Digital Commons Network^™

Targeting The Id1-Kif11 Axis In Triple-Negative Breast Cancer Using Combination Therapy, Archana P. Thankamony, Reshma Murali, Nitheesh Karthikeyan, Binitha Anu Varghese

Open Access archive

The basic helix-loop-helix (bHLH) transcription factors inhibitor of differentiation 1 (Id1) and inhibitor of differentiation 3 (Id3) (referred to as Id) have an important role in maintaining the cancer stem cell (CSC) phenotype in the triple-negative breast cancer (TNBC) subtype. In this study, we aimed to understand the molecular mechanism underlying Id control of CSC phenotype and exploit it for therapeutic purposes. We used two different TNBC tumor models marked by either Id depletion or Id1 expression in order to identify Id targets using a combinatorial analysis of RNA sequencing and microarray data. Phenotypically, Id protein depletion leads to cell …

“When I Breastfeed, It Feels As If My Soul Leaves The Body”: Maternal Capabilities For Healthy Child Growth In Rural Southeastern Tanzania, Zaina Mchome, Sepideh Yousefzadeh, Ajay Bailey, Hinke Haisma

Open Access archive

The burden of childhood stunting in Tanzania is persistently high, even in high food-producing regions. This calls for a paradigm shift in Child Growth Monitoring (CGM) to a multi-dimensional approach that also includes the contextual information of an individual child and her/his caregivers. To contribute to the further development of CGM to reflect local contexts, we engaged the Capability Framework for Child Growth (CFCG) to identify maternal capabilities for ensuring healthy child growth. Ethnographic fieldwork was conducted in Southeastern Tanzania using in-depth interviews, key informant interviews, participant observation, and focus group discussions with caregivers for under-fives. Three maternal capabilities for …

Urban Transportation System Flood Vulnerability Assessment With Special Reference To Low Income And Minority Neighborhoods, Courtney Crosson, Daoqin Tong, Yinan Zhang

TREC Final Reports

A flood vulnerability assessment of the City of Tucson, Arizona’s transportation systems was conducted with special reference to low-income and minority neighborhoods. Short-term flooding from extreme storm events pose a serious challenge to transportation system reliability and emergency response in cities across the United States. This problem, which is anticipated to grow over the next century due to climate change, is often hardest on vulnerable populations, including low-income and minority neighborhoods. Our work aimed to advance national research methods for assessing multi-modal transportation degradation due to flooding. We identified priority locations for Tucson to make transportation improvement investments for the …

“Enriching Lives Within Sedimentary Geology”: Actionable Recommendations For Making Sepm A Diverse, Equitable And Inclusive Society For All Sedimentary Geologists, R.C. Mahon, A.M. Fernandes, A. Abeyta, R. Martindale, K.D Bergman, C. Jackson, Et Al

Earth and Environmental Sciences Faculty Publications

Innovative science benefits from diversity of thought and influence at all waypoints along the scientific journey, from early education to career-length contributions in research and mentorship. Scientific societies, like the Society for Sedimentary Geology (SEPM), steward their innovators and the direction of the science, thereby defining the societal impact and evolution of a discipline. They are uniquely positioned to promote the representation and success of all scientists, including those from minoritized populations, through proactive advocacy, and inclusive mentorship, awards, and leadership. We introspectively review available records of SEPM membership, leadership, awardees, and editorial boards to identify areas for growth and …

Escaping Extermination: Hungarian Prodigy To American Musician, Feminist, And Activist, Agi Jambor, Frances Pinter

Purdue University Press Book Previews

Written shortly after the close of World War II, Escaping Extermination tells the poignant story of war, survival, and rebirth for a young, already acclaimed, Jewish Hungarian concert pianist, Agi Jambor. From the hell that was the siege of Budapest to a fresh start in America. Agi Jambor describes how she and her husband escaped the extermination of Hungary’s Jews through a combination of luck and wit.

