Digital Commons Network^™

The Cardiovascular Response To Acute Hypoxic Conditions In Danio Rerio, Bryce Fetterman

Williams Honors College, Honors Research Projects

There are many fish that can withstand hypoxia levels. One in particular is the zebrafish (Danio rerio). The zebrafish is a small-sized, Cyprinid teleost fish, and has been used in a laboratory setting for many reasons. A few reasons being that they are widely available, easy to care for, and the cost for these fish are very low. There are various reasons why these fish are used as a model. One main reason is because their cardiovascular system is one of the first developing organs. This allows for better resolution when studying the cardiovascular system. The purpose of …

Analyzing The Effects Of Opioids On Cortical Pore Networks In Rabbit Tibiae And Femora, Kassidy Wilson

Williams Honors College, Honors Research Projects

The following project was approved by the Institutional Animal Care and Use Committee (IACUC) (Protocol number #18-11-12 ARC). This study was completed as a subset of Dr. Andronowski's overarching lab project. Femora and tibiae were procured from New Zealand White rabbits to study the prolonged effects of opioid use in bone remodeling. This specific project analyzed the effects of opioids on the pore networks and the pore orientation.

Oxidative Stress Analysis Of Placental Tissue In The Rupp Pregnant Rat, Natalie Ganios

Williams Honors College, Honors Research Projects

Preeclampsia is a disease associated with a vasoconstrictive phenotype due to disrupted signaling in the vascular endothelial growth factor (VEGF) relaxation pathway. The purpose of these studies is to determine the level of oxidative damage that is occurring in the placenta of the reduced uterine perfusion pressure (RUPP) rat, which serves as a common model for preeclampsia. RUPP and SHAM placenta tissue will be examined for oxidative stress as an indicator of tissue damage associated with the pathologically induced ischemia. Oxidative stress in the placental tissue will be measured by performing the following oxidative stress assays: 8-isoprostane test, TBARS assay, …

Networks Of Empathy, Thomas E. Kadri

Articles

Digital abuse is on the rise. People increasingly use technology to perpetrate and exacerbate abusive conduct like stalking and harassment, manipulating digital tools to control and harm their victims. By some accounts, 95% of domestic-abuse cases involve technology, while a sizeable chunk of the U.S. population now admits to having suffered or perpetrated serious abuse online. To make matters worse, people often trivialize digital abuse or underestimate its prevalence. Even among those who do appreciate its severity, there remains ample disagreement about how to address it.

Although law can be a powerful tool to regulate digital abuse, legal responses are …

The Facebook Oversight Board: Creating An Independent Institution To Adjudicate Online Free Expression, Kate Klonick

Faculty Publications

For a decade and a half, Facebook has dominated the landscape of digital social networks, becoming one of the most powerful arbiters of online speech. Twenty-four hours a day, seven days a week, over two billion users leverage the platform to post, share, discuss, react to, and access content from all over the globe. Through a system of semipublic rules called “Community Standards,” Facebook has created a body of “laws” and a system of governance that dictate what users may say on the platform. In recent years, as this intricately built system to dispatch the company’s immense private power over …

Economic Analysis Of Jewish Law, Keith Sharfman

Faculty Publications

(Excerpt)

Like any legal system, Jewish law is amenable to economic analysis, both positive and normative. Economic analysis can help to explain how and why the various rules comprising Jewish law arose and persisted over time. It also can facilitate a direct assessment of Jewish law on the merits. In practice, however, it is a mainly positive economic analysis of Jewish law that scholars have emphasized, while normative analysis has, for the most part, been underemphasized.

