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2019

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An Electron Paramagnetic Resonance Study Of The Magnesium Acceptor In Gallium Nitride In Different Crystal Field Environments, Ustun Robert Sunay Jan 2019

An Electron Paramagnetic Resonance Study Of The Magnesium Acceptor In Gallium Nitride In Different Crystal Field Environments, Ustun Robert Sunay

All ETDs from UAB

Non-uniform strain phenomena localized to Mg acceptor sites were investigated in Mg-doped GaN single crystals using electron paramagnetic resonance (EPR) spectroscopy. Samples in this study were grown either as µm thick thin film or mm thick free standing samples with the Mg concentration ranging from 3 150 x1018 cm-3. In all samples, the Mg related EPR signal was observed but the g-factor, intensity, and lineshape anisotropy characteristics varied significantly depending on the magnitude of the bi axial crystal field Δx local to the Mg acceptor. By modelling the Mg acceptor as basal atomic 2p orbitals, the angular dependent intensity could …

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Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun Jan 2019

Deciphering The Roles Of Hopd1 In Carbon Metabolism During Pathogen Infection, Yali Sun

All ETDs from UAB

Plants are equipped with various immune responses including MAMP-triggered immunity (MTI) and effector-triggered immunity (ETI) to fight against pathogens, while virulent pathogens release virulent proteins (effectors) and phytotoxins to compete with host immune responses. Comprehensively, plant-pathogen interactions involve multi- layered and highly coordinated processes, and dynamic regulation at both transcriptional and translational levels plays a pivotal role in plant defense. For example, NPR1, a key immune regulator, is regulated by hosts and manipulated by pathogens at different levels during different stages of plant-pathogen interaction. However, besides the competition over immune responses, bacterial pathogens also need to gain nutrients from host …

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Drive-By Bridge Monitoring And Damage Detection, Chengjun Tan Jan 2019

Drive-By Bridge Monitoring And Damage Detection, Chengjun Tan

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Bridges are key components of the transportation network, and their safety is essential to maintain effective and safe operation of the transportation facilities. To maintain the structural integrity of the bridges, it is essential to estimate the extent and location of the structural damage through periodic monitoring. Therefore, there is considerable interest in bridge damage detection and considerable progress has been made in recent years. The traditional bridge health monitoring requires many sensors installed on the bridge to collect vibration data for damage assessment, which is expensive, time-consuming, and even dangerous in-site. Compared with traditional ways, the concept of indirect …

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Acetylcholine Signaling In Glioblastoma Invasion And Peritumoral Hyperexcitability, Emily Grace Thompson Jan 2019

Acetylcholine Signaling In Glioblastoma Invasion And Peritumoral Hyperexcitability, Emily Grace Thompson

All ETDs from UAB

Glioblastomas are the most common and deadly form of primary brain cancer in adults. Current treatment strategies are aggressive, including a combination of surgical resection, radiotherapy, and chemotherapy. However, median patient survival has remained stagnant at 12 to 15 months for the last several decades. This dismal patient outcome has prompted efforts to understand the unique characteristics of these tumors, since traditional therapeutics have not been efficacious. Extensive invasion is a salient feature of glioblastomas that significantly diminishes the effectiveness of current treatment strategies and is ultimately the cause of tumor recurrence within 2 years in approximately 80% of patients. …

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Intraocular Pressure Dynamics, Daniel Coleman Turner Jan 2019

Intraocular Pressure Dynamics, Daniel Coleman Turner

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While cataracts (the leading cause of blindness worldwide) can be reversed surgical-ly, glaucoma is the leading cause of irreversible blindness, affecting over 70 million people worldwide [1]. Elevated intraocular pressure (IOP) and age are the primary risk factors for glaucoma [2] and lowering IOP is the only proven treatment for the disease [3]. IOP and its fluctuations affect nearly every aspect of ocular physiology and homeo-stasis, as well as playing a dominant role in glaucoma pathophysiology, yet very little is known about IOP due to the current clinical standard of measuring mean IOP during infre-quent clinic visits. We use a …

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Recognizing Compound Expressions And Emotion Intensity, William Wagner Jan 2019

