Digital Commons Network^™

Characterization Of The Putative Polysaccharide Synthase Cpsa And Its Effects On The Virulence Of The Human Pathogen Aspergillus Fumigatus, Binita Nepal

Graduate Research Theses & Dissertations

The fungus Aspergillus fumigatus is a ubiquitous opportunistic human pathogen capable of causing a life-threatening disease called invasive aspergillosis, or IA, with an associated 40–90% mortality rate in immunocompromised patients. Of the approximately 250 species known in the genus Aspergillus, A. fumigatus is responsible for up to 90% of IA infections. This study focuses on examining the role of the putative polysaccharide synthase cpsA gene in A. fumigatus virulence. Additionally, we evaluated its role in cellular processes that influence invasion and colonization of host tissue. Importantly, our results support that cpsA is indispensable for virulence in A. fumigatus infection of …

Model-Based Network Reconstruction From Cascade Dynamics, Katherine Irena Chwistek

Graduate Research Theses & Dissertations

Network representation provides a natural framework for the study of real world complex systems. From social networks and animal groups to interneuronal communications and power grid systems, complex patterns of interaction can be captured and modeled using networks in a simple mathematical form. In many cases, however, a faithful network representation of the system is not readily available. For this reason, network reconstruction has become a growing topic of interest in recent years, the goal of which is to discover the hidden interaction patterns among individuals by fitting input-output data from multiple experiments to candidate network topologies.

During a cascade, …

Physical Activity And Depression In Mothers Of A Child With A Special Health Care Need: Informing Future Interventions, Brianna Jean Black

Theses and Dissertations

In the United States, approximately 20 percent of all children have a special health care need. Additionally, mothers of a child with a special health care need have worse overall well-being, mental and physical health compared to mothers of typically developing children. Physical activity may improve depressive symptoms and overall health in these mothers; however, little is known about the acceptability of physical activity interventions for mothers of a child with a special health care need. Therefore, the primary aim of this study was to understand more about mother’s desire to use physical activity to improve depressive symptoms after having …

A Study Of The Feasibility Of Growth, Extraction, And Industrial Scale Up Processing Of Microalgae Lipids., Jasmine Oleksik

Theses and Dissertations

The interest in microalgae as a plausible alternative to crop oils as a raw material in the form of triglycerides and free fatty acids (FA oils) for renewable fuels and chemicals is increasing and it is a widespread research topic at the lab scale. Microalgae contain a higher lipid content on a dry weight basis compared to oilseeds such as soybeans. Additionally, the growth and cultivation cycle of microalgae is 15 days, in comparison to soybeans where the cycle occurs once or twice annually. Despite these advantages, to date it has been uneconomical to produce microalgae oils in a world-scale …

The Role Of Prediction Error In A Behavioral Memory Reconsolidation Intervention For The Treatment Of Posttraumatic Stress Symptoms: Original Proposal And Update Due To The Covid-19 Global Pandemic, Benjamin Darnell

Graduate Research Theses & Dissertations

A failure to naturally resolve posttraumatic stress symptoms (PTSS) following exposure to a traumatic event is associated with costly and debilitating consequences. Interventions for PTSS are successful for only 40%-70% of patients, and treatment drop-out and symptom relapse are common. Recent research targeting memory reconsolidation mechanisms to augment the memory may provide important information regarding possible paradigms for improving the efficacy of trauma-focused interventions. This research indicates that the use of prediction error during a memory activation cue may result in memory destabilization allowing for the destabilized memory to be updated. Considering that PTSS are inherently memory-dependent, an intervention targeting …

Engineering Ph-Dependent Antibody Interactions Through Linked Protonation Events In Interdomain Interfaces, Hyeyoung Eom

Graduate Research Theses & Dissertations

Engineered antibodies are frequently used in life science applications, such as therapeutics and clinical diagnostics. These customized antibodies typically possess enhanced binding affinity and/or specificity, yet these interactions are only one-way binding events that cannot be easily controlled without extreme changes in conditions, such as pH, denaturant, and/or temperature that likely irreversible damage the antibody and antigen. Here, we explore the design of proton-linked binding events in the context of both antibody/hapten (i.e., a low molecular weight ligand target) and antibody/antigen complexes. Specifically, this work looks to overcome the challenges of engineering pH-dependent small ligand/protein interactions, as well as develop …

