Digital Commons Network^™

Targeting Innate Immunity For Tuberculosis Vaccination, Shabaana A. Khader, Maziar Divangahi, Willem Hanekom, Philip C. Hill, Markus Maeurer, Karen W. Makar, Katrin D. Mayer-Barber, Musa M. Mhlanga, Elisa Nemes, Larry S. Schlesinger, Reinout Van Crevel, Ramakrishna Vankalayapati, Ramnik J. Xavier, Mihai G. Netea, On Behalf Of The Bill And Melinda Gates Foundation Collaboration For Tb Vaccine Discovery Innate Immunity Working Group

Open Access Publications

No abstract provided.

Two-Period Linear Mixed Effects Models To Analyze Clinical Trials With Run-In Data When The Primary Outcome Is Continuous: Applications To Alzheimer's Disease., Guoqiao Wang, Andrew J Aschenbrenner, Yan Li, Eric Mcdade, Lei Liu, Tammie L S Benzinger, Randall J Bateman, John C Morris, Jason J Hassenstab, Chengjie Xiong

Open Access Publications

Introduction: Study outcomes can be measured repeatedly based on the clinical trial protocol before randomization during what is known as the "run-in" period. However, it has not been established how best to incorporate run-in data into the primary analysis of the trial.

Methods: We proposed two-period (run-in period and randomization period) linear mixed effects models to simultaneously model the run-in data and the postrandomization data.

Results: Compared with the traditional models, the two-period linear mixed effects models can increase the power up to 15% and yield similar power for both unequal randomization and equal randomization.

Discussion: Given that analysis of …

Behavioral Predictors Of Autism Recurrence Are Genetically Independent And Influence Social Reciprocity: Evidence That Polygenic Asd Risk Is Mediated By Separable Elements Of Developmental Liability, Alexa Pohl, Warren R. Jones, Natasha Marrus, Yi Zhang, Ami Klin, John N. Constantino

Open Access Publications

No abstract provided.

Related And Unrelated Donor Transplantation For B-Thalassemia Major: Results Of An International Survey, Chunfu Li, Shalini Shenoy, Et Al.

Open Access Publications

No abstract provided.

Oral Selinexor–Dexamethasone For Triple-Class Refractory Multiple Myeloma, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

A Window On The Lung: Molecular Imaging As A Tool To Dissect Pathophysiologic Mechanisms Of Acute Lung Disease, Guido Musch

Open Access Publications

No abstract provided.

Maternal Pomegranate Juice Intake And Brain Structure And Function In Infants With Intrauterine Growth Restriction: A Randomized Controlled Pilot Study., Lillian G. Matthews, Christopher D. Smyser, Sara Cherkerzian, Dimitrios Alexopoulos, Jeanette Kenley, Methodius G. Tuuli, D. Michael Nelson, Terrie E. Inder

Open Access Publications

Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk newborns, such as those with intrauterine growth restriction (IUGR). This was a randomized, placebo-controlled, double-blind pilot study to investigate the impact of maternal pomegranate juice intake in pregnancies with IUGR, on newborn brain structure and function at term-equivalent age (TEA). Mothers with IUGR at 24-34 weeks' gestation were recruited from Barnes-Jewish Hospital obstetrical clinic. Consented mothers were randomized to treatment (8 oz. pomegranate juice) or placebo (8 oz. …

Dosing Pole Recommendations For Lymphatic Filariasis Elimination: A Height-Weight Quantile Regression Modeling Approach, Charles W. Goss, Katiuscia O'Brian, Christine Dubray, Peter U. Fischer, Myra Hardy, Purushothaman Jambulingam, Christopher L. King, Moses Laman, Jean Frantz Lemoine, Leanne J. Robinson, Josaia Samuela, Swaminathan Subramanian, Taniawati Supali, Gary J. Weil, Kenneth B. Schechtman

Open Access Publications

BACKGROUND: The World Health Organization (WHO) currently recommends height or age-based dosing as alternatives to weight-based dosing for mass drug administration lymphatic filariasis (LF) elimination programs. The goals of our study were to compare these alternative dosing strategies to weight-based dosing and to develop and evaluate new height-based dosing pole scenarios.

