Digital Commons Network^™

Sympathy For The Microbiota: How Changes In Gut Microbial Composition Influence The Immune System And Basic Physiology By Way Of The Sympathetic Nervous System, Paul Andrew Muller

Student Theses and Dissertations

The gastro-intestinal tract is the most extensive mucosal surface in mammals and harbors the most numerous immune cell reservoir as well as a complex and autonomous nervous system. The GI tract is continuously exposed to foreign antigen and potentially toxic chemicals through the ingestion of food. In addition, the lumen of the human GI tract is populated with approximately 1013 bacteria, which is equivalent to the number of cells in the entire human body (Sender et al., 2016). The intestinal microbiome, which aids in host metabolism, represents a diverse population of microorganisms separated from the inside of the body by …

Green Space Ideas And Practices In European Cities, Mike Kohout, Jan Kopp

Geography and Environmental Studies Faculty Publications

No abstract provided.

Why Do Cognitive Prompts Hurt Learning In Older Adults?, Kurt Kraiger, Thomas M. Cavanagh, Collin M. G. Willis

Barowsky School of Business | Faculty Scholarship

The purposes of the present investigation were to attempt to replicate the negative effects for learning prompts in older adults reported by Cavanagh, Kraiger and Peters (2016), determine if the impact of learning prompts depends on type of prompt, and investigate the two possible explanations of the negative impact of prompts – increased cognitive load and higher negative affect. Learning prompts refer to short text inserted into training content to encourage trainees to rehearse new content or engage in meta‐cognitive activity. Although learning prompts generally lead to greater learning in training, Cavanagh et al. reported a negative impact for prompts …

Jefferson Digital Commons Quarterly Report: October-December 2019, Kelsey Duinkerken, Msi, James Copeland, Libt, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Dean's Research Development Lunch Conference
• Dissertations
• Educational Materials
• From the Archives
• Grand Rounds and Lectures
• Journals and Newsletters
• Population Health Presentation Materials
• Posters
• Reports
• Symposiums
• What People are Saying About the Jefferson Digital Commons

The Effect Of Advanced Glycation End Products (Ages) On Macrophages, And Their Implications For Prostate Cancer Progression, Callan C. Frye

MUSC Theses and Dissertations

Advanced glycation end products (AGEs) are sugar-protein adducts that may worsen cancer severity and may contribute to health disparity outcomes among prostate cancer (PCa) patients. AGEs are formed endogenously via a slow, nonenzymic reaction; however, AGEs are also formed in foods as a result of subjecting meats and sugars to high-heat conditions. AGEs are therefore prolific in the Western Pattern Diet (WPD), which has become increasingly common among industrialized nations. Previous work has identified dietary AGE as contributing to MYC-driven PCa progression, and the dependence of this process upon stromal receptor for advanced glycation end products (RAGE). This study therefore …

Sublimating Municipal Home Rule And Separation Of Powers In Knick V. Township Of Scott, Robert H. Thomas

Fordham Urban Law Journal

No abstract provided.

The 2018 Pan-Canadian Securities Regulation Reference: Dualist Federalism To The Rescue Of Cooperative Federalism, Johanne Poirier

The Supreme Court Law Review: Osgoode’s Annual Constitutional Cases Conference

In 2018, the impact of Canadian federalism on securities regulation returned one more time to the Supreme Court of Canada. In its Reference re Pan-Canadian Securities Regulation, the Court had once more to clarify “who can do what” with regards to capital markets. But it was also tasked with assessing the normative instruments through which federal partners were attempting to act in a coordinated fashion. The Court’s advisory opinion offers a relatively predictable interpretation of the division of powers in economic matters, and more specifically, the scope of federal jurisdiction over “Trade and Commerce”. However, more significantly, the reference raised …

Mast Cells As Novel Effector Cells In The Pathogenesis Of Chronic Graft-Versus-Host Disease, Ethan Strattan

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Hematopoietic stem cell transplantation (HSCT) is most commonly a treatment for inborn defects of hematopoiesis or acute leukemias. Widespread use of HSCT, a potentially curative therapy, is hampered by onset of graft-versus-host-disease (GVHD), a condition wherein the donor cells recognize the patient tissues as non-self. GVHD can manifest anywhere from weeks to decades post-transplant and is classified as either acute or chronic GVHD, both of which are significant causes of transplant-related morbidity and mortality.

