Digital Commons Network^™

Dach1 Mutation Frequency In Endometrial Cancer Is Associated With High Tumor Mutation Burden, Mckayla J. Riggs, Nan Lin, Chi Wang, Dava W. Piecoro, Rachel W. Miller, Oliver A. Hampton, Mahadev Rao, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

OBJECTIVE: DACH1 is a transcriptional repressor and tumor suppressor gene frequently mutated in melanoma, bladder, and prostate cancer. Loss of DACH1 expression is associated with poor prognostic features and reduced overall survival in uterine cancer. In this study, we utilized the Oncology Research Information Exchange Network (ORIEN) Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer in our Kentucky population.

METHODS: We obtained clinical and genomic data for 65 patients with endometrial cancer from the Markey Cancer Center (MCC). We examined the clinical attributes of the cancers by DACH1 status by comparing whole-exome sequencing (WES), …

Psychological Reactions To Covid-19: Survey Data Assessing Perceived Susceptibility, Distress, Mindfulness, And Preventive Health Behaviors, William H. O'Brien, Shan Wang, Huanzhen Xu, Shiwei Wang, Zaiying Yang, Joy Ting Yang, Qinwanxian Liu, Xin Zhang, Lingli Tang, Aniko V. Varga, Tracy Sims, Chung Xiann Lim, Somboon Jarukasemthawee, Kullaya Pisitsungkagarn

Psychology Faculty Publications

The COVID-19 pandemic created a complex psychological environment for persons in America. A total of 450 USA MTurk workers completed measures of: (a) basic demographic characteristics; (b) health risk factors for COVID-19; (c) perceived susceptibility variables related to COVID-19; (d) COVID-19 preventive health behaviors; and (e) distress, physical symptoms, and quality of life measures. The surveys were completed between April 9, 2020 and April 18, 2020. This recruitment period corresponded to the first 2-3 weeks of lockdown in most of the USA. Follow-up surveys were completed by 151 of the USA participants between June 19, 2020 and July 11, 2020 …

Lahti Named Chair Of The Department Of Psychiatry And Behavioral Neurobiology, Alicia Rohan

Browse All News

No abstract provided.

Multifaceted Highly Targeted Sequential Multidrug Treatment Of Early Ambulatory High-Risk Sars-Cov-2 Infection (Covid-19), Peter A. Mccullough, Paul E. Alexander, Robin Armstrong, Cristian Arvinte, Alan F. Bain, Richard P. Bartlett, Robert L. Berkowitz, Andrew C. Berry, Thomas J. Borody, Joseph H. Brewer, Adam M. Brufsky, Teryn Clarke, Roland Derwand, Alieta Eck, John Eck, Richard A. Eisner, George C. Fareed, Angelina Farella, Silvia Ns Fonseca, Charles E. Geyer, Russell S. Gonnering, Karladine E. Graves, Kenneth Bv Gross, Sabine Hazan, Kristin S. Held, H. Thomas Hight, Stella Immanuel, Michael M. Jacobs, Joseph A. Ladapo, Lionel H. Lee, John Littell, Ivette Lozano, Harpal S. Mangat, Ben Marble, John E. Mckinnon, Lee D. Merritt, Jane M. Orient, Ramin Oskoui, Donald C. Pompan, Brian C. Procter, Chad Prodromos, Juliana Cepelowicz Rajter, Jean-Jacques Rajter, C. Venkata S. Ram, Salete S. Rios, Harvey A. Risch, Michael Ja Robb, Molly Rutherford, Martin Scholz, Marilyn M. Singleton, James A. Tumlin, Brian M. Tyson, Richard G. Urso, Kelly Victory, Elizabeth Lee Vliet, Craig M. Wax, Alexandre G. Wolkoff, Vicki Wooll, Vladimir Zelenko

Infectious Diseases Articles

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, …

Arts And Folklor Resources As Attraction And Development Of Indonesian Cultural Tourism, Priyanto Priyanto, Nur Fadilah Dewi

