (400, 800 and 1200 mg/kg)-treated; and two pregnant control groups. On 18 and 19 days of pregnancy, cesarean section performed …

A Systematic Review And Meta-Analysis: Evaluatia Systematic Review And Meta-Analysis: Evaluation Of The Β-Human Papillomavirus In Immunosuppressed Individuals With Cutaneous Squamous Cell Carcinoma With Cutaneous Squamous Cell Carcinoma, Mazaher Ramezani, Farideh Baharzadeh, Afshin Almasi, Masoud Sadeghi

BioMedicine

Background: Some types of beta-human papillomavirus (β-HPV) may be one of the probable causes of squamous cell carcinoma (SCC) in transplant recipients. β-HPVs are linked to SCC in the literature with small number of subjects. Aim: Herein, the first meta-analysis was carried out on the association between β-HPVs and cutaneous SCC in immunosuppressed patients. Methods: A systematic search was carried out in the PubMed and Scopus databases up to December 2018. The odds ratio (OR) were calculated by RevMan 5.3 software and the event rate (ER) by Comprehensive Meta-Analysis 2.0 software with a 95% confidence interval (CI). …

Domestic Violence In Criminal Courts: The Larger Implications For Victims, Jason Johnson

Bridges: An Undergraduate Journal of Contemporary Connections

Academics have considered the treatment of domestic violence in Canada inadequate (Bell, Perez, Goodman, & Dutton, 2011) and “…an indicator of society's inattentiveness to violence against women…” (Garner & Maxwell, 2009, p. 44). Van Wormer (2009) further notes that there is still “…widespread dissatisfaction by battered women … and their advocates with the current system…” (p. 107). While much of the literature focuses on early aspects of the criminal justice system (police action, decision to prosecute, for e.g.), few authors have sought to understand victims opinions about the trial process (Hare, 2010; Smith, 2001). This paper conducts a literature review …

Isolation Versus Engagement: The Economic Factors In Sino-Canadian Relations, 1960s-1970s, Brendan Williams

Bridges: An Undergraduate Journal of Contemporary Connections

This essay seeks to present a historic overview of this relationship as it developed between the 1960s and 1970s and showcase how certain events impacted this development. Canada has had a steadily growing economic relationship with the People’s Republic of China (PRC) since the latter’s reform and opening up policy under Deng Xiaoping in 1978. The development of this relationship was not a forgone conclusion, as Cold War tensions initially heightened ideological tensions between Maoist China and capitalist democracies like Canada. The path of normalization was impacted by both domestic and international events involving both Canada and the PRC, which …

100 Maasai Women’S Perspectives On The Impact Of Female Genital Cutting On Social And Economic Wellbeing, Rebecca Vandekemp-Mclellan

Bridges: An Undergraduate Journal of Contemporary Connections

Interviews with 100 Maasai women in Narok District, Kenya, explored FGC, early marriage, and financial autonomy, among other topics. Respondents drew a telling picture of the significant social value that FGC holds for the Maasai communities in this study, namely, that FGC is an initiation ceremony that turns children into adults, and is an eligibility requirement for marriage and childbearing. Not only does circumcision create multiple opportunities for increased social status, but it also represents increases in economic security through its power to bring about marriage and reproduction. The overall perspectives of the women on the FGC procedure itself showed …

Vol.48 N.19 November 26th 2020, Voice Media Ventures

Black Voice News

No abstract provided.

Brain Metabolite Levels In Sedentary Women And Non-Contact Athletes Differ From Contact Athletes, Amy L. Schranz, Gregory A. Dekaban, Lisa Fischer, Kevin Blackney, Christy Barreira, Timothy J. Doherty, Douglas D. Fraser, Arthur Brown, Jeff Holmes, Ravi S. Menon, Robert Bartha

Medical Biophysics Publications

White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy (MRS) in the prefrontal white matter at the beginning (In-Season) and end (Off-Season) of season in contact (N = 54, rugby players) and non-contact (N = 23, swimmers and rowers) varsity athletes. Sedentary women (N = 23) were scanned once, at a time equivalent to the Off-Season …

2020-11-26_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of the date of the collection of a sample for diagnostic testing …

Brain Metabolite Levels In Sedentary Women And Non-Contact Athletes Differ From Contact Athletes, Amy L. Schranz, Gregory A. Dekaban, Lisa Fischer, Kevin Blackney, Christy Barreira, Timothy J. Doherty, Douglas D. Fraser, Arthur Brown, Jeff Holmes, Ravi S. Menon, Robert Bartha

Brain and Mind Institute Researchers' Publications

White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy (MRS) in the prefrontal white matter at the beginning (In-Season) and end (Off-Season) of season in contact (N = 54, rugby players) and non-contact (N = 23, swimmers and rowers) varsity athletes. Sedentary women (N = 23) were scanned once, at a time equivalent to the Off-Season …

The Effect Of Obesity On Operative Time And Postoperative Complications For Peritrochanteric Femur Fractures., Hayden B Schuette, William M Durkin, Braden J Passias, Daniel Degenova, Carina Bertolini, Philip Myers, Benjamin C Taylor

Surgery Articles

Introduction The high prevalence of obesity among adults in the United States presents significant challenges to orthopedic surgeons. Obesity has been shown to increase operative time and complications in both elective and nonelective orthopedic surgeries. Despite this, there is a lack of literature evaluating the effect obesity has on operative time and postoperative complications following peritrochanteric fracture surgery. Methods and Materials We performed a retrospective review of patients who underwent isolated operative stabilization of a peritrochanteric femur fracture at our urban level one trauma center between 2010 and 2018. Patients were divided into an obese group, as defined by a …

Choirs From Wales And The University Of Alabama At Birmingham Unite Virtually In Song Of Hope, Shannon Thomason

Browse All News

No abstract provided.