Take, for example, the application of law and economics to biblical exegesis. The legal-economic work in this field has been largely descriptive rather than …

Real Insider Trading, Michael A. Perino

Faculty Publications

In popular rhetoric, insider trading cases are about leveling the playing field between elite market participants and ordinary investors. Academic critiques vary. Some depict an untethered insider trading doctrine that enforcers use to expand their power and enhance their discretion. Others see enforcers beset with agency cost problems who bring predominantly simple, easily resolved cases to create the veneer of vigorous enforcement. The debate has, to this point, been based mostly on anecdote and conjecture rather than empirical evidence. This Article addresses that gap by collecting extensive data on 465 individual defendants in civil, criminal, and administrative actions to assess …

Applying Stable Isotopes Of Carbon (Δ$^{13}$C) And Nitrogen (Δ$^{15}$N) To Examine The Role Ofpikeperch (Sander Lucioperca Linnaeus, 1758) In Structuring The Food Web Oflake Eğirdir (Central Anatolia), Turkey, Meral Apaydin Yağci, Şenol Akin, Ahmet Alp, Abdulkadi̇r Yağci, Mehmet Cesur, Rahmi̇ Uysal, Fuat Bi̇lgi̇n, Vedat Yegen

Turkish Journal of Zoology

The aim of this study was to examine the role of pikeperch (Sander lucioperca L., 1758) in structuring the seasonal food web of Lake Eğirdir using carbon (δ$^{13}$C) and nitrogen (δ$^{15}$N) stable isotopes. The samples for stable isotopes were collected during the spring and autumn seasons. Sander lucioperca, as expected, was determined as a top predator with a substantially higher trophic position during both seasons (3.96, spring, δ$^{15}$N (mean ± SE = 13.09 ± 0.17) and δ$^{13}$C (mean ± SE = -17.23 ± 0.19) (4.10, autumn, δ$^{15}$N (mean ± SE = 14.14 ± 0.19) and δ$^{13}$C (mean ± SE = …

Insecticidal Effect Of Diatomaceous Earth And Dolomite Powder Against Corn Weevilsitophilus Zeamais Motschulsky, 1855 (Coleoptera: Curculionidae), Alyssa Cristina Oliveira Freitas, Adriana Aparecida Sinopólis Gigliolli, Ronaldo Roberto Tait Caleffe Caleffe, Helio Conte

Turkish Journal of Zoology

Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) which develops inside the grain, is an aggressive pest of stored grains. Here, we evaluated the efficiency of diatomaceous earth (DE), Diatomita CI/325 CX, and dolomite (DOL), Dolomita Dr. Kanyo, against S. zeamais reared on corn under laboratory conditions and observed external alterations on treated insects using scanning electron microscopy (SEM). Insects treated with both DE and DOL were impregnated with particles on the body surface, and they showed 100% mortality after 10 days of exposure. Damages caused by inert dusts may have contributed to dehydration and desiccation, consequently, leading insects to death. Thus, …

Improving Kentucky's Winter Wheat And Double Crop Soybean Rotation, Katherine Susan Rod

Theses and Dissertations--Plant and Soil Sciences

The winter wheat double crop soybean rotation is an economically viable rotation for Kentucky farmers. Recent decreases in commodity prices has warranted the need to evaluate intensive management practices that can increase yields and profitability in this crop rotation. There were three goals of this dissertation: 1.) identify management practices that would decrease deoxynivalenol (DON) in harvested wheat grain and increase wheat heading and anthesis uniformity, 2.) evaluate double crop soybean planting timing and identify intensive management practices to increase seed yield, and 3.) determine the profitability of these management options. These studies were conducted in Princeton KY between 2016 …

Glyphosate Plus Dicamba Spray Solution Deposition, Coverage, And Efficacy As Influenced By Spray Nozzle Design And Weed Density, Madison Dru Kramer

Theses and Dissertations--Plant and Soil Sciences

Dicamba injury to sensitive soybean and other broadleaf crops due to drift is a major issue and label restrictions have been created to mitigate dicamba drift. One restriction is the mandated use of low drift nozzles to spray dicamba; these nozzles produce larger droplets and minimize the production of driftable fines. Experiments were conducted to evaluate herbicide coverage, deposition, and efficacy. Three spray nozzle designs and different weed densities were the main factors in the analysis. Dicamba plus glyphosate was applied to 5 to 10 cm tall weeds with a Turbo TeeJet (TT11005) nozzle and two drift reduction nozzles approved …

The Current Role Of The Environment In Reinforcing Acts Of Domestic Terrorism: How Fear Of A Climate Change Apocalypse May Strengthen Right-Wing Hate Groups, Hope M. Babcock

