Digital Commons Network^™

Phil 337-453: World Religions, Charles Brooks

Humanities Syllabi

No abstract provided.

Phil 337-455: World Religions, Charles Brooks

Humanities Syllabi

No abstract provided.

Hss 408-H03: Philosophy Of Animal Minds, Adam See

Humanities Syllabi

No abstract provided.

Making A Bee-Line For Food With Octopamine, Lauren E. Nadler

Marine & Environmental Sciences Faculty Articles

No abstract provided.

Tropical Cyclone Landfall Frequency And Large-Scale Environmental Impacts Along Karstic Coastal Regions (Yucatan Peninsula, Mexico), Victor H. Rivera-Monroy, Luis M. Farfan, Luis Brito-Castillo, Jorge Cortes-Ramos, Eduardo Gonzalez-Rodriguez, Eurico D'Sa, Jorge I. Euan-Avila

Faculty Publications

Tropical cyclones (TCs) are natural systems that develop over ocean basins and are key components of the atmospheric activity during the warm season. However, there are still knowledge gaps about the combined positive and negative TC impacts on the structure and function of coastal socio-ecosystems. Using remote sensing tools, we analyzed the frequency, trajectory, and intensity of 1894 TCs from 1851-2019 to identify vulnerable "hotspots" across the Yucatan Peninsula (YP), Mexico. A total of 151 events hit the YP, with 96% of landings on the eastern coast. We focused on three major hurricanes (Emily and Wilma, 2005; Dean, 2007) and …

Disease Modification Trials In Parkinsons Disease: A Review, Ramla Nayaib Hashmi, Ummul Kiram

Pakistan Journal of Neurological Sciences (PJNS)

Among the common neurological disorders worldwide, Parkinson’s disease has a major share. Currently, only symptomatic therapies are available for it without any approved neuromodulation drugs as all the previously done disease modification trials have failed. There is a dire need for such therapies. Disease modification trials include all types of intervention targeting the degeneration process which underlies the disease process and thus slows it down or the treatment aim to regenerate or replace the neurons which are lost. There are many reasons for the failure of trials. This review emphasize the need for disease modification trials, causes of failure of …

Sep2020, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Impact Of Lysine On Mouse Reproductive Behavior, Wren Dieterman, Corissa Kern, Mark Garbrecht

Student Research and Creative Projects 2020-2021

Lysine, an essential amino acid, has a large effect on growth in mammals. C57BL/6 mice were measured on different variables throughout their entire life; starting at the juvenile stage, followed by pregnancy, and as newborns. Weight gain/loss, food consumption, and pup weight gain, activity, color and hair growth were completed with the mice in a low lysine group, which had 4 g/kg of lysine in their diet, and with mice in the control group, which had 14 g/kg of lysine in their diet. During pregnancy, observations were made on weight gain, as well as on food consumption. The results revealed …

Luteolin Induces Cytotoxicity In Mix Cellularity Classical Hodgkin's Lymphoma Via Caspase Activated-Cell Death, Rajendra Gharbaran, Enyuan Shang, Onyekwere Onwumere, Naomi Codrington, Evangelina Dankwa Sarpong, Stephen M. Redenti

Publications and Research

Background/aim: We investigated the effects of luteolin (LUT) on classical Hodgkin's lymphoma (cHL), since such studies in malignant lymphomas are lacking.

Materials and methods: Effect of LUT on cell growth was assessed with water-soluble tetrazolium 1 (WST-1) cell proliferation assay and automated hemocytometry on trypan blue-exclusion assay. Cell death was investigated with acridine orange/ethidium bromide live-dead assay, propidium iodide (PI) flow cytometry, and Annexin-V-PI microscopy. Caspase activation was studied using CellEvent Caspase-3/7 Green detection reagent. High resolution immunofluorescence microscopy was used to detect cleaved-PARP-1.

Results: LUT induced a dose-dependent decrease in the growth of KMH2 and L428 cells, cellular models …

Early Childhood In Portland: Perspectives On Child Care And Development, Emilie Swenson Msw, Susy Hawes

Children, Youth, & Families

The purpose of this project was to ascertain a more detailed understanding of parents’ views on developmental screenings and family, friend, and neighbor care¹ for young children from immigrant, refugee, and/or asylee² communities that speak either Arabic, French, or Somali in Portland, Maine³ with the intention of informing future strategies that can be implemented by the Cumberland County Developmental Screening Community Initiative (DSCI) and Starting Strong, the early childhood initiative that is a part of Portland ConnectED.

