Digital Commons Network^™

Reconstruction Of Propeller And Complex Ship Hull Surface Based On Reverse Engineering, Guan Guan, Wen-Wen Gu1

Journal of Marine Science and Technology–Taiwan

To quickly obtain the digital model of ship surface for detection and redesign, a reconstruction method for propeller and ship surface is proposed. Three-dimensional point cloud data of ship hull was obtained by laser scanning technology and the cloud data was preprocessed by iterative closest point (ICP) algorithm and chord deviation method. Then the surface was reconstructed with traditional surface modeling method and fast surface modeling method. By comparing the reconstructed surface with the initial point cloud data, the error of the reconstructed model was obtained. The result shows that the reconstructed surface gains good smoothness and small error. With …

Implementing A Fall Prevention Program: A Quality Improvement Project To Promote Patient Mobility On The Medical-Surgical Unit, Alba Araiza

Master's Projects and Capstones

Implementing a fall prevention program is imperative in acute healthcare settings. Falls are one of the top reported events that occur in hospitals and it is a patient safety concern that requires the implementation of evidence-based practices to reduce falls. This quality improvement project will be developed by a master’s prepared clinical nurse leader (CNL) on a medical-surgical unit to improve patient safety.

Problem

Maintaining patient safety is the most important priority in health care. Health care organizations implement protocols, policies and procedures to ensure that care is provided in a safe manner to minimize preventable harms. However, falls are …

Securing Reproductive Justice In India: A Casebook, Aparna Chandra, Mrinal Satish

Books

No abstract provided.

Select Criminal Law And Procedure Cases From The U.S. Supreme Court's 2018-2019 Term, Eve Brensike Primus, Kristin Froehle

Articles

Although the 2018-19 Term at the Supreme Court did not include any blockbuster rulings like Carpenter v. United States, the Court issued a number of significant criminal law and procedure rulings. It addressed warrantless blood-alcohol testing, the dual-sovereignty doctrine, the right to trial by jury, ineffective assistance of trial counsel, questions of incorporation, prisoners' competence to be executed, permissible methods of execution, and some important statutory interpretation questions. Looking back on the Term, Justice Gorsuch clearly solidified his position as the libertarian "swing" vote in criminal procedure cases. He joined the liberals to uphold a defendant's right to trial …

Ryan Miller, Appellant/Petitioner V. Trial Court Brenda Miller, Appellee/Respondent. : Brief Of Appellant, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

Appeal from the Second District Court, Layton, Davis County Judge Michael S. Edwards

Jonathan Hibshman (12552), Marco Brown (13156), Counsel for Appellant/Petitioner

Dustin D. Gibb, Counsel for Appellee/Respondent

Evidence For Late-Stage Eruptive Mass Loss In The Progenitor To Sn2018gep, A Broad-Lined Ic Supernova: Pre-Explosion Emission And A Rapidly Rising Luminous Transient, Anna Y.Q. Ho, Daniel A. Goldstein, Steve Schulze, David K. Khatami, Daniel A. Perley, Mattias Ergon, Avishay Gal-Yam, Alessandra Corsi, Igor Andreoni, Cristina Barbarino, Eric C. Bellm, Nadia Blagorodnova, Joe S. Bright, E. Burns, S. Bradley Cenko, Virginia Cunningham, Kishalay De, Richard Dekany, Alison Dugas, Rob P. Fender, Claes Fransson, Christoffer Fremling, Adam Goldstein, Matthew J. Graham, David Hale, Assaf Horesh, Tiara Hung, Mansi M. Kasliwal, N. Paul M. Kuin, S. R. Kulkarni, Thomas Kupfer, Ragnhild Lunnan, Frank J. Masci