Journal of Indonesian Tourism and Policy Studies

Art and folklore is a culture that has been passed down from the ancestors. Folklore is often used as research material and study material. Folklore must be used properly so that it can be useful for everyone. Folklore art itself has many elements such as artistic elements, namely drama, sound, literature, music, movement and fine arts. Folklore art is also one of the development tools in the tourism sector for schools, campuses, cultural villages, tourist attractions and other historical buildings. The use of folklore art can increase knowledge for children today, where culture in Indonesia must be sought first and …

The Perspective Of Millenial Tourists On Halal Tourism And Itsreflection To Halal Tourism Development In West Sumatera, Diaz Pranita, Deni Danial Kesa

Journal of Indonesian Tourism and Policy Studies

As halal tourism demand show significant growth due to increase awareness of muslim tourists on consuming halal products and services during their travels, muslim millennials travelers becomes the most targeted market from destinations in the world, especially as they represent 25% of total tourism visitor arrivals. Therefore, this paper intends to reveal the perception of millennials on halal tourism and after that , the results to be projected in the development strategy of halal tourism in West Sumatera. It is an exploratory descriptive research in which primary data are collected through the distribution of questionnaire to 185 millennials in Jakarta. …

Integration Of Cardiovascular Risk Assessment With Covid-19 Using Artificial Intelligence., Jasjit S Suri, Anudeep Puvvula, Misha Majhail, Mainak Biswas, Ankush D Jamthikar, Luca Saba, Gavino Faa, Inder M Singh, Ronald Oberleitner, Monika Turk, Saurabh Srivastava, Paramjit S Chadha, Harman S Suri, Amer M Johri, Vijay Nambi, J Miguel Sanches, Narendra N Khanna, Klaudija Viskovic, Sophie Mavrogeni, John R Laird, Arindam Bit, Gyan Pareek, Martin Miner, Antonella Balestrieri, Petros P Sfikakis, George Tsoulfas, Athanasios Protogerou, Durga Prasanna Misra, Vikas Agarwal, George D Kitas, Raghu Kolluri, Jagjit Teji, Michele Porcu, Mustafa Al-Maini, Ann Agbakoba, Meyypan Sockalingam, Ajit Sexena, Andrew Nicolaides, Aditya Sharma, Vijay Rathore, Vijay Viswanathan, Subbaram Naidu, Deepak L Bhatt

Heart and Vascular Articles

Artificial Intelligence (AI), in general, refers to the machines (or computers) that mimic "cognitive" functions that we associate with our mind, such as "learning" and "solving problem". New biomarkers derived from medical imaging are being discovered and are then fused with non-imaging biomarkers (such as office, laboratory, physiological, genetic, epidemiological, and clinical-based biomarkers) in a big data framework, to develop AI systems. These systems can support risk prediction and monitoring. This perspective narrative shows the powerful methods of AI for tracking cardiovascular risks. We conclude that AI could potentially become an integral part of the COVID-19 disease management system. Countries, …

Testing Compliance, Brandon L. Garrett, Gregory Mitchell

Law and Contemporary Problems

No abstract provided.

Some Realism About Corporate Crime, James D. Nelson

Law and Contemporary Problems

No abstract provided.

The Meeting Point Of Neo-Sufism And School Counselors Competencies, Ridwan Ridwan, Anwar Sutoyo, Ali Mansur

Jurnal Kajian Bimbingan dan Konseling

Neo-sufism is the recent Sufi movement that actively develops society. Historically, sufism has brought forth arif billâh individuals who have great faith and devotion to Allah, excellent pedagogical competence, as well as social and professional skills. This study aims to construct the meeting point between neo-sufism character and school counselor competence. It was carried out using a qualitative approach with the Hermeneutic analysis from Paul Ricoeur. The data was obtained from documents and interviews. The results reveal the meeting point between neo-sufism character and four counselors competencies. Makrifatullah (depth comprehension of God) character is linear with pedagogical and personality competence. …

Students’ Academic Resilience Profiles Based On Gender And Cohort, Suciani Latif, Muhammad Amirullah