METHODOLOGY/PRINCIPAL FINDINGS: Age, height and weight data were collected from >26,000 individuals in five countries during a cluster randomized LF clinical trial. Weight-based dosing for diethylcarbamazine (DEC; 6 mg/kg) and ivermectin (IVM; 200 ug/kg) with tablet numbers derived from a table of weight intervals was treated as the "gold …

Trial Of Sage-217 In Patients With Major Depressive Disorder, Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey Jonas, James J. Doherty, Stephen J. Kanes

Open Access Publications

No abstract provided.

Longitudinal Evaluation Of Cognition After Stroke - A Systematic Scoping Review, Juan Pablo Saa, Tamara Tse, Carolyn Baum, Toby Cumming, Naomi Josman, Miranda Rose, Leeanne Carey

Open Access Publications

BACKGROUND: Cognitive impairment affects up to 80 percent of the stroke population, however, both the available evidence about post-stroke cognition and the measures used to evaluate it longitudinally have not been well described. The aims of this systematic scoping review were: to identify and characterize studies evaluating cognition longitudinally after stroke; to summarize the cognitive instruments used and the domains they target; and to organize cognitive domains assessed using the International Classification of Functioning, Disability and Health (ICF).

METHODS: We used a systematic scoping approach to search for peer-reviewed articles involving adults with stroke that evaluated cognition longitudinally. Screening of …

Evaluating Multisite Rcbv Consistency From Dsc-Mri Imaging Protocols And Postprocessing Software Across The Nci Quantitative Imaging Network Sites Using A Digital Reference Object (Dro), Laura C. Bell, Hongyu An, Cihat Eldeniz, Richard Wahl, Et Al

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights From 2018 [Version 1; Peer Review: 2 Approved], Olivia Rose, Andreas Hartmann, Yulia Worbe, Jeremiah M. Scharf, Kevin J. Black

Open Access Publications

No abstract provided.

Acute Kidney Injury On Chronic Kidney Disease: From Congestive Heart Failure To Light Chain Deposition Disease And Cast Nephropathy In Multiple Myeloma, Sana Shaikh, Christian Nwankwo, Alexandre Lacasse, Steven Cheng

Open Access Publications

Acute on chronic renal failure is a common but notably broad diagnosis. We present a 64-year-old man with a history of diastolic heart failure and chronic kidney disease, admitted for an elevated creatinine. History and physical examination were suggestive of decompensated heart failure; however, the careful interpretation of urinalysis rendered the diagnosis of multiple myeloma. On renal biopsy, the patient was found to have light chain deposition disease with cast nephropathy. Combination lesions in multiple myeloma are rare and require diligent histopathology for detection, including light microscopy, immunofluorescence and electron microscopy. These patients portray different demographics, renal manifestations, oncologic characteristics …

Cell Type-Specific Modulation Of Sensory And Affective Components Of Itch In The Periaqueductal Gray, Vijay K. Samineni, Jose G. Grajales-Reyes, Saranya S. Sundaram, Judy J. Yoo, Robert W. Gereau Iv

Open Access Publications

No abstract provided.

The Social And Functional Implications Of High- Versus Low-Dose Opioids On Chronic Non-Cancer Pain, Yohei Denawa, Will Kurtz, Till Conermann

Open Access Publications

No abstract provided.

Na+-H+ Exchanger 1 Determines Atherosclerotic Lesion Acidification And Promotes Atherogenesis, Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi

Open Access Publications

No abstract provided.

Tropomyosin Isoforms Differentially Tune Actin Filament Length And Disassembly, Silvia Jansen, Bruce L. Goode

Open Access Publications

No abstract provided.

Plasmodium Niemann-Pick Type C1-Related Protein Is A Druggable Target Required For Parasite Membrane Homeostasis, Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinas, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth Winzeler, Akhil B. Vaidya, Daniel E. Goldberg

Open Access Publications

No abstract provided.

Risks Of Harm With Cannabinoids, Cannabis, And Cannabis-Based Medicine For Pain Management Relevant To Patients Receiving Pain Treatment: Protocol For An Overview Of Systematic Reviews, Ian Gilron, Fiona M. Blyth, Louisa Degenhardt, Marta Di Forti, Christopher Eccleston, Simon Haroutounian, Andrew Moore, Andrew S.C. Rice, Mark Wallace

Open Access Publications

No abstract provided.