As a child prodigy studying with the great musicians of Budapest and Berlin before the war, Agi played piano duets with Albert Einstein and won a prize in the 1937 International Chopin Piano …

Context-Specific Challenges, Opportunities, And Ethics Of Drones For Healthcare Delivery In The Eyes Of Program Managers And Field Staff: A Multi-Site Qualitative Study, Vyshnave Jeyabalan, Elysée Nouvet, Patrick Meier, Lorie Donelle Phd, Rn, Fcan

Publications

Unmanned aerial vehicles (UAVs), also known as drones, have significant potential in the healthcare field. Ethical and practical concerns, challenges, and complexities of using drones for specific and diverse healthcare purposes have been minimally explored to date. This paper aims to document and advance awareness of diverse context-specific concerns, challenges, and complexities encountered by individuals working on the front lines of drones for health. It draws on original qualitative research and data from semi-structured interviews (N = 16) with drones for health program managers and field staff in nine countries. Directed thematic analysis was used to analyze interviews and identify …

Development Of Frenet-Serret Frame And The Apollonian Window, Syeda Fareeza Karimushan

Theses

The present study focuses on developing a Frenet-Serret frame and the Apollonian Window. In the first part of the study Apollonian disks are generated for first four generations by developing visual basic codes in excel. For the second part of the study, three orthonormal basis vectors, namely, tangent, normal, and binormal vectors have been calculated for the tangent points of Apollonian discs for the first three generations. Equations of the Normal, Osculating and Rectifying planes and Taylor Series approximation have been calculated for specific theta. Because Apollonian Window consists of planar curves with constant curvature, torsion is nowhere present. The …

Contributions Of Optical Remote Sensing To Permafrost Mapping In Donnelly Training Area, Alaska, Kiran Thapa

Theses

AN ABSTRACT OF THE THESIS OFKiran Thapa, for the Master of Science degree in Geography and Environmental Resources, presented on April 8, 2020, at Southern Illinois University Carbondale.TITLE: CONTRIBUTIONS OF OPTICAL REMOTE SENSING TO PERMAFROST MAPPING IN DONNELLY TRAINING AREA, ALASKA MAJOR PROFESSOR: Dr. Guangxing Wang Permafrost occupies about a quarter of the northern hemisphere land with 25.5 million ha. Global warming and anthropogenic activities affect the dynamics of permafrost. Snow and permafrost, in turn, serve as an indicator of climate change and human activity disturbance. The dynamics of permafrost are often estimated using interferometric Synthetic Aperture Radar (InSAR) methods. …

Video Games, Virtual Reality, And The Progression Of The Cinema Of Interactions, Samuel James Luedtke

Lawrence University Honors Projects

If a person were to walk in to almost any amusement park, they could surely find some sort of mixed reality experience. Often these consist of a combination of moving seating and 3D projection. While rides like these may seem futuristic and involving cutting-edge technology, their ideology actually traces back to the very beginning of cinema itself. See, one of the first known depictions of camera movement in cinema was used to display the movement of a train in Départ de Jérusalem en chemin de fer (Leaving Jerusalem by Railway, Alexandre Promio, 1897). This was a phantom ride, a genre …

Trade And Health Linkages: A Global Panel Data Analysis Using The Gravity Model, Pallavi Panda

School of Business

This paper provides empirical evidence on the effect of trade openness on child health using the data from 171 countries between the mid-1990s to mid-2000s. Using an instrumental variable approach with a geographic gravity model framework, this study finds that a 1% increase in openness leads to a 0.2% decrease in infant mortality rates across countries, which at the sample mean is about 8 infant deaths per 1000 live births. The result is robust to country-specific time-invariant heterogeneity as well as outliers. The main channels of operation seem to be through increasing incomes, increasing health expenditures, and decreasing inequality.

High-Severity And Short-Interval Wildfires Limit Forest Recovery In The Central Cascade Range, Sebastian Upton Busby, Kevan B. Moffett, Andres Holz

Geography Faculty Publications and Presentations

Increasing forest fuel aridity with climate change may be expanding mid-to-high-elevation forests’ vulnerability to large, severe, and frequent wildfire. Long-lasting changes in forests’ structure and composition may occur if dominant tree species are poorly adapted to shifting wildfire patterns. We hypothesized that altered fire activity may lower existing forest resilience and disrupt the recovery of upper-montane and subalpine conifer forest types. We empirically tested this hypothesis by quantifying post-fire forest structure and conifer tree regeneration after spatially large, severe, and rapidly repeated wildfires (

Forging Alternatively Sacred Spaces In Singapore's Integrated Religious Marketplace, Orlando Woods

Research Collection School of Social Sciences

This paper expands the notion of sacred space within the geographies of religion by arguing that spaces of religious praxis need to be understood in relation to the broader spatial logics within which they are embedded. Given that the spatial logics of urban environments tend to be secular and neoliberal in nature, it considers how religious groups respond to the realities of the marketplaces in which they operate by forging “alternatively sacred” spaces. These spaces augment the appeal of religious groups in non-religious ways, thus making them more competitive players in a religious marketplace. Specifically, it explores how independent churches …

Improving Climate Change Mitigation Analysis: A Framework For Examining Feasibility, Michael P. Vandenbergh, Kristian S. Nielsen, Et. Al.