Faculty Publications

We present detailed observations of ZTF18abukavn (SN2018gep), discovered in high-cadence data from the Zwicky Transient Facility as a rapidly rising (1.4 ± 0.1 mag hr-1) and luminous (Mg,peak = -20 mag) transient. It is spectroscopically classified as a broad-lined stripped-envelope supernova (Ic-BL SN). The high peak luminosity (Lbol ≳ 3 × 1044 erg s-1), the short rise time (trise = 3 days in g band), and the blue colors at peak (g-r ∼ -0.4) all resemble the high-redshift Ic-BL iPTF16asu, as well as several other unclassified fast transients. The early discovery of SN2018gep (within an hour of shock breakout) enabled …

Troubling “Technologies”: Exploring The Global Learning Xprize Using The Frameworks Of Skinner And Foucault, Tanya Elias

Current Issues in Emerging eLearning

This work focuses on the question: What might be wrong with large-scale approaches to learning? In posing this question, my purpose is not to suggest that large-scale approaches have no role to play within a complex educational landscape. Rather, I seek to introduce a starting point for more critical and nuanced approaches to achieving proper scale within digital learning, whether big and small. Organized around a series of stories from a train-ride home, I introduce a series of process-based “technologies” as defined by Skinner (1971) and Foucault (1988). After contrasting key concepts of Skinner and Foucault, I apply Foucault’s framework …

Personal Reflections / 12.20.19, José M. Torres

Personal Reflections

Happy Holidays. After a week of final exams and projects, our students are headed off to spend a couple of weeks at home with their families. Others will be traveling as part of Intersession trips to Spain, Hawaii, Mexico and Poland, just to name a few. One of our faculty members, Paavo Husen, will host a Russian teacher in his home as part of an exchange program with students from Lyceum Physical Technical High School, St. Petersburg. Our staff, including faculty, will also spend some time away re-energizing and recovering from what seemed like an incredibly speedy first semester. My …

Book Review: Phenomena Of Power: Authority, Domination, And Violence, Kerri J. Malloy

Genocide Studies and Prevention: An International Journal

No abstract provided.

Scenarios Of Intractability: Reframing Intractable Conflict And Its Transformation, Kerry Whigham

Genocide Studies and Prevention: An International Journal

For those working toward long-term conflict transformation and atrocity prevention, cases of so-called “intractable conflict” are an enduring source of frustration, continually resisting what seems to be an otherwise useful toolbox of "lessons learnt" and "best practices." Referring to these cases as intractable, however, only serves to naturalize their intractability, rendering it an essential and immutable quality of the conflicts, and thus foreclosing options for engagement and prevention. Moreover, it obscures interventions that may have already emerged from within these conflicts that are transforming the way they play out. This article suggests, instead, to perceive these cases as scenarios of …

An Exploration Of Communication Ethics Scholarship And Economic Spheres, Andrew Tinker

Electronic Theses and Dissertations

This project examines communication ethics scholarship to understand how economics is understood within the field and to establish coordinates for scholars to discuss economic spheres as phenomena that affect communication ethics. Scholars draw from the tradition of virtue ethics to mark communication ethics inquiry as that which explores the practices that protect and promote the “good.” Philosophers of communication and communication ethicists have developed paradigmatic metaphors for the field that allow us to understand the formation of ethical guidelines within communities both familial, corporate, and national, that promote and protect various goods. These metaphors include “hierarchy” and “sameness” from Charles …

A Pilot Study Examining Differences In Tactile Sensory Processing As A Function Of Borderline Personality Disorder Symptomatology And Non-Suicidal Self-Injury, Julia Elizabeth Hooker

Theses - ALL

Borderline Personality Disorder (BPD) is characterized by a pattern of instability in self-image, interpersonal relationships, emotional regulation, and impulsivity that significantly impacts functioning in everyday life. Non-suicidal self-injury (NSSI) is a hallmark symptom of BPD that serves to regulate affective instability and relieve inner aversive tension. Experimental pain modalities are commonly employed to assess sensory perception in the context of BPD. Although the experience of self-inflicted pain during NSSI is thought to contribute to emotional regulation, individuals with BPD tend to exhibit reduced experimental pain sensitivity when compared to healthy controls. Thus, experimental pain reactivity may not adequately reflect mechanisms …

