Digital Commons Network^™

How A Small Business Negotiates Digital Inclusion Of People With Disabilities: A Case Study, Belo Miguel Cipriani

University of the Pacific Theses and Dissertations

Technology has provided more people access products and services, yet some individuals who would benefit the most from digital access to resources are frequently excluded from participation. One group that is largely neglected is the disability community. Despite federal regulations intended to ensure that people with physical/mental disabilities are included in public digital platforms, organizations continuously design websites, applications, and interfaces without people with disabilities in mind. This is particularly the case with small businesses, which are most commonly reported as having inaccessible digital platforms.

Digital inclusion attempts to ensure equity in digital properties by providing a model to operationalize …

Approaches To The Search Of Platinum Anticancer Agents: Derivatizing Current Drugs And Incorporating Hdac Inhibition, Chao Feng

University of the Pacific Theses and Dissertations

Platinum-based anticancer drugs, such as cisplatin, carboplatin, and oxaliplatin, have been approved for clinical use worldwide for decades. Despite their enormous success, their widespread application is hindered by either cross-resistance or toxic side effects, including nephrotoxicity and neurotoxicity. The need to overcome these drawbacks has stimulated the search for new platinum-based drugs.

This dissertation will start with the accidental discovery of cisplatin, followed by an introduction of other platinum-based anticancer agents, including the action mechanism, general structures, and development history. Picoplatin is a newer generation of platinum-based anticancer agent. The bulky 2-methylpyridine as a non-leaving group on picoplatin could reduce …

Exploring The Molecular Origin Of Jet Fuel Thermal Oxidative Deposition Through Statistical Analysis Of Mass Spectral Data And Pyrolysis Gas Chromatography/Mass Spectrometry Of Deposits, Krege Matthew Christison

University of the Pacific Theses and Dissertations

ASTM D3241 (Standard Test Method for Thermal Oxidation Stability of Aviation Turbine Fuels) measures the thermal oxidative stability of jet fuels under elevated temperature and pressure conditions. When jet fuels fail ASTM D3241, either at the refinery or in the distribution system, there can be supply disruptions and financial losses. Understanding the causes of poor thermal oxidative stability in jet fuels could help prevent or mitigate issues. In order to develop a deeper understanding of the molecular precursors that lead to ASTM D3241 failures, a number of analytical methodologies and data treatment techniques have been developed, applied, and reported here. …

The Effects Of The Flipped Classroom Model On Students' Learning In A College English Class In Shanghai, China, Xiaoying Wei

University of the Pacific Theses and Dissertations

For many decades, college English teaching in China has been teacher-centered, mainly focusing on the enhancement of students’ four basic English language skills of listening, speaking, reading and writing, with little attention paid to the cultivation of students’ higher order thinking skills (Tang, 2016; Wang, Xu, & Zhou, 2016). The teacher-centered teaching approach has led to the problem that after having learned English for many years, students cannot speak English fluently (Dai, 2001). There has been a call for promoting the student-centered teaching model in China (NACFLT, 2000). One relatively new approach to support student-centered active learning is flipped instruction …

Dialogue During Team Problem Solving Using Visual Representation Boundary Objects: A Case Study, Julie Marie Webb

University of the Pacific Theses and Dissertations

Organizations benefit from the knowledge held by individual members as well as knowledge that is shared among those members. In order for knowledge to co-develop between members, and to spread, organizations must provide opportunities for members to collaborate. Organizational teams sometimes require assistance with interpersonal communication, establishing consensus, and sharing knowledge when collaborating. Group facilitators can offer guidance and intervene when teams need support. In addition, teams can find support through the use of visual representation boundary objects (VRBOs) to build trust, improve communication, increase cooperation, and share ideas. This study explores how knowledge is shared between team members and …

I3: Isomerization Of Isomer Ions, Krisztián Gabor Torma

University of the Pacific Theses and Dissertations

Photoelectron Photoion Coincidence (PEPICO) spectroscopy is a robust tool for elucidating complex unimolecular dissociation mechanisms and for determining thermochemical and kinetic data of gas-phase ion dissociations with high accuracy. In this work, the dissociative photoionization of two sets of isomeric systems were analyzed with PEPICO: 1) C7H7+ ions of toluene (Tol) and 1,3,5-cycloheptatriene (CHT), and 2) two butyl alcohol isomers, 1-butanol and isobutanol. Threshold dissociative photoionization data on these four molecules of interest were collected on the imaging PEPICO apparatus at the VUV beamline of the Swiss Light Source. Data analysis was aided by ab initio calculations and Rice-Ramsperger-Kassel-Marcus (RRKM) …