The Role Of Endophytes In Conferring Salinity Tolerance In Prairie Cordgrass And The Winter Wheat Mint Variety, Jeffery Bartel

Electronic Theses and Dissertations

Prairie Cordgrass (PCG) Spartina pectinata is a native grass to North America that survives saline conditions, can be harvested multiple times in a year, and can be used as biofuel. Endophytes are bacteria that reside in plant tissues and often have growthpromoting capabilities. They can assist plants by obtaining nutrients by improving the tolerance of plants against a broad range of stresses, such as plant pathogens, viruses, flooding, drought, acids, or bases. PCG can survive ocean levels of salinity. Endophytes that naturally bond with PCG may not only be able to not only help PCG but be transferred to other …

Screening Of Catalysts For The Subcritical Water Depolymerization Of Lignin, Balawanthrao Jadhav

Electronic Theses and Dissertations

The current world population is completely rely on the non-renewable resources such as coal, fossils, and natural gas to get the energy, fuel and value-added chemicals. The increasing the demand of utilizing non renewable resources leads to severe problems such as global warming, climate changes, and environmental pollution. The renewable resources such as wind, solar energy, and biomass is an alternative sources to overcome these problems and to save the environment. Biomass made up with the cellulose, hemicellulose, and Lignin. Lignin is a copolymer of phenolic monomers and inexpensive naturally occurring complex material to produce the value-added chemicals and various …

Burning With Potential: Understanding The Relationship Between Biochar And Agriculture Of The Northern Glaciated Plains Ecoregion, Kaitlyn Abrahamson

Electronic Theses and Dissertations

Achieving global sustainable agriculture is one of the most incredible challenges of this century, yet many continue to try to solve this problem through the development of precision technologies. Biotechnologies, such as biochar, can perform like a precision technology while protecting agricultural land from soil erosion and fertility loss. The Northern Glaciated Plains ecoregion of the United States is little researched in the benefits from the use of biochar through improved soil nutrient capture and water retention, crop health improvements, and yield increases. The study plot has four sections of corn stover biochar and eight sections of control sections. This …

Fishes Of The Dakotas, Kathryn Schlafke

Electronic Theses and Dissertations

Biological reference materials play a critical role in studies of species biodiversity, biology, distribution, and historic diversity. Since the publications Fishes of North Dakota (Hankinson, 1929) and Fishes of South Dakota (Bailey and Allum, 1962), no new books have attempted to update the knowledge gained from the past decades of fish surveys and incorporate georeferenced collections at the state level. The last published book with the most complete accounts of fishes from North Dakota and South Dakota is the Distribution of Fishes in North and South Dakota Basins affected by the Garrison Diversion Unit (Owen et al. 1981) which includes …

Food & Culture In Greece, University Of New England Applied Nutrition Program

All Student-Created Educational Resources

This is a fact sheet about the food culture of Greece. The purpose is to educate the audience on Greece’s traditional cuisine and eating patterns. Information includes traditional foods and dishes, traditional eating patterns, holidays and religious traditions, traditional health beliefs, and more current food practices in Greece.

Food Culture Of India, University Of New England Applied Nutrition Program

All Student-Created Educational Resources

This handout informs audience of traditional foods within India. It addresses traditional eating patterns by identifying foods and beverages typically eaten, as well as how and when these foods are consumed. It also addresses traditional health beliefs and current food practices to those living in both India and the United States.