Recognizing Compound Expressions And Emotion Intensity, William Wagner

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Six facial expressions of emotion (anger, disgust, fear, happiness, sadness, and surprise) have been identified as panculturally recognizable. Though recognition of those facial expressions appears to be developmentally innate, there is variation in emotion recognition between individuals. Specifically, those with autism spectrum disorder often have difficulty with this skill, contributing to issues in their social interactions. Another important skill for social interactions is identifying when someone feels more than one emotion at a time, and some evidence suggests that those emotional states are expressed with panculturally recognizable affects, termed compound expressions. Yet another skill involves determining the intensity of someone’s …

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The Anti-Tumor Effects Of Hur Inhibition In Glioblastoma, Jiping Wang Jan 2019

The Anti-Tumor Effects Of Hur Inhibition In Glioblastoma, Jiping Wang

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Glioblastomas (GBMs) are the most malignant primary brain tumor. GBMs represent 14.7% of total primary CNS tumors and 47.7% of malignant CNS tumors. The median survival of GBM is 18-20 months, while five-year survival rate is only 5.6%. GBMs are maintained by glioma stem cells (GSCs), and poor treatment outcomes are linked to the high resistance of GSCs to radiation and chemotherapy, and the immunosuppressive tumor microenvironment. The mRNA binding protein HuR is a key regulator of tumor growth and development based upon the fact that HuR targets mRNAs that are broadly involved in tumorigenesis. We have previously shown that …

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Obesity In People With Spinal Cord Injury: Secondary Data Analysis Of National Spinal Cord Injury Database, Huacong Wen Jan 2019

Obesity In People With Spinal Cord Injury: Secondary Data Analysis Of National Spinal Cord Injury Database, Huacong Wen

All ETDs from UAB

People with disabilities are 1.5-2.5 times more likely to be obese than those without disabling conditions. We have learned a lot about obesity in the general population. However, the neurological deficits of people with spinal cord injury (SCI) make it difficult to generalize the findings in the general population to the SCI population. Therefore, the purposes of this dissertation were to 1) assess racial differences in body mass index (BMI) change over 5 years; 2) evaluate the role of neighborhood in the relationship between race and obesity; 3) examine the impact of BMI at the time of injury on 1-year …

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Exploring Dose Effect Of An Early Palliative Care Intervention For Advanced Heart Failure Patients, Rachel Duncan Wells Jan 2019

Exploring Dose Effect Of An Early Palliative Care Intervention For Advanced Heart Failure Patients, Rachel Duncan Wells

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Heart failure (HF), a progressive condition with reduced quality of life (QoL) and high healthcare use, affects 6.5 million US adults. Research supports positive effects of palliative care integration into HF care, but there is limited consensus about the most beneficial intervention ‘dose’ (e.g. amount, duration, frequency, intensity). To date, no studies examining dose in palliative care HF interventions have been completed. Therefore, we examined dose using an existing data from the ENABLE CHF-PC trial (Educate, Nurture, Advise, Before Life Ends Comprehensive Heart Care for Patients and Caregivers; NCT02505425). Operationalizing dose as dichotomous complete/noncomplete of all intervention components (6-weekly, psychoeducational …

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Characterization Of The Tgfb Pathway And Its Role In Prostaglandin Metabolism In C. Elegans, Muhan Hu Jan 2019

Characterization Of The Tgfb Pathway And Its Role In Prostaglandin Metabolism In C. Elegans, Muhan Hu

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Cell to cell communication is fundamental to all life processes, from fertilization to death. The TGFߟ superfamily is a large family of proteins that is involved in a wide array of physiological and pathological processes, including development, wound healing, immune system function, cancer, and reproduction. This group of signaling peptides is well conserved across many organisms, from basic nematode to humans. While many studies have aimed to delineate the functions of TGFߟ, they have also unveiled the complexity of this multifunctional family of ligands. In this thesis, I take advantage of the simple C. elegans model system to study the …

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Mike And Ikes 'N Buttered Bricks: My Adventures In Scouting, Kasey Duane Hullett Jan 2019