Through a collaborative process, Starting Strong, DSCI, the Data Innovation Project (DIP), and Maine Immigrant Access Network (MAIN) sought to …

Characterization Of The Cazy Repertoire From The Marine-Derived Fungus Stemphylium Lucomagnoense In Relation To Saline Conditions, Wissal Ben Ali, David Navarro, Abhishek Kumar, Elodie Drula

Open Access archive

Even if the ocean represents a large part of Earth’s surface, only a few studies describe marine-derived fungi compared to their terrestrial homologues. In this ecosystem, marine-derived fungi have had to adapt to the salinity and to the plant biomass composition. This articles studies the growth of five marine isolates and the tuning of lignocellulolytic activities under different conditions, including the salinity. A de novo transcriptome sequencing and assembly were used in combination with a proteomic approach to characterize the Carbohydrate Active Enzymes (CAZy) repertoire of one of these strains. Following these approaches, Stemphylium lucomagnoense was selected for its adapted …

Microglial Response To Aspergillus Flavus And Candida Albicans: Implications In Endophthalmitis, Jaishree Gandhi, Poonam Naik, Inderjeet Kaur, Ashok Kumar

Open Access archive

Aspergillus flavus is the most common etiology of fungal endophthalmitis in India, while Candida albicans is the causative agent in the West. In this study, we determined the role of microglial cells in evoking an inflammatory response following an infection with A. flavus and C. albicans strains isolated from patients with endophthalmitis. Microglia (CHME-3) cells were infected with A. flavus and C. albicans and the expression of Toll-Like Receptors (TLRs), cytokines and Matrix metalloproteinases (MMPs) were assessed at various time intervals. A. flavus infected cells induced higher expressions of TLR-1,-2,-5,-6,-7 and-9 and cytokines such as IL-1α, IL-6, IL-8, IL-10 and …

Recognition And Repetition Counting For Local Muscular Endurance Exercises In Exercise-Based Rehabilitation: A Comparative Study Using Artificial Intelligence Models, Ghanashyama Prabhu, Noel E. O’Connor, Kieran Moran

Open Access archive

Exercise-based cardiac rehabilitation requires patients to perform a set of certain prescribed exercises a specific number of times. Local muscular endurance exercises are an important part of the rehabilitation program. Automatic exercise recognition and repetition counting, from wearable sensor data, is an important technology to enable patients to perform exercises independently in remote settings, e.g., their own home. In this paper, we first report on a comparison of traditional approaches to exercise recognition and repetition counting (supervised ML and peak detection) with Convolutional Neural Networks (CNNs). We investigated CNN models based on the AlexNet architecture and found that the performance …

Vol. 24, No. 1: Full Issue, Water Law Review

Water Law Review

No abstract provided.

Vol. 24, No. 1: Masthead, Water Law Review

Water Law Review

No abstract provided.

A New Day: Empowering Groundwater Conservation Districts To Manage Groundwater In Texas, Emily A. Fouts

Water Law Review

The social and economic effects of water scarcity are well known and beginning to become more prevalent in many communities. More and more frequently, Texas citizens are experiencing severe and prolonged drought, often supplementing surface water shortages with available groundwater. Addition ally, as populations increase, municipalities rely on groundwater resources to fill their growing needs. Citizens' of Texas have always recognized the importance of groundwater management and conservation and created a regulatory structure designed to manage groundwater resources at the local level through Groundwater Conservation Districts ("GCD"s). Texas's unique approach to groundwater management, the rule of capture, is here to …

California, Claira Rolfson, Evan Weis

Water Law Review

No abstract provided.

