Digital Commons Network^™

Characterization Of Pallid Sturgeon (Scaphirhynchus Albus) Spawning Habitat In The Lower Missouri River, Caroline M. Elliott, Aaron J. Delonay, Kimberly Chojnacki, Robert B. Jacobson

United States Geological Survey: Staff Publications

Acipenseriformes (sturgeons and paddlefish) globally have declined throughout their range due to river fragmentation, habitat loss, overfishing, and degradation of water quality. In North America, pallid sturgeon (Scaphirhynchus albus) populations have experienced poor to no recruitment, or substantial levels of hybridization with the closely related shovelnose sturgeon (S. platorynchus). The Lower Missouri River is the only portion of the species’ range where successful reproduction and recruitment of genetically pure pallid sturgeon have been documented. This paper documents spawning habitat and behavior on the Lower Missouri River, which comprises over 1,300 km of unfragmented river habitat. The …

Simultaneous Cognate Epitope Recognition By Bovine Cd4 And Cd8 T Cells Is Essential For Primary Expansion Of Antigen-Specific Cytotoxic T-Cells Following Ex Vivo Stimulation With A Candidate Mycobacterium Avium Subsp. Paratuberculosis Peptide Vaccine, Gaber S. Abdellrazeq, Lindsay M. Fry, Mahmoud M. Elnaggar, J. P. Bannantine, David A. Schneider, William M. Chamberlin, Asmaa H.A. Mahmoud, Kun-Taek Park, Victoria Hulubei, William C. Davis

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria, develop following stimulation of monocyte-depleted peripheral blood mononuclear cells (mdPBMC) with antigen-presenting cells (APC, i.e. conventional dendritic cells [cDC] and monocyte-derived DC [MoDC]) pulsed with MMP, a membrane protein from Mycobacterium avium subsp. paratuberculosis (Map) encoded byMAP2121c. CTL activity was diminished if CD4 T cells were depleted from mdPBMC before antigen (Ag) presentation by APC, suggesting simultaneous cognate recognition of MMP epitopes presented by MHC I and MHC II molecules to CD4 and CD8 T cells is essential for development of CTL activity. To …

International Law And Theories Of Global Justice: Remarks, Steven R. Ratner, James Stewart, Jiewuh Song, Carmen Pavel

Articles

International law (IL) and political philosophy represent two rich disciplines for exploring issues of global justice. At their core, each seeks to build a better world based on some universally agreed norms, rules, and practices, backed by effective institutions. International lawyers, even the most positivist of them, have some underlying assumptions about a just world order that predisposes their interpretive methods; legal scholars have incorporated concepts of justice in their work even as their overall pragmatic orientation has limited the nature of their inquiries. Many philospophers, for their part, have engaged with IL to some extent—at a minimum recognizing that …

Proof At The Salem Witch Trials, Leonard M. Niehoff

Articles

As of the writing of this article, President Donald Trump's tweets have included roughly 400 references to "witch hunts." In a sense, this is unsurprising. The Salem witch trials have a special place in our national identity and vocabulary. Most Americans understand the reference, even if they know few of the historical details. And the phrase "witch hunt" serves as a useful shorthand for any frenzied chase after something that does not exist. The Salem trials also inspire a peculiar fascination: Perhaps no other site of deadly mass hysteria has become a major tourist destination.

Still, most practicing litigators probably …

The Impact Of Lifestyle Medicine On Nonalcoholic Fatty Liver Disease, Kelli L. Noble

DNP Research Projects

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The main risk factor for the development of NAFLD is metabolic syndrome. Women are at greatest risk, typically in their 5th to 6th decade of life. The more aggressive form of NAFLD is nonalcoholic steatohepatitis (NASH) which is characterized by inflammation associated with NAFLD. NASH has the greatest tendency to progress into cirrhosis. However, lifestyle intervention has been shown to effectively treat, and even reverse NAFLD. The purpose of this quantitative, quasi-experimental study was to lend additional research and demonstrate improvement in NAFLD through lifestyle intervention with 1) …

The Observational Investigation Of Vitamin D And The Effect On Hypertension (Oiveh) Study, Warren Burke

DNP Research Projects

Background

It is uncertain if vitamin D supplementation improves cardiovascular health, more specifically, the systolic and diastolic blood pressures, and the data from previous trials investigating supplementation and the effects on the blood pressure are limited.

