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Computer-Based And Paper-And-Pencil Tests: A Study In Calculus For Stem Majors, Lawrence Smolinsky, Brian D. Marx, Gestur Olafsson, Yanxia A. Ma

Faculty Publications

Computer-based testing is an expanding use of technology offering advantages to teachers and students. We studied Calculus II classes for science, technology, engineering, and mathematics majors using different testing modes. Three sections with 324 students employed: paper-and-pencil testing, computer-based testing, and both. Computer tests gave immediate feedback and allowed multiple submissions and pooling. Paper-and-pencil tests (PPTs) required work and explanation allowing inspection of high cognitive demand tasks. Each test mode used the strength of its method. Students were given the same lecture by the same instructor on the same day and the same homework assignments and due dates. The design …

17Β-Estradiol Promotes Acute Refeeding In Hungry Mice Via Membrane-Initiated Erα Signaling, Kaifan Yu, Yanlin He, Ilirjana Hyseni, Zhou Pei, Yongjie Yang, Pingwen Xu, Xing Cai, Hesong Liu, Na Qu, Hailan Liu, Yang He, Meng Yu, Chen Liang, Tingting Yang, Julia Wang, Pierre Gourdy, Jean Francois Arnal, Francoise Lenfant, Yong Xu, Chunmei Wang

Division of Basic Science Faculty Publications

Objective: Estrogen protects animals from obesity through estrogen receptor α (ERα), partially by inhibiting overeating in animals fed ad libitum. However, the effects of estrogen on feeding behavior in hungry animals remain unclear. In this study, we examined the roles of 17β-estradiol (E2) and ERα in the regulation of feeding in hungry female animals and explored the underlying mechanisms. Methods: Wild-type female mice with surgical depletion of endogenous estrogens were used to examine the effects of E2 supplementation on acute refeeding behavior after starvation. ERα-C451A mutant mice deficient in membrane-bound ERα activity and ERα-AF20 mutant mice lacking ERα transcriptional activity …

Estrogen Receptor-Α Expressing Neurons In The Ventrolateral Vmh Regulate Glucose Balance, Yanlin He, Pingwen Xu, Chunmei Wang, Yan Xia, Meng Yu, Yongjie Yang, Kaifan Yu, Xing Cai, Na Qu, Kenji Saito, Julia Wang, Ilirjana Hyseni, Matthew Robertson, Badrajee Piyarathna, Min Gao, Sohaib A. Khan, Feng Liu, Rui Chen, Cristian Coarfa, Zhongming Zhao, Qingchun Tong, Zheng Sun, Yong Xu

Division of Basic Science Faculty Publications

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are unclear. Here we report that estrogen receptor-α (ERα)-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuations, being glucose-inhibited neurons (GI-ERαvlVMH) or glucose-excited neurons (GE-ERαvlVMH). Hypoglycemia activates GI-ERαvlVMH neurons via the anoctamin 4 channel, and inhibits GE-ERαvlVMH neurons through opening the ATP-sensitive potassium channel. Further, we show that GI-ERαvlVMH neurons preferentially project to the medioposterior arcuate nucleus of the hypothalamus (mpARH) and GE-ERαvlVMH neurons preferentially project to the dorsal Raphe nuclei (DRN). Activation of ERαvlVMH …

Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor In Mice, Zhi Zhang, Fernando M.C.V. Reis, Yanlin He, Jae W. Park, Johnathon R. Divittorio, Nilla Sivakumar, J. Edward Van Veen, Sandra Maesta-Pereira, Michael Shum, India Nichols, Megan G. Massa, Shawn Anderson, Ketema Paul, Marc Liesa, Olujimi A. Ajijola, Yong Xu, Avishek Adhikari, Stephanie M. Correa