Designing Analog Learning Games: Genre Affordances, Limitations And Multi-Game Approaches, Owen Gottlieb, Ian Schreiber

Articles

This chapter explores what the authors discovered about analog games and game design during the many iterative processes that have led to the Lost & Found series, and how they found certain constraints and affordances (that which an artifact assists, promotes or allows) provided by the boardgame genre. Some findings were counter-intuitive. What choices would allow for the modeling of complex systems, such as legal and economic systems? What choices would allow for gameplay within the time of a class-period? What mechanics could promote discussions of tradeoff decisions? If players are expending too much cognition on arithmetic strategizing, could that …

Analyses Of The Expression, Immunohistochemical Properties And Serodiagnostic Potential Of Schistosoma Japonicum Peroxiredoxin-4, Minh-Anh Dang-Trinh, Jose Ma. M. Angeles, Kharleezelle J. Moendeg, Adrian Miki C. Macalanda, Thu-Thuy Nguyen, Luna Higuchi, Shotaro Nakagun, Masahi Kirinoki, Yuichi Chigusa, Yasuyuki Goto, Shin-Ichiro Kawazu

Biology Faculty Publications

Background

Schistosoma japonicum, which inhabits the mesenteric vein of the mammalian hosts for about 20 to 30 years, is subjected to the oxidative stresses from the host defense mechanism during their intra-mammalian stages. To counteract this host immune attack, the parasite utilizes their antioxidant system for survival inside the host. Peroxiredoxins (Prxs), thiol-specific antioxidant proteins, play an essential role for protecting the parasite against oxidative stress by reducing hydrogen peroxide to water. Only three types of 2-Cys Prxs have been previously characterized in S. japonicum whereas a fourth Prx has been identified for Schistosoma mansoni as Prx-4. A sequence …

Forage News [2020-09], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Genealib Archive 2020-09, Genealib

GENEALIB Archive

No abstract provided.

Defining The Proteolytic Landscape During Enterovirus Infection., Mohsan Saeed, Sebastian Kapell, Nicholas T Hertz, Xianfang Wu, Kierstin Bell, Alison W Ashbrook, Milica Tesic Mark, Henry A Zebroski, Maxwell L Neal, Malin Flodström-Tullberg, Margaret R Macdonald, John D Aitchison, Henrik Molina, Charles M Rice

Articles, Abstracts, and Reports

Viruses cleave cellular proteins to remodel the host proteome. The study of these cleavages has revealed mechanisms of immune evasion, resource exploitation, and pathogenesis. However, the full extent of virus-induced proteolysis in infected cells is unknown, mainly because until recently the technology for a global view of proteolysis within cells was lacking. Here, we report the first comprehensive catalog of proteins cleaved upon enterovirus infection and identify the sites within proteins where the cleavages occur. We employed multiple strategies to confirm protein cleavages and assigned them to one of the two enteroviral proteases. Detailed characterization of one substrate, LSM14A, a …

Unh: The Magazine Of The University Of New Hampshire, Fall 2020, Unh Magazine

UNH Magazine

This editon of UNH Magazine was digital only due to the COVID-19 Pandemic. This is an archived version of web content originally found at https://magazine.unh.edu/

The Quest For Greener Pastures: Evaluating The Livelihoods Impacts Of Providing Vegetation Condition Maps To Pastoralists In Eastern Africa, Elia Machado, Helene Purcell, Andrew M. Simons, Stephanie Swinehart

Publications and Research

The survival of millions of pastoral households in Eastern Africa has become increasingly at risk. Due to mounting socioeconomic and climatic stressors, pastoral households are faced with making migration decisions under increasing uncertainty about resource availability and limited coping strategies. We assess the potential of providing vegetation condition maps to support the migration decision of pastoralists in Ethiopia and Tanzania and the effect of map usage on their herd condition and size. The maps were generated from remotely sensed data using the Normalized Difference Vegetation Index (NDVI) as a proxy for vegetation condition and overlain with pastoralists’ preferred grazing areas. …

Ubc-9 Acts In Gaba Neurons To Control Neuromuscular Signaling In C. Elegans, Victoria A. Kreyden, Elly B. Mawi, Jennifer Kowalski

Scholarship and Professional Work - LAS

Regulation of excitatory to inhibitory signaling balance is essential to nervous system health and is maintained by numerous enzyme systems that modulate the activity, localization, and abundance of synaptic proteins. SUMOylation is a key post-translational regulator of protein function in diverse cells, including neurons. There, its role in regulating synaptic transmission through pre- and postsynaptic effects has been shown primarily at glutamatergic central nervous system synapses, where the sole SUMO-conjugating enzyme Ubc9 is a critical player. However, whether Ubc9 functions globally at other synapses, including inhibitory synapses, has not been explored. Here, we investigated the role of UBC-9 and the …