Georgetown Law Faculty Publications and Other Works

Right-wing extremist organizations, like white supremacists and nativists, are using the environment as a rallying cry to gain supporters of their anti-social agendas. Apocalyptic rhetoric about climate change and the lack of action to combat it has frightened some people into accepting the simplistic, violent worldview of these groups. Although the violence is new, the coupling of racism and anti-immigration rants with environmental goals is not—it is part of our cultural history. This Article provides some background on the threats of environmental and domestic terrorism facing our nation and describes how the present-day rhetoric of fear of an environmental Armageddon …

Robert F. Kennedy And The Attorney General's Referral Authority: A Blueprint For The Biden Administration, Patrick J. Glen

Georgetown Law Faculty Publications and Other Works

For nearly four years, the Trump Administration’s use of the Attorney General’s referral authority has been criticized by the legal left on both substantive and procedural grounds. With the advent of the Biden Administration, however, use of the authority for liberal ends deserves serious consideration. To conclude otherwise would be throwing the baby out with the bath water. This article argues that the referral authority can be used for liberal constructions of the immigration laws, and that the perfect model for the incoming administration is former Attorney General Robert Kennedy and his use of the authority for just such ends. …

Hsp90 Inhibition And Modulation Of The Proteome: Therapeutical Implications For Idiopathic Pulmonary Fibrosis (Ipf), Ruben Manuel Luciano Colunga Biancatelli, Pavel Solopov, Betsy Gregory, John D. Catravas

Bioelectrics Publications

Idiopathic Pulmonary fibrosis (IPF) is a catastrophic disease with poor outcomes and limited pharmacological approaches. Heat shock protein 90 (HSP90) has been recently involved in the wound-healing pathological response that leads to collagen deposition in patients with IPF and its inhibition represents an exciting drug target against the development of pulmonary fibrosis. Under physiological conditions, HSP90 guarantees proteostasis through the refolding of damaged proteins and the degradation of irreversibly damaged ones. Additionally, its inhibition, by specific HSP90 inhibitors (e.g., 17 AAG, 17 DAG, and AUY-922) has proven beneficial in different preclinical models of human disease. HSP90 inhibition modulates a complex …

Accuracy Of Predicted Energy Expenditure From A Fitbit Inspire Hr Activity Monitor During Short- And Long-Duration Exercise, Cailyn Van Camp

Master's Theses and Doctoral Dissertations

PURPOSE: To determine the accuracy of predicted Energy Expenditure (EE) reported by a wrist-worn activity monitor compared to measured EE during both a long- and short-duration exercise. METHODS: In addition to a VO_2max treadmill test, a running speed at approximately 70 - 75% of that VO_2max was found during the first visit. The second and third visit was comprised of either a 30-minute or 10-minute run at the speed previously determined. A wrist activity monitor was worn and VO2 and EE were recorded by a metabolic cart. Pearson correlation, paired samples t-test, and repeated measures ANOVAs compared predicted …

Review Of Drug And Biologics Recalls: 2009 Through 2019, Vimala Devi Gollamudi

Master's Theses and Doctoral Dissertations

This study analyzed drugs and biologics recalls for the period of 2009 and 2019. The data used in the study was generated from Food and Drug Administration records. A total of 466 drugs and 84 biologics were recalled during the 11-year period. The common causes of drug product recalls included contamination, defective products, and mislabeling. Defective product, mislabeling, and defective packaging were observed to be the common causes of recall for biologics. Injectables have the highest percentage of recalls in drug products, and blood and blood products had the highest percentage of recalls in biologics. Controlling the contamination of injectable …

Polymer Chemistry Education To Increase Student Awareness Of Plastic Pervasiveness And Environmental Impact, Victoria Hill

Master's Theses and Doctoral Dissertations

A polymer-pollution-focused laboratory sequence was written to teach general chemistry concepts in a course for pre-service elementary teachers. Students experienced the difficulties related to polymer pollution clean-up and made bio-based materials to see possible alternatives. In order to determine whether this laboratory sequence changed student understanding of the importance of polymers and their environmental impact, student opinions were gathered with pre/post-course sequence surveys, observations, post-laboratory surveys, and focus group interviews. These same data collection methods were also used to determine the likelihood that the pre-service elementary teachers would teach these polymer and environmental laboratories or their concepts in the future. …