Methods

The following scholarly project was a retrospective observational study, examining randomly selected participants with chronic kidney disease and hypertension from a local nephrology practice. The Student’s t-test, Pearson’s r correlation, and ANOVA statistical tests were utilized to determine if vitamin D supplementation improved the systolic and diastolic blood pressures.

Results

A total of 260 participants were examined. The mean systolic blood pressure …

Cyber Mobs, Disinformation, And Death Videos: The Internet As It Is (And As It Should Be), Danielle K. Citron

Faculty Scholarship

Fiction and visual representations can alter our understanding of human experiences and struggles. They help us understand human frailties and suffering in a visceral way. Nick Drnaso’s graphic novel Sabrina does that in spades. In Sabrina, a woman is murdered by a misogynist, and a video of her execution is leaked. Conspiracy theorists deem her murder a hoax. A cyber mob smears the woman’s loved ones as crisis actors, posts death threats, and spreads their personal information. The attacks continue until a shooting massacre redirects the cyber mob’s wrath to other mourners. Sabrina captures the breathtaking velocity of disinformation online …

Antibiotic Development — Economic, Regulatory And Societal Challenges, Christine Årdal, Manica Balasegaram, Ramanan Laxminarayan, David Mcadams, Kevin Outterson, John H. Rex, Nithima Sumpradit

Faculty Scholarship

Antibiotic resistance is undoubtedly one of the greatest challenges to global health, and the emergence of resistance has outpaced the development of new antibiotics. However, investments by the pharmaceutical industry and biotechnology companies for research into and development of new antibiotics are diminishing. The public health implications of a drying antibiotic pipeline are recognized by policymakers, regulators and many companies. In this Viewpoint article, seven experts discuss the challenges that are contributing to the decline in antibiotic drug discovery and development, and the national and international initiatives aimed at incentivizing research and the development of new antibiotics to improve the …

Admissions Viewbook, 2020-2021, Illinois State University, Office Of Admissions

Admissions Viewbook

Recruitment booklet created by Illinois State University's Office of Admissions

Social, Cultural And Economic Aspects Of Antimicrobial Resistance, Timo Minssen, Kevin Outterson, Susan Rogers Van Katwyk, Pedro Henrique D Batista, Clare I. R. Chandler, Francesco Ciabuschi, Stephan Harbarth, Aaron Kesselheim, Ramanan Laxminarayan, Kathleen Liddell, Michael T. Osterholm, Lance Price, Steven J. Hoffman

Faculty Scholarship

Although often considered only a medical problem, antimicrobial resistance is an evolutionary challenge accelerated by social, cultural and economic factors that lead to the misuse, overuse and abuse of life-saving antimicrobial medicines. The antimicrobial resistance challenge is compounded by inadequate attention to disease prevention and response, global circulation of people and products, differences in industry and market regulations across countries, and a fragile pipeline of new antibiotics and their alternatives. While the discovery of new antimicrobials will provide temporary solutions, sustainable success requires rigorous social science research that explores the drivers of antimicrobial resistance. These solutions should promote balance between …

High Fat Diet Significantly Changed The Global Gene Expression Profile Involved In Hepatic Drug Metabolism And Pharmacokinetic System In Mice., Yuqi He, Tao Yang, Yimei Du, Lin Qin, Feifei Ma, Zunping Wu, Hua Ling, Li Yang, Zhengtao Wang, Qingdi Zhou, Guangbo Ge, Yanliu Lu

PCOM Scholarly Works

Background: High fat diet impact transcription of hepatic genes responsible for drug metabolism and pharmacokinetics. Until now, researches just focused on a couple specific genes without a global profile showing. Age-dependent manner was also not noted well. This study aims to investigate the high fat diet effect on transcriptome of drug metabolism and pharmacokinetic system in mouse livers and show the age-dependent evidence.

