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2020

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Lactate-Protechypoglycemia (Lph), Matthew L Goodwin, L Bruce Gladden, Maarten W N Nijsten Jan 2020

Lactate-Protechypoglycemia (Lph), Matthew L Goodwin, L Bruce Gladden, Maarten W N Nijsten

Open Access Publications

Here, we provide an overview of the concept of a lactate-protected hypoglycemia ("LPH"), originally proposed as lowering glucose while simultaneously increasing lactate concentration as a method by which tumors might be targeted. Central to this hypothesis is that lactate can act as a critical salvage fuel for the central nervous system, allowing for wide perturbations in whole body and central nervous system glucose concentrations. Further, many tumors exhibit "the Warburg" effect, consuming glucose and producing and exporting lactate despite adequate oxygenation. While some recent data have provided evidence for a "reverse-Warburg," where some tumors may preferentially consume lactate, many of …

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Hypoxia Protects Rat Bone Marrow Mesenchymal Stem Cells Against Compression-Induced Apoptosis In The Degenerative Disc Microenvironment Through Activation Of The Hif-1a/Yap Signaling Pathway, Zhe Wang, Min Cui, Yanji Qu, Ruijun He, Wei Wu, Hui Lin, Zengwu Shao Jan 2020

Hypoxia Protects Rat Bone Marrow Mesenchymal Stem Cells Against Compression-Induced Apoptosis In The Degenerative Disc Microenvironment Through Activation Of The Hif-1a/Yap Signaling Pathway, Zhe Wang, Min Cui, Yanji Qu, Ruijun He, Wei Wu, Hui Lin, Zengwu Shao

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No abstract provided.

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Huntingtin-Interacting Protein Family Members Have A Conserved Pro-Viral Function From Caenorhabditis Elegans To Humans, Hongbing Jiang, Luis Enrique Sandoval Del Prado, Christian Leung, David Wang Jan 2020

Huntingtin-Interacting Protein Family Members Have A Conserved Pro-Viral Function From Caenorhabditis Elegans To Humans, Hongbing Jiang, Luis Enrique Sandoval Del Prado, Christian Leung, David Wang

Open Access Publications

No abstract provided.

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Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor Jan 2020

Discovery Of A Novel Simian Pegivirus In Common Marmosets (Callithrix Jacchus) With Lymphocytic Enterocolitis, Anna S. Heffron, Michael Lauck, Elizabeth D. Somsen, Elizabeth C. Townsend, Adam L. Bailey, Megan Sosa, Jens Eickhoff, Saverio Capuano Iii, Christina M. Newman, Jens H. Kuhn, Andres Mejia, Heather A. Simmons, David H. O'Connor

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No abstract provided.

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Mitochondrial Calcium Uniporter (Mcu) Defciency Reveals An Alternate Path For ­Ca2+ Uptake In Photoreceptor Mitochondria, Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff Jan 2020

Mitochondrial Calcium Uniporter (Mcu) Defciency Reveals An Alternate Path For ­Ca2+ Uptake In Photoreceptor Mitochondria, Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff

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No abstract provided.

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Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss Jan 2020

Six-Year Follow-Up Of A Trial Of Antenatal Vitamin D For Asthma Reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, Scott T. Weiss

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No abstract provided.

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Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al. Jan 2020

Generation Of Light-Producing Somatic-Transgenic Mice Using Adeno-Associated Virus Vectors, Rajvinder Karda, Jonathan D. Cooper, Et Al.

Open Access Publications

No abstract provided.

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Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick Jan 2020

Lack Of Neurosteroid Selectivity At Δ Vs. Γ2-Containing Gabaa Receptors In Dentate Granule Neurons, Xinguo Lu, Charles F Zorumski, Steven Mennerick

Open Access Publications

GABA

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Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett Jan 2020

Improved Small Blob Detection In 3d Images Using Jointly Constrained Deep Learning And Hessian Analysis, Yanzhe Xu, Teresa Wu, Fei Gao, Jennifer R. Charlton, Kevin M. Bennett

Open Access Publications

No abstract provided.

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Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody Jan 2020

Live Neuron High-Content Screening Reveals Synaptotoxic Activity In Alzheimer Mouse Model Homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, David L. Brody

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No abstract provided.