A Novel Flow Cytometric Assay To Identify Inhibitors Of Rbpj-Dna Interactions, Robert J. Lake, Mark K. Haynes, Kostiantyn Dreval, Rabeya Bilkis, Larry A. Sklar, Hua-Ying Fan

Pathology Research and Scholarship

Notch signaling is often involved in cancer cell initiation and proliferation. Aberrant Notch activation underlies more than 50% of T-cell acute lymphoblastic leukemia (T-ALL); accordingly, chemicals disrupting Notch signaling are of potential to treat Notch-dependent cancer. Here, we developed a flow cytometry-based high-throughput assay to identify compounds that disrupt the interactions of DNA and RBPJ, the major downstream effector of Notch signaling. From 1492 compounds, we identified 18 compounds that disrupt RBPJ-DNA interactions in a dose-dependent manner. Cell-based assays further revealed that auranofin downregulates Notch-dependent transcription and decreases RBPJ-chromatin interactions in cells. Most strikingly, T-ALL cells that depend on Notch …

Tcl1 Transgenic Mice As A Model For Cd49d-High Chronic Lymphocytic Leukemia, Eva Szenes, Andrea Härzschel, Sarah Decker, Erika Tissino, Justine Pischeli, Julia Christine Gutjahr, Sandra Kissel, Sandra Pennisi, Jan Philip Höpner, Alexander Egle, Nadja Zaborsky, Christine Dierks, Marie Follo, Alexandre Chigaev, Antonella Zucchetto, Richard Greil, Valter Gattei, Tanja Nicole Hartmann

Pathology Research and Scholarship

With the advent of small molecule inhibitors, sustained responses in chronic lymphocytic leukemia (CLL) patients have been achieved. Ibrutinib, an inhibitor of Bruton’s tyr- osine kinase (BTK), is a particularly potent treatment for CLL, with overall response rates of 82% in treatment-naive and 43% in relapsed-refractory patients [1]. These responses are accompanied by transient lymphocytosis in 50–70% of patients and a concomitant reduction of tumor burden in lymphoid organs [2]. We have recently demonstrated that the high-risk, CD49d-high CLL subgroup [3] displays reduced lymphocytosis and minor lymph node shrinkage upon ibru- tinib treatment [4]. CD49d is the alpha subunit of …

Summer Field Report, June-July 2020, W. Ross Silcock

Nebraska Bird Review

Overall, this was a fairly routine summer although birders in Nebraska know that “routine” still holds promise of a few happenings out of the ordinary. The summer season primarily examines new breeding records, range expansions, and changes in numbers, up or down. Mississippi Kites were conspicuous, a pair providing Scottsbluff’s first breeding record, but a repeating pair in Lincoln, Lancaster lost its nest in a windstorm. The first nesting record for Violet-Green Swallow for Sheridan, 7th nesting for White-winged Dove, and 9th for Short-eared Owl were all encouraging, as was an apparent family group of Northern Saw-whet Owls in Sioux. …

Robert Wolcott And The Art Of Nest Records, Thomas E. Labedz

Nebraska Bird Review

The autumn of 1894 was fortuitous for Nebraska ornithology because it is when Robert Henry Wolcott accepted an assistantship at the University of Nebraska, moving to Lincoln from the University of Michigan (Swenk 1935). Wolcott, from that point onward, made significant contributions to our knowledge of Nebraska birds (Bruner et al. 1903, Wolcott 1909, 1919), was a founding member of the Nebraska Ornithologists’ Union (NOU), and was editor for the first three Proceedings of the NOU from 1899-1902. His work expanded beyond local focus and he eventually authored a text on animal biology (Wolcott 1933). The topic of this paper, …

The Nebraska Bird Review, Volume 88 September 2020, Number 3

Nebraska Bird Review

Summer Field Report, June - July 2020, by W. Ross Silcock …94.

Robert Wolcott and the Art of Nest Records, by Thomas E. Labedz …112

2019 (31st) Report of the NOU Records Committee, by Mark A. Brogie …124

Subscription and Organization Information …135