Vanderbilt Law School Faculty Publications

Limiting global warming to 2`C or less compared with pre-industrial temperatures will require unprecedented rates of decarbonization globally. The scale and scope of transformational change required across sectors and actors in society raises critical questions of feasibility. Much of the literature on mitigation pathways addresses technological and economic aspects of feasibility, but overlooks the behavioral, cultural, and social factors that affect theoretical and practical mitigation pathways. We present a tripartite framework that ‘‘unpacks’’ the concept of mitigation pathways by distinguishing three factors that together determine actual mitigation: technical potential, initiative feasibility, and behavioral plasticity. The framework aims to integrate and …

Using Church History Documents In Your Classroom, Keith A. Erekson

Religious Educator: Perspectives on the Restored Gospel

Each of the standard works was compiled from previous historical documents. The Bible emerged from letters and writings selected and evaluated over hundreds of years. Joseph Smith received revelations for more than a decade before some were published in the Doctrine and Covenants. Members of the Quorum of the Twelve Apostles selected some of Joseph Smith’s other writings for inclusion in the Pearl of Great Price. Mormon and Moroni abridged Nephite records to prepare the plates that Joseph Smith translated as the Book of Mormon.

Follow-Up Care For Breast And Colorectal Cancer Across The Globe: Survey Findings From 27 Countries, Michelle A. Mollica, Deborah K. Mayer, Kevin C. Oeffinger, Youngmee Kim, Susan S. Buckenmaier, Sudha Sivaram, Catherine Muha, Nur Aishah Taib, Elisabeth Andritsch, Asim Jamal

Internal Medicine, East Africa

Purpose: The purpose of this study was to describe follow-up care for breast and colorectal cancer survivors in countries with varying levels of resources and highlight challenges regarding posttreatment survivorship care.

Methods: We surveyed one key stakeholder from each of 27 countries with expertise in survivorship care on questions including the components/structure of follow-up care, delivery of treatment summaries and survivorship care plans, and involvement of primary care in survivorship. Descriptive analyses were performed to characterize results across countries and variations between the WHO income categories (low, middle, high). We also performed a qualitative content analysis of narratives related to …

Consuming History In A Political Context: Motivations Of Turkish Visitors Of The Gallipoli Battlefields, Ulvi Cenap Topcu

Journal of Global Business Insights

Certain unconventional tourism activities such as visiting battlefields, old prisons, or crash sites encompass dark tourism and have become the focus of scholarly pursuit. The term was established in relation to the Gallipoli Battlefields; which has been examined mostly in the context of its importance to Australian and New Zealander national identities. As represented by numerous memorials and well-established historical narration, the Battle in Gallipoli is credited as one of the most important representations of Turkish nationality. This research aims to investigate the motivations of Turkish visitors to Gallipoli in terms of consumption experiences and to clarify empirically motivations of …

Moving The Needle Or Spinning Our Wheels? A Framework For Long-Lasting, Equitable Change In Education, Heather Mccambly, Eleanor R. Anderson

The Foundation Review

In the quest for equitable and lasting reform in postsecondary education, philanthropy’s great strength is its flexibility to make use of multiple strategies. However, as most grantmakers know firsthand, not all strategy combinations lead to lasting systemic change.

This article offers an actionable approach for designing and analyzing philanthropically funded movements in order to remake an area of educational policy or practice. It begins with a review of philanthropic literature that identifies the primary change strategies used by funders in the education sector. It then introduces a tool, rooted in organizational research, to understand and predict the circumstances under which …

Partnering For Postsecondary Success In Rural Texas, Allison Pennington

The Foundation Review

Although students living in rural areas perform academically on par with their peers, they are less likely to complete a postsecondary credential due to geographic, economic, and other barriers. Greater Texas Foundation, a private grantmaker focused on postsecondary student success in Texas, fosters rural collaborations as part of its philanthropic strategy.