However, GVHD is a complex, multifactorial, and enigmatic disease. The factors driving GVHD at the cellular and molecular level are incompletely understood. Immunosuppression targeting T-cells has …

2020 Comencement Program, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2020 commencement programs of Morehead State University.

“Innocent Bystanders”: White Guilt And The Destruction Of Native Americans In Us Literature, 1824-1830, Noor Al-Attar

Theses and Dissertations--English

Stereotypes describing the Native Peoples as lacking in many attributes such as religion, civilization, self-control, and even family bonds originated in the early years of contact, popularized through captivity narratives, and used in nineteenth century writings to justify the “vanishing” of the Native people. My dissertation adds to the discussion of myth of the Vanishing American by focusing on overlooked representations of Native illness. Illness, a shared human experience, was preserved for white characters in white authors’ writings. Ailing Native peoples were either denied any stories narrating this experience of human vulnerability or were depicted as resorting to superstitious and …

Expectation Versus Reality: Star Trek, Nyota Uhura, And The Female Role, Cecelia Otto-Griffiths

All Graduate Theses, Dissertations, and Other Capstone Projects

In a media saturated world, there is an abundance of stereotypes perpetuated for women. Since the late 1960’s, however, Star Trek has been one example of how television and film can challenge stereotypes and what is considered normal. This study sought to understand the extent of change in how women’s physical and role representations are presented through the artifact of Lt. Uhura in the 1979 film Star Trek: The Motion Picture and the 2016 film Star Trek: Beyond. Using feminist theory as a lens to conduct a content analysis of these films, this study used frequently identified “feminine” characteristics in …

Improving Educational Attainment For Girls: A Case Study Of One Rural Kenyan School, Eloise Hockett

Faculty Publications - College of Education

The purpose of this qualitative study was to examine one rural Kenyan community’s attempts to improve the educational attainment for primary school girls in the region. Data were gathered through field notes; school artifacts; and interviews with teachers, community members, and grade eight girls. The asset-building theory of change (social, human, physical, and economic) was used to analyze the barriers to education, solutions to those barriers, and results from those solutions. Although some research studies of school improvements in Kenya exist, this research addresses a critical gap in understanding how even small improvements in a school can positively impact educational …

The Impact Of Parent Education With Augmentative And Alternative Communication, Kirsta Von Hellens

Occupational Therapy Doctorate Capstone Projects

Communication is an essential part of who we are, as we participate in our occupational roles, even for those who utilize augmentative and alternative communication. The purpose of this project was to evaluate the impact of a parental training program, as parents utilized a communication device, in order to increase the number of opportunities for their child to engage with and participate with at home and in the community. This project utilized the Human Activity Assistive Technology and the Person, Environment, Occupation, and Performance model. A descriptive mixed methods case study with a sequential exploratory design was used in this …

Salamander Stress And Duress: The Relationship Between Cort, Autotomy And Regeneration, And Exploratory Behaviour, Aaron M. Sullivan, Jacquelyn L. Lewis

Faculty Publications - Department of Biological & Molecular Science

Responses to stress are generally mediated through the production of glucocorticoids by the hypothalamic-pituitary-adrenal (or -interrenal) axis. The prolonged production of stress hormones can contribute to delayed wound healing and growth, but little is known about their influence on regeneration following tail autotomy, or exploratory behaviour in autotomized individuals. Here we examined the relationship between stress, re-generation, and exploratory behaviour in Allegheny Mountain dusky salamanders (Desmognathus ochrophaeus) by manipulating corticosterone (CORT) levels via cutaneous patch. First, we measured tail regeneration in salamanders with elevated CORT for 13 weeks after the induction of tail autotomy. Test subjects received a weekly patch …

