Digital Commons Network^™

The Delivery Of Mixed Communities In The Regeneration Of Urban Waterfronts: An Investigation Of The Comparative Experience Of Plymouth And Bristol, Daniel Thorning, Christopher Balch, Stephen Essex

School of Geography, Earth and Environmental Sciences

The raison d’être of spatial planning is to secure public benefits or goods through the regulation of private development. Under neoliberalism, where economic growth is privileged over community interests, the ability of planning to deliver public goods can be compromised. The aim of this research was to investigate the delivery of mixed communities in the regeneration of waterfront sites in two outwardly comparable, but in detail, rather different port cities, namely Plymouth and Bristol. The range of dwelling types, extent of affordable housing and associated practicalities of delivery were evaluated using planning application data, 2000–2017 and semi-structured interviews with key …

Knowledge Sharing And Innovative Strategies In Organisational Collaborative Relationships: The Potential Of Open Strategy, Anna Wulf

Plymouth Business School Theses

Today’s challenges presented by a rapidly changing business environment can be met by collaborative relationships between businesses. Businesses can exchange or share key resources that companies are unable to develop alone. Knowledge is one of the most important organisational resources and one which businesses can share in order to increase their competitive advantages, under the right circumstances. Networks are one form of collaborative relationship being already well known and widely researched. Business ecosystems are an even broader conception of inter-company relationships. The two research streams, network theory and business ecosystem theory, complement each other. Whilst network theory focuses on structures, …

Message Factors That Favourably Drive Consumer’S Attitudes And Behavioural Intentions Towards Social Network And Media Platforms, Sarhang Majid

Plymouth Business School Theses

As consumers are increasingly utilising social network and media platforms for pre-purchase information, managers are confronted with producing effective social network and media platform (SNMP) messages that can favourably influence buyers’ attitudes and behavioural intentions towards brands and products. To ensure a thorough investigation of this research realm, and to develop awareness of the factors influencing the effectiveness of social media marketing, this study adopted a mixed methods approach involving a combination of both qualitative and quantitative research. An exploratory sequential research design was followed, starting with an in-depth, elite interview investigation with social media marketing experts. Adopting a thematic …

The Holistic Exploration Of The Multifaceted Relationship Between Healthcare Professionals’ Job Satisfaction And Quality Of Care., Moya Lerigo-Sampson

Plymouth Business School Theses

Problem definition: Healthcare is a professional field, which most individuals will encounter at some point in their life, directly or indirectly. In the UK, healthcare organisations are facing significant challenges, including financial pressures, shortages in staffing levels, and changes in the way healthcare is delivered. In addition, patient demand for such healthcare systems has been increasing dramatically year on year, in part, due to societal changes towards unhealthier lifestyles. Consequently, amid such adversities, it is important to understand how these issues are affecting both the providers and receivers of healthcare. Therefore, the current study will explore how healthcare professionals’ job …

'As You Were': Military-Bureaucratic Control And The Employment Relationship In The British Armed Forces, Margaret Prior

Plymouth Business School Theses

Service in the British armed forces has not previously been considered a subject for employment and industrial relations research, but military personnel are in an employment relationship and thus worthy of such study. Drawing on an extensive literature review, documentary analysis and a qualitative survey and interviews with ex-service personnel, this study adopts a critical realist philosophy and retroduction to examine how the military employment relationship is regulated, experienced and contested, with particular reference to discipline and voice. It also compares military service with civilian employment, noting that the two, once similar, have diverged. The study uncovers a complex web …

Strategic Management In Improving Total Quality In Bahrain’S Public Sector, Abdulrahman M. Alnoaimi

Plymouth Business School Theses

This study determined the strategic management in improving total quality in Bahrain’s public sector. More specifically, the concerns of this study were: 1) the demographic characteristics of the respondents in terms of gender, nationality, number of years in public sector, category of specialisation, position in the organisation, and field which team work is relevant; 2) the strategic management practices and TQM application along institutionalising the planning function, establishing the strategic foundation, strategic situational diagnosis, and managing TQM implementation; and 3) TQM factors implemented in Bahrain’s public sector; 4) applying TQM and influenced the Bahrain’s public sector competitiveness; 5) the role …