Division of Basic Science Faculty Publications

Homeotherms maintain a stable internal body temperature despite changing environments. During energy deficiency, some species can cease to defend their body temperature and enter a hypothermic and hypometabolic state known as torpor. Recent advances have revealed the medial preoptic area (MPA) as a key site for the regulation of torpor in mice. The MPA is estrogen-sensitive and estrogens also have potent effects on both temperature and metabolism. Here, we demonstrate that estrogen-sensitive neurons in the MPA can coordinate hypothermia and hypometabolism in mice. Selectively activating estrogen-sensitive MPA neurons was sufficient to drive a coordinated depression of metabolic rate and body …

Review Of The Validity And Feasibility Of Image-Assisted Methods For Dietary Assessment, Christoph Höchsmann, Corby K. Martin

Clinical Research Faculty Publications

Accurately quantifying dietary intake is essential to understanding the effect of diet on health and evaluating the efficacy of dietary interventions. Self-report methods (e.g., food records) are frequently utilized despite evident inaccuracy of these methods at assessing energy and nutrient intake. Methods that assess food intake via images of foods have overcome many of the limitations of traditional self-report. In cafeteria settings, digital photography has proven to be unobtrusive and accurate and is the method of choice for assessing food provision, plate waste, and food intake. In free-living conditions, image capture of food selection and plate waste via the user’s …

Families Coping With Financial Loss Following The Deepwater Horizon Oil Spill, Kathryn Sweet Keating, Sarah Becker, Ifeyinwa F. Davis, Thomas Chandler, Tim Slack, Jaishree Beedasy

Faculty Publications

Objective: This study examines family strategies for coping and adaptation to social disruption from the 2010 Deepwater Horizon oil spill (DHOS) in south Louisiana. Background: The DHOS is a technological disaster of unprecedented scale and ongoing impact, including the socioeconomic disruption of families. Method: Using data from focus groups, grounded-theory methods informed a thematic analysis of spill-related economic loss and coping mechanisms among families in the spill-affected region. Results: Key findings were as follows: (a) long-term economic impacts persisted but were nuanced and differed across places; (b) for families living in multistressor environments, concerns about the DHOS spilled over into …

2020 Who Guidelines On Physical Activity And Sedentary Behaviour For Children And Adolescents Aged 5–17 Years: Summary Of The Evidence, Jean Philippe Chaput, Juana Willumsen, Fiona Bull, Roger Chou, Ulf Ekelund, Joseph Firth, Russell Jago, Francisco B. Ortega, Peter T. Katzmarzyk

Population and Public Health Science Faculty Publications

Background: The World Health Organization (WHO) released in 2020 updated global guidelines on physical activity and sedentary behaviour for children, adolescents, adults, older adults and sub-populations such as pregnant and postpartum women and those living with chronic conditions or disabilities. Objective: To summarize the evidence on the associations between physical activity, sedentary behaviour, and health-related outcomes used to inform the 2020 WHO guidelines on physical activity and sedentary behaviour for children and adolescents aged 5–17 years. Methods: The update of the WHO guideline recommendations for children and adolescents utilized and systematically updated the evidence syntheses on physical activity and sedentary …

New Global Guidelines On Sedentary Behaviour And Health For Adults: Broadening The Behavioural Targets, Paddy C. Dempsey, Stuart J.H. Biddle, Matthew P. Buman, Sebastien Chastin, Ulf Ekelund, Christine M. Friedenreich, Peter T. Katzmarzyk, Michael F. Leitzmann, Emmanuel Stamatakis, Hidde P. Van Der Ploeg, Juana Willumsen, Fiona Bull

Population and Public Health Science Faculty Publications

Background: In 2018, the World Health Organisation (WHO) commenced a program of work to update the 2010 Global Recommendations on Physical Activity for Health, for the first-time providing population-based guidelines on sedentary behaviour. This paper briefly summarizes and highlights the scientific evidence behind the new sedentary behaviour guidelines for all adults and discusses its strengths and limitations, including evidence gaps/research needs and potential implications for public health practice. Methods: An overview of the scope and methods used to update the evidence is provided, along with quality assessment and grading methods for the eligible new systematic reviews. The literature search update …

