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Cardioprotective Roles Of Hydrogen Sulfide Donor Treatment In Diabetic Cardiomyopathy, Sumit Kar

Theses & Dissertations

Diabetes mellitus (DM) increases the risk of heart failure 2-4-fold. Intensive glycemic control does not abate this risk in DM patients, suggesting that DM-induced heart failure is beyond hyperglycemia. DM silently induces cardiac muscle disorder termed diabetic cardiomyopathy (DMCM), which progresses to heart failure. The objective of this dissertation is to understand the mechanistic underpinnings of DMCM to develop new solutions to diagnose and treat heart failure in DM.

The heart pumps blood due to the contraction and relaxation of terminally differentiated cardiomyocytes with limited regenerative capacity. The DM environment of hyperglycemia, hyperlipidemia, and inflammation causes cardiomyocyte death and leads …

Characterizing The Critical Role Of Metabolic And Redox Homeostasis In Colorectal Cancer, Danielle Frodyma

Theses & Dissertations

Metabolic alterations are a hallmark of cancer and the mechanism by which these adaptations sustain cancer cell growth are complex and dependent on tissue type. In colon cancer, Peroxisome Proliferator Activated Receptor γ Coactivator 1 β(PGC1��) and Estrogen-Related Receptor α (ERR��) are overexpressed and contribute to tumor growth. Previous studies have shown that PGC1�� and ERR�� regulate many metabolic processes by controlling vital gene expression. Here, we show that PGC1�� and ERR�� drive oxidative phosphorylation and glycolysis in colon cancer cell lines and we evaluated downstream effectors and processes.

A dysfunction in the reductive and oxidative capacity of the cell …

Glycemic Variability In Patients With Stage Ii-Iii Colon Cancer, Natalie Mandolfo

Theses & Dissertations

Patients with cancer experience metabolic changes such as hypoglycemia, hyperglycemia, and glycemic variability; collectively termed malglycemia. Glycemic variability, defined as fluctuations in glucose, is a marker of metabolic instability. Higher glycemic variability is associated with adverse health outcomes in the general population and in those with diabetes. Little is known about glycemic variability in patients with cancer, especially those with solid tumor malignancies. Glycemic variability is associated with increased infection, shorter periods of remission, and higher mortality in patients with hematological cancer. This body of work describes the concept and measurement of glycemic variability to assess glycemic control in patients …

Polymeric Drug Delivery Systems For Cancer Therapy And Radionuclide Decorporation, Sameer A. Alshehri

Theses & Dissertations

The main objective of this body of work is to develop polymeric drug delivery systems for cancer radiotherapy and the decorporation of radiological materials. The polymeric systems for radiotherapy were evaluated in vitro and in vivo (in normal, prostate, and ovarian cancer mice models). The polymeric system for radionuclide decorporation was also evaluated in vitro and in a normal mouse model. Due to its attractive properties, the N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer was utilized as the main carrier for the developed systems.

Chapter 1 provides an overview of prostate and ovarian cancer, targeted radiopharmaceuticals, nanomedicine-based drug delivery for cancer, HPMA copolymers, …

Bayesian Modeling For Longitudinal Count Data: Applications In Biomedical Research, Morshed Alam

Theses & Dissertations

Biomedical count data such as the number of seizures for epilepsy patients, number of new tumors at each visit or the number vomiting after each chemo-radiation for the cancer patients are common. Often these counts are measured longitudinally from patients or within clusters in multi-site trials. The Poisson and negative binomial models may not be adequate when data exhibit over or under-dispersion, respectively. On the contrary, a variety of dispersion conditions in count data can be captured by Conway-Maxwell Poisson (CMP) model.