Hidden In Plain Sight-An Analysis Of The Influence Of Strategic Leadership Characteristics And Styles Of The Chair, Chair/Ceo, Ceo And Cfo In Banking Failure, Recapitalisation Or Bailout (1999-2017). A Grounded Theory Approach, Alison Louise Miles

Plymouth Business School Theses

The global financial crisis (2007-2009) caused the most severe global economic downturn since the Great Depression and in the 10 years since, the global banking sector has witnessed an onslaught of banking scandals such as: LIBOR, FOREX, money laundering, and tax avoidance. In the wake of these ongoing issues, there is a clear need to explore alternative methods to tackle failures and scandals in the banking sector. A key weakness in the current discourse is the lack of analysis of the leadership characteristics and styles of board members of leading banks. This study responds to this weakness, contributing in three …

Supply Chain Financial Performance In Liquefied Natural Gas Systems, Nasiru Zubairu

Plymouth Business School Theses

Liquefied natural gas (LNG) is a rapidly growing energy source, with highly competitive supply chain networks, sensitive to global macro-economic developments. To date, supply chain finance studies have failed to explore supply chain financial performance (SCFP) in the LNG sector and few have demonstrated the potential impact of supply chain practices on financial performance. This study aims to evaluate the relationship between supply chain strategies and the financial performance of Nigeria liquefied natural gas (NLNG) systems, to guide practitioners to review and adopt supply chain initiatives that drive business survival and growth, while creating value for investors. To identify key …

Measuring Sustainability In Less Developed Countries: Case Of Tourism In The Gorilla Parks Of The Democratic Republic Of Congo, Vincent-Bouky Kakuru Luhunde

Plymouth Business School Theses

This research proposes a method and tool for measuring the sustainability of tourism in Less Developed Countries (LDCs), more specifically the gorilla tourism of the D.R. Congo. Since the Brundtland Report several assessment models have been proposed but have all failed to capture the centrality of sustainability, i.e. stakeholders, the very ones who can take action for sustainability to be achieved or not. This research has helped to design a holistic and stakeholder-centred method and tool for measuring sustainability of tourism, the Sustainability Value Model (SVM) using Social Network Analysis (SNA) method. The SVM tool provides a visual assessment of …

10,000 Years Of Climate Control Over Carbon Accumulation In An Iberian Bog (Southwestern Europe), Xabier Pontevedra-Pombal, Daniel Castro, Martín Souto, Isabel Fraga, William H. Blake, Maarten Blaauw, José A. López-Sáez, Sebastián Pérez-Díaz, Marcos Valcárcel, Eduardo García-Rodeja

School of Geography, Earth and Environmental Sciences

© 2018 China University of Geosciences (Beijing) and Peking University The northwest region of the Iberian Peninsula is home to a unique ecosystem of bogs, which are particularly sensitive to projected climate change. In this context, the rate of carbon (C) accumulation in Chao de Veiga Mol, an intact raised bog, was analysed. Changes in the accumulation rate over the past 10 millennia were determined in a peat core of 847 cm in depth, with a high mean rate of peat growth (11 yr cm−1, 0.09 cm yr−1). An age-depth model was generated from 22 14C dates and fallout radionuclides. …

Molecular Mechanisms And Tissue Targets Of Brominated Flame Retardants, Bde-47 And Tbbpa, In Embryo-Larval Life Stages Of Zebrafish (Danio Rerio)., A Parsons, A Lange, Th Hutchinson, S Miyagawa, T Iguchi, T Kudoh, Cr Tyler

School of Geography, Earth and Environmental Sciences

Brominated flame retardants are known to disrupt thyroid hormone (TH) homeostasis in several vertebrate species, but the molecular mechanisms underlying this process and their effects on TH-sensitive tissues during the stages of early development are not well characterised. In this study, we exposed zebrafish (Danio rerio) embryo-larvae to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and tetrabromobisphenol A (TBBPA) via the water for 96 h from fertilisation and assessed for lethality, effects on development and on the expression of a suite of genes in the hypothalamic-pituitary-thyroid (HPT) axis via both real time quantitative PCR (qRT-PCR) on whole body extracts and whole mount in situ …

Predictors Of Morbidity And Mortality Among Thoracic Trauma Patients, Jeremy Patrick Mcconnell

