Digital Commons Network^™

Generation Of Induced Pluripotent Stem Cells From Blood Cell Of Glucose-6-Phosphate Dehydrogenase (G6pd) Deficiency, Malinee Tongbaen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common genetic enzyme disorder that affects more than 400 million people worldwide. Insufficient of G6PD enzyme or defect in enzyme activity can cause acute hemolysis after exposure to oxidative stress. The disease model used for pathogenesis study underlying oxidative damage or drug screening in G6PD deficient patients is still needed. In vitro generation of human-induced pluripotent stem cells (iPSCs) afford the potential source of the disease model in medical research. This study aimed to generate the iPSCs derived from G6PD deficient-subjects for used as a specific-disease model. The G6PD-derived iPSCs were generated from …

Is Authorship Sufficient For Today’S Collaborative Research? A Call For Contributor Roles, Nicole A. Vasilevsky, Ehsan Mohammadi, Mohammad Hosseini, Samantha Teplitzky, Violeta Ilik, Juliane Schneider, Barbara Kern, Julien Colomb, Scott C. Edmunds, Karen Gutzman, Daniel S. Himmelstein, Marijane White, Britton Smith, Lisa O'Keefe, Melissa Haendel, Kristi L. Holmes

Faculty Publications

Assigning authorship and recognizing contributions to scholarly works is challenging on many levels. Here we discuss ethical, social, and technical challenges to the concept of authorship that may impede the recognition of contributions to a scholarly work. Recent work in the field of authorship shows that shifting to a more inclusive contributorship approach may address these challenges. Recent efforts to enable better recognition of contributions to scholarship include the development of the Contributor Role Ontology (CRO), which extends the CRediT taxonomy and can be used in information systems for structuring contributions. We also introduce the Contributor Attribution Model (CAM), which …

A Case Study Of Pana Coffee Company Limited On Coffee Production Analysis, Paninee Jongwutiwes

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pana Coffee Group is a Thai organic coffee manufacturer in Chiang Mai, the northern part of Thailand. Organic Sustainable Value Chain is what they adhere. They handle the organic supply chain from upstream to downstream. They grow seedlings to saplings. They plant the saplings at own lands where the altitude, temperature, and humidity suit well without using any chemical substances, for instance, herbicides, pesticides, and fertilizers. They harvest the coffee once the coffee fruits are ripe. They have the mill which is fully-equipped with cutting-edge and environmental friendly machines to produce organic coffee that is supreme in quality. They also …

Chinese Fans’ Attitude Towards Thai Boy's Love Tv Dramas, Boy Love Tv Actors And Their Intention To Travel To Thailand, Jialin Gu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, more and more subcultures have emerged, such as fan culture, and the resulting fan economic impact is also growing. Certain brands or industries have already developed to use the enthusiasm of fans to achieve specific promotional effects. Therefore, the objectives of this research are to examine the Chinese fans' exposure to Thai BL TV dramas, their attitude toward BL celebrities, and intention to travel to Thailand, as well as the relationship between Chinese fans' attitudes towards Thai BL TV dramas and their attitudes towards celebrities in BL TV dramas, and the relationship between Chinese fans' attitudes towards celebrities in …

Consumer's Media Exposure, Attitude And Purchasing Behavior On "Café Amazon For Chance", Sirapassorn Cheepborisut

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objective of this research was to study the media exposure, consumers’ attitude and consumers’ purchasing behavior toward Café Amazon for Chance by using surveys to collect the data from current customers at Café Amazon for Chance aged 18 and above. Two hundred and seven were collected. The result shows that the media exposure of Café Amazon for Chance’s is low level. However, the majority of the sample has a good attitude toward the social enterprise concept of Café Amazon for Chance that supports social disabilities to have a career and be able to work equivalent to normal employees. Moreover, …

Consumers’ Exposure To Facebook Pages Regarding Environment, Environmental Awareness, And Behavioral Tendency In Thailand, Porntip Jakmongkolchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aims to analyze the exposure to Facebook pages regarding environment, consumers’ environmental awareness, and their behavioral tendency. The research explores the relationship between the exposure to Facebook pages and consumers’ environmental awareness, as well as relationship between consumers’ environmental awareness and their behavioral tendency. This quantitative research was conducted through an online survey which collected data from 200 respondents, aged between 18 to 64 years old who currently reside in Thailand. The results from the study reveals that respondents frequently see both text post and photo post equally (M = 2.47) from Environman or 3WheelsUncle or other Facebook …

Raising The Meter In Rhode Island: A Better Approach To Rhode Island’S Net Metering Laws, Alyssa Lauren Lemire

Roger Williams University Law Review

No abstract provided.