Modulation Of Receptor Interacting Protein Kinase 1 (Ripk1) Signaling During Dengue Virus Infection, Darshika Jeewanthi Udawatte

Open Access Dissertations

Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease. There are estimated 100 million symptomatic cases of dengue disease per year worldwide. A lack of effective antiviral therapies or vaccines makes DENV infections a major global health concern. Therefore, understanding the viral and host factors contributing to the disease pathogenesis is critical. DENV has been shown to effectively counteract host innate immune mechanisms. In particular, DENV protease, NS3 has emerged as an inhibitor of host cellular signaling by targeting crucial host proteins. Here we identified RIPK1 as a novel target of DENV NS3. RIPK1 is a central mediator …

The Frequent Flyer’S Guide To Migration: How Songbird Metabolism And Oxidative Status Respond To Endurance Flight And Diet Quality, Kristen J. Demoranville

Open Access Dissertations

Migratory songbirds are among the best high-performance endurance athletes on the planet and during their annual peregrinations they are particularly vulnerable to oxidative damage because they maintain relatively high metabolic rates at rest, they are able to fly for long durations while operating at 9 times their resting metabolic rate, and they rely on fats to fuel this exercise which increases reactive oxygen species (ROS) formation. The concept of evolutionary economic design of physiological systems considers such phenotypic flexibility in metabolic and antioxidant responses adaptive in that it allows birds to match the capacity of key physiological systems to prevailing …

Design And Validation Of Smart Fabric Sensors Based On Semiconductive Polymer Composites, Arar Alkhader

Open Access Dissertations

Smart Fabric Sensors (SFSs) have recently gained much interest as they are convenient as a long-term wearable as well as for their simplicity, lightweight, low manufacturing cost, high sensitivity, and flexibility. Semiconductive polymer composites SCPCs can be used as smart fabrics to create force or pressure sensors based on the piezoresistive effect, however, their wider application is limited due to their narrow sensing range, hysteresis and output drift issues as well as due to the lack of literature studying their voltage response related errors especially under high impact forces. In this Doctoral research, eight proposed designs of a smart fabric …

On The Chirp Function, The Chirplet Transform And The Optimal Communication Of Information, Jonathan Blackledge

Articles

—The purpose of this extended paper is to provide a review of the chirp function and the chirplet transform and to investigate the application of chirplet modulation for digital communications, in particular, the transmission of binary strings. The significance of the chirp function in the solution to a range of fundamental problems in physics is revisited to provide a background to the case and to present the context in which the chirp function plays a central role, the material presented being designed to show a variety of problems with solutions and applications that are characterized by a chirp function in …

Northern Plains Resource Council V. United States Army Corps Of Engineers, Liz M. Forster

Public Land & Resources Law Review

Environmental activist and indigenous rights groups have challenged the validity of the Keystone XL Pipeline since its initial approval in 2010. In April 2020, less than a month after crews broke ground, the opposing groups notched a major win when the United States District Court for the District of Montana revoked a key permit for the project on the grounds that the United States Army Corps of Engineers had inadequately assessed the pipeline’s impact on endangered species.

The Death Of Administrative Democracy, Joshua Ulan Galperin

Elisabeth Haub School of Law Faculty Publications

Everybody agrees. Everybody is certain. There are no elected bureaucrats.

That pervasive certainty must come as quite a surprise to elected bureaucrats.

The federal bureaucracy presents examples of administrative elections, but the most significant is the United States Department of Agriculture’s elected farmer committees. There are over 7,500 elected farmers sitting on over 2,000 committees, and these committees carry out paradigmatic administrative duties including policymaking and adjudication.