University of the Pacific Theses and Dissertations

Background. There are roughly 300,000 rib fractures treated for in the United States each year. These represent 10-26% of thoracic trauma injuries and have about a 10% mortality rate. There is a common belief that mortality in rib fracture patients can be contributed to the diagnosis of pneumonia, but this study does not support that claim. Purpose. To determine the predictors of morbidity and mortality in rib fracture patients. Methods. Using a level 1 trauma center patient registry, we retrospectively analyzed all patients that were admitted with at least one rib fracture (n=1,344). All predictors were analyzed with linear regressions. …

Goal Orientations And Beliefs About Success In Age Group Swimmers, Nathan Alexander Rhea

University of the Pacific Theses and Dissertations

The purpose of this study was to expand on goal orientation theory and its relationship with beliefs about the causes of sport success by differentiating by age group in youth USA Swimming registered swimmers, ages 11-18. 80 swimmers from six different USA Swimming clubs completed the Task and Ego Orientation in Sport Questionnaire (TEOSQ) and the Beliefs About the Causes of Sport Success Questionnaire (BACSSQ) after providing parent consent and child assent to take part in the study. Similar to previous research, the ego orientation was found to have a significant positive relationship with ability and deception as beliefs about …

Exploring The Attitudes And Beliefs Of Audiology Students About People Who Are Deaf Or Hard Of Hearing, Nancy Grosz Sager

University of the Pacific Theses and Dissertations

This study was undertaken to explore and understand the attitudes and beliefs of audiology students about Deaf and Hard of Hearing people. The problem of practice was that some audiologists continue to advise parents not to sign with their Deaf or Hard of Hearing children. This problem was studied using the conceptual framework of General Systems Theory, looking at the problem through the lens of Critical Disability Theory, to determine if audiology students view Deaf and Hard of Hearing people from a medical model or from a social/cultural model. Using a qualitative case study methodology, I interviewed six first-year doctor …

The Evolution Of Sunset Magazine's Cooking Department: The Accommodation Of Men's And Women's Cooking In The 1930s, Jennifer Hoolhorst Pagano

University of the Pacific Theses and Dissertations

The Western regional magazine Sunset has been published under a series of owners and publishers since 1898. In 1928, Sunset was purchased by Lawrence Lane, a Midwestern magazine executive who transformed it from a failing turn-of-the-century, general interest publication about the West, into a successful magazine about living in the West for the Western middle-class. Sunset had always been a magazine for men and women, and one that appealed to both male and female intellectuals at the time Lane purchased it. Lane and his editors attempted to interject more rigid middle-class ideals into a magazine that had espoused ideas that …

The Role Of Aryl Hydrocarbon Receptor (Ahr) In Drug-Drug Interaction And The Expression Of Ahr In Pichia Pastoris, Yujuan Zheng

University of the Pacific Theses and Dissertations

The aryl hydrocarbon receptor is a ligand-activated transcription factor that is involved in many important functions in the body. To study the role and function of AHR, an abundant amount of in vitro expressed and purified protein is needed. A baculovirus insect expression system is commonly employed to express AHR, however, there are several drawbacks with this method, such as mutation potential and high cost. A better in overexpression system is needed and we hypothesize that Pichia pastoris, a yeast expression system, could stably express AHR and ARNT (aryl hydrocarbon receptor nuclear translocator) in sufficient amount with reasonable cost. Codon …

Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin

University of the Pacific Theses and Dissertations

Structure based computational peptide design methods have gained significant interest in recent years with the availability of structural insights of protein-protein interactions obtained from the crystal structures. Most of these approaches design new peptide ligands by connecting the crucial amino acid residues from the protein interface and are generally not based on any predicted receptor-ligand interaction. In this work, a peptide design method based on the Knob-Socket model was used to identify the specific ligand residues packing into the receptor interface. This method enables rational peptide ligand design by predicting amino acid residues that will fit best at the binding …

Factors Underlying High School Mathematics Teachers' Perceptions Of Challenging Math Tasks, Mariya Anne Sullivan