World Health Organization 2020 Guidelines On Physical Activity And Sedentary Behaviour, Fiona C. Bull, Salih S. Al-Ansari, Stuart Biddle, Katja Borodulin, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Loretta Dipietro, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Vicky Wari, Juana F. Willumsen

Population and Public Health Science Faculty Publications

Objectives To describe new WHO 2020 guidelines on physical activity and sedentary behaviour. Methods The guidelines were developed in accordance with WHO protocols. An expert Guideline Development Group reviewed evidence to assess associations between physical activity and sedentary behaviour for an agreed set of health outcomes and population groups. The assessment used and systematically updated recent relevant systematic reviews; new primary reviews addressed additional health outcomes or subpopulations. Results The new guidelines address children, adolescents, adults, older adults and include new specific recommendations for pregnant and postpartum women and people living with chronic conditions or disability. All adults should undertake …

Advancing The Global Physical Activity Agenda: Recommendations For Future Research By The 2020 Who Physical Activity And Sedentary Behavior Guidelines Development Group, Loretta Dipietro, Salih Saad Al-Ansari, Stuart J.H. Biddle, Katja Borodulin, Fiona C. Bull, Matthew P. Buman, Greet Cardon, Catherine Carty, Jean Philippe Chaput, Sebastien Chastin, Roger Chou, Paddy C. Dempsey, Ulf Ekelund, Joseph Firth, Christine M. Friedenreich, Leandro Garcia, Muthoni Gichu, Russell Jago, Peter T. Katzmarzyk, Estelle Lambert, Michael Leitzmann, Karen Milton, Francisco B. Ortega, Chathuranga Ranasinghe, Emmanuel Stamatakis, Anne Tiedemann, Richard P. Troiano, Hidde P. Van Der Ploeg, Juana F. Willumsen

Population and Public Health Science Faculty Publications

Background: In July, 2019, the World Health Organization (WHO) commenced work to update the 2010 Global Recommendations on Physical Activity for Health and established a Guideline Development Group (GDG) comprising expert public health scientists and practitioners to inform the drafting of the 2020 Guidelines on Physical Activity and Sedentary Behavior. The overall task of the GDG was to review the scientific evidence and provide expert advice to the WHO on the amount of physical activity and sedentary behavior associated with optimal health in children and adolescents, adults, older adults (> 64 years), and also specifically in pregnant and postpartum women …

Chronic Intermittent Hypoxia Triggers A Senescence-Like Phenotype In Human White Preadipocytes, Katarzyna Polonis, Christiane Becari, C. Anwar A. Chahal, Yuebo Zhang, Alina M. Allen, Todd A. Kellogg, Virend K. Somers, Prachi Singh

Clinical Research Faculty Publications

Obstructive sleep apnea (OSA) is a common sleep disorder associated with obesity. Emerging evidence suggest that OSA increases the risk of cardiovascular morbidity and mortality partly via accelerating the process of cellular aging. Thus, we sought to examine the effects of intermittent hypoxia (IH), a hallmark of OSA, on senescence in human white preadipocytes. We demonstrate that chronic IH is associated with an increased generation of mitochondrial reactive oxygen species along with increased prevalence of cells with nuclear localization of γH2AX & p16. A higher prevalence of cells positive for senescence-associated β-galactosidase activity was also evident with chronic IH exposure. …

Genetic Correlations And Genome-Wide Associations Of Cortical Structure In General Population Samples Of 22,824 Adults, Edith Hofer, Gennady V. Roshchupkin, Hieab H.H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. Van Der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser

Clinical Research Faculty Publications

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain …

Long-Term Change In Physiological Markers And Cognitive Performance In Type 2 Diabetes: The Look Ahead Study, Owen T. Carmichael, Rebecca H. Neiberg, Gareth R. Dutton, Kathleen M. Hayden, Edward Horton, F. Xavier Pi-Sunyer, Karen C. Johnson, Stephen R. Rapp, Adam P. Spira, Mark A. Espeland