Acetaldehyde Production By Rothia Mucilaginosa Isolates From Patients With Oral Leukoplakia., Abdrazak Amer, Aine Whelan, Nezar N. Al-Hebshi, Claire M. Healy, Gary P. Moran

Articles

Rothia mucilaginosa has been found at high abundance on oral leukoplakia (OLK). The ability of clinical isolates to produce acetaldehyde (ACH) from ethanol has not been investigated. The objective of the current study was to determine the capacity of R. mucilaginosa isolates recovered from OLK to generate ACH. Analysis of R. mucilaginosa genomes (n = 70) shows that this species does not normally encode acetaldehyde dehydrogenase (ALDH) required for detoxification of ACH. The predicted OLK metagenome also exhibited reduced ALDH coding capacity. We analysed ACH production in 8 isolates of R. mucilaginosa and showed that this species is capable of …

Prognostic Role Of Homeostasis Model Assessment And Oral Glucose Tolerance Test Innondiabetic Patients With Bell's Palsy, Tuğba Karagöz, Ömer Bayir, Emel Çadalli Tatar, Erman Çakal, Ali̇ Özdek, Kemal Keseroğlu, Mustafa Şahi̇n, Mehmet Hakan Korkmaz

Turkish Journal of Medical Sciences

Background/aim: We aimed to reveal the incidence and predictive role of insulin resistance and distorted oral glucose tolerance test in nondiabetic patients with Bell's Palsy (BP). Materials and methods: Eighty-six patients with BP and 28 control subjects; all with normal blood glucose levels and no history of diabetes, were enrolled in the study. We investigated insulin resistance (IR) in all subjects, in terms of HOMA-IR greater than 2.7. Sixtytwo of the patients also underwent an oral glucose tolerance test (OGTT). Results: The mean HOMA-IR value was significantly increased in patients, compared to the control group (3.2 vs 1.6; P < 0.01). IR was detected more in BP patients than in controls (P < 0.05). The patients with higher HOMA-IR values had more severe facial dysfunction at the initial presentation and complete recovery time took longer than the patients with normal HOMA-IR value (75 days vs 42 days; P < 0.05). Following a 2h-OGTT, impaired glucose tolerance and newly diagnosed DM were found in 60% of the patients. Recovery time was significantly longer in prediabetics and newly diagnosed diabetic patients than in patients with normal glycemia (68 days, 52 days, and 32 days, respectively; P < 0.01). Conclusion: There is a strong linkage between HOMA-IR value and BP prognosis so HOMA-IR value may have a significant role of predicting BP prognosis at presentation.

Does Commodification Corrupt? Lessons From Paintings And Prostitutes, Stephen Clowney

Seton Hall Law Review

No abstract provided.

Toward A Holistic Agricultural Student Recruitment Model: A National Analysis Of The Factors Affecting Students’ Decision To Pursue An Agricultural Related Degree, Antoine J. Alston, Richie Roberts, Chastity W. English

Journal of Research in Technical Careers

Currently, the agricultural industry struggles to fill positions with qualified agricultural workers. Therefore, it is critical to attract high caliber individuals to agricultural degree programs that are prepared to enter the workforce with the skills needed to navigate complex issues and problems. The purpose of this national study was to identify key factors that influence the recruitment of agriculture students at land-grant and non-land-grant universities. Using Chapman’s model of student success as our conceptual lens, we tested 66 factors identified in the literature as successful recruitment strategies for colleges of agriculture based on students’ personal characteristics as well as key …

Games In Agriculture, Food, And Natural Resources Education, Aaron J. Mckim, Robert Bud Mckendree, Catlin M. Pauley

Journal of Research in Technical Careers

Educational games provide learners with team-based, experiential, and problem-centered learning opportunities. Therefore, educational games are recommended to encourage learner success in an increasingly complex and collaborative world. Research exploring interventions to increase teacher affinity toward games is needed to inform expansion of games within classrooms. The current study leveraged the input, environment, and outcomes model to analyze perceptions of games held by school-based agriculture, food, and natural resources (AFNR) educators before and after a professional development experience focused on educational games. Results indicate teachers held a favorable perception of games before engaging in the professional development. Engagement in the professional …

Teaching Students With Special Needs In School-Based, Agricultural Education: A Historical Inquiry, Kathryn L. Teixeira, M. Craig Edwards

Journal of Research in Technical Careers

The purpose of this historical study was to investigate the inclusion of students with special needs in school-based, agricultural education as reported by The Agricultural Education Magazine and the Journal of Agricultural Education over a time period of six decades. The impact of landmark legislation, such as the Vocational Education Act of 1963, the Elementary and Secondary Education Act of 1965, the Education for All Handicapped Children Act of 1975, and the Individuals with Disabilities Act of 1990, were examined. This legislation motivated and supported agricultural education’s efforts to meet the learning needs of special education students by providing modified …

Trial By Surprise: When Character And Fitness Investigations Violate The Ada And Create Dangerous Lawyers, Michelina Lucia

Minnesota Journal of Law & Inequality

No abstract provided.