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Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li Jan 2020

Comparison Of Three Magnetization Transfer Ratio Parameters For Assessment Of Intestinal Fibrosis In Patients With Crohn’S Disease, Jixin Meng, Siyun Huang, Canhui Sun, Zhong-Wei Zhang, Ren Mao, Yan-Hong Yang, Shi-Ting Feng, Zi-Ping Li, Xuehua Li

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No abstract provided.

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Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley Jan 2020

Remethylation Of Dnmt3a−/− Hematopoietic Cells Is Associated With Partial Correction Of Gene Dysregulation And Reduced Myeloid Skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, Timothy J. Ley

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No abstract provided.

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Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner Jan 2020

Nutrition In Necrotizing Enterocolitis And Following Intestinal Resection, Jocelyn Ou, Cathleen M Courtney, Allie E Steinberger, Maria E Tecos, Brad W Warner

Open Access Publications

This review aims to discuss the role of nutrition and feeding practices in necrotizing enterocolitis (NEC), NEC prevention, and its complications, including surgical treatment. A thorough PubMed search was performed with a focus on meta-analyses and randomized controlled trials when available. There are several variables in nutrition and the feeding of preterm infants with the intention of preventing necrotizing enterocolitis (NEC). Starting feeds later rather than earlier, advancing feeds slowly and continuous feeds have not been shown to prevent NEC and breast milk remains the only effective prevention strategy. The lack of medical treatment options for NEC often leads to …

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A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al Jan 2020

A Single-Nucleotide Polymorphism In A Plasmodium Berghei Apiap2 Transcription Factor Alters The Development Of Host Immunity, Munir Akkaya, Patrick W Sheehan, Et Al

Open Access Publications

The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite

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A Spinal Neural Circuitry For Converting Touch To Itch Sensation, Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen Jan 2020

A Spinal Neural Circuitry For Converting Touch To Itch Sensation, Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen

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No abstract provided.

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Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah Jan 2020

Altered Outer Hair Cell Mitochondrial And Subsurface Cisternae Connectomics Are Candidate Mechanisms For Hearing Loss In Mice, Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C. Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N. Yamoah

Open Access Publications

Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca

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Satellite Glial Cells Promote Regenerative Growth In Sensory Neurons, Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli Jan 2020

Satellite Glial Cells Promote Regenerative Growth In Sensory Neurons, Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli

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No abstract provided.

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Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya Jan 2020

Braf Alteration In Central And Peripheral Nervous System Tumors, Komal Srinivasa, Kevin A Cross, Sonika Dahiya

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No abstract provided.

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Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak Jan 2020

Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation And Immunity, Min Xu, Wei Yang, Xuanchuan Wang, Deepak Kumar Nayak

Open Access Publications

Alveolar macrophage (AM) is a mononuclear phagocyte key to the defense against respiratory infections. To understand AM's role in airway disease development, we examined the influence of Secretoglobin family 1a member 1 (SCGB1A1), a pulmonary surfactant protein, on AM development and function. In a murine model, high-throughput RNA-sequencing and gene expression analyses were performed on purified AMs isolated from mice lacking in

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Deconstructing Tumor Heterogeneity: The Stromal Perspective, Renee E. Vickman, Douglas V. Faget, Sheila A. Stewart, Et Al Jan 2020

Deconstructing Tumor Heterogeneity: The Stromal Perspective, Renee E. Vickman, Douglas V. Faget, Sheila A. Stewart, Et Al

Open Access Publications

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive

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Orsay Virus Cp-Δ Adopts A Novel Β-Bracelet Structural Fold And Incorporates Into Virions As A Head Fiber, Yusong R. Guo, Yanlin Fan, Ying Zhou, Miao Jin, Jim L. Zhang, Hongbing Jiang, Matthew V. Holt, Tao Wang, Nicolas L. Young, David Wang, Weiwei Zhong, Yizhi J. Tao Jan 2020

Orsay Virus Cp-Δ Adopts A Novel Β-Bracelet Structural Fold And Incorporates Into Virions As A Head Fiber, Yusong R. Guo, Yanlin Fan, Ying Zhou, Miao Jin, Jim L. Zhang, Hongbing Jiang, Matthew V. Holt, Tao Wang, Nicolas L. Young, David Wang, Weiwei Zhong, Yizhi J. Tao