Methods: C57BL/6 male mice were used in this experiment. High fat diet was used to treat mice for 16 and 38 weeks. Serum total cholesterol, low density lipoprotein cholesterol, aspartate transaminase, and alanine transaminaselevels were measured. Meanwhile, …

Myo/Nog Cells Are Nonprofessional Phagocytes, Jacquelyn Gerhart, Lindsay Gugerty, Paul Lecker, Fathma Abdalla, Mark Martin, Olivia Gerhart, Colby Gerhart, Karanveer Johal, Jake Bernstein, John Spikes, Keith Mathers, Arturo Bravo Nuevo, Mindy George-Weinstein

PCOM Scholarly Works

Myo/Nog cells were discovered in the chick embryo epiblast. Their expression of MyoD reflects a commitment to the skeletal muscle lineage and capacity to differentiate into myofibroblasts. Release of Noggin by Myo/Nog cells is essential for normal morphogenesis. Myo/Nog cells rapidly respond to wounding in the skin and eyes. In this report, we present evidence suggesting that Myo/Nog cells phagocytose tattoo ink in tissue sections of human skin and engulf cell corpses in cultures of anterior human lens tissue and magnetic beads injected into the anterior chamber of mice in vivo. Myo/Nog cells are distinct from macrophages in the skin …

Brain-Specific Angiogenesis Inhibitor 1 Is Expressed In The Myo/Nog Cell Lineage., Jacquelyn Gerhart, Jessica Bowers, Lindsay Gugerty, Colby Gerhart, Mark Martin, Fathma Abdalla, Arturo Bravo Nuevo, Jonathan Tabb Sullivan, Rebecca Rimkunas, Amie Albertus, Lou Casta, Lori Getts, Robert Getts, Mindy George-Weinstein

PCOM Scholarly Works

The Myo/Nog cell lineage was discovered in the chick embryo and is also present in adult mammalian tissues. The cells are named for their expression of mRNA for the skeletal muscle specific transcription factor MyoD and bone morphogenetic protein inhibitor Noggin. A third marker for Myo/Nog cells is the cell surface molecule recognized by the G8 monoclonal antibody (mAb). G8 has been used to detect, track, isolate and kill Myo/Nog cells. In this study, we screened a membrane proteome array for the target of the G8 mAb. The array consisted of >5,000 molecules, each synthesized in their native confirmation with …

When William T. Wiley And Bruce Nauman Wrote To H.C. Westermann, David Mccarthy

Art Inquiries

No abstract provided.

The Avant-Garde Networks Of Amauta: Argentina, Mexico, And Peru In The 1920s, Michele Greet

Art Inquiries

No abstract provided.

Art Making To Inform Dialogue Across Spiritual Otherness In The Therapeutic Space, Caitlin Brosious, Emma Burgin, Andrea Dyer, Maggie Knobbe

LMU Theses and Dissertations

This research was a preliminary pilot study meant to encourage further exploration on the intersection of art therapy, art making, spirituality, and dialogue. This study topic is an important area of investigation due to the long-standing challenges of interfaith dialogue, both historically and currently. An abundance of reviewed literature linking interfaith dialogue and dialogue through art making guided the research hypothesis, which states that the act of viewing and being viewed by the spiritual other through art making could deepen one’s own spiritual practice, increase empathy, foster dialogue, and inform clinical work as psychotherapists. To explore this, the researchers held …

Accessscience, Rob Tench

Libraries Faculty & Staff Publications

The article reviews the Web site AccessScience from publisher McGraw-Hill located at accessscience.com.

Response To Oliar And Stern: On Duration, The Idea/Expression Dichotomy, And Time, Wendy J. Gordon

Faculty Scholarship

Courts often use possession to determine who should own unclaimed resources. Yet, as Oliar and Stern demonstrate, the concept of possession is little more than a metaphor, capable of being applied to a broad range of phenomena. The authors helpfully deploy “time” as a metric to sort through the rules determining what should count as possession, and they survey the likely costs and benefits attached to choosing earlier versus later events as triggers for acquiring title.

With those tools in hand, Oliar and Stern employ “time” and the analogy of physical possession to address problems in copyright, patent, and trademark …

Early Surgery For Traumatic Spinal Cord Injury: Where Are We Now?, Jefferson R. Wilson, Christopher D. Witiw, Jetan Badhiwala, Brian K. Kwon, Michael G. Fehlings, James Harrop

Department of Neurosurgery Faculty Papers

Study Design: Narrative review.

Objective: There is a strong biological rationale to perform early decompression after traumatic spinal cord injury (SCI). With an enlarging clinical evidence base, most spine surgeons internationally now favor early decompression for the majority of SCI patients; however, a number of pertinent questions remain surrounding this therapy.