Mike And Ikes 'N Buttered Bricks: My Adventures In Scouting, Kasey Duane Hullett

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I started my time in the Boy Scouts of America at age eight. Some of my earliest memories in the cub program consisted of pine wood derbies, tying square knots, and looking up at the stars at Moundville Archaeological Park. I was a kid tied to the outdoors and the organization always allowed me to nurture that relationship. Over the years, I went up in the ranks. I made it through the five ranks of the Cub Scouts to get my Arrow of Light to transition to the Boy Scouts. Once there, I earned over 50 merit badges that ranged …

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A Low-Cost Planar Inkjet-Printed Carbon Nanotube Field Effect Transistor For Sensor And Circuit Applications, Md Toriqul Islam Jan 2019

A Low-Cost Planar Inkjet-Printed Carbon Nanotube Field Effect Transistor For Sensor And Circuit Applications, Md Toriqul Islam

All ETDs from UAB

The semiconductor-based transistor is an essential building block of electronic components, computing applications, and sensors. However, the fabrication of this primary electronic element is complex and costly, especially when considering flexible electronics for bio-sensing applications. This thesis work proposes a new circuit manufacturing technique to print planar inkjet-printed carbon nanotube field effect transistor (CNTFET), sensor and circuits on paper and polyethylene terephthalate (PET) film substrate to reduce the complexity of the system and to lower the cost of conventional fabrication schemes. Single walled carbon nanotubes (SWCNTs) are being used as semiconductor ink for an inkjet-printer to facilitate and fabricate two …

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The Role Of The St6gal-I Sialyltrasferase In Protecting Tumor Cells From Hypoxic Stress, Robert Brent Jones Jan 2019

The Role Of The St6gal-I Sialyltrasferase In Protecting Tumor Cells From Hypoxic Stress, Robert Brent Jones

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An emerging concept in cancer biology is that surface glycosylation can play important roles in the regulation of cancer development and progression. Our group and others have shown that ST6Gal-I, a sialyltransferase that adds α2-6-linked sialic acids to N-glycosylated proteins, is upregulated in many cancers. Furthermore, data has indicated that ST6Gal-I acts as a pro-survival factor in a variety of settings, including resistance to chemotherapeutic drugs, radiotherapy resistance, and serum deprivation. The work presented in this dissertation adds to this understanding of ST6Gal-I’s role as a potent pro-survival factor and explores ST6Gal-I’s function in aiding tumor cells to survive hypoxic …

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Bk Polyomavirus Activates The Dna Damage Response To Hijack Host Cell Cycle Control, Joshua L. Justice Jan 2019

Bk Polyomavirus Activates The Dna Damage Response To Hijack Host Cell Cycle Control, Joshua L. Justice

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BK Polyomavirus (BKPyV) is a DNA tumor virus that latently infects the >90% of humanity. BKPyV infection is inconsequential in healthy individuals; however, the immunocompromised carry increased risk of viral reactivation that can lead to a number of genitourinary diseases. Overall, BKPyV reactivation is a major risk factor for kidney dysfunction and failure following solid organ transplantation. There are no approved therapeutics to treat BKPyV infection, therefore studies have focused on understanding the host/virus interactions that drive infection to identify therapeutic targets. The PyV genome is small and does not encode a polymerase. Cellular transformation by the viral oncogene, T …

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A Microfocal Effect In Photoreceptor Light Capture, Vasantha Kumari Kanukuntla Jan 2019

A Microfocal Effect In Photoreceptor Light Capture, Vasantha Kumari Kanukuntla

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In human eyes, accomodation brings light rays into focus on the retina in order to achieve a clear images. The plane of best focus within the depth of the retina is thought to be within the photoreceptor layer, but pinpointing the exact focal position axially has not been determined. With help of adaptive optics aberration correction and its ability to have microscopic control of a retinal stimulus, we explored how sensitive human subjects are to defocus on the micron scale. We found that focal position can be reliably judged within 0.02 D, which is equivalent to about 6 microns in …

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The Electronic Health Record And The Clinical Informatics Researcher: A Journey To Predicting False Positive Alerts With Patient Characteristics, Timothy Kennell Jan 2019