Open Access Publications

Fiber proteins are commonly found in eukaryotic and prokaryotic viruses, where they play important roles in mediating viral attachment and host cell entry. They typically form trimeric structures and are incorporated into virions via noncovalent interactions. Orsay virus, a small RNA virus which specifically infects the laboratory model nematode

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Sex Differences In Population Dynamics During Formation Of Kidney Bacterial Communities By Uropathogenic Escherichia Coli, Lisa K. Mclellan, Allyssa L. Daugherty, David A. Hunstad Jan 2020

Sex Differences In Population Dynamics During Formation Of Kidney Bacterial Communities By Uropathogenic Escherichia Coli, Lisa K. Mclellan, Allyssa L. Daugherty, David A. Hunstad

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No abstract provided.

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Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, And Associated Risk Factors Among Young Children In Rural Ethiopia: A Cross-Sectional Study From The Campylobacter Genomics And Environmental Enteric Dysfunction (Caged) Project, Dehao Chen, Mark J Manary, Et Al Jan 2020

Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, And Associated Risk Factors Among Young Children In Rural Ethiopia: A Cross-Sectional Study From The Campylobacter Genomics And Environmental Enteric Dysfunction (Caged) Project, Dehao Chen, Mark J Manary, Et Al

Open Access Publications

Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by

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Cd4 Inhibits Helper T Cell Activation At Lower Affinity Threshold For Full-Length T Cell Receptors Than Single Chain Signaling Constructs, Deborah K Johnson, Wyatt Magoffin, Sheldon J Myers, Jordan G Finnell, John C Hancock, Taylor S Orton, Stephen P Persaud, Kenneth A Christensen, K Scott Weber Jan 2020

Cd4 Inhibits Helper T Cell Activation At Lower Affinity Threshold For Full-Length T Cell Receptors Than Single Chain Signaling Constructs, Deborah K Johnson, Wyatt Magoffin, Sheldon J Myers, Jordan G Finnell, John C Hancock, Taylor S Orton, Stephen P Persaud, Kenneth A Christensen, K Scott Weber

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CD4

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Insights From Genetic Studies Of Cerebral Palsy, Sara A Lewis, Sheetal Shetty, Bryce A Wilson, Aris J Huang, Sheng Chih Jin, Hayley Smithers-Sheedy, Michael C Fahey, Michael C Kruer Jan 2020

Insights From Genetic Studies Of Cerebral Palsy, Sara A Lewis, Sheetal Shetty, Bryce A Wilson, Aris J Huang, Sheng Chih Jin, Hayley Smithers-Sheedy, Michael C Fahey, Michael C Kruer

Open Access Publications

Cohort-based whole exome and whole genome sequencing and copy number variant (CNV) studies have identified genetic etiologies for a sizable proportion of patients with cerebral palsy (CP). These findings indicate that genetic mutations collectively comprise an important cause of CP. We review findings in CP genomics and propose criteria for CP-associated genes at the level of gene discovery, research study, and clinical application. We review the published literature and report 18 genes and 5 CNVs from genomics studies with strong evidence of for the pathophysiology of CP. CP-associated genes often disrupt early brain developmental programming or predispose individuals to known …

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Nonmicrobial Activation Of Tlrs Controls Intestinal Growth, Wound Repair, And Radioprotection, William F Stenson, Matthew A Ciorba Jan 2020

Nonmicrobial Activation Of Tlrs Controls Intestinal Growth, Wound Repair, And Radioprotection, William F Stenson, Matthew A Ciorba

Open Access Publications

TLRs, key components of the innate immune system, recognize microbial molecules. However, TLRs also recognize some nonmicrobial molecules. In particular, TLR2 and TLR4 recognize hyaluronic acid, a glycosaminoglycan in the extracellular matrix. In neonatal mice endogenous hyaluronic acid binding to TLR4 drives normal intestinal growth. Hyaluronic acid binding to TLR4 in pericryptal macrophages results in cyclooxygenase2- dependent PGE

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Regulatory T Cells Developing Peri-Weaning Are Continually Required To Restrain Th2 Systemic Responses Later In Life, Kathryn A. Knoop, Keely G Mcdonald, Chyi-Song Hsieh, Phillip I Tarr, Rodney D Newberry Jan 2020