Jurnal Kajian Bimbingan dan Konseling

This study examined the differences in the students’ academic resilience based on gender and cohort. Participants were students of Department of Educational Psychology and Guidance, Faculty of Education, Universitas Negeri Makassar in the academic years of 2013, 2014, and 2015. They were comprised of 103 students, 77 females and 26 males. The instrument in this study was Academic Resilience Scale (ARS) adopted and modified from Martin and Marsh. Data were analyzed through Mann-Whitney statistical of non-parametric tests in order to measure the academic resilience level of gender difference and Kruskal Wallis to measure academic resilience of cohort difference. Results revealed …

Protocol For A Trial Assessing The Impacts Of School-Based Wash Interventions On Children’S Health Literacy, Handwashing, And Nutrition Status In Low- And Middle-Income Countries, Stephanie O. Sangalang, Shelley Anne J. Medina, Zheina J. Ottong, Allen Lemuel G. Lemence, Donrey Totanes, John Cedrick Valencia, Patricia Andrea A. Singson, Mikaela Olaguera, Nelissa O. Prado, Roezel Mari Z. Ocaña, Rovin James F. Canja, Alfem John T. Benolirao, Shyrill Mae F. Mariano, Jergil Gyle Gavieres, Clarisse P. Aquino, Edison C. Latag, Maria Vianca Jasmin C. Anglo, Christian Borgemeister, Thoomas Kistemann

Development Studies Faculty Publications

Diarrhea, soil-transmitted helminth infection and malnutrition are leading causes of child mortality in low- and middle-income countries (LMICs). To reduce the prevalence of these diseases, effective interventions for adequate water, sanitation, and hygiene (WaSH) should be implemented. This paper describes the design of a cluster-randomized controlled trial that will compare the efficacy of four school-based WaSH interventions for improving children’s health literacy, handwashing, and nutrition. Interventions consisted of (1) WaSH policy reinforcement; (2) low-, medium-, or high-volume health education; (3) hygiene supplies; and (4) WaSH facilities (e.g., toilets, urinals, handwashing basins) improvements. We randomly allocated school clusters from the intervention …

Sensitivity Analysis Of An Agent-Based Simulation Model Using Reconstructability Analysis, Andey M. Nunes, Martin Zwick, Wayne Wakeland

Complex Systems Faculty Publications and Presentations

Reconstructability analysis, a methodology based on information theory and graph theory, was used to perform a sensitivity analysis of an agent-based model. The NetLogo BehaviorSpace tool was employed to do a full 2^k factorial parameter sweep on Uri Wilensky’s Wealth Distribution NetLogo model, to which a Gini-coefficient convergence condition was added. The analysis identified the most influential predictors (parameters and their interactions) of the Gini coefficient wealth inequality outcome. Implications of this type of analysis for building and testing agent-based simulation models are discussed.

Chief Guest Address At The Launch Of Global Islamic Economy Report – 2020-21, Ishrat Husain Dr.

Faculty Research - Talks, Speeches, & Discourse

Let me first of all thank the organizers of this Conference for inviting me to participate in this launch ceremony. Am glad that this Report takes stock of the current status of Islamic Economy and has thematic focus on the state of halal products market.

May I suggest that the report should not be complacent and self-congratulatory but position the Muslim countries against established international benchmarks. For example, what is the share of these countries in global halal products market? What percentage of global financial assets belong to Islamic financial assets? Are we capturing or losing market shares? The analysis …

Urgency Of Resilience And Optimism In Improving Students’ Mental Health, Retno Mangestuti, Yulia Sholichatun, Rahmat Aziz, Esa Nur Wahyuni

Jurnal Kajian Bimbingan dan Konseling

Mental health study has become an intriguing and vital carried out by various experts according to their scientific discipline. This study aims to test the role of optimism as a mediator for the relationship of resilience with students’ mental health. The subjects were 320 students in four state Islamic colleges in East Java, Indonesia. Data obtained through the mental health scale, resilience scale, and optimism scale. Data were analyzed using regression analysis techniques. The analysis shows that the resilience has direct effects of 1.398 (p bigger than 0.01) and indirect effects of 0.312 (p bigger than 0.01) through optimism on …

Greenhouse Gas Emissions From Lithium-Ion Batteries Operating In California's Electrical Grid In 2019, Peter J. Hilkene