Rapid Adaptation To Changing Mechanical Load By Ordered Recruitment Of Identified Motor Neurons, Hillel J. Chiel

Faculty Scholarship

As they interact with their environment and encounter challenges, animals adjust their behavior on a moment-to-moment basis to maintain task fitness. This dynamic process of adaptive motor control occurs in the nervous system, but an understanding of the biomechanics of the body is essential to properly interpret the behavioral outcomes. To study how animals respond to changing task conditions, we used a model system in which the functional roles of identified neurons and the relevant biomechanics are well understood and can be studied in intact behaving animals: feeding in the marine mollusc Aplysia. We monitored the motor neuronal output of …

Comparison Of Unused Water And Year-Old Used Water For Production Of Channel Catfish In The Biofloc Technology System, Bartholomew W. Green, Kevin K. Schrader, Steven D. Rawles, Carl D. Webster, Matthew E. Mcentire

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Since excreted feed nitrogen is bio-transformed efficiently in a fully functional mixotrophic biofloc technology production system, re-using this biofloc water over multiple production cycles should be beneficial. The present study, conducted in an outdoor biofloc technology production system, evaluated impacts on fish production characteristics and mineral status, common microbial off-flavors, and water quality dynamics for channel catfish (Ictalurus punctatus) reared in one-year-old waters with low or high total suspended solids used previously for two consecutive catfish biofloc studies or in unused (new) water. Total suspended solids were maintained at 300 to 400 mg/L in the unused and low …

Modulation Of Epileptogenesis: A Paradigm For The Integration Of Enzyme-Based Microelectrode Arrays And Optogenetics, Corwin R. Butler, Jeffery A. Boychuk, Francois Pomerleau, Ramona Alcala, Peter Huettl, Yi Ai, Johan Jakobsson, Sidney W. Whiteheart, Greg A. Gerhardt, Bret N. Smith, John T. Slevin

Physiology Faculty Publications

BACKGROUND: Genesis of acquired epilepsy includes transformations spanning genetic-to- network-level modifications, disrupting the regional excitatory/inhibitory balance. Methodology concurrently tracking changes at multiple levels is lacking. Here, viral vectors are used to differentially express two opsin proteins in neuronal populations within dentate gyrus (DG) of hippocampus. When activated, these opsins induced excitatory or inhibitory neural output that differentially affected neural networks and epileptogenesis. In vivo measures included behavioral observation coupled to real-time measures of regional glutamate flux using ceramic-based amperometric microelectrode arrays (MEAs).

RESULTS: Using MEA technology, phasic increases of extracellular glutamate were recorded immediately upon application of blue light/488 nm …

Beyond Our Borders: Barriers And Solutions To Applying Environmental Regulations To U.S. Corporations That Outsource Production, Jordan Becker

Colorado Environmental Law Journal

No abstract provided.

Black And Yellow Letter Law: Managing Rusty Patched Bumble Bee Conservation Under The Endangered Species Act, Daniel Franz

Colorado Environmental Law Journal

No abstract provided.

The Construction And Analysis Of Dream Metaphors From The Standpoint Of Co-Creative Dream Theory, Gregory Scott Sparrow

Counseling Faculty Publications

Co-creative dream theory posits that the dream is co-determined through the reciprocal interplay between the witnessing dream ego and the emergent content. Consequently, the resulting dream can be seen as one of many contingent outcomes based on the dreamer’s range of response through the course of the dream, as well as the broad constraints of underlying domains that account for the nature and thrust of the emergent content. From this relational view of the dream, the visual imagery is not the content itself, but rather the “mutable interface” (Sparrow, 2013) between the dream ego and the emergent content. The purpose …

Research Handbook On Feminist Engagement In International Law [Book Review], Penelope Andrews

Articles & Chapters

No abstract provided.