Methods: A narrative review evaluating the status of early surgery for SCI. In particular, we addressed the following questions: (1) Which patients stand to benefit most from early surgery? 2) What is the most appropriate time threshold defining early surgery?

Results: Although heterogeneity exists, the evidence generally seems to …

Conserving Spawning Stocks Through Harvest Slot Limits And No-Take Protected Areas, Gaya Gnanalingam, Holly Gaff, Mark J. Butler Iv

Biological Sciences Faculty Publications

The key to the conservation of harvested species is the maintenance of reproductive success. Yet for many marine species large, old individuals are targeted despite their disproportionate contribution to reproduction. We hypothesized that a combination of no-take marine protected areas (MPAs) and harvest slot limits (maximum and minimum size limits) would result in the conservation of large spawning individuals under heavy harvest. We tested this approach under different harvest intensities with a 2-sex, stage-structured metapopulation model for the Caribbean spiny lobster (Panulirus argus). P. argus is intensively harvested in the Caribbean, and in many localities large, mature individuals no longer …

Patterns Of Genetic Diversity In Highly Invasive Species: Cogongrass (Imperata Cylindrica) Expansion In The Invaded Range Of The Southern United States (Us), Rima D. Lucardi, Lisa E. Wallace, Gary N. Ervin

Biological Sciences Faculty Publications

The spatial expansions of invasive organisms in the novel range are generally expected to follow an isolation-by-distance relationship (IBD) if the invasion is biologically driven; however, many invasions are facilitated anthropogenically. This research focused on the extant expansion patterns of cogongrass (Imperata cylindrica). Cogongrass is a widespread invasive species throughout the southern United States (US). Patterns of infestation vary among US states. Cogongrass is pyrogenic, and its invasion threatens softwood (Pinus spp.) plantations, a substantial economic market for this US region. Over 600 individuals were sampled from seven invaded US states, using amplified fragment length polymorphisms (AFLPs) …

Phenotypic Variation Of Partridge Pea (Chamaecrista Fasciculata) From Mississippi Persists In A Common Garden, Lisa E. Wallace, Mahboubeh Hosseinalizadeh-Nobarinezhad, Robert Coltharp

Biological Sciences Faculty Publications

Intraspecific phenotypic variation occurs for many different reasons and understanding its basis has applications in taxonomy, ecology, and evolution. Chamaecrista fasciculata (partridge pea) is a widely distributed species with much phenotypic variation and varied interactions with other species in communities where it grows. Botanists have often noted that phenotypic variation in some traits of this species increases from north to south in the eastern United States. In this study, we grew seeds collected from five Mississippi populations in a common greenhouse environment to determine if the observed variation in leaf and stem traits is maintained in this environment. Interpopulation variation …

Squids Use Multiple Escape Jet Patterns Throughout Ontogeny, Carly A. York, Ian K. Bartol, Paul S. Krueger, Joseph T. Thompson

Biological Sciences Faculty Publications

Throughout their lives, squids are both predators and prey for a multitude of animals, many of which are at the top of ocean food webs, making them an integral component of the trophic structure of marine ecosystems. The escape jet, which is produced by the rapid expulsion of water from the mantle cavity through a funnel, is central to a cephalopod's ability to avoid predation throughout its life. Although squid undergo morphological and behavioral changes and experience remarkably different Reynolds number regimes throughout their development, little is known about the dynamics and propulsive efficiency of escape jets throughout ontogeny. We …

Tick-Borne Flavivirus Inhibits Sphingomyelinase (Issmase), A Venomous Spider Ortholog To Increase Sphingomyelin Lipid Levels For Its Survival In Ixodes Scapularis Ticks, Pravesh Regmi, Supreet Khanal, Girish Neelakanta, Hameda Sultana

Biological Sciences Faculty Publications

Our previous study showed that cells from medically important arthropods, such as ticks, secrete extracellular vesicles (EVs) including exosomes that mediate transmission of flavivirus RNA and proteins to the human cells. Understanding the molecular determinants and mechanism(s) of arthropod-borne flavivirus transmission via exosome biogenesis is very important. In this current study, we showed that in the presence of tick-borne Langat Virus (LGTV; a member of tick-borne encephalitis virus complex), the expression of arthropod IsSMase, a sphingomyelinase D (SMase D) that catalyzes the hydrolytic cleavage of substrates like sphingomyelin (SM) lipids, was significantly reduced in both Ixodes scapularis ticks (in vivo) …