Rhode Island American Federation Of Teachers/Retired Local 8037 V. Johnston School Committee, 212 A.3d 156 (R.I. 2019), Rachel Ricci

Roger Williams University Law Review

No abstract provided.

Ileal Atresia, Obiyo O. Osuchukwu, Rebecca M. Rentea

Manuscripts, Articles, Book Chapters and Other Papers

Ileal and jejunal atresias are usually described together as jejunoileal atresia (JIA). JIA is a common cause of intestinal obstruction in neonates. It is seen in 1 in 5000 to 1 in 14000 live births. Intestinal atresia can occur in any location on the small bowel as a solitary or even multiple lesions. Distally located atresia usually presents with delayed symptoms compared to proximal ones. Occasionally, JIA is associated with other malformations such as cardiac anomalies, gastroschisis, and cystic fibrosis. Evaluation can be initiated before birth with prenatal diagnosis using ultrasound findings of evidence of intestinal obstruction reported in 29% …

Mitochondrial Utilization Of Competing Fuels Is Altered In Insulin Resistant Skeletal Muscle Of Non-Obese Rats (Goto-Kakizaki), Nicola Lai, Ciarán E. Fealy, Chinna M. Kummitha, Silvia Cabras, John P. Kirwan, Charles L. Hoppel

Electrical & Computer Engineering Faculty Publications

Aim: Insulin-resistant skeletal muscle is characterized by metabolic inflexibility with associated alterations in substrate selection, mediated by peroxisome-proliferator activated receptor 𝜹 (PPAR𝜹). Although it is established that PPAR𝜹 contributes to the alteration of energy metabolism, it is not clear whether it plays a role in mitochondrial fuel competition. While nutrient overload may impair metabolic flexibility by fuel congestion within mitochondria, in absence of obesity defects at a mitochondrial level have not yet been excluded. We sought to determine whether reduced PPAR𝜹 content in insulin-resistant rat skeletal muscle of a non-obese rat model of T2DM (Goto-Kakizaki, GK) ameliorate the inhibitory effect …

Bioenergetic Functions In Subpopulations Of Heart Mitochondria Are Preserved In A Non-Obese Type 2 Diabetes Rat Model (Goto-Kakizaki), Nicola Lai, C. M. Kummitha, F. Loy, R. Isola, C. L. Hoppel

Electrical & Computer Engineering Faculty Publications

A distinct bioenergetic impairment of heart mitochondrial subpopulations in diabetic cardiomyopathy is associated with obesity; however, many type 2 diabetic (T2DM) patients with high-risk for cardiovascular disease are not obese. In the absence of obesity, it is unclear whether bioenergetic function in the subpopulations of mitochondria is affected in heart with T2DM. To address this issue, a rat model of non-obese T2DM was used to study heart mitochondrial energy metabolism, measuring bioenergetics and enzyme activities of the electron transport chain (ETC). Oxidative phosphorylation in the presence of substrates for ETC and ETC activities in both populations of heart mitochondria in …

Going For Wood, Molly Vaux

Bryant Literary Review

I.

I would never have chosen a window seat, but there I was, staring at great banks of clouds while the plane, rocked by invisible currents, sailed upward.

Digging Into Algorithms: Legal Ethics And Legal Access, Carla L. Reyes, Jeff Ward

Faculty Journal Articles and Book Chapters

The current discussions around algorithms, legal ethics, and expanding legal access through technological tools gravitate around two themes: (1) protection of the integrity of the legal profession and (2) a desire to ensure greater access to legal services. The hype cycle often pits the desire to protect the integrity of the legal profession against the ability to use algorithms to provide greater access to legal services, as though they are mutually exclusive. In reality, the arguments around protecting the profession from the threats posed by algorithms represent an over-fit in relation to what algorithms can actually achieve, while the visions …