This doctoral dissertation relegates to developing a statistical methodology to model longitudinal count data distributed as CMP via …

Targeted Therapies In Select Gastrointestinal Cancers And Cancer Cachexia, Scott Mulder

Theses & Dissertations

Hepatocellular carcinomas exhibit metabolic alterations to support their proliferative and biosynthetic needs. We identified that elevated expression of the mitochondrial oxidative carboxylase, malic enzyme 2 (ME2), correlates with poorer hepatocellular carcinoma patient survival. Hepatocellular carcinoma patient tumors with high ME2 expression exhibit transcriptomic alterations indicative of PI3K/AKT/mTOR and c-Myc signaling as well as elevated central carbon, fatty acid, and redox metabolism pathways. Depletion of ME2 in the hepatocellular carcinoma cell line PLC or in the livers of mice treated with diethylnitrosamine to chemically induce hepatocellular carcinomas, results in impaired proliferation and reduced tumor formation. Additionally, the loss of …

Theatre Arts Integration For Deeper Learning In The English-As-A-Foreign-Language Classroom, Andrew Zutell

LSU New Orleans Theses and Dissertations

This quasi-experimental case study examines the impact of theatre arts integration in an English-as-a foreign language (EFL) course in a competency-based international high school. Aiming to engage students in a process of deeper learning through drama, this study focuses on the domain of speaking and oral communicative competence. Although widely recognized as one of the most important college-and-career-readiness skills, oral communication is often overshadowed by high-stakes testing priorities such as reading and writing. In particular, many Chinese students of English struggle to achieve confident oral fluency despite years of study. This research was designed to investigate whether theatre arts integration …

Taking Up Space: A Phenomenological Study Of The Shared Experiences Of Black Women In Stem Graduate Programs At Predominantly White Institutions, Ebony C. Blackwell

LSU New Orleans Theses and Dissertations

In the U.S., marginalized populations are underrepresented in STEM. Specifically, there is a disparity in the number of Black women attaining STEM graduate degrees and entering the STEM workforce. The purpose of this qualitative, phenomenological study was to examine the essence of the shared experiences of Black women currently enrolled in STEM graduate programs at predominantly White institutions (PWIs), in order to increase retention of Black women through STEM graduate programs and into careers; as well as to use participant’s experiences to expose any barriers they encountered related to their educational pursuits, and examine how they were able to navigate …

'Seeds Of Happiness': An Oral History Of Members Of Soka Gakkai International-New Orleans, Lorvelis Amelia Madueño

LSU New Orleans Theses and Dissertations

Soka Gakkai International (SGI) is a Japanese new religious movement present in 192 countries. Despite the substantial amount of academic work that has been produced on SGI’s overseas expansion, many scholars continue to overlook the local context when analyzing the organization’s global presence. This paper is based on oral history interviews and examines the experiences of five members of the SGI-USA New Orleans Buddhist Center, located in the city of New Orleans, Louisiana. This thesis argues that many SGI practitioners choose to join and remain in the organization because it fills specific spiritual and emotional voids in their lives, creates …

Applied Molecular Dynamics: From Targeting Viral Helicases, To Understanding The Interactions Of Cucurbituril Complexes In Ionic Solutions, Bryan Raubenolt

LSU New Orleans Theses and Dissertations

Molecular Dynamics simulations are a highly useful tool in helping understand the fundamental interactions present in a variety of chemical systems. The work discussed here illustrates it’s use in determining the conformational dynamics of the Zika and SARS-Cov-2 helicase in a physiological environment, largely in an effort to discover inhibitors capable of rendering the protein inert. Additionally, we show how it can be used to understand paradoxical trends in the anion-induced precipitation of Cucurbituril cavitands.