This article reflects on lessons learned by foundation staff from this strand of work. It describes innovative models for postsecondary support developed by the foundation’s rural partners, discusses the need to balance direct program support and capacity building, and emphasizes the importance of visiting rural communities in person.

To …

Advancing Social Determinants Of Health Through Investments In Postsecondary Attainment And Sustaining Employment, Melissa B. Eggen, J’Aime C. Jennings, Molly O’Keefe, Brandy N. Kelly Pryor, Leslie Clements

The Foundation Review

In 2018, the Humana Foundation shifted the focus of its work to the social determinants of health, with the key aim of promoting health equity. With this new focus came a recognition that larger, long-term investments would be needed to support strategies addressing upstream determinants of health. The foundation also recognized the need to co-create processes with communities to understand how to provide essential holistic supports.

This article explores one area of the foundation’s new efforts, the Strategic Community Investment Program, which focuses in part on postsecondary attainment and sustaining employment. The foundation partnered with the University of Louisville’s Center …

Gamifying Place, Reimagining Publicness: The Heterotopic Inscriptions Of Pokémon Go, Orlando Woods

Research Collection School of Social Sciences

This paper explores the transformative effects of augmented reality mobile games on society and space. By layering playfulness onto public space through a digital interface, augmented reality mobile games create a pervasive sense of play that can be accessed by players potentially anywhere, and at any time. Games like these can therefore be understood as heterotopic inscriptions on otherwise mundane environments. Since being released in 2016, Pokémon Go has become one of the most popular augmented reality games in the world. It gamifies place by embedding digital objects within public spaces; in doing so, it can bring about a reimagination …

Towards More Inclusive Smart Cities: Reconciling The Divergent Logics Of Data And Discourse At The Margins, Jane Yeonjae Lee, Orlando Woods, Lily Kong

Research Collection School of Social Sciences

In this article, we survey a growing body of literature within geography and other intersecting fields that trains attention on what inclusive smart cities are, or what they could be. In doing so, we build on debates around smart citizens, smart public participation, and grassroots and bottom-up smart cities that are concerned with making smart cities more inclusive. The growing critical scholarship on such dis- courses, however, alerts us to the knowledge politics that are involved in, and the urban inequalities that are deeply rooted within, the urban. Technological interventions con- tribute to these politics and inequalities in various ways. …

Introduction, Catherine Gomes, Lily Kong, Orlando Woods

Research Collection School of Social Sciences

Contemporary society is evolving at a pace never experienced before. Existing human processes of movement and settlement are becoming more frequent, whilst advances in technology have given rise to new processes of digitally-mediated connection, community-building and content-creation. Religion intersects with all of these processes; guiding them, and being transformed by them in turn. Indeed, in the two decades or so since Rudolph’s (1997, p. 1) observation that ‘religious communities are among the oldest of the transnationals’, research into the role of religion amongst diasporic and migrant communities around the world has ‘exploded’ (Johnson 2012, p. 95).

Cosm Diversity & Inclusion Newsletter, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

Welcome to Fall 2020!

The Diversity & Inclusion Newsletter is delivered monthly via email during the fall and spring semesters and is always available on the new COSM D&I webpage. Send contributions and suggestions to any of the COSM D&I Ambassadors (list at the bottom of the newsletter and on the webpage).

Experiencing God: Engaging Elementary-Aged Children In Corporate Worship, Laura Rushing Hancock

Doctoral Dissertations and Projects

The engagement of children in meaningful worship has been neglected, despite the investment of modern churches in essential safety protocols and digital media in children’s ministry. The twenty-first-century consumerist mindset is driving worship design, essentially undermining the worship leader’s role as the shepherd of a child-centered and Christ-focused approach. Many churches are neglecting the biblical instruction to cast vision and express value for children’s corporate worship. A sense of awe and wonder is notably absent in many corporate services designed for children. Drawing upon biblical principles, educational theory, and corporate worship practices throughout history, this qualitative historical study seeks to …

All Day In The Trey-Fold: Sound, Objecthood, And Place In The Mixtapes Of Dj Screw, Matthew K. Carter