Regulatory T Cells Developing Peri-Weaning Are Continually Required To Restrain Th2 Systemic Responses Later In Life, Kathryn A. Knoop, Keely G Mcdonald, Chyi-Song Hsieh, Phillip I Tarr, Rodney D Newberry

Open Access Publications

Atopic disorders including allergic rhinitis, asthma, food allergy, and dermatitis, are increasingly prevalent in Western societies. These disorders are largely characterized by T helper type 2 (Th2) immune responses to environmental triggers, particularly inhaled and dietary allergens. Exposure to such stimuli during early childhood reduces the frequency of allergies in at-risk children. These allergic responses can be restrained by regulatory T cells (Tregs), particularly Tregs arising in the gut. The unique attributes of how early life exposure to diet and microbes shape the intestinal Treg population is a topic of significant interest. While imprinting during early life promotes the development …

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Advances In Modeling The Immune Microenvironment Of Colorectal Cancer, Paul Sukwoo Yoon, Nuala Del Piccolo, Venktesh S Shirure, Yushuan Peng, Amanda Kirane, Robert J Canter, Ryan C Fields, Steven C George, Sepideh Gholami Jan 2020

Advances In Modeling The Immune Microenvironment Of Colorectal Cancer, Paul Sukwoo Yoon, Nuala Del Piccolo, Venktesh S Shirure, Yushuan Peng, Amanda Kirane, Robert J Canter, Ryan C Fields, Steven C George, Sepideh Gholami

Open Access Publications

Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related death in the US. CRC frequently metastasizes to the liver and these patients have a particularly poor prognosis. The infiltration of immune cells into CRC tumors and liver metastases accurately predicts disease progression and patient survival. Despite the evident influence of immune cells in the CRC tumor microenvironment (TME), efforts to identify immunotherapies for CRC patients have been limited. Here, we argue that preclinical model systems that recapitulate key features of the tumor microenvironment-including tumor, stromal, and immune cells; the extracellular matrix; and the vasculature-are …

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Ige And T Cell Reactivity To A Comprehensive Panel Of Cockroach Allergens In Relation To Disease, Anna Pomés, Véronique Schulten, Jill Glesner, Ricardo Da Silva Antunes, Aaron Sutherland, Leonard B Bacharier, Avraham Beigelman, Paula Busse, April Frazier, Alessandro Sette Jan 2020

Ige And T Cell Reactivity To A Comprehensive Panel Of Cockroach Allergens In Relation To Disease, Anna Pomés, Véronique Schulten, Jill Glesner, Ricardo Da Silva Antunes, Aaron Sutherland, Leonard B Bacharier, Avraham Beigelman, Paula Busse, April Frazier, Alessandro Sette

Open Access Publications

IgE sensitization to cockroach allergens is associated with development of allergic diseases, such as asthma. To understand the relevance of different cockroach allergens for diagnosis and immunotherapy, a comprehensive analysis of IgE antibody levels and T cell reactivity to an expanded set of cockroach allergens and their relationship to disease was performed in a cohort of USA cockroach sensitized patients. IgE antibody levels to recombinant chitinase and hemocyanin were measured for 23 subjects by custom-made ImmunoCAPs and compared with IgE levels to eight cockroach allergens we previously reported for the same cohort.

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Toxic Effects Of Endoplasmic Reticulum Stress Transducer Bbf2h7-Derived Small Peptide Fragments On Neuronal Cells, Koji Matsuhisa, Longjie Cai, Atsushi Saito, Fumika Sakaue, Yasunao Kamikawa, Sachiko Fujiwara, Rie Asada, Yukitsuka Kudo, Kazunori Imaizumi Jan 2020

Toxic Effects Of Endoplasmic Reticulum Stress Transducer Bbf2h7-Derived Small Peptide Fragments On Neuronal Cells, Koji Matsuhisa, Longjie Cai, Atsushi Saito, Fumika Sakaue, Yasunao Kamikawa, Sachiko Fujiwara, Rie Asada, Yukitsuka Kudo, Kazunori Imaizumi

Open Access Publications

No abstract provided.

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