Taking for granted that administrators are unelected, judges have shaped an ascendant doctrine of Presidentialism. This doctrine presumes that the administrative state is only legitimate insofar as it is under the direct control …

Constitutionalizing Nature's Law: Dignity And The Regulation Of Biotechnology In Switzerland, James Toomey

Elisabeth Haub School of Law Faculty Publications

The Swiss Constitution was amended by referendum in 1992 to include two unique provisions: Article 119, which imposes strict limits on genetic and reproductive technologies in humans in order to protect ‘human dignity’, and Article 120, which commits the Swiss federal government to limiting genetic technologies in non-human species on the basis of the ‘dignity of the creature’. This article analyzes the role of ‘dignity’ as a limit on biotechnologies in the Swiss constitutional order. It concludes that the understanding of dignity the constitution embraces codifies a contestable metaphysical theory of value at the constitutional level. Specifically, the Swiss constitutional …

Dehumanization 'Because Of Sex': The Multiaxial Approach To The Title Vii Rights Of Sexual Minorities, Shirley Lin

Elisabeth Haub School of Law Faculty Publications

Although Title VII prohibits discrimination against any employee “because of such individual’s . . . sex,” legal commentators have not yet accurately appraised Title VII’s trait and causation requirements embodied in that phrase. Since 2015, most courts assessing the sex discrimination claims of LGBT employees began to intentionally analyze “sex” as a trait using social-construction evidence, and evaluated separately whether the discriminatory motive caused the workplace harm. Responding to what this Article terms a “doctrinal correction” to causation within this groundswell of decisions, the Supreme Court recently issued an “expansive” and “sweeping” reformulation of but-for causation in Bostock v. Clayton …

Paradox Of Hierarchy And Conflicts Of Values: International Law, Human Rights, And Global Governance, Jootaek Lee

Northwestern Journal of Human Rights

In an international society, hierarchies are set up differently among different countries and societies based on different values, which are naturally conflicting and colliding with each other and result in unstable conditions. Is hierarchy really necessary in an international society? Does more hierarchical order in international society mean more peace? Do we need a supranational organization like the European Union whose laws can pierce state sovereignty and bind citizens of each member state? Does the United Nations need to be reformed to create an effective hierarchy, which will give international society more peace, security, and protection of human rights? This …

Gardner-Webb, The Magazine 2020, Fall (Volume 55), Noel T. Manning

Gardner-Webb, The Magazine

Gardner-Webb, The Magazine, previously titled The Webb Magazine, focuses on alumni news and campus events from Gardner-Webb College; now Gardner-Webb University. This issue includes articles on the COIVD-19 pandemic, alumnus Clayton King's mission work in Africa, GWU students standing against racism, the installation of new football coach Tre Lamb, the Fay Webb Gardner Collection and O. Max Gardner Foundation, and the Brinkley gift of the GWU Marching Band uniforms.

Issue was awarded the Davey Award. The Davey is sanctioned and judged by the Academy of Interactive and Visual Arts.

Development Of Thermoplastic Polyurethane/Polyaniline-Doped Membranes Forthe Separation Of Glycine Through Electrodialysis, Khurram ., Asif Ali Qaiser, Rashid Saleem, Naveed Shahzad Ali, Shahbaz Nazir, Tousif Hussain, Abdul Ghaffar

Turkish Journal of Chemistry

Recently, membrane-based separation processes, particularly electrodialysis, have attracted attention for the separation and purification of organic and amino acids from animal feedstock waste. In this study, cation exchange membranes were synthesized by making a composite of thermoplastic polyurethane and polyaniline (PANI) via the doping of various aromatic sulfonic acids, such as ß -naphthol sulfonic acid and phenol sulfonic acid. The PANI was prepared using a standard method, which was further used in the composite blending at varying concentrations of 10%- 20%. The impact of the concentration of PANI and the nature of the dopant on the membrane characteristics were comparatively …

Choline Derivatives Immobilized On Silica To Catalyze Transesterification Reaction For Production Of Glycerophosphocholine, Longhui Wei, Binglin Li, Xiaoli Zhang, Kai Tang, Wenwen Zheng, Dan Chen, Binxia Zhao

Turkish Journal of Chemistry

Choline derivatives were covalently immobilized on the surface of γ -aminated silica. The obtained immobilized choline derivative was then successfully used for a transesterification reaction to produce glycerophosphocholine (GPC). Fourier transform infrared analysis and thermogravimetric analysis/differential thermal gravimetry indicated that the surface of the γ -aminated silica was covered by choline derivatives and the highest immobilization amount reached 1.1 mmol/g under optimal conditions. More importantly, the highest yield of GPC reached 97.9% during transesterification. With regard to GPC in food or medicine for human use, the immobilization technology can avoid catalyst contamination of the product and increase the safety of …