Dissertations, Theses, and Capstone Projects

This dissertation traces the impact of the mixtapes of DJ Screw on the emergence of Houston hip hop culture in the 1990s. The relationship between these “screwtapes” and local culture resists demonstration through conventional modes of representational analyses, due in part to the screwtape’s preponderant use of hip hop tracks that originally represent other places. I suggest that representation itself is the result of the structuring tension emerging from a threefold field of representation of sound, objecthood, and place, and that when a hip hop artist or critic or fan claims to "represent" Houston (or any other constituted and constituting …

Data And Information As Our New Transport Infrastructure: An Exploration Into How The Modern Transport System Is Being Shaped By Information Communication Technology, Adam Davidson

Dissertations, Theses, and Capstone Projects

This dissertation is focuses on the role that data and information has in creating and altering behavior related to transportation. To do so, it lays out a theoretical model of technological transition and then follows it up with three case studies. The theoretical model provides a structure to consider how different actors in our transportation ecosystem – users, firms, policy actors – mix with technological evolution to uphold or incrementally recreate our transportation landscape. The case studies stand on their own to highlight important findings about how data and information are impacting transportation scenarios, but collectively reinforce the theoretical models. …

Many Forms Of Black Death: Coal Extraction, Transnational Activism And The Value Of Life In Colombia, Oscar H. Pedraza Vargas

Dissertations, Theses, and Capstone Projects

After the murder of the president and vice president of the coal union by paramilitaries in the department of Cesár, Colombia, the union is left adrift. Its fragility is only heightened when the person who decides to take over, is killed six months later. The union has been vocal on their critique of environmental destruction produced by coal and argues that their criticism is part of the reasons why they were targeted. Not far from there, in the department of Guajira, the conglomerate in charge of Cerrejón, the largest open-pit coal mine of South America, wants to divert a creek …

Norman Lewis: Linearity, Politics, And Pedagogy In His Abstract Expressionism, 1946–1964, Andrianna T. Campbell-Lafleur

Dissertations, Theses, and Capstone Projects

This dissertation focuses on Norman Lewis’s studio practice between the years 1946-1964 in particular his associations with the painters Romare Bearden, Robert Motherwell, Ad Reinhardt, and David Smith. Lewis’s influence extended far into the twenty-first century. As told by numerous contemporary art practitioners—Firelei Baez, Mark Bradford, David Kennedy Cutler, Charles Gaines, Rashid Johnson, Julie Mehretu, RJ Messineo, and Jack Whitten—Lewis was the mentor, friend, father and grandfather figure of an innovative black artist working with abstraction. In Chapter 1: An Integrative Line of Becoming, I trace Lewis’s change from Social Realism in the 1930s to semi-abstract portraits and genre paintings …

Defining Relictual Biodiversity: Conservation Units In Speckled Dace (Leuciscidae: Rhinichthys Osculus) Of The Greater Death Valley Ecosystem, Steven M. Mussmann, Marlis R. Douglas, David D. Oakey, Michael E. Douglas

Biological Sciences Faculty Publications and Presentations

The tips in the tree of life serve as foci for conservation and management, yet clear delimitations are masked by inherent variance at the species–population interface. Analyses using thousands of nuclear loci can potentially sort inconsistencies, yet standard categories applied to this parsing are themselves potentially conflicting and/or subjective [e.g., DPS (distinct population segments); DUs (Diagnosable Units-Canada); MUs (management units); SSP (subspecies); ESUs (Evolutionarily Significant Units); and UIEUs (uniquely identified evolutionary units)]. One potential solution for consistent categorization is to create a comparative framework by accumulating statistical results from independent studies and evaluating congruence among data sets. Our study illustrates …

Examining Teacher Perceptions Of Primary Grade Level Collaboration On Professional Development And Growth, Tracey Muff

Dissertations

Teacher collaboration has been embedded in teachers’ schedules across the country as many school leaders believe it improves student achievement. It is mandated within the school system wherein this study was conducted. However, the major emphasis is on student achievement with little to no emphasis on soft skills, which are desperately needed. Teachers need to be trained in fostering learning and on how to be empathetic, supportive, and culturally sensitive. Notwithstanding, if they do not believe collaboration is beneficial to them in the classroom and to their professional development and growth, it would not be an effective tool for student …