Investigation Of The Effects Of A Yoga Intervention On Experiential Avoidance, Symptoms Of Psychological Distress, And Substance Use, Samantha Sinegar

Theses - ALL

The current study sought to examine the utility of yoga for reducing experiential avoidance (EA), as well as symptoms of psychological distress (SPD) and substance use. EA refers to the attempt to avoid or control adverse bodily sensations, thoughts, feelings, and memories despite negative consequences. Yoga is a holistic system of mind-body practices which includes physical postures, stretching, and breathing exercises aimed at maintaining and improving both mental and physical health. Undergraduates (n = 43) from a yoga class and basic exercise classes were recruited to participate and served as the intervention and active control group, respectively. Self-reported measures of …

The Art Of Subtitling: A Case Study Of A Chinese Online Fansub Group, Xianwei Wu

Theses - ALL

Online fan subtitling (hereafter fansub) groups are a recent phenomenon that have quickly gained global popularity. They are groups of volunteers who produce and distribute subtitles of English televisions shows and films for free. However, to date not much academic attention has been paid to this phenomenon in a critical capacity, with the exception of anime fansubbing. This study closely examines one fansub group in China using a single-case design case study. The methods of data collection include: in-depth interviews with the translators; participant observation as a subtitle translator; and textual/discourse analysis of the subtitles. This study will use the …

Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng

Theses & Dissertations

Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …

Molecular Insights Into Major Peripheral T-Cell Lymphoma Entities With Advances In A Representative Model System, Tayla B. Heavican

Theses & Dissertations

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Genomic copy number analysis and targeted sequencing revealed unique genomic abnormalities and oncogenic pathways, indicating distinct oncogenic evolution. PTCL-GATA3 exhibited higher genomic complexity characterized by frequent loss or mutation of tumor suppressor genes targeting the CDKN2A/B-TP53 axis and PTEN-PI3K pathways. …

The Development Of Hyaluronan-Based Contract Agents For The Intraoperative Detection Of Pancreatic Tumors, Bowen Qi

Theses & Dissertations

Pancreatic ductal adenocarcinoma is highly lethal and surgical resection is the only potential curative treatment for the disease. Tumor-specific intraoperative fluorescence imaging could improve staging and surgical resection, thereby improving prognosis. In the first study, hyaluronic acid derived NPs with physico-chemically entrapped indocyanine green, termed NanoICG, were utilized for intraoperative near infrared fluorescence detection of pancreatic cancer. NanoICG accumulated significantly in an orthotopic pancreatic ductal adenocarcinoma model with safety profile both in vitro and in vivo. To maximize tumor signal, while minimizing signal in healthy pancreas and RES capture of macromolecules, in the next study, we describe the rational …

Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud

Theses & Dissertations

The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. PPARγ is a target for insulin-sensitizing drugs, and it plays a significant function in prostate cancer. PPARγ antagonists have anti-proliferative effects in a broad range of hematopoietic and epithelial cell lines. The ligand binding domain (LBD) of PPARγ is large and has orthosteric and allosteric binding sites. Several PPARγ-ligand co-crystal structures show two bound molecules, one to the orthosteric pocket and a second to the allosteric …

Enhancing The Identification Of Rheumatoid Arthritis-Associated Lung Disease, Bryant England

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predisposes afflicted individuals to reduced quality of life, physical disability, and premature mortality. While joint involvement is the primary manifestation of RA, extra-articular features including lung disease are responsible for a significant portion of the excess mortality. In this dissertation I demonstrate the contribution of chronic lung diseases to premature mortality in RA, contrasting with the more widely recognized comorbidity in RA of cardiovascular disease. Then, I establish that a novel serum biomarker, anti-malondialdehyde-acetaldehyde adduct (MAA) antibody, is associated with the presence of interstitial lung disease (ILD) in RA subjects. Further …