Clinical Research Faculty Publications

Context: The effects of physiological improvements on cognitive function among persons with type 2 diabetes mellitus (T2DM) are not fully understood. Objective: To determine whether improvements in physiological markers (body weight, blood sugar control, and physical activity) during intensive lifestyle intervention (ILI) are associated with enhancements in cognitive function in older adults with T2DM. Design: Multisite randomized controlled trial. Setting: Academic research centers. Patients or Other Participants: Participants were aged 45-76 years, with T2DM. Intervention: The Action for Health in Diabetes (Look AHEAD) study, a randomized, controlled clinical trial of ILI. Main Outcome Measure: Two to 3 cognitive assessments were …

Functional Brain Architecture Is Associated With The Rate Of Tau Accumulation In Alzheimer’S Disease, Nicolai Franzmeier, Julia Neitzel, Anna Rubinski, Ruben Smith, Olof Strandberg, Rik Ossenkoppele, Oskar Hansson, Michael Ewers, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff

Clinical Research Faculty Publications

In Alzheimer’s diseases (AD), tau pathology is strongly associated with cognitive decline. Preclinical evidence suggests that tau spreads across connected neurons in an activity-dependent manner. Supporting this, cross-sectional AD studies show that tau deposition patterns resemble functional brain networks. However, whether higher functional connectivity is associated with higher rates of tau accumulation is unclear. Here, we combine resting-state fMRI with longitudinal tau-PET in two independent samples including 53 (ADNI) and 41 (BioFINDER) amyloid-biomarker defined AD subjects and 28 (ADNI) vs. 16 (BioFINDER) amyloid-negative healthy controls. In both samples, AD subjects show faster tau accumulation than controls. Second, in AD, higher …

Spread Of Pathological Tau Proteins Through Communicating Neurons In Human Alzheimer's Disease, Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli

Clinical Research Faculty Publications

Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these simulations to observed patterns measured using tau-PET in 312 individuals along Alzheimer’s disease continuum. Up to 70% of the variance in the overall spatial pattern of tau can be explained by our model. Surprisingly, the ESM predicts the spatial patterns of tau irrespective of whether brain Aβ is present, but regions with greater Aβ …

Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease, Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with AD and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-β (Aβ) via its N-terminal Aβ binding domain, and facilitates Aβ aggregation. Intracerebroventricular infusion or forced expression of this protein exacerbates neuroinflammation and cognitive dysfunction …

Influence Of Energy Removal Rate On The Quality Of Minced Meat From Undersized Crawfish During Frozen Storage, Franklin Bonilla, Vondel Reyes, Alexander Chouljenko, Bennett Dzandu, Subramaniam Sathivel

Faculty Publications

Abstract: Undersized crawfish have little economic value and are often discarded. Producing crawfish minced meat (CMM) from undersized crawfish and using an appropriate freezing technique may enable an economically viable market. The objective of this research was to evaluate the effect of the energy removal rate using two techniques, cryogenic freezing (CF) and air blast freezing (BF), on CMM’s quality during frozen storage. CMM was separated into two batches; one batch was cryogenically frozen with liquid nitrogen and the other batch was frozen with an air blast freezer. CMM batches were frozen and stored at − 18 °C. They were …

Food & Feelings

In Case You Missed It

DECEMBER 2020

A Snapshot Semester: Students’ Reflections Of Performance And Mental State Throughout A Graduate Course, Bradley D. Borges

Graduate Theses and Dissertations

Graduate students are anecdotally reputed to be among the most stressed groups of young adults. Common sources of stress for graduate students have included coursework, assistantships, finances, career preparation, and family (Wyatt & Oswalt, 2013; Mazzola, Walker, Shockley & Spector, 2011; Oswalt & Riddock, 2007). Guided reflection can be used by educators to assist students in both learning (Boud, Keogh & Walker, 2013; Kolb, 1984) and managing stress (Shoulders, Whitehead, & Morrison, 2018). By understanding how students’ progress through a semester in terms of both their learning and their management of stress, instructors and academic advisors can better anticipate times …