Eighth Amendment Values, William W. Berry Iii, Meghan J. Ryan

Faculty Journal Articles and Book Chapters

As with many constitutional provisions, the language of the Eighth Amendment is open-ended and vague in its proscription of excessive bail, excessive fines, and cruel and unusual punishments. Because the language of the Constitution does not provide any additional descriptive information concerning what might make bail or fines excessive, or punishments cruel and unusual, courts must look beyond the text itself to ascertain the meaning of the Eighth Amendment. With respect to the prohibition on cruel and unusual punishments, the U.S. Supreme Court has, over the course of several decades, articulated a number of relevant underlying values that offer some …

Microbial Degradation Of Urea Oligomers: Potential Slow Release Nitrogen Fertilizers, Maddy Bygd

Departmental Honors Projects

Urea is the most commonly used nitrogen compound in fertilizers across the world. It provides the most nitrogen at the lowest cost. However, with the size and solubility of this compound, it is easily washed out of the soil. This results in the need to continuously add fertilizer to fields, creating adverse effects on the environment due to nitrogen runoff and leading to increased expenses for farmers. Triuret, a urea oligomer, is a compound with promising potential for use as a nitrogen source, providing a slower release of nitrogen into the soil. It is hypothesized that this compound can be …

Just What The Doctor Ordered: Treatment Methods Of Homosexuality In Minnesota, 1920-1950, Paige Daniels

Departmental Honors Projects

In Minnesota, throughout the 19th century, the concept of homosexuality was associated with sin/illegality due to the strict religious ordinances and legislation passed with the intent to criminalize homosexuality. However, influenced by European notions, this correlation of morality and legality started expanding to a more medicalized perception. With a push to decriminalize homosexuality, much of the United States began to adopt the philosophy of homosexuality’s existence either as or because of an illness. While other studies have explored treatment methods practiced in the U.S. and Europe, this research focuses only on Minnesota history and its practices. An analysis of Minnesota …

Divine Satisficing And The Ethics Of The Problem Of Evil, Chris Tucker

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Rna Sequencing Of Human Peripheral Nerve In Response To Injury: Distinctive Analysis Of The Nerve Repair Pathways., Andrew S. Welleford, Jorge E. Quintero, Nader El Seblani, Eric Blalock, Sumedha Gunewardena, Steven M. Shapiro, Sean M. Riordan, Peter Huettl, Zain Guduru, John A. Stanford, Craig G. Van Horne, Greg A. Gerhardt

Manuscripts, Articles, Book Chapters and Other Papers

The development of regenerative therapies for central nervous system diseases can likely benefit from an understanding of the peripheral nervous system repair process, particularly in identifying potential gene pathways involved in human nerve repair. This study employed RNA sequencing (RNA-seq) technology to analyze the whole transcriptome profile of the human peripheral nerve in response to an injury. The distal sural nerve was exposed, completely transected, and a 1 to 2 cm section of nerve fascicles was collected for RNA-seq from six participants with Parkinson's disease, ranging in age between 53 and 70 yr. Two weeks after the initial injury, another …

Crispr Parents And Informed Consent, Naomi Cahn

SMU Science and Technology Law Review

No abstract provided.

Crispr And The Future Of Fertility Innovation, June R. Carbone

SMU Science and Technology Law Review

No abstract provided.

Wellness Measurement, Timothy P. Melchert

College of Education Faculty Research and Publications

Incorporating wellness into considerations of health, healthcare, and social policy has reached an exciting point. Aristotle, Buddha, and other philosophers, sages, and religious leaders throughout history developed great insights into the topic, but only in recent decades has the construct of wellness been examined and clarified through systematic empirical research. There are still major debates regarding several aspects of the topic, but it is now widely considered a measurable construct that should play a role in healthcare and social policy. This volume represents another step forward in bringing wellness into the mainstream of health and healthcare.

Wellness often means different …

Invertebrate Welfare In The Wild, Asher Soryl

Animal Sentience

Mikhalevich & Powell argue that certain cognitive-affective biases might distort people’s consideration of invertebrate minds and that the moral risks of false negatives in sentience research deserve greater consideration under precautionary frameworks. In this commentary, I draw comparisons between biases that concern wild animals and conditions in nature, arguing that the moral risks of disregarding the possible mental welfare of invertebrates are compounded by facts about their lives in the wild.