Buck V. Bell, American Eugenics, And The Bad Man Test: Putting Limits On Newgenics In The 21st Century, Alessandra Suuberg

Minnesota Journal of Law & Inequality

No abstract provided.

Bio-Regenerative Life Support Systems Functional Stability And Limitations, A Theoretical Modeling Approach, Curt I. Holmer

Theses and Dissertations

Experiments with Ecological Closed Life Support Systems (ECLSS) for moderate sized crews have shown instability when supporting crews over long periods of time required for deep space travel. Tests such as Russia’s BIOS series, NASA’s Lunar-Mars Life Support Test Project (LMLSTP), ESA’s Micro-Ecological Life Support System Alternative (MELiSSA), and Japan’s Closed Ecology Experiment Facilities (CEEF) have shown that microalgae and higher plants combined with physical-chemical material converters can be a successful part of a Biological Life Support System or a Closed Ecological Life Support System. LMLSTP, MELiSSA, and CEBAS experiments as well as commercial Ecosphere products have proven stability at …

How Fishy Is Your Fish? Authentication, Provenance And Traceability In Fish And Seafood By Means Of Vibrational Spectroscopy, Aoife Power, Daniel Cozzolino

Articles

Food authenticity, traceability and provenance are emerging issues of major concern forconsumers, industries and regulatory bodies worldwide. In addition, both food safety and securityare an intrinsic component of food quality where the above issues are key in modern traceabilityand management systems. It has been reported that substitution of a high-quality species by lessexpensive ones might be a frequent practice in seafood products such as fish and shellfish. In thistype of products, the source (e.g., origin) and identification of the species are complex. Althoughdifferent countries have implemented strict regulations and labelling protocols, these issues still are ofconcern. This article briefly reviews …

The Effect Of Neonicotinoid Clothianidin On Ring-Necked Pheasant Survival And Reproduction, Michael Sundall

Electronic Theses and Dissertations

Ring-necked pheasants (Phasianus colchicus) are economically important to the state of South Dakota bringing in over one hundred million dollars in revenue each season. The population is known to fluctuate temporally for many reasons, often weather related. Unfortunately, no research has been conducted involving ring-necked pheasants that evaluated the impact or interaction of neonicotinoids on the species. The objective of our study was to gain an understanding of how the neonicotinoid, Clothianidin, affects survival and breeding in pheasants. Our first experiment was to determine if there was a selection bias for seeds treated with neonicotinoids. In this experiment, eight ring-necked …

Biophysical And Socioeconomic Impacts Of Farmer Managed Natural Regeneration In Burkina Faso, Basnewende Brice Fulgence Zoungrana

Electronic Theses and Dissertations

Human actions such as overgrazing, the development of cities at the expense of forests, high intensity and poor agricultural management, and so forth, reduce the resources available for future generations. Because Earth has limited resources, it is important to judiciously use and manage natural resources. Human actions towards nature are the focus of my research in Africa. Increased demands for grazing, agriculture, and ecosystem services led some farmers in developing countries to use unsustainable practices, which may lead to low incomes and poor food nutrition for households. Farmer managed natural regeneration (FMNR) may be a solution to these issues. FMNR …

How Adult Learners Participate In Collaborative Learning Within A University Environment, Dennis Keechul Awen

Graduate Research Theses & Dissertations

Innovation and creativity are the “competitive edges” needed for businesses, government agencies, universities, communities, and private individuals to “stay and feel alive” and compete in our global world. Collaborative learning allows the birth of new kinds of thinking and new perspectives. Regardless of age, gender, race, and academic background, innovation and creativity through collaborative learning allows any individual, group, and organization to “jump start their batteries” and create something new. For this research study, I discovered what collaborative learning is, how it works, and what allows collaborative learning to occur.