The Electronic Health Record And The Clinical Informatics Researcher: A Journey To Predicting False Positive Alerts With Patient Characteristics, Timothy Kennell

All ETDs from UAB

Since their introduction in the 1960s, electronic medical systems have brought with them tremendous opportunities and difficult challenges. In order to address patient safety, Clinical Decision Support (CDS) was added to the system, many times in the form of "pop-up" alerts. However, traditional alert typically do not incorporate enough patient-specific context resulting in inaccurate warnings. In response, clinicians override many of them. However, the high exposure to false positive alerts results in alert fatigue, a desensitization to future ones. This issue decreases patient safety by causing clinicians to ignore legitimate alerts. Despite some shortcomings, the data in modern Electronic Health …

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Sexual Health Risk And Hiv Prevention: An Exploratory Study Of Behavior Among Heterosexual, African American Men And Women In Birmingham, Alabama., Kiko J. King Jan 2019

Sexual Health Risk And Hiv Prevention: An Exploratory Study Of Behavior Among Heterosexual, African American Men And Women In Birmingham, Alabama., Kiko J. King

All ETDs from UAB

ABSTRACT The Deep South of the U.S. continues to have increased incidence of new cases of HIV since its inception, despite many advancements in HIV testing, treatment, and prevention. According to data by the CDC, rates are increasingly high among heterosexual African American (AA) men and women compared to their non-AA counterparts (CDC/HIV, 2017). In 2015, heterosexual transmission accounted for a share of new diagnoses for AA men and is the most common transmission route for AA women (KFF, 2017). The primary population affected by HIV/AIDS in Alabama is men who have sex with men (MSM) at 62.2%, followed by …

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Structural And Functional Insights Into The Influenza A Virus Non-Structural Protein 1 Effector Domain, Alex Kleinpeter Jan 2019

Structural And Functional Insights Into The Influenza A Virus Non-Structural Protein 1 Effector Domain, Alex Kleinpeter

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The influenza A virus (IAV) non-structural protein 1 (NS1) is a highly multifunctional viral protein responsible for antagonizing the type-I interferon (IFN) response to infection. NS1 has therefore been identified as a potentially effective target for the development of novel anti-influenza compounds. Furthermore, it is important to understand the molecular underpinnings driving NS1 function to more effectively elucidate antiviral targets. In this dissertation, we have contributed significant insight into NS1’s potential as an antiviral target, and the structure-function relationships driving its activity in an infected cell. First, we structurally characterized the binding of two known influenza inhibitors (A9 and A22) …

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Rapid Melting Of Aluminum Alloys By Induction Melting, Carlos Alfonso Larrazabal Colina Jan 2019

Rapid Melting Of Aluminum Alloys By Induction Melting, Carlos Alfonso Larrazabal Colina

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RAPID MELTING OF ALUMINUM ALLOYS BY INDUCTION MELTING CARLOS ALFONSO LARRAZABAL COLINA MATERIAL SCIENCE AND ENGINEERING ABSTRACT Die-casting and high-pressure die-casting are manufacturing processes meant to produce high volumes of parts. However, the die-casting industry suffers when the market is low or when short quantities of a part are needed, because this process may not be as flexible in small quantities. In such situations, one piece of the operation that is inflexible is running excess melting and holding furnace capacity. Rapid induction melting systems are proposed here as an alternative to big furnaces to provide amounts of molten metal in …

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Person Re-Identification By Deep Structured Prediction: A Generative Approach, Xinpeng Liao Jan 2019

Person Re-Identification By Deep Structured Prediction: A Generative Approach, Xinpeng Liao

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Visual appearance based person re-identification (re-ID) is the task of assigning the same identifier to all instances of a particular individual captured in images or videos, even after the occurrence of significant gaps over time or space. The state-of-the-art methods can be categorized into two main approaches: Given a set of gallery images with known IDs, the task is to infer either the ID label of a probe image individually (person re-ID via image retrieval) or the collective ID labeling of all probe images simultaneously (person re-ID via a highly-crafted re-ID structure). This dissertation is primarily focused on exploring the …

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Kinetics Of Thermal Decomposition And Polymerization During Continuous Cooling, Tatsiana Liavitskaya Jan 2019