Brca1 & Ctdp1 Brct Domainomics In The Dna Damage Response, Kimiko L. Krieger

Theses & Dissertations

Genomic instability is one of the enabling characteristics of cancer. DNA damage response pathways are important for genomic integrity and cell cycle progression. Defects in DNA damage repair can often lead to cell cycle arrest, cell death, or tumorigenesis. The activation of the DNA damage response includes tightly regulated signaling cascades that involve kinase phosphorylation and modular domains that scaffold phosphorylated motifs to coordinate recruitment of DNA repair proteins. Modular domains are conserved tertiary structures of a protein that can fold, function, and evolve independently from an intact protein. One of the most common modular domains involved in DNA damage …

The Role Of E3 Ubiquitin Ligase Fbxo9 In Normal And Malignant Hematopoiesis, R. Willow Hynes-Smith

Theses & Dissertations

Hematopoiesis is a critical system that provides blood cells necessary for nutrient and oxygen transfer throughout an organism and for protection from harmful agents. It is maintained throughout life by the hematopoietic stem cells (HSCs) that reside within the bone marrow (BM) and are responsible for providing billions of new cells each day. HSCs maintain a careful balance between a quiescent state, that sustains the integrity of the stem cells, and a proliferative state, that provides new cells to replenish those that undergo apoptosis. Hematopoiesis is regulated by a variety of intrinsic pathways and extrinsic signals such as cytokine signaling, …

Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann

Theses & Dissertations

RATIONALE: Our laboratories birthed the field of human immunodeficiency virus (HIV) theranostics. The new field allows simultaneous detection (diagnostics) and treatment (therapeutic) for the identification, treatment and inevitable elimination of virus in cell and tissue compartments. By employing theranostics, antiretroviral drugs (ARVs) can be tracked in lymph nodes, gut, spleen and liver. Cellular viral reservoirs including CD4+ T cell populations and mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) along with subcellular endosomal structures can now be targeted for drug delivery bringing therapeutics to areas where virus replicates. The overarching idea rests in improving precision targeted ARV delivery. …

Characterizing The Combination Of Rpa Inhibitors With Parp Inhibitors In High-Grade Serous Ovarian Cancer, Yat Tang

Theses & Dissertations

High-grade serous ovarian cancer (HGSC) is the most common and deadly gynecologic malignancy. HGSC patients with BRCA1/2 mutations have homologous recombination deficiency (HRD), requiring parallel pathways to maintain genome integrity (e.g., PARP1, PARP2). Approximately 50% of ovarian carcinomas are estimated to exhibit HRD. For the remaining 50% and the large percentage of HRD patients with acquired or innate resistance to single-agent PARP inhibitors, there is a need to develop alternative therapeutic strategies.

Replication Protein A (RPA) is a heterotrimeric protein crucial for genome maintenance. Phosphorylation of RPA in DNA damage response (DDR) is a negative regulator of DNA end resection. …

Targeted Inhibition Of Histone Deacetyltransferases For Pancreatic Cancer Therapy, Richard Laschanzky

Theses & Dissertations

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a dismal five-year survival rate of less than 10%. One major obstacle in PDAC treatment is acquired drug resistance. Pan-histone deacetylase inhibitors (pan-HDACi) are a relatively new class of anti-cancer drugs, with demonstrated ability to overcome drug resistance and re-sensitize PDAC tumors to Gemcitabine (Gem). These agents target HDACs, a family of 18 enzymes (divided into four classes, I-IV) that catalyze the deacetylation of histones and other cellular proteins and have multiple effects on cell growth, differentiation, survival, and tumorigenesis. Although pan-HDACi have shown significant efficacy in preclinical analysis, and some …

Evaluating The Use Of Competing Items In A Multiple Schedule During Reinforcement Schedule Thinning, Scott A. Miller

