Digital Commons Network^™

Low Cost Graphene Oxide Aerogels For The Removal Of Pb+2 From Drinking Water, S Awan, J Bloor, D Jenkins, R Handy

School of Engineering, Computing and Mathematics

No abstract provided.

Hemizygous Uba5 Missense Mutation Unmasks Recessive Disorder In A Patient With Infantile-Onset Encephalopathy, Acquired Microcephaly, Small Cerebellum, Movement Disorder And Severe Neurodevelopmental Delay, Karen J. Low, J. Baptista, M. Babiker, R. Caswell, C. King, S. Ellard, I. Scurr

Peninsula Medical School

Introduction Ubiquitin-fold modifier 1 (UFM1) is involved in the post-translational modification of proteins and has been implicated in various human diseases (Padala et al., 2017). UFM1 is ubiquitously expressed and has been demonstrated to play a crucial role in cellular stress response and has also been implicated in cancer pathways (Daniel and Liebau, 2014). However the role of the UFM1 cascade in the nervous system is not well understood. In order for proteins to be modified by ufmylation, UFM1 must first be activated by UBA5, a non-canonical E1 activating enzyme, then transferred to an E2 enzyme (UFC1 in the case …

Book Review: Jonathan P. Thompson, River Of Lost Souls: The Science, Politics, And Green Behind The Gold King Mine Disaster (2018), Clifford J. Villa

Faculty Scholarship

On August 5, 2015, contractors for the U.S. Environmental Protection Agency (EPA) investigating the Gold King Mine in southwestern Colorado accidently released some three million gallons of contaminated water into the Animas River, triggering weeks of front-page headlines, months of congressional hearings, and now years of litigation. River of Lost Souls: The Science, Politics, and Greed Behind the Gold King Mine Disaster, a new book by Jonathan P. Thompson, suggests by its title a human folly behind this “disaster” much broader and deeper than one tragic accident wrought by EPA contractors. On this thesis, Thompson certainly delivers. However, what …

Can A State's Water Rights Be Damned? Environmental Flows And Federal Dams In The Supreme Court, Reed D. Benson

Faculty Scholarship

Interstate rivers are subject to the doctrine of equitable apportionment, whereby the Supreme Court seeks to ensure that all states that share such rivers get a fair portion of their benefits. The Court has rarely issued an equitable apportionment decree, however, and there is little law on whether the doctrine protects river flows for environmental purposes. The ongoing Florida v. Georgia litigation in the Supreme Court raises this issue, as Florida seeks to limit consumptive uses by upstream Georgia to preserve flows in the Apalachicola River, which provide both economic and environmental benefits. This Article summarizes both the equitable apportionment …

It’S Still Me: Safeguarding Vulnerable Transgender Elders, Sarah Steadman

Faculty Scholarship

Transgender individuals have many reasons to be concerned about their welfare in the current political and legislative climate. Transgender elders are especially vulnerable. They are more likely to be disabled than the general elder population. Moreover, transgender elders profoundly fear a future when they must rely on others to maintain and protect their gender identity and dignity. This fear is alarmingly realistic because if a transgender elder becomes incapacitated or requires institutional care, they are likely to face discrimination and other harms by their caretakers. In addition, transgender elders who are incapacitated are particularly at-risk if a non-affirming guardian is …

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …

Motion In The Ocean – Paradigm Shift In Movement Ecology Requires “Sedentary” Organisms To Be Redefined, Emma V. Sheehan

School of Biological and Marine Sciences

No abstract provided.

The Importance Of Inter‐Individual Variation In Predicting Species' Responses To Global Change Drivers, Ella Guscelli, John I. Spicer, Piero Calosi

School of Biological and Marine Sciences

No abstract provided.

Evaluating Judicial Standards Of Conduct In The Current Political And Social Climate: The Need To Strengthen Impropriety Standards And Removal Remedies To Include Procedural Justice And Community Harm, Joshua E. Kastenberg

Faculty Scholarship

Chief Justice Warren Burger warned that when “people who have long been exploited . . . come to believe that courts cannot vindicate their legal rights from fraud,” an “incalculable damage [is done] to society.”

Part I of this Article presents an examination of the current common frameworks shared by the states for addressing judicial conduct appealing to popular social and political influences. Included in this section is an analysis of the interrelationship between implicit bias and impropriety, as well as on community harm and procedural justice.