Tribal Consultation Policy And Practice:A Case Study Of The Confederated Salish And Kootenai Tribes And Nmisuletkʷ (The Middle Fork Of The Clark Fork River) As A Tribal Trust Resource, Jennifer J. Harrington

Graduate Student Theses, Dissertations, & Professional Papers

Formal, government-to-government Consultation between sovereign nations is a process of continuous relationship-building, a partnership and an agreement made with all points-of-view included in the process, with results that have the fingerprint of all nations involved evident. The Federal Government is obligated to work with Federally-recognized Tribes as sovereign nations in matters that have or will impact each Nation’s people and places (reservations, treaty-protected areas)—a process legally known as Consultation. The Environmental Protection Agency (EPA), as a federal agency, must uphold the Federal Trust responsibility which includes the act of Consulting with Federally-recognized Tribes on matters involving human health and the …

Understanding Native American Hemp Production, Cynthia Marie Steckdaub Coleman

Graduate Student Theses, Dissertations, & Professional Papers

In this thesis, I take an in-depth look at Native American hemp production through the lens of three hemp projects. My research sits within the history of colonization and dispossession. I look at two tribal hemp projects and one individual Native American hemp farm and describe how each project reaches for tribal sovereignty through hemp production. I look at how hemp fits into tribal worldviews, cultures, and the relationship tribal farmers have with hemp. Focusing on key elements of relationship, like respect, reciprocity, and responsibility, I examine how hemp production can be incorporated into Indigenous communities. Beyond relationships with the …

Perceived Threat And Left-Wing Authoritarianism: The Effect Of Framing On Persuasive Messages, James Donald Mcfarland

Graduate Student Theses, Dissertations, & Professional Papers

Past research reveals a strong connection between feeling threatened and Right-Wing Authoritarianism (RWA). This relationship is considered to be an integral part of authoritarianism and the nature of its presence in the left-leaning populace is still being fully explored. This study examined the relationship between perceived threat and Left-Wing Authoritarianism (LWA) through the framing of persuasive messages. Participants (n = 256) were recruited through Amazon’s Mechanical Turk (MTurk) and given a list of reward- or threat-framed statements concerning the possible ramifications of voting in future elections and then asked to rate the quality and persuasiveness of the respective statements. …

Conceptions And Receptions: A Case Study Analysis Of Community Engagement At Four Local Museums, Mary L. Casey

Graduate Student Theses, Dissertations, & Professional Papers

The theme of community engagement has been a prevalent topic of debate and discussion among museum professionals across the country, and so this thesis seeks to examine how four local museums connect with their local audiences in meaningful and successful ways. I focus on local museums because they have the unique opportunity to intimately engage their immediate community’s perceptions of identity and heritage, and relate the interpreted past in innovative ways that effectively resonate with the contemporary lives of current residents.The Historical Museum at Fort Missoula, Strawbery Banke Museum, The Tuck Museum of Hampton History, and the James House Museum, …

2890-Fish On Fluoxetine: Before During And After Behavioral Analysis, Susan Marie Greene

Graduate Student Theses, Dissertations, & Professional Papers

Chemical concentrations of antidepressants have increased over the years steadily building in surface waters globally. These drugs have had various impacts on the animals tested, such as impacts on movement, motivation, and reproduction. In order to further investigate the effects of the antidepressant fluoxetine, male Betta splendens were exposed to the drug. These fish are naturally aggressive for reproduction purposes and have easily observable aggressive responses to other male fish. These characteristics make them a good model for studying Fluoxetine’s impact on reproduction, motivation, and movement. Males in this study were primed with either a female or empty chamber prior …

Tending To The Tapestry: An Ecofeminist Interpretation Of Women Farmer-Artists' Stories, Aubrey Pongluelert

Graduate Student Theses, Dissertations, & Professional Papers

There is a disconnect in Western academia, between classroom conversations concerning the impact of environmental degradation on rural communities, and engagement with those communities whom we are discussing. Those working in environmental studies are confronted with the question of how to effectively communicate the concerns addressed by the field in ways which are accessible to, and engage broader audiences. Creative languages such as the visual arts, storytelling, and music are invaluable tools in this task because they offer accessible and culturally relevant means of conveying ideas, perspectives, and experiences. This project examines the ways in which these creative languages contribute …