Validation Of A Swahili Version Of The 9-Item Patient Health Questionnaire (Phq-9) Among Adults Living With Hiv Compared To A Community Sample From Kilifi, Kenya, Paul Mwangi, Moses K. Nyongesa, Hans M. Koot, Pim Cuijpers, Charles R.J.C. Newton, Abubakar Abdillah

Institute for Human Development, East Africa

Background: Depression remains under-investigated in people living with HIV in sub-Saharan Africa due to paucity of adequately validated measures. This study aimed to validate an adapted version of the 9-item Pa- tient Health Questionnaire (PHQ-9) among adults living with HIV compared to those from the community in Kilifi, Kenya.

Methods: Analysis of data from 450 adults living with HIV and 337 adults from the community was conducted examining the reliability, factorial structure, measurement invariance and discriminant validity of interviewer- administered PHQ-9, Swahili version.

Results: Internal consistency of the Swahili PHQ-9 was good overall, in adults living with …

Kansas, Jeff M. Pike

Texas A&M Journal of Property Law

2019 provided no shortage of excitement, as there were more oil and gas opinions issued by the Kansas Supreme Court than in a usual year. These cases will be the main focus of this Survey, as there are no major legislative developments to report for this year. The first case decided whether the common-law rule against perpetuities should be applied to exceptions of defeasible term mineral interests. The second case is “yet another round in [a] high-dollar subsurface prize fight” about who has the right to gas that has escaped from an under- ground natural gas storage facility. The third …

December 2020 Magazine

Ergo

No abstract provided.

Recognition To Treatment: The Roles Of Emergency Medical Service Providers And Mobile Intensive Care Nurses In Suspecting Sepsis, Jodee Lejnieks, Cyndie Strader, Linda Chirieleison, Cherry Tanjapatkul, Ahlam Jadalla

General Submissions: Presentations (Oral and Poster)

Local evidence suggested that Emergency Medical Service Providers (EMSPs) and Mobile Intensive Care Nurses (MICNs) are challenged with recognizing sepsis. Early recognition of sepsis in the pre-hospital setting and notification to the receiving hospital may decrease time to treatment (TTT) on arrival, which may improve patient outcomes. The project objective was to improve the recognition of suspected sepsis by EMSPs and MICNs and decrease TTT.

Electronic Handoff Process For Ed Boarders Admitted To Medical-Surgical And Telemetry Units, Katherine Medina

General Submissions: Presentations (Oral and Poster)

The telephonic hand off process utilized to transfer ED boarders with assigned beds was causing major delays. The time from bed assignment to admission on the inpatient medical-surgical and telemetry units was 2 hours on average. This was contributing to overcrowding in the Emergency Department. The goal of this project was to expedite the movement of these patients in the Emergency Department to the medical-surgical and telemetry units by eliminating the telephonic hand off process and replacing it with an electronic hand off process.

Development, Validation, And Pilot Of A Guideline To Improve Clinical Event Debriefing At A Level I Adult And Level Ii Pediatric Trauma Center, Steven Tyler, Jane Dixon, Janet Parkosewich, Paul Mullan, Amish Aghera

General Submissions: Presentations (Oral and Poster)

Clinical event debriefing (CED) is recommended by the American Heart Association and the European Resuscitation Council to provide an opportunity for teams to improve performance. Lack of validated CED guidelines and tools are a barrier to consistent CEDs in the emergency department (ED). Objectives: 1) To create and validate an evidence-based CED practice guideline and CED instrument (CEDI); 2) pilot the new CED tools; and 3) survey CED facilitators about their experience.