In this qualitative study, I explored how a group of …

Hippocampal Cholinergic Function And Exploratory Behavior Throughout Development In A Genetic Mouse Model Of Alzheimer’S Disease, Ashley Andrea Blackwell

Graduate Research Theses & Dissertations

Dementia of the Alzheimer’s type is the most common form of dementia, affecting millions of people worldwide. Specific genetic mutations increase Alzheimer’s disease-related neuropathology and cognitive impairments. Deficits are observed in spatial orientation throughout the progression of Alzheimer’s disease, including wandering behavior or becoming lost in a familiar environment. Dementia of the Alzheimer’s type patients also exhibit disruptions in radial optic flow, which underlies self-movement cue processing. Currently, no treatments exist for Alzheimer’s disease. Genetic mouse models of Alzheimer’s disease have been developed to investigate the disease onset and progression and, further, to evaluate potential therapies and behavioral assessments. As …

The Effect Of Music Attention Control Training (Mact) For Pre-Adolescents With Autism Spectrum Disorder, Vienna Sa

University of the Pacific Theses and Dissertations

The purposes of this study are to investigate the effect of the Music Attention Control Training (MACT) on three types of attention (sustained, selective, switching) in pre-adolescents (10-14 years old) with Autism Spectrum Disorder (ASD) and to identify the impact of the level of severity (mild, moderate, severe) on changes in attention scores. This modified replication study included 23 participants randomly assigned to treatment and control group stratified based on severity of ASD. Significant results via two-tailed paired-sample t-test (p< .10) indicated significant positive trends with the treatment group for the 3 out of 4 subtests of selective attention: Hector Cancellation, Hector-B Cancellation, and Hecuba Visual Search; 1 out of 4 subtests of sustained attention: Sustained Attention Response Test (SART); and the single subtest of switching attention: Red & Blues, Bags & Shoes (RBBS). Results call for modifications to further support the role of MACT on attention skills with pre-adolescents with ASD. Implications for future research and contributions to clinical practices in music therapy are discussed.

Exercise Training As Adjunct Therapy For Substance Use Disorder, Emily Lynn Roessel

University of the Pacific Theses and Dissertations

Exercise training for clients at out-patient drug rehabilitation centers likely helps with coping skills. However, a better examination of the mechanisms producing changes may help identify effective interventions. PURPOSE: To test the effect of a vigorous exercise prescription on drug abstinence in voluntary rehabilitation patients. METHODS: 25 surveyed participants in a male drug treatment program underwent a 12-week minimum training program. The program included moderate-rigorous exercise and psychotherapy. Three days per week all subjects participated in EP for 90 minutes. Subjects also participated in ABIT 3 days per week where each session lasted 2 hours. Subjects also participated in ESM …

Multicellular Spheroids Of A549 And A549-Irfp As An In Vitro Model Of Lung Cancer, Xinyu Pei

University of the Pacific Theses and Dissertations

Lung cancer is the second most common cancer in both men and women around the world, and 85% of it is non-small cell lung cancer (NSCLC). It is estimated that in 2020, there will be 228,820 cases of lung cancer and 135,720 deaths from lung (American Cancer Society, 2020). The prognosis of lung cancer is poor (

Traditionally, the most commonly used in vitro method for screening therapeutic drugs is monolayer cell cultures, which are reproducible, convenient and of low cost. However, monolayer cell culture models are unable to reproduce many properties of in vivo solid tumors such as the …

Listener Responses Can Influence The Presentation Of Restricted Interest Topics To Individuals With Asd, Sadaf Fakharzadeh

University of the Pacific Theses and Dissertations

The behavior of individuals diagnosed with autism spectrum disorder (ASD) can influence caregiver responses that lead to countertherapeutic outcomes. However, there are few experimental evaluations of variables that can cause potentially undesirable interactions between those with ASD and their caregivers. Specifically, little is known about the effects of listener interest on the restricted topics presented by caregivers. We evaluated the influence of listener responses exhibited by a confederate acting as a person with ASD on the topics presented by three undergraduate students who were interested in working with individuals diagnosed with ASD. Each session consisted of a 5-min conversation, during …