The Effects Of Listening To Motivational Music On Performance Of Knee Extension And Flexion In Healthy Adults, Alexander Lesser

University of the Pacific Theses and Dissertations

The purpose of this study was to determine whether listening to motivational music prior to performing leg extensions and flexions effected peak torque performance. Participants included 23 adults between the ages 18 and 48 years. Participants engaged in three sets of leg extensions and flexions utilizing a Cybex Humac NORM system following a warm-up period consisting of listening to either researcher-selected music, self-selected music, and in silence. Two one-way ANOVAs comparing participants’ data showed significant results in leg flexions performed following warm-up while listening to self-selected music. Significant results were not achieved for leg extensions yet a similar trend was …

Visual Feedback In Voice Therapy For Individuals With Parkinson's Disease, Rachel Brooke Convey

University of the Pacific Theses and Dissertations

Parkinson ’s disease (PD) is a progressive neurological disorder that affects one’s movement. As the disease develops, individuals begin to present with symptoms that include but are not limited to bradykinesia, rigidity, tremors, and hypokinetic dysarthria. These symptoms affect a person’s entire body, including his/her voice. The Lee Silverman Voice Treatment (LSVT) program for treating individuals with PD is supported by over twenty-five years of research. It is considered a safe, non-invasive method to improve vocal loudness and speech clarity in individuals with PD. However, simply because LSVT is effective in its current state, it does not mean that the …

Disrupting The Prison-To-Prison Pipeline: Doing Restorative Identity Work With Offender-Labeled Youth, Jahmon Londre Gibbs

University of the Pacific Theses and Dissertations

The purpose of this qualitative ethnographic study was to addresses how the existence of counterspaces influences the psychological well-being of offender-labeled youth transitioning back into society. A counterspace has been defined as a social setting where two or more individuals come together to challenge deficit notions. No longer is recidivism solely being placed on offender-labeled youth that reside within juvenile correctional facilities, therefore the need for innovative programs that help develop resistance narratives and promote reengagement with the educational system are needed. In this 12-week qualitative ethnographic study the two concepts of restorative practices and narrative identity work are blended …

Effects Of Eye Tracking During Infancy On Social Ambiguity And Emotional Distress, Gabriela Hernandez

University of the Pacific Theses and Dissertations

The purpose of this study was to investigate the relationship between early eye tracking and later non-suicidal self-injury, and whether this relationship was negatively impacted by distress and impulsivity, and conversely alleviated by emotional regulation and problem solving abilities. Briggs-Gowan et al. (2001) found that young children with recurrent and comorbid externalizing and internalizing problems have the most impairment; they exhibit greater difficulty with emotional stability, and require greater utilization of mental health services. Little research has focused on the relationship between eye tracking in early infancy and suicidal self-injurious (NSSI) behavior in early childhood. Multiple regression analysis was used …

How Data Science Can Advance Mental Health Research, Tc Russ, E Woelbert, Kas Davis, Jd Hafferty, Et Al

Peninsula Medical School

Accessibility of powerful computers and availability of so-called big data from a variety of sources means that data science approaches are becoming pervasive. However, their application in mental health research is often considered to be at an earlier stage than in other areas despite the complexity of mental health and illness making such a sophisticated approach particularly suitable. In this Perspective, we discuss current and potential applications of data science in mental health research using the UK Clinical Research Collaboration classification: underpinning research; aetiology; detection and diagnosis; treatment development; treatment evaluation; disease management; and health services research. We demonstrate that …

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …

Investigating Variation And Strength In Social Networks, Timothy D. Immelman, Richard M. Wielkiewicz

Psychology Faculty Publications

Participants were 318 college students from two small, Catholic liberal arts institutions in the Upper Midwest. Variation (i.e., having friends with varied interests and activities) of an individual’s social network was measured by a researcher-developed inventory, the Social Network Variation Scale (SNVS). Social network strength was measured by the researcher-developed Social Network Strength Scale (SNSS). People with more variation or more strength in their social network had higher levels of happiness and lower levels of stress. Autonomy mediated the relationships between variation and stress and strength and stress. Personality moderated the relationships between variation and happiness and variation and stress.