Kinetics Of Thermal Decomposition And Polymerization During Continuous Cooling, Tatsiana Liavitskaya

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The processes that naturally occur on heating such as thermal decompositions and polymerizations can be made to proceed on cooling. Studying the resulting cooling kinetics is the major objective of this work. The kinetics of the reactions are explored by using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) in combination with isoconversional kinetic analysis. The kinetic parameters obtained on cooling are compared to the ones evaluated on heating and physical insights into the differences and similarities in the kinetics of the processes on heating and cooling are proposed. The study is driven by the hypothesis that the kinetics on …

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Effects Of Protein Timing And Energy Balance On Body Composition In Collegiate Athletes, Ashley Licata Jan 2019

Effects Of Protein Timing And Energy Balance On Body Composition In Collegiate Athletes, Ashley Licata

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The current literature indicates that energy balance and protein consumption influence body composition. However, the effects of protein intake, timed protein supplementation, and energy balance on body composition have not yet been fully investigated in collegiate athletes. The purpose of this research was to assess collegiate athletes using hourly food and exercise data to examine how protein timing and energy balance relate to body composition. Aims 1 and 2 focus on collegiate female soccer athletes and further our understanding of the potential roles that protein amount and frequency and hourly energy balance play in optimizing fat mass and fat-free mass. …

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External Root Resorption In The Orthodontic Patients, Frank Earl Litchfield Jan 2019

External Root Resorption In The Orthodontic Patients, Frank Earl Litchfield

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External Apical Root Resorption (EARR) is a side effect of orthodontic treatment that results in root shortening in about one-third of orthodontic patients. Great variability among patients exists in their susceptibility to this multifactorial condition, and both treatment and patient specific factors contribute to EARR. Root resorption values were found to be higher in Hispanics compared to Asians and Caucasians (1). However, the prevalence of EARR is not well documented in all populations. Since African Americans represent the largest minority group in the United States, establishing the prevalence and risk factors for EARR within this ethnicity is important. Objective: To …

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Design, Develop And Manufacture A Low-Cost 32-Channel Biosignal Amplifier And D/A Converter Device For Multi- Electrode Neural Recording, Yen-Tze Liu Jan 2019

Design, Develop And Manufacture A Low-Cost 32-Channel Biosignal Amplifier And D/A Converter Device For Multi- Electrode Neural Recording, Yen-Tze Liu

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In the current market, there are many multichannel neural recording devices are available. However, they are either very expensive or physically big so that it cannot be used too close to the specimen because of the space limitations due to experimental setting such as Faraday cage, microscope, and other stimuli apparatus. In addition to that, the large electronic devices in the cell recording area are susceptible to create electrical noise, especially if they are not battery operated. This thesis work will try to deliver solutions following three main problems. The first problem we address is the device cost per recording …

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Smile Outcome Comparison Of Orthodontic Cases Treated With Different Extraction Patterns, Gregory Long Jan 2019

Smile Outcome Comparison Of Orthodontic Cases Treated With Different Extraction Patterns, Gregory Long

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Extraction of premolar teeth for orthodontic purposes is a common treatment approach. The effects of premolar extraction on the occlusion and the face have been studied extensively in the past. To date, however, the effects of premolar extractions on the smile have not been comprehensively quantified in the literature. The purpose of this study was to compare the smile outcome of patients treated with premolar extractions. Methods: This retrospective case-control study established 4 groups of 33 patients each for comparison. Three groups of patients with the same malocclusion were treated with different premolar extraction patterns. The remaining group of patients …

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Insuring Graduation: An Analysis Of The Association Between Student Health Insurance And Graduation, John Robert Lovett Jan 2019

Insuring Graduation: An Analysis Of The Association Between Student Health Insurance And Graduation, John Robert Lovett

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Most college students have access to basic health services through their campus’ college health program. Unfortunately, students who lack health insurance may be limited in their access to health services beyond the acute care provided, which may manifest in a myriad of adverse outcomes; ultimately resulting in withdrawal from college without graduating. Student health insurance plans (SHIPs) are high-quality, affordable insurance plans specially designed to meet this need. This study utilized survival analysis to examine the temporal nature of college graduation behavior, as it related to student health insurance status. The results of this study show no significant relationship between …