Investigation Of The Effect Of Pan And Pan/Zno Photocatalysts On 100% Degradation Of Congo Red Under Uv Visible Light Irradiation And Lightless Environment, Si̇bel Zor, Bi̇lge Budak

Turkish Journal of Chemistry

PAn (polyaniline) and PAn/ZnO photocatalysts were synthesized using chemical polymerization of aniline. The structure characterization of the synthesized samples was analysed by using X-ray diffraction (XRD), Fourier transforminfraredspectroscopy(FT-IR),scanningelectronmicroscopy(SEM),transmissionelectronmicroscopy(TEM), and UV-Vis spectroscopy measurements, and thermal gravimetric analysis (TGA). The photocatalytic activities of PAn and PAn/ZnO (0.1g/100ml) on the degradation of the Congo red (CR) dye were studied under the UV visible light irradiation and the lightless environment and the efficiency of catalysts have been explained in details. Contribution of UV visible light irradiation on the 100% degradation of CR dye for the PAn and PAn/ZnO photocatalyst is determined. The reaction kinetics …

2-[(3-Aminoalkyl-(Alkaryl-,Aryl-))-1 H-1,2,4-Triazol-5-Yl]Anilines: Synthesis And Anticonvulsant Activity, Yulya Martynenko, Galina Berest, Nina Bukhtiayrova, Igor Belenichev, Oleksiy Voskoboinik, Sergiy Kovalenko

Turkish Journal of Chemistry

The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1$H$-1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure) and acid hydrolysis of corresponding $N$-acylated {([1,2,4]triazolo[1,5-$c$]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)} amines. The regioselectivity of hydrazinolysis and hydrolysis were established. The features of spectral characteristics were studied and discussed. Characteristic patterns of protons signals splitting in $^{1}$H NMR of the synthesized compounds were established. The effect of the synthesized compounds on the pentylenetetrazol seizures was studied. It was found that according to some indicators, anticonvulsant activity of 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1$H$-1,2,4-triazolo]anilines superior or comparable with effect of the reference drug "Lamotrigine". It …

A Review: A Comparison Of Different Adsorbents For Removal Of Cr (Vi), Cd (Ii) And Ni (Ii), Anja Pfeifer, Mojca Skerget

Turkish Journal of Chemistry

A review of the studies dealing with the removal of chromium, cadmium, and nickel ions with different adsorbents published in the literature between 2014 and 2018 is given in tabular form, along with the adsorption conditions, adsorption isotherm, and kinetic models applied by the authors to model the experimental data and adsorption capacities. The review focuses on the efficiency of ion removal.

Evaluation Of A Novel Nanocrystalline Hydroxyapatite Powder And A Solid Hydroxyapatite/Chitosan-Gelatin Bioceramic For Scaffold Preparation Used As A Bone Substitute Material, Sharmin Rahman, Kazi Hanium Maria, Mohammad Saif Ishtiaque, Arijun Nahar, Harinarayan Das, Sheikh Manjura Hoque

Turkish Journal of Chemistry

Artificially fabricated hydroxyapatite (HAP) shows excellent biocompatibility with various kinds of cells and tissues which makes it an ideal candidate for a bone substitute material. In this study, hydroxyapatite nanoparticles have been prepared by using the wet chemical precipitation method using calcium nitrate tetra-hydrate [Ca(NO$_{3})_{2}$.4H$_{2}$O] and di-ammonium hydrogen phosphate [(NH$_{4})_{2}$HPO$_{4}$] as precursors. The composite scaffolds have been prepared by a freeze-drying method with hydroxyapatite, chitosan, and gelatin which form a 3D network of interconnected pores. Glutaraldehyde solution has been used in the scaffolds to crosslink the amino groups ($\vert $NH$_{2})$ of gelatin with the aldehyde groups ($\vert $CHO) of chitosan. …