Master's Theses

This work examines the impact on greenhouse gas emissions of energy storage devices operating on the California electrical grid during the year 2019. As solar power gains a greater share in California’s energy production, tools for storing the intermittent energy produced from solar and other variable generation sources become important in continuing their growth. In this study, the impact of the deployment of energy storage capacity in California was determined using three charging and discharging strategies. The first, meeting peak net-demand with solar, looked at battery charging when solar production was highest and discharging when net-demand is highest. The second …

A Silicon Valley Life: A Silicon Valley Love Story, Sharon Simonson

Master's Theses

In the last three decades, Silicon Valley has become one of the world’s most watched and imitated communities. Daily news reporters, long-form journalists, cinema and television-programming producers have crafted a public image, but it represents nothing of the lives of hundreds of thousands of Valley residents. These fabrications obscure and diminish our complex human profile and reduce our uniquely beautiful geography to a place to generate financial profits, with all the damaging disregard such attitudes foster. The essays of A Silicon Valley Life: A Silicon Valley Love Story seek to show our true self: our rich mix of people drawn …

Lstm-Enabled Level Curve Tracking In Scalar Fields Using Multiple Mobile Robots, Kunj J. Parikh

Master's Theses

Autonomous mobile sensor networks are ideal candidates for exploring large-scaleunknown fields with tasks ranging from source seeking, level curve tracking, mapping an unknown field, and many more. In this work, we investigate the problem of level curve tracking in unknown scalar fields using a limited number of mobile sensors. The level curve tracking problem has been studied in many applications such as monitoring the propagation of fire boundaries and the algae blooms. We design and implement a long short term memory (LSTM) enabled control strategy for a mobile sensor network to detect and track the desired level curve. We develop …

Inclusive Leadership, Psychological Empowerment, And Affective Organizational Commitment: A Mediated Model, Mariah Lyn Van Buskirk

Master's Theses

Inclusive leadership has become an important contextual factor to study in organizations given its impact on positive workplace outcomes. However, little is known about the ability of inclusive leadership to affect a wider range of outcomes and the various mediating mechanisms between inclusive leadership and outcomes. Therefore, the present study explored the mediating role of psychological empowerment on the relationship between inclusive leadership and affective organizational commitment. It was hypothesized that inclusive leadership would be positively related to affective organizational commitment both directly and indirectly through psychological empowerment. Results of an online survey from 189 employed individuals showed that inclusive …

Prevalence Of Avoidant/Restrictive Food Intake Disorder And Association With Nutrition Status In Patients With Inflammatory Bowel Diseases, Emily Yelencich

Master's Theses

There is a large body of research on the relationship between inflammatory bowel disease (IBD) and diet; however, few conclusive, generalizable recommendations have been determined. Regardless, IBD patients often alter their normal dietary intake, which is concerning considering the prevalence of malnutrition in the IBD population. Avoidant/restrictive food intake disorder (ARFID) is a feeding disorder that was recently added to the Diagnostic and Statistical Manual of Mental Disorders and its prevalence and impact on the nutritional status of IBD patients has not previously been described. In this study ARFID risk was measured using the Nine-Item ARFID Screen and in the …

Auditing Accounts Receivable And Allowance For Doubtful Accounts At Cardinal Corporation, Sarah S. Lureau

The North American Accounting Studies

The audit of accounts receivable can be complex with numerous issues for an audit engagement team. In this simulation/case, students are exposed to various issues as they audit Cardinal Corporation. Students assume the role of an experienced associate auditor heading into her second busy season as she leads the fieldwork for accounts receivable and allowance for doubtful accounts. The case provides the accounts receivable audit program; students complete each step and select samples with a focus around the aging of accounts receivable analysis test for allowance for doubtful accounts. Work papers such as confirmations, invoices and bills of lading have …

Governor's Office Of Diversity Business Enterprise (Go-Dbe) 2020 Annual Report, Tennessee. Department Of General Services.

GO-DBE Report

No abstract provided.

Bilingual English-Spanish Louisiana Civil Code, Book I, Titles Iv-X, Mariano Vitetta

Journal of Civil Law Studies

No abstract provided.