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An Exploratory Study Of The Influence Of Perceived Organizational Support, Coworker Social Support, The Nursing Practice Environment, And Nurse Demographics On Burnout In Palliative Care Nurses, Marcia Ann Lowe Jan 2019

An Exploratory Study Of The Influence Of Perceived Organizational Support, Coworker Social Support, The Nursing Practice Environment, And Nurse Demographics On Burnout In Palliative Care Nurses, Marcia Ann Lowe

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AN EXPLORATORY STUDY OF THE INFLUENCE OF PERCEIVED ORGANIZATIONAL SUPPORT, COWORKER SOCIAL SUPPORT, THE NURSING PRACTICE ENVIRONMENT, AND NURSE DEMOGRAPHICS ON BURNOUT IN PALLIATIVE CARE NURSES MARCIA A. LOWE SCHOOL OF NURSING ABSTRACT Burnout, a condition characterized by emotional exhaustion, depersonalization, and decreased personal accomplishment, has been studied in many disciplines in healthcare, including nursing, medicine, and social work. Working with palliative care patients and their families is innately challenging and may predispose nurses to burnout. The purpose of this study is to examine the influence of perceived organizational support (POS), coworker social support, the nursing practice environment, and nurse …

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Light Transmission And Wear Of Translucent Zirconia After Conventional And Fast Sintering Cycle, Anvita Maharishi Jan 2019

Light Transmission And Wear Of Translucent Zirconia After Conventional And Fast Sintering Cycle, Anvita Maharishi

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ABSTRACT Introduction: Zirconia is classified by the mole percentage of yttria contained in the zirconia. The most strong and opaque material contains 3 mol % yttria, intermediate strength and opacity contain 4 mol %, and whereas 5 mol % is the weakest but most translucent zirconia. Refined zirconia powder is pressed into a mold to form a disc which is then milled to form a restoration. Post milling of sintered zirconia restorations is necessary to obtain final mechanical and physical properties of the restoration. Traditionally conventional sintering cycles required 6-8 hours to sinter. Whereas, fast sintering cycles have been have …

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Structural Studies Of Some Proteins Responsible For Bacterial Pathogenesis, Kartik Manne Jan 2019

Structural Studies Of Some Proteins Responsible For Bacterial Pathogenesis, Kartik Manne

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A wide range of infections is attributed to the pathogenesis of Gram-positive bacteria. The emergence of multi-drug-resistant Gram-positive pathogens has been a significant health concern and present serious therapeutic challenges globally. Some of the common Gram-positive bacterial species like Streptococcus pneumonia, Group B Streptococcus, and Staphylococcus aureus are infectious by employing several virulence factors for initial adhesion, colonization, biofilm initiation and dispersion, complement evasion, nutrient acquisition, and infection. The structural insights into these virulence factors are essential for understanding their mode of action, and also for developing a new class of antibiotics; a significant interest of many researchers. Pneumococcal adhesive …

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Endothelial N-Glycan Hypoglycosylation Enhances Cd16+ Monocyte Adhesion: A Role For Alpha-Mannosidases, Kellie Regal Mcdonald Jan 2019

Endothelial N-Glycan Hypoglycosylation Enhances Cd16+ Monocyte Adhesion: A Role For Alpha-Mannosidases, Kellie Regal Mcdonald

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Monocyte extravasation through the endothelial layer is a hallmark of atherosclerotic plaque development and is mediated by heavily glycosylated surface adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1). Human monocytes have been classified into three distinct groups: classical (anti-inflammatory; CD14+/CD16-), nonclassical (patrolling; CD14+/CD16++), and intermediate (pro-inflammatory; CD14++/CD16+). The CD16+ nonclassical / intermediate monocytes have been implicated in atherosclerosis progression and their levels positively associate with adverse cardiac events. However, there is a relative lack of understanding as to whether there are distinct mechanisms that regulate CD16+ vs. CD16- monocyte adhesion to the inflamed endothelium. Our previous data identified a high-mannose …

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