Sentience In Evolutionary Context, Jon Mallatt, Todd E. Feinberg

Animal Sentience

We appreciate the goals of Mikhalevich & Powell (M&P) and largely agree with their conclusions but we differ on some of their definitions and terms. Affects (emotional feelings) should be part of sentience. Although the evidence presented for insect sentience is strong, we list some of the counterevidence that should be considered. Our own research supports M&P’s choice of arthropods, cephalopods, and vertebrates as the only sentient organisms with moral status.

Moral Treatment For All, Eric Dietrich, Tara Fox Hall

Animal Sentience

There is no way to include invertebrates within the moral sphere without being “extreme” — to use Mikhalevich & Powell’s term. This is because of the profound difficulties in correctly attributing sentience. This commentary argues that we have a moral duty to be extreme.

Toward A Non-Anthropocentric View On The Environment And Animal Welfare: Possible Psychological Interventions, Sarah Gradidge, Magdalena Zawisza

Animal Sentience

Treves, Santiago-Avila, and Lynn (2019) argue for adopting a non-anthropocentric worldview to prevent further environmental damage and lack of consideration for animals. We discuss psychological interventions that might help achieve this.

China's Lack Of Animal Welfare Legislation Increases The Risk Of Further Pandemics, Amanda Whitfort

Animal Sentience

Legislation enforcing positive animal welfare standards provides an important buffer against the spread of disease when other safeguards to promote animal health have failed. The continuing absence of animal welfare legislation in China increases the risk of future pandemics, like COVID-19, and puts animal health, and consequently public health in danger.

Elephants And Pandemics, Adrian Treves

Animal Sentience

Baker & Winkler’s critique of Asian elephant tourism and conservation in Thailand has convinced me that this was “an industry with too many victims.” Yet I fear that B&W’s proposed remedy of returning to past elephant husbandry by Karen hill-peoples has little likelihood of improving the lives of the elephants for long. Who can predict whether the Karen will live up to this hope? B&W advocate for the Karen, but not for “an abolitionist stance on elephant-human relationships.” In my view, whether we discuss elephants or the wild mammals that carry SARS-CoV-2, abolition of many human uses of animals is …

Bromocriptine Improves Glucose Tolerance Independent Of Circadian Timing, Prolactin, Or The Melanocortin-4 Receptor, Sarah N. Framnes-Deboer, Ellen Bakke, Suma Yalamanchili, Hannah Peterson, Darleen A. Sandoval, Randy J. Seeley, Deanna M. Arble

Biological Sciences Faculty Research and Publications

Bromocriptine, a dopamine D2 receptor agonist originally used for the treatment of hyperprolactinemia, is largely successful in reducing hyperglycemia and improving glucose tolerance in type 2 diabetics. However, the mechanism behind bromocriptine’s effect on glucose intolerance is unclear. Here, we tested three hypotheses, that bromocriptine may exert its effects on glucose metabolism by 1) decreasing prolactin secretion, 2) indirectly increasing activity of key melanocortin receptors in the central nervous system, or 3) improving/restoring circadian rhythms. Using a diet-induced obese (DIO) mouse model, we established that a 2-wk treatment of bromocriptine is robustly effective at improving glucose tolerance. …

Distinct Patterns Of Pigment Development Underlie Convergent Hyperpigmentation Between Nocturnal And Diurnal Geckos (Squamata: Gekkota), Aaron H. Griffing, Tony Gamble, Aaron M. Bauer

Biological Sciences Faculty Research and Publications

Background

Evolutionary transitions in temporal niche necessitates specialized morphology, physiology, and behaviors. Diurnal, heliothermic squamates (lizards and snakes) that bask require protection from ultraviolet radiation (UV) that can damage internal organs such as the brain, viscera, and gonads. Many smaller squamates have accomplished this protection by hyperpigmentation of the peritoneum and subcutaneous dorsum. Typically, nocturnal species do not require these protections from ultraviolet light. However, some nocturnal species that exhibit extreme crypsis may be exposed to sunlight and UV and require some means of mediating that damage. One such species is Gekko (Ptychozoon) kuhli, a nocturnal, arboreal …

The Roman Martyrs: Introduction, Translations, And Commentary [Review] / Lapidge, Michael., Rodrigo Galiza

Andrews University Seminary Studies (AUSS)

Book Review