Improving Emergency Department Management Of Diabetic Ketoacidosis In Children, Nicole Dumas, Katherine Leaming-Van Zandt

General Submissions: Presentations (Oral and Poster)

Diabetic ketoacidosis (DKA) occurs in 26% of children with new-onset type 1 diabetes and is the leading cause of morbidity and mortality in children with diabetes. For patients with DKA, the main principles of management include rapid assessment and treatment with insulin and intravenous fluid administration. A nursing-led process was designed to improve identification of this high-risk population and expedite the delivery of insulin within one hour from insulin order and two hours from triage assessment.

Effects Of Prehospital Communication Times In Stemi Patients, Melissa Connor, Kate Hurley, Ning Yao, Theresa Nicholson, Morgan Harris, Tyler Rodriguez, Nicholas Jackson, Pamela Miller

General Submissions: Presentations (Oral and Poster)

Expedient transfer of a ST-elevation myocardial infarction (STEMI) patient presenting to the Emergency Department (ED) to a cath lab for percutaneous coronary intervention (PCI) is well understood to make a difference in the patient outcome. The American Heart Association has given a goal of 30-30-30 from first medical contact (FMC) to device time, meaning that patients should spend no more than 30 minutes at each step when transported to a hospital, evaluated in an ED and re-perfused in a cath lab. In Los Angeles County, Mobile Intensive Care Unit (MICN) nurses are certified to provide specialty pre-hospital guidance from the …

Team Up Against Sepsis; 6 Tasks In 60 Minutes, Karin Kloppel, Barbara Richards

General Submissions: Presentations (Oral and Poster)

This project has a three-pronged purpose: 1. Improve compliance with sepsis bundles. 2. Improve early recognition of possible SIRS/Sepsis and reduce sepsis mortality. 3. Improve times in obtaining labs, lactate, 2 blood cultures, IV access, IV fluid resuscitation and initiating antibiotics by 80%. Sepsis is the number one cause of mortality in hospitals nationwide. Our hospital system has identified sepsis mortality reduction as a top priority. Early recognition and treatment through improving sepsis bundle compliance was the selected focus in our 40-bed emergency department.

A Bibliometric Analysis Of The Aga Khan University Research Contribution In Early Child Development, Peter Gatiti, Anil Khamis

Libraries

The research contribution of the Aga Khan University to the Sustainable Development Goals (SDGs) has been explored through a bibliometric analysis. The analysis shows exponential growth of research across the SDGs undertaken by AKU-affiliated researchers. The analysis identified areas of interdisciplinary research, with a significant focus on societal development of interest to AKU, as per its mandate, and reflective of the work of the Aga Khan Development Network (AKDN) of which AKU is an integral part. Building on the bibliometric analysis, this paper focuses on early childhood development and early childhood education with reference to the SDGs. A specific query …

Microglia Control Vascular Architecture Via A Tgfβ1 Dependent Paracrine Mechanism Linked To Tissue Mechanics, Tejasvi Dudiki, Julia Meller, Gautam Mahajan, Huan Liu, Irina Zhevlakova, Samantha Stefl, Conner Witherow, Eugene Podrez, Chandrasekhar R. Kothapalli, Tatiana V. Byzova

Chemical & Biomedical Engineering Faculty Publications

© 2020, The Author(s). Tissue microarchitecture and mechanics are important in development and pathologies of the Central Nervous System (CNS); however, their coordinating mechanisms are unclear. Here, we report that during colonization of the retina, microglia contacts the deep layer of high stiffness, which coincides with microglial bipolarization, reduction in TGFβ1 signaling and termination of vascular growth. Likewise, stiff substrates induce microglial bipolarization and diminish TGFβ1 expression in hydrogels. Both microglial bipolarization in vivo and the responses to stiff substrates in vitro require intracellular adaptor Kindlin3 but not microglial integrins. Lack of Kindlin3 causes high microglial contractility, dysregulation of ERK …