Discovery Of Exosomes From Tick Saliva And Salivary Glands Reveals Therapeutic Roles For Cxcl12 And Il-8 In Wound Healing At The Tick-Human Skin Interface, Wenshuo Zhou, Faizan Tahir, Joseph Che-Yen Wang, Michael Woodson, Michael B. Sherman, Shahid Karim, Girish Neelakanta, Hameeda Sultana

Biological Sciences Faculty Publications

Ticks secrete various anti-coagulatory, anti-vasoconstrictory, anti-inflammatory, and anti-platelet aggregation factors in their saliva at the bite site during feeding to evade host immunological surveillance and responses. For the first time, we report successful isolation of exosomes (small membrane-bound extracellular signaling vesicles) from saliva and salivary glands of partially fed or unfed ixodid ticks. Our data showed a novel role of these in vivo exosomes in the inhibition of wound healing via downregulation of C-X-C motif chemokine ligand 12 (CXCL12) and upregulation of interleukin-8 (IL-8). Cryo-electron microscopy (cryo-EM) analysis revealed that tick saliva and salivary glands are composed of heterogeneous populations …

Effects Of Phosphorus On Mycorrhizal Colonization Of Wetland Plants Under Natural And Controlled Conditions, Miriah Tucker

Theses and Dissertations (Comprehensive)

An important symbiotic relationship that forms in wetland environments occurs between plants and arbuscular mycorrhizal fungi (AMF). In terrestrial communities AMF colonization is limited by phosphorus; excessive phosphorus can lead to an uncoupling of the relationship. Few studies have examined the relationship between AMF and phosphorus concentration in wetland plants. The studies that have, found a decrease in AMF colonization at phosphorus concentrations as low as 0.03 mg/L P, however, methodological issues limit the interpretation of these results. To address this, a field and greenhouse study were completed using more realistic exposure conditions, field deployable assays (FDA), and natural intact …

Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze

Theses and Dissertations (Comprehensive)

Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …

Beyond A Mapping Exercise: Inclusion Of Aboriginal Traditional Ecological Knowledge In Parks And Protected Areas Management, David Cook

Theses and Dissertations (Comprehensive)

This paper examines current approaches for Parks and Protected Areas (PPA) managers in incorporating Aboriginal Traditional and Ecological Knowledge (ATEK) into their management plans. This paper focuses on two case-studies. They are Nahanni National Park and Reserve in the Dehcho region of the Northwest Territories, and the Whitefeather Forest Protected Area in the Pikangikum First Nations Traditional Territory in Ontario. They were chosen because of their unique approaches to include Aboriginal communities in the planning process and their designation as UNESCO World Heritage sites. The broader indigenous involvement policies of both Parks Canada and Ontario Parks are examined using academic …

Seeking A Path To Wellness And Flourishing: Exploring Ecological Citizenship, Systems Thinking, And Environmental Governance In Southwest Yukon, Amanda Solmes

Theses and Dissertations (Comprehensive)

While efforts toward environmental management (EM) have been increasing, the state of our natural world is getting worse. Numerous reports have outlined that today’s environmental problems are predominantly human-induced, yet approaches to EM often only address “environmental” rather than “human” issues. More holistic approaches are required. This thesis explores “ecological citizenship” (EC) as an alternative framework that may have the potential to address elements too often left out of top-down and reductionist approaches. Academic and case-based notions of this concept are explored, and a new definition for the term is developed. A case study, drawn from the rich results of …

Abiotic Conditions, Algal Biomass & Fish Growth Rates Affect Fish Mercury Concentrations In Two Subarctic Lakes, Ari Yamaguchi

Theses and Dissertations (Comprehensive)

Kakisa Lake and Tathlina Lake, located in the Dehcho Region of the Northwest Territories, support important fisheries for the local Ka’a’gee Tu First Nation (KTFN). Recently, Walleye (Sander vitreus) of typical catch size in Tathlina Lake were found to have mercury concentrations above Health Canada’s commercial sale guideline of 0.5 ppm. Wild foods with elevated mercury concentrations can pose health risks to the humans who consume them, depending on consumption amounts and vulnerability factors such as age and pregnancy. Because wild fish can accumulate relatively high mercury levels and subsistence fishing contributes greatly to food security in northern …