Part II provides both a historical and contemporary analysis of “populism,” including the …

Efficacy Of Non-Pharmacological Interventions To Treat Malnutrition In Older Persons: A Systematic Review And Meta-Analysis. The Senator Project Ontop Series And Manuel Knowledge Hub Project., Andrea Correa-Pérez, Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Groot Lcpgm De, Van Der Schueren Mae De, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O'Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J.Cruz Jentoft

School of Health Professions

INTRODUCTION: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. METHODS: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. RESULTS: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body …

Protein Provision In Critically Ill Adults Requiring Enteral Nutrition: Are Guidelines Being Met?, Avril Collinson, Alexandra Mitchell, Stephen Taylor, Claire Downer, Rowan Clemente, Kaylee Allan, Frances Greer

School of Health Professions

No abstract provided.

Early Hour, Golden Hour: An Exploration Of Slovenian Older People’S Meaningful Occupations, Tanja Križaj, Anne Roberts, Alison Warren, Anita Slade

School of Health Professions

No abstract provided.

Will Giant Polar Amphipods Be First To Fare Badly In An Oxygen-Poor Ocean? Testing Hypotheses Linking Oxygen To Body Size, John I. Spicer, Simon A. Morley

School of Biological and Marine Sciences

No abstract provided.

Dietary Intake Of Inorganic Nitrate In Vegetarians And Omnivores And Its Impact On Blood Pressure, Resting Metabolic Rate And The Oral Microbiome, Ann Ashworth, Craig Clarke, Garry Farnham, Luke Liddle, Mia Burleigh, Ana Rodiles, Carla Sillitti, Michele Kiernan, Melanie Moore, Mary Hickson, Chris Easton, Raul Bescos

School of Health Professions

No abstract provided.

Book Review: Aisling Swaine, Conflict-Related Violence Against Women: Transforming Transition (2018), Jennifer Moore

Faculty Scholarship

Acknowledging that rape is sometimes utilized as a “weapon of war” represents an important development in humanitarian action and scholarly inquiry. However, Aisling Swaine instructs this is but one important facet of the range of harms women experience in time of war, not to mention in peacetime. Swaine articulates two powerful themes: the variant nature of violence against women in times of war, and the other concerns its ambulant nature over time.

Swaine’s treatment of “conflict-related violence against women” represents an important contribution to the canon of feminist scholarship on gender-based violence. Her insights emerge from qualitative research she conducted …

An Improved Prediction Of The Effective Range Of Stress Intensity Factor In Fatigue Crack Growth, B Yang, Mn James, Y Huang, Jm Vasco-Olmo, Fa Díaz

School of Engineering, Computing and Mathematics

No abstract provided.

Coexistence And The Niche In A Nurse-Cactus Interaction: Is Cyclic Dynamics Justified?, Arnoldo Flores-Torres, Carlos Montaña, Miguel Franco

School of Biological and Marine Sciences

1. The interaction between the nurse plant Larrea tridentata and the cacti Cylindropuntia leptocaulis is thought to follow cyclical-replacement dynamics. However, the required changing nature of their interaction, from facilitation to competition, has not been investigated through their full life cycle. 2. In order to test the hypothesised cyclical dynamics, we compared the demography of four sub-populations (LA = Larrea associated to Cylindropuntia; CA = Cylindropuntia associated to Larrea, LS = solitary Larrea; CS = solitary Cylindropuntia) in the Mapimí Biosphere Reserve, Mexico, over the period 2008-2015. This allowed us to compare their demography at varying levels of the generally …

An Investigation Of Reliability Of The Sunderland Tracheosophageal Voice Perceptual Scale., Margaret M. Coffey, Neil Tolley, David Howard, Mary Hickson

School of Health Professions

BACKGROUND: The Sunderland Tracheosophageal Voice Perceptual scale (SToPS) is the only perceptual rating scale designed specifically for tracheosophageal voice [Hurren et al.: Clin Otolaryngol. 2009 Dec; 34(6): 533-8]. OBJECTIVE: To investigate the inter rater reliability of the SToPS when analyzing alaryngeal voice. METHODS: Prospective evaluation of inter rater reliability of the SToPS based on audio recordings of 230 voice samples from 41 laryngectomy patients rated by 3 experts. Interval data were analyzed using intraclass correlation coefficients (ICC) while categorical data were analyzed using Kappa. RESULTS: ICC of above 0.6 was observed between raters for each prosthesis on a majority of …

Primary Care Models For Community-Dwelling Adults With Long-Term Conditions: A Scoping Review Protocol, Samantha Whiting, David Robertson, Katrina Bannigan

School of Health Professions

No abstract provided.

Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang

Peninsula Medical School

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both …

Obeticholic Acid For The Treatment Of Non-Alcoholic Steatohepatitis: Interim Analysis From A Multicentre, Randomised, Placebo-Controlled Phase 3 Trial, Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N. Newsome, David Sheridan, Muhammad Y. Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F. Abdelmalek, Kris V. Kowdley, Aldo J. Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean Francois Dufour, David Shapiro, David Shapiro, Luna Zaru, Leigh Macconell, Reshma Shringarpure, Stephen Harrison, Arun J. Sanyal, Manal F. Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin M. Anstee, Rodolphe Anty, V Araya, Ruiz Ji Arenas, P Arkkila, M Arora, T Asselah, J Au, O Ayonrinde, Rj Bailey, M Balakrishnan, K Bambha, M Bansal, S Barritt, J Bate, J Beato, Susanne Beckebaum, J Behari, P Bellot, Ari Z Ben, M Bennett, M Berenguer, Bt Beretta-Piccoli, T Berg, M Bonacini, L Bonet, B Borg, M Bourliere, Jerome Boursier, W Bowman, D Bradley, M Brankovic, M Braun, J-P Bronowicki, S Bruno, Elisabetta Bugianesi, C Cai, Panero Jl Calleja

Peninsula Medical School

No abstract provided.

Mitochondrial Integrity In Neurodegeneration, Katrina Cowan, Oleg Anichtchik, Shouqing Luo

Peninsula Medical School

No abstract provided.

From Mental Disorder To Shared Understanding: A Non-Categorical Approach To Support Individuals With Distress In Primary Care, Richard Byng, Nora Groos, Christopher Dowrick

Peninsula Medical School

This article argues that, rather than aiming for a psychiatric diagnosis, generalist professionals such as those working in primary care, as well as in other hospital and community settings, should use a non-diagnostic framework when encountering distress. The conceptual and empirical limitations of the psychiatric diagnostic system and evidence that psychological phenomena are dimensional suggest the need for an alternative approach; one that might also address problems of overdiagnosis and overmedication.1 There are three key problems with the current Diagnostic Statistical Manual (DSM) and International Classification of Diseases (ICD) systems of psychiatric classification. The process can be stigmatising; diagnoses are …

Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira

Peninsula Medical School

No abstract provided.

Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng

Peninsula Medical School

No abstract provided.

Deterrence And Prevention-Based Model To Mitigate Information Security Insider Threats In Organisations, N Safa, C Maple, Sm Furnell, M Azad, C Perera, M Dabbagh

School of Engineering, Computing and Mathematics

Previous studies show that information security breaches and privacy violations are important issues for organisations and people. It is acknowledged that decreasing the risk in this domain requires consideration of the technological aspects of information security alongside human aspects. Employees intentionally or unintentionally account for a significant portion of the threats to information assets in organisations. This research presents a novel conceptual framework to mitigate the risk of insiders using deterrence and prevention approaches. Deterrence factors discourage employees from engaging in information security misbehaviour in organisations, and situational crime prevention factors encourage them to prevent information security misconduct. Our findings …

Exploring How Patients Respond To Gp Recommendations For Mental Health Treatment: An Analysis Of Communication In Primary Care Consultations, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe

Peninsula Medical School

BackgroundPatient take-up and adherence to antidepressants and talking therapy is low. However, little is known about how GPs recommend these treatments and whether patients accept them.AimTo examine how GPs recommend antidepressants and talking therapy, and how patients respond.Design & settingA total of 52 recorded primary care consultations for depression, anxiety, and stress were analysed.MethodUsing a standardised coding scheme, five ways doctors recommend treatment were coded, conveying varying authority and endorsement. The treatment recommendation types were as follows: more directive pronouncements (I’ll start you on X); proposals (How about we start X?); less directive suggestions (Would you like to try X?); …

Towards Simulated Morality Systems: Role-Playing Games As Artificial Societies, J Casas-Roma, M Nelson, J Arnedo-Moreno, S Gaudl, R Saunders

School of Engineering, Computing and Mathematics

No abstract provided.

Pre-Intermediate Accounting, Natasha Ware

Syllabus Repository

No abstract provided.

Managerial Cost Accounting, Christopher M. Fairchild

Syllabus Repository

No abstract provided.