University of the Pacific Theses and Dissertations

In this confirmatory factor analysis, factors previously identified to explain the variability in Middle School Mathematics Teachers’ perception of the Common Core State Standards of Mathematics were considered as factors hypothesized to effect high school math teachers’ perceptions of challenging math tasks (CMTs). The factor of student characterization (i.e., disposition, academic preparation, and student behavior) was additionally considered as a factor hypothesized to explain teachers’ perceptions of CMTs, as well as site-based variables (i.e., curriculum, assessment and evaluation, professional development, and collaboration). In addition, teachers’ understanding of the importance of the mathematical practice standards and teacher familiarity with enacting CMTs …

Structural Characterization Of Black Widow Spider Dragline Silk Proteins Crp1 And Crp4, Mikayla Shanafelt

University of the Pacific Theses and Dissertations

Spider dragline silk is a biomaterial with outstanding material properties, possessing high-tensile strength and toughness. In nature, dragline silk serves a central role during spider locomotion and web construction. Today, scientists are racing to elucidate the molecular machinery governing silk extrusion, attempting to translate this knowledge into a mimicry process in the laboratory to create synthetic fibers for a wide range of different applications. During extrusion, it has been established that biochemical and mechanical forces govern spidroin folding, aggregation, and assembly. In black widow spiders, at least 7 different proteins have been identified as constituents of dragline silk fibers. These …

Faculty Adaptation To Emerging Instructional Technologies In Higher Education, Marilyn Murrillo

University of the Pacific Theses and Dissertations

This study examined how and why faculty adopt podcasting as an instructional technology tool in their teaching. Podcasting is an instructional technology tool being used for teaching and learning in higher education. Faculty may record lectures with audio, video, and/or PowerPoint slides to instruct students on class material. Students may access podcasts at their convenience through various devices, including mobile devices and computers. Research has shown that students who use podcasts to study for tests tend to perform more successfully on tests. This study was a qualitative multiple case study of seven California community college faculty using podcasting as an …

An Autoethnographic Study: An Identity Lost And A Passage Discovered, Simone Shonte Martinez

University of the Pacific Theses and Dissertations

The professional careers of teachers with a chronic illness can sometimes be devastating. This study addresses the insufficient understanding of the identity crisis a teacher goes through when one is suddenly diagnosed with a chronic illness. While researching different types of theories, identity theory best fit this topic and my interest. Within identity theory, there are four perspectives to view identity. The four perspectives are Nature, Institution, Discourse, and Affinity identities. In order to understand identity, one must understand how identity is formed. Chronic illness identity is a change from all other identities that have been constructed. This study uses …

The Potency Of Ag10 In Stabilizing Transthyretin Is Driven By Interactions Mimicking The Disease-Suppressing T119m Variant, Dengpan Liang

University of the Pacific Theses and Dissertations

Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a fatal disease with no available disease-modifying therapies. While destabilizing TTR mutations increase the risk of developing ATTR-CM, the naturally occurring Thr119Met (T119M) variant stabilizes TTR and prevent disease. The two Serine 117 and Serine 117’ (S117/S117’) side chain hydroxyl groups of monomers A and B in T119M variant TTR form direct hydrogen bonds with each other. AG10 is an orally available, small molecule TTR stabilizer in Phase 3 clinical development for ATTR-CM. Structural features that infer high potency of AG10 for stabilizing TTR remains incompletely characterized.

In order to investigate the contribution of …

Fliposomes With A Ph-Sensitive Conformational Switch For Anticancer Drug Delivery Against Triple Negative Breast Cancer, Yifan Lu

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death in the US and worldwide, accounting for 16% of deaths worldwide in 2015. Of more than 100 types of cancers affecting humans, breast cancer is the most common cancer among women and is the second leading cause of death in women. Triple negative breast cancer (TNBC) is a subtype of breast carcinomas defined by the lack of the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2 /neu). The prognosis and survival of TNBC patients remains the poor due to the lack of effective targeted therapy. …

Intrapulmonary Inoculation Of Multicellular Tumor Spheroids To Construct An Orthotopic Lung Cancer Xenograft Model That Mimics Four Clinical Stages Of Non-Small Cell Lung Cancer, Yingbo Huang

University of the Pacific Theses and Dissertations

Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development and progression of lung cancer as seen …

Evaluating Methods Of Obtaining Male Pheromone From Hymenochirus Sp. Using Analytical Chemistry, Vincent Wing-Kun Leung