Viral helicases are motor proteins tasked with unwinding the viral dsRNA, a crucial step in preparing the strand to be translatable by host cells. By …

Assessing Differentiation Of Self In Multiple Cultural Contexts: Initial Validation Of The Multicultural Differentiation Of Self Inventory (Mdsi), Nasima Rahman Khan

LSU New Orleans Theses and Dissertations

Researchers have shown that current instruments used to assess an individual’s level of differentiation of self or differentiation are biased towards an individualistic cultural context, therefore current instruments lack cultural validity (Alaedein, 2008; Chung & Gale, 2006, 2009; Kim et al., 2015; O’Hara & Meteyard, 2011). When counseling from Bowen’s family systems theoretical perspective, accurate assessment of an individual’s differentiation is integral for treatment planning and intervention (Bowen & Kerr, 1988). To address the existing gap in assessment of differentiation within multiple cultural contexts (i.e., individualistic, collectivistic, transcultural), the purpose of the present research was to develop the Multicultural Differentiation …

Ud In The News Dec. 11-18, University Of Dayton

News Releases

A pair of faculty contributed pieces for The Conversation while others shared their expertise with the Huffington Post and the Sinclair Broadcasting Group in a story picked up nationwide. Ohio cable news outlet Spectrum News 1 and Dayton TV station ABC22/Fox45 featured the W.S. McIntosh Memorial Leadership Award & Scholarship winner. The Dayton Business Journal also profiled the success of the Virtual Learning Community for Faith Formation in 2020.

Rna Structure And Function: Biological Relevance In Neurodegenerative And Infectious Disease Pathogenesis, Joshua Imperatore

Electronic Theses and Dissertations

The studies outlined in this dissertation encompass a broad focus, relating to the pathogenesis of neurological disorders such as Alzheimer’s disease, fragile X syndrome, and amyotrophic lateral sclerosis, as well as a novel infectious disease, COVID-19. However, all four studies detailed within this dissertation contain similar elements, namely, the coordinated role of RNA structure and function in essential molecular mechanisms. The results of these investigations allow us to speculate on various disease- related mechanisms, including dysregulated microRNA processing pathways, nucleocytoplasmic shuttling via distinct RNA-protein interactions, and fine-tuned molecular switches controlling genomic dimerization and viral hijacking of host cellular microRNAs. Taken …

Impact Of A Nicu Bedside Reading Initiative On Self-Reported Maternal Stress And Mother-Infant Attachment, Lauren Lorenzi Quigley

Electronic Theses and Dissertations

Premature birth and a corresponding hospitalization in the Neonatal Intensive Care Unit (NICU) presents infants and their families with an array of medical and psychosocial stressors that have the potential to impact neurodevelopment and social-emotional functioning in both the long-and short-term. Research has demonstrated the importance of family-integrated, developmental care interventions and a need for supportive environmental and sensory stimulation for the infant to optimize developmental, social, and emotional outcomes. Engaging parents in bedside care that fosters sensory development, supports cognitive and language skills, and lays a strong foundation for bonding and attachment can be monumental for the dyad. Implementation …

Department Of History News, Georgia Southern University

History: News & Publications

• Dr. Christopher Hendricks Talks About Origins of Jingle Bells in WSAV

• History Grad Lee Ann Hitt featured in George Anne

Adaptive Analytics: It’S About Time, Charles Dziuban, Colm Howlin, Patsy Moskal, Tammy Muhs, Connie Johnson, Rachel Griffin, Carissa Hamilton

Current Issues in Emerging eLearning

This article describes a cooperative research partnership among a large public university, a for-profit private institution and their common adaptive learning platform provider. The focus of this work explored adaptive analytics that uses data the investigators describe as metaphorical “digital learning dust” produced by the platform as a matter of course. The information configured itself into acquired knowledge, growth, baseline status and engagement. Two complimentary models evolved. The first, in the public university, captured end-of-course data for predicting success. The second approach, in the private university, formed the basis of a dynamic real-time data analytic algorithm. In both cases the …

Student Perceptions Of The Effectiveness Of Adaptive Courseware For Learning, Patricia O'Sullivan, Christina Forgette, Stephen Monroe, M. Tyler England