Cannabinoids, Cannabis, And Cannabis-Based Medicine For Pain Management: A Protocol For An Overview Of Systematic Reviews And A Systematic Review Of Randomised Controlled Trials, Emma Fisher, Christopher Eccleston, Louisa Degenhardt, David P. Finn, Nanna B. Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S.C. Rice, Michael Rowbotham, Mark Wallace, R. Andrew Moore

Open Access Publications

No abstract provided.

High-Density Functional Diffuse Optical Tomography Based On Frequency-Domain Measurements Improves Image Quality And Spatial Resolution, Matthaios Doulgerakis, Adam T. Eggebrecht, Hamid Dehghani

Open Access Publications

No abstract provided.

A Protocol For The Systematic Review And Meta-Analysis Of Studies In Which Cannabinoids Were Tested For Antinociceptive Effects In Animal Models Of Pathological Or Injury-Related Persistent Pain, Nadia Soliman, Andrea G. Hohmann, Simon Haroutounian, Kimberley Wever, Andrew S.C. Rice, David P. Finn

Open Access Publications

No abstract provided.

Irsp53 Coordinates Ampk And 14-3-3 Signaling To Regulate Filopodia Dynamics And Directed Cell Migration, David J. Kast, Roberto Dominquez

Open Access Publications

No abstract provided.

Association Between Mortality And Implantable Cardioverter-Defibrillators By Aetiology Of Heart Failure: A Propensity-Matched Analysis Of The Warcef Trial, Tetz C. Lee, Douglas L. Mann, Et Al

Open Access Publications

No abstract provided.

A Promising Bioconjugate Vaccine Against Hypervirulent Klebsiella Pneumoniae, Mario F. Feldman, Anne E. Mayer Bridwell, Nichollas E. Scott, Evgeny Vinogradov, Samuel R. Mckee, Sthefany M. Chavez, Joy Twentyman, Christina L. Stallings, David A. Rosen, Christian M. Harding

Open Access Publications

No abstract provided.

A Rubisco-Binding Protein Is Required For Normal Pyrenoid Number And Starch Sheath Morphology In Chlamydomonas Reinhardtii, Alan K. Itakura, Kher Xing Chan, Nicky Atkinson, Leif Pallesen, Lianyong Wang, Gregory Reeves, Weronika Patena, Oliver Caspari, Robyn Roth, Ursula Goodenough, Alistair J. Mccormick, Howard Griffiths, Martin C. Jonikas

Open Access Publications

No abstract provided.

Primary Adenoid Cystic Carcinoma Of The Liver: Case Report And Review Of The Literature, Jianbo Zhang, Yuanyuan Wang, Dengfeng Cao

Open Access Publications

Adenoid cystic carcinoma (ACC) is an uncommon tumor primarily occurring in the salivary glands and is relatively rare in other sites. In the liver, only one primary adenoid cystic carcinoma has been reported in the English literature. Here we presented a primary hepatic adenoid cystic carcinoma in a 44 years old male. We described its histopathologic features and its immunohistochemical profile, and reviewed the literature. The surgical treatment and patient follow up information was also presented.

Combined Anti-Inflammatory And Neuroprotective Treatments Have The Potential To Impact Disease Phenotypes In Cln3−/− Mice, Marta A. Tarczyluk-Wells, Christoph Salzlechner, Allison R. Najafi, Ming J. Lim, David Smith, Frances M. Platt, Brenda P. Williams, Jonathan D. Cooper

Open Access Publications

No abstract provided.

Riding The Rhythm Of Melatonin Through Pregnancy To Deliver On Time, Ronald Mccarthy, Emily S. Jungheim, Justin C. Fay, Keenan Bates, Erik D. Herzog, Sarah K. England

Open Access Publications

No abstract provided.

The Nuclear Receptor Rev-Erbα Modulates Th17 Cell-Mediated Autoimmune Disease, Christina Chang, Chin-San Loo, Xuan Zhao, Laura A. Solt, Yuqiong Liang, Sagar P. Bapat, Han Cho, Theodore M. Kamenecka, Mathias Leblanc, Annette R. Atkins, Ruth T. Yu, Michael Downes, Thomas P. Burris, Ronald M. Evans, Ye Zheng

Open Access Publications

No abstract provided.