Theses & Dissertations

Multiple schedules are schedules of reinforcement that are often used to facilitate more manageable rates of a replacement behavior such as a communication response following functional communication training as an intervention for destructive behavior. Commonly, reinforcement schedule thinning involves multiple fading steps that can take more than 100 sessions to achieve therapeutic goals. The purpose of this experiment was to evaluate a method for rapidly achieving fading steps in a multiple schedule by including competing items during the extinction interval. Four children diagnosed with autism successfully reached the terminal extinction interval with a ≥80% reduction in problem behavior. Two of …

Transcription Regulation Of Human Il1b Gene In Monocytes And Lymphoid Cd4 T Cells, Sree H. Pulugulla

Electronic Theses and Dissertations

Cytokines are key regulators of the inflammatory response and play an important role in facilitating intercellular communication between various immune cell types. Interleukin‑1β (IL‑1β) is a potent pro-inflammatory cytokine that is required for robust initiation of innate immune response and subsequent development of adaptive immunity. IL-1β is first synthesized as an inactive cytoplasmic, non‑glycosylated, precursor molecule (proIL‑1β) by monocytes and macrophages in response to invading pathogenic microbes. The activation of caspase‑1 by inflammasomes cleaves proIL-1β into mature biologically active IL-1β that is released from cells via a non-classical, endoplasmic reticulum‑independent secretory pathway directly from the cytoplasm via Gasdermin D membrane …

Evaluating Perceptions Of Student Voice And School Membership Of 9th Grade Students And Teachers, Dan Beck

Electronic Theses and Dissertations

Adolescence marks a developmental period of rapid cognitive, emotional, and physical growth where teenagers are tasked with establishing an identity and strong sense of self. Students and parents often report that transition to ninth grade is a formidable social challenge amidst increased academic demands and stress, and some research suggests that females have a more difficult time in the transition to high school than males. Student voice is a range of student opportunities to interact, collaborate, and partner with adults in an exploration of ideas and perspectives. However, student voice opportunities are often only available to a select group of …

Towards Collaboration: A Comparative, Longitudinal, Conversation Analysis Of Change In Talk-In-Interaction In Psychotherapy, Kai Bekkeli

Electronic Theses and Dissertations

The study utilizes conversation analysis to describe changes at the level of talk-in-interaction across four points of time (beginning, middle, late, and ending sessions) in four different psychotherapies: two “successful” psychotherapies and two “unsuccessful” ones, with the author of this study conducting the psychotherapies in each case. The analytic domains, practices, and sequence types of interest were not pre-defined at the outset, though the analysis showed alignment to be of principal interest. Patients whose therapies were “successful” progressively aligned with therapeutic activities over time, with a difference revealed in how quickly this alignment occurred according to the ‘type’ of activity …

The Beliefs Literacy Specialists Hold Regarding Processes That Assist Struggling Readers With The Comprehension Of Informational Text, Marguerite Haldin

Electronic Theses and Dissertations

Children have a basic human right to read. It is the evolving work of the reading/literacy specialists to provide support and build confidence in readers struggling in all components of reading. The purpose of this study is to explore the beliefs of reading/literacy specialists regarding the processes that assist struggling readers with the comprehension of informational text. The methods used were designed to address the research question: What are the beliefs reading/literacy specialists hold regarding processes that assist struggling readers with the comprehension of informational text? Nineteen members of a professional learning group from an intermediate unit in Southwestern Pennsylvania, …

Effective Instructional Strategies In Sixth Grade Inclusion Mathematics Classrooms: The Effect Of Active And Passive Engagement On Concept Learning And Opportunity To Learn, Christy Mikolaj

Electronic Theses and Dissertations

The purpose of this mixed-method study focused on the effect of active engagement on opportunity to learn and concept learning among sixth grade special education students participating in the inclusion mathematical setting. By implementing two instructional strategies and using the theoretical frameworks of Vygotsky’s Social Constructivism and Erikson’s Stage of Psychosocial Development of Industry vs. Inferiority, findings showed there was a significant negative relationship between active engagement time during instruction and concept learning. The study showed students with identified needs within an inclusion mathematics setting increased concept learning in both instructional classrooms. Therefore, there was no difference in concept learning …