Current Issues in Emerging eLearning

Despite the increasing research on the effectiveness of adaptive learning courseware by vendors and academic institutions, there are few published, peer-reviewed studies on adaptive courseware that address the student experience and student perception of this teaching and learning tool. Over the course of two academic years, 2017/2018 and 2018/2019, researchers at the University of Mississippi conducted 16 course-based student focus groups and gathered data from 4 end-of-semester surveys to understand how students are experiencing adaptive courseware and whether or not they find it adds value to their education. Our study found that, although students generally find courseware to be helpful …

'Some Few Miles From Edinburgh': Commemorating The Scenes Of The Gentle Shepherd In Ramsay Country, Craig Lamont

Studies in Scottish Literature

Traces the history of Ramsay commemoration, from the obelisk at Penicuik with an inscription from 1759 onwards, and successive attempts to identify actual settings for scenes and incidents in his ballad opera The Gentle Shepherd, in illustrations (notably by David Allan for the Foulis edition of 1788), other editions and memoirs, and competing contributions by the ministers of rival parishes to the Statistical Account of Scotland, giving particular attention to the roles in the "battle over Ramsay country" of two local landowners, Alexander Fraser Tytler (Lord Woodhouselee) and Robert Brown of Newhall; providing maps and illustrations to clarify …

'Some Pastoral Improvement' In The Gentle Shepherd: Mediation, Remediation, And Minority, Steve Newman

Studies in Scottish Literature

This essay shows how in The Gentle Shepherd Allan Ramsay engages in the complex work of "pastoral improvement" on an individual and national scale and foresees--to a point--how his work will be received in the decades and even centuries to come. After situating his work within the uprising of the Galloway Levellers, pastoral, and the early work of agricultural improvement, I consider how the concept of improvement shapes the reception of his work in the Linley-Tickell production of the 1780s--including a surprising appearance from the Shakespearean forger, William Henry Ireland--and the key role The Gentle Shepherd plays in "The Young …

The Ethical Challenge For Hipaa’S Privacy Rule In The Genomics Era Of Data Analytics., Reem Shinawi

Electronic Theses and Dissertations

The thesis of this dissertation focuses on the Ethical Challenge for HIPAA’s Privacy Rule in the Genomics Era of Data Analytics. Data Analytics in Genomic Medicine challenges the individuals’ right to privacy. Hence, a balance is needed between the previous centrality of individual privacy and the need for population information to make breakthroughs in Genomic Medicine using Data Analytics. Such a problem demands regulatory solutions. And such solutions require the collaboration of professionals. Genomic Medicine is a field that deals with sensitive genetic information in both medicine, and research, it is essential to view it through HIPAA as it is …

Hcv-Associated Exosomes Upregulate Runxor And Runx1 Expressions To Promote Mdsc Expansion And Suppressive Functions Through Stat3-Mir124 Axis, Bal Krishna Chand Thakuri, Jinyu Zhang, Juan Zhao, Lam N. Nguyen, Lam N.T. Nguyen, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Zeyuan Lu, Xiao Y. Wu, Yong Jiang, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported that myeloid-derived suppressor cells (MDSCs) expand and inhibit host immune responses during chronic viral infections; however, the mechanisms responsible for MDSC differentiation and suppressive functions, in particular the role of RUNXOR-RUNX1, remain unclear. Here, we demonstrated that RUNXOR and RUNX1 expressions are significantly upregulated and associated with elevated levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of …

Immature Platelet Dynamics In Immune-Mediated Thrombocytopenic States, Hollie M. Reeves, Robert W. Maitta

Faculty Scholarship

A major challenge encountered by clinicians is differentiating presentations characterized by significant thrombocytopenia due to overlapping clinical symptoms and signs in the setting of ambiguous laboratory results. Immature platelets represent the youngest platelets that can be measured in peripheral blood by current hematology analyzers. These young platelets are larger, with higher RNA content recently released from the bone marrow. Thrombocytopenic presentations caused directly or indirectly by immune responses can lead to compensatory bone marrow responses seeking to normalize the platelet count; thus obtaining absolute immature platelet counts may be informative while triaging patients. Over the last decade, their use has …

Pharmacy Education In Emerging Health Care Systems: Clinical Training In The United Arab Emirates, Amad Al-Azzawi

Journal of Comparative & International Higher Education

No abstract provided.