University of the Pacific Theses and Dissertations

Male Hymenochirus sp. frogs are known to release pheromone that attracts females of the same species. Four methods for collecting secretions containing pheromone in Hymenochirus sp. were tested: norepinephrine injection, gonadotropin-releasing hormone injection, homogenization of gland tissue, and electrostimulation of the skin over the breeding gland area. The samples collected were analyzed using high-performance liquid chromatography (HPLC) and mass spectrometry. The HPLC chromatograph for the male norepinephrine sample contained a peak at 6.4 min that was not in the female norepinephrine sample HPLC chromatograph. The male norepinephrine sample mass spectrum had a peak of m/z 292.0 not in the female …

Blubber Transcriptome And Proteome Responses To Repeated Adrenocorticotropic Hormone Administration In A Marine Mammal, Jared Deyarmin

University of the Pacific Theses and Dissertations

Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction and immunity. This can be especially deleterious for capital breeding carnivores, such as marine mammals, which rely on lipid stores accrued during intensive foraging to sustain prolonged periods of fasting associated with reproduction. Therefore, chronic stress may cause a decrease in fitness in these animals, leading to population declines and potentially detrimental shifts in food web dynamics as a result. However, the impacts and indicators of chronic stress in animals are currently poorly understood. To identify downstream mediators of repeated stress responses in marine mammals, adrenocorticotropic hormone …

Sexual Dimorphism In Aortic Function Of Uc Davis Type 2 Diabetes Mellitus Rat Model: Estrogen Specific Responses, Farjana Akther

University of the Pacific Theses and Dissertations

Little is known about the interaction between diabetes and sex in vasculature. This study was designed to investigate the effects of estrogen as well as type 2 diabetes (T2D) on aortic function in rats with respect to sex. To test the effects of T2D and sex, UC Davis Type 2 Diabetes Mellitus (UCD-T2DM) rat model was used. To study the effects of estrogen, ovariectomized Sprague- Dawley female rats and UCD-T2DM rats at pre-diabetic stage were used and the rats were implanted subcutaneously either with placebo or 17 β-estradiol pellets (60 days release, 1.5mg/pellets). The plasma analytes for metabolic parameters and …

Phylogenomic Analyses Clarify Butterfly Species Within The Genus Speyeria Despite Evidence Of A Recent Adaptive Radiation, Erin Thompson

University of the Pacific Theses and Dissertations

The North American genus Speyeria is an especially challenging radiation of butterflies due to ongoing hybridization, incomplete lineage sorting, and similar morphological characters among species. Adaptive radiations often require considerable evidence in order to resolve the evolutionary relationships of closely related individuals. Previous studies of this genus have found paraphyly among species and have been unable to disentangle these taxa due to a lack of data and/or incomplete sampling of the genus. As a result, the interspecific relationships among Speyeria remain unresolved. In an attempt to achieve phylogenetic resolution of the genus, we conducted population genomic and phylogenomic analyses of …

Improving Teacher Retention By Addressing Teachers' Compassion Fatigue, Jacquelyn Ollison

University of the Pacific Theses and Dissertations

California is experiencing a massive teacher shortage, and urban schools are disproportionately affected by it negatively. Retention efforts to date have not included strategies to address Compassion Fatigue (burnout and secondary trauma) teachers experience when working with traumatized students at urban schools. This dissertation explores whether Compassion Fatigue is an unaddressed reason for teacher attrition at urban schools. A mixed method practical action research approach using the Professional Quality of Life Scale Version Five (ProQOL 5) and qualitative interviews, portions of which were turned into illustrative vignettes drove the exploration. Approximately 114 teachers completed the ProQOL 5. Statistical analysis of …

Exercise And Patient Populations: A Community-Based Exercise Intervention On Cancer And Type 2 Diabetes, Cynthia Villalobos

University of the Pacific Theses and Dissertations

Cancer and diabetes are the second and seventh leading causes of death in the United States, respectively (Kochanek et al., 2017). When including prediabetes and the entire cancer continuum, both diseases affect over 150 million individuals in the United States each year (Bullard et al., 2018; Siegel et al., 2019). Furthermore, there exists an alarming rise in patients presenting with both type 2 diabetes and obesity-related cancers concurrently, as both diseases share similar risk factors (Vigneri et al., 2009). An aging adult population, physical inactivity and unhealthy eating habits are continuing to rise, and the prevalence of individuals with obesity-related …