The Government’S Prioritization Of Information Over Sanction: Implications For Compliance, Veronica Root Martinez

Law and Contemporary Problems

No abstract provided.

Using The Corporate Prosecution And Sentencing Model For Individuals: The Case For A Unified Federal Approach, Rachel E. Barkow

Law and Contemporary Problems

No abstract provided.

Epidemiology Of Non-Alcoholic Fatty Liver Disease And Risk Of Hepatocellular Carcinoma Progression, Krishna Chaitanya Thandra, Adam Barsouk, Kalyan Saginala, John Sukumar Aluru, Prashanth Rawla, Alexander Barsouk

Kimmel Cancer Center Faculty Papers

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. Its incidence has grown alongside the increasing global prevalence of type 2 diabetes, obesity, and metabolic syndrome. The risk of progression to hepatocellular carcinoma for nonalcoholic steatohepatitis patients over 5 years is 8%, and despite targeted and immunotherapy treatment advances, HCC maintains a bleak 5-year survival of 19%. NAFLD’s primary risk factors are components of metabolic syndrome as well as possible sleep disturbances. NAFLD is most common among men 50-60 years of age, though incidence in women catches up after menopause. In the US, Hispanics are …

Root Dentine Strain Generation During Root Canal Instrumentation With Rotation And Reciprocation Motions, Bnar O. Hamafaraj, Raed F. Salman

Polytechnic Journal

The aim of the study is to measure and compare strain generated on root dentine surface by two different instrumentation motions. Thirty extracted single canal premolars were used in this study which randomly was divided into two groups, one group was prepared with ProTaper NEXT X2 file in rotation motion, and the second group was prepared by WaveOne GOLD primary file in reciprocation motion, the canals were irrigated during canal preparation by 2 ml of sodium hypochlorite and 17% EDTA gel was used. Strain measurement was performed by strain gauges and a digital strain output reader, data were recorded every …

Association Of Lipid Profile With Body Mass Index In Public Employees In Halabja City, Kurdistan Region Of Iraq, Tareq H. Abdullah, Hardi R. Baqi, Salar H. Karim, Dashty A. Ghafor

Polytechnic Journal

Obesity and overweight are extensive phenomena that reached epidemics extent worldwide, including the Kurdistan region of Iraq. The aim of this study is to evaluate the values of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), and the state of physical activity in Halabja’s public employees. Overall 355 adults aged from 19 to 63 including 246 males and 109 females contributed to the study. The lipid profiles were tested in all subjects after over-night fasting. In addition, anthropometry measurements were taken; the mean height for males is 1.7129 m and 1.5732 …

Prevalence And Phylogenetic Analysis Of Babesia Ovis Isolated From Sheep And Goats In Erbil Province, Kurdistan Region- Iraq, Zuber I. Hassan

Polytechnic Journal

A total of 143 blood smears were obtained from sheep and goats (n = 98) and (n = 45), respectively, by jugular venipuncture between February 2019 and December 2019. Samples were examined for parasite occurrences. Results reveal that the prevalence of infection by the parasite was 12.24% and 11.11%, respectively (microscopically), while 20.41% sheep and 17.78% goats (molecular-based identification using 18S SSU rRNA sequence). Both methods revealed the specificity and sensitivity of the diagnostic assays. Phylogenetic analysis of Babesia ovis (MN309736-MN309745) displays that the pathogens identified in this study are clustered together, which indicating similar molecular characteristics. Overall, these results …

Effect Of Adding Magnesium Oxide Nanoparticles On The Antimicrobial Activity Of A Denture Soft Liner, Hoshang Kh. Abdel-Rahman,, Salem A. Alem Al-Sammaraie

Polytechnic Journal

Microbial growth and colonization are one of the disadvantages after the long-term use of denture soft liners. This study was aimed to evaluate the effect of the addition of magnesium oxide nanoparticles (MgONPs) on the antimicrobial activity of a denture soft liner. A total of 84 samples were prepared from a soft denture liner and divided into two groups, control group and test group to which 3% by weight of MgONPs were added, antimicrobial tests for Candida albicans, Staphylococcus aureus,and a mixture of the biofilm of both microorganisms were done, cell density count and adherence assay test was recorded before …