Pride And Prejudice: An Intersectional Look At Graduate Employability Of Transgender And Queer International Students, Trang Le Thuy, Vuong Tran Hoang, Giang Le Nguyen Hoang

Journal of Comparative & International Higher Education

No abstract provided.

Leading The Many, Considering The Few - University Presidents’ Perspectives On International Students During Covid-19, Sarah Maria Schiffecker

Journal of Comparative & International Higher Education

No abstract provided.

Case Series: Resolution Of Vertigo Symptoms In Patients With Eustachian Tube Dysfunction Following Eustachian Tube Dilation., Macaulay A. Ojeaga Jr., Vincent Honrubia

MEDI 9331 Scholarly Activities Clinical Years

Abstract

Objective/hypothesis: This study aims to demonstrate that Eustachian Tube Dilation is a safe and effective treatment for patients with Eustachian tube dysfunction suffering from vertigo.

Study design: A retrospective chart review.

Methods: This case series analyzes the medical records of 5 patients who underwent Eustachian tube dilation for chronic vertigo secondary to Eustachian tube dysfunction. The charts of patient initial, perioperative, and post-operative clinical encounters were reviewed. Patients’ age and demographic information were also reviewed.

Results: A total of 5 patient encounters were investigated. The cohort included one male and four females. The average age of patients evaluated was …

Resilientxs: El Impacto De La Covid-19 En La Comunidad Trans Latinx De Nueva York, Oscar Molina, Ariel Goodman

Capstones

The Trans Latinx Community has been one of the most harmed due to the coronavirus pandemic in New York. According to a survey by the Williams Institute at the University of California Law School (UCLA), there were 17,300 self-identified transgender Latinas in 2016 in the State of New York. Most of them are people of color, undocumented, without any type of health insurance or job stability. To these vulnerabilities must be added the violence and prejudices that still exist against this community, which affect the equality of their rights.

There is no official data that shows how many transgender people …

Her Story: Ecuadorian Women In New York City, Benjamin Chambers

Capstones

My Capstone Project is an 80-photo reportage about women of Ecuadorian origin living in New York City, including text and video elements. The project is broken down into a general introduction; four photo stories each with captions and story text; and two videos. The project is entitled:

HER STORY: ECUADORIAN WOMEN IN NEW YORK CITY

https://www.chambersphotojournalist.com/capstone/

Biological Pretreatment Of Biomass For Enhanced Biogas Production, Skylar F. Van Horne

Undergraduate Honors Theses

The biogas output efficiency of controlled anaerobic digestion (AD) can be enhanced by several different pretreatment methods to produce renewable energy. According to the literature, there are pros and cons to each pretreatment method. Biological pretreatment provides environmentally safe and renewable means for enhancing biodegradability and net energy output. Current research has yet to reliably demonstrate the ability of bacterial strains, such as Caldicellulosiruptor bescii (C. bescii), to digest common waste substrates in efficient ways. Novel methods in key intermediate molecular quantification and alkalinity tracking are used here to explore C. bescii’s ability to digest lignocellulosic material in …

Development And Implementation Of An Orthopedic Enhanced Recovery After Surgery Protocol, Beth Mccoy

Doctor of Nursing Practice Projects

Abstract

As life expectancy rates have grown and individuals desire a more active lifestyle the number of total hip arthroplasty and total knee arthroplasty surgeries performed has grown significantly. Enhanced recovery after surgery (ERAS) protocols have been shown to decrease the financial impact and improve patient outcomes in total joint surgeries. After a literature review a multidisciplinary team met and developed an ERAS protocol for total joint replacement surgeries to be implemented at a 250-bed community hospital in central Illinois. After an eleven-question pre-test was given to 34 participants consisting of perioperative nursing staff, anesthesia, and surgeons assessing their knowledge …