Exploring The Buffering Effects Of Holding Behaviors On The Negative Consequences Of Workplace Discrimination For People Of Color, Heather A. Kohlman Olsen

Industrial-Organizational Psychology Dissertations

Previous research suggests that discrimination is still a prevalent problem within organizations even with the current laws and policies in place in the United States to ensure equality of opportunity for minority groups. Therefore, people of color continue to report experiencing inequality and exclusion in the workplace. The broad purpose of the current investigation is to provide guidance to organizations regarding proactive strategies for mollifying the deleterious consequences that people of color often experience as a result of enduring numerous incidences of subtle discrimination in the workplace. Specifically, I proposed that when people of color report having trusting, supportive relationships …

De Pilares Y Fundamentos: Siete Tesis Respecto De La Hermenéutica Del Pentateuco, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

An Opportunity To Be Creative, S. Joseph Kidder, Kristy L. Hudson

Faculty Publications

No abstract provided.

Finding God In Community, S. Joseph Kidder, Jonny Wesley Moor

Faculty Publications

"God exists in community. Before the angels, before the universe, before perhaps time itself, the Father, Son, and Spirit shared a continuous love that can exist only in community.¹ Community is God’s primal manifestation of existence and reality. When God created humanity, He intended for us to be able to relate to Him, so the Lord made us male and female (Gen. 1:27), counterparts equal but distinct in community. Jürgen Moltmann argues that truly knowing something involves being able to participate with that entity.² For example, rather than learning physics merely to recite formulas and laws, …

Food Choice By A Free-Ranging Antillean Manatee (Trichechus Manatus Manatus) In Tabasco, Mexico, Daniel Gonzalez-Socoloske, David Olivera-Gomez

Faculty Publications

Understanding foraging ecology is an important element of effective conservation strategies. While West Indian manatees (Trichechus manatus) have been documented to consume a wide variety of vascular plants and algae, little is known about the diet of the Endangered Antillean subspecies (T. m. manatus) at freshwater sites such as the wetlands of Tabasco, the largest manatee habitat in Mexico. Here we present the results of a study of wild manatee diet in a freshwater site in Mexico. Controlled food choice experiments were conducted on a wild adult manatee during the dry seasons of 2011 and 2012. …

Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek

Faculty Publications

No abstract provided.

Parenting Adolescents In Today’S World, Alina M. Baltazar

Faculty Publications

No abstract provided.

First Mission Outpost: The Family, Alina M. Baltazar, Silvia Bacchiocchi

Faculty Publications

No abstract provided.

The Library As A Lab For Student Work (Chapter 3), Cindy Pierard, Suzanne M. Schadl, Amy S. Jackson

University Libraries & Learning Sciences Faculty and Staff Publications

Students are emerging scholars whose work should be recognized and shared along with work created by established scholars. Libraries are actively engaged with student-created content and encourage students to see themselves as producers, not just consumers, of information. By shifting priorities, libraries should include student-created content in their spaces, and become participants in high-impact educational practices, increasing student investment in their learning, their engagement with scholarship at the institutional level, and their success and retention. These new priorities also open the library to new campus partnerships, making student scholarship and content a common goal.

Scholarship in the Sandbox is broken …

Undesirable Difficulties: Investigating Barriers To Students' Learning With Ebooks In A Semester-Length Course, Cindy Pierard, Vanessa Lynn Svihla, Susanne K. Clement, Bing-Shan Fazio

University Libraries & Learning Sciences Faculty and Staff Publications

Our ability to make informed decisions about ebooks is constrained by our limited understanding of how students perceive and use them. A team of librarians and a professor in learning sciences asked graduate students to serve as informants on student experience with ebooks. In two semester-long studies we analyzed student work, focusing on barriers and affordances they identified. In the first cohort, students who chose to explore ebooks uncovered affordances. In the second cohort, student comfort levels with PDF formats increased, while comfort with ebooks decreased. We discuss strategies for minimizing challenges and increasing desirable difficulties to support ebooks as …

Paper Presented At The National Council Of Preservation Education Conference, Samuel E. Sisneros

University Libraries & Learning Sciences Faculty and Staff Publications

Historic preservation’s principles and practices directly correlate and support the charge of librarians and archivists to provide resources for the public and contribute to scholarship and community building. This paper, presented at the National Council of Preservation Education conference in Denver, Colorado (Oct. 10-12, 2019), will discuss the research methodologies, historical context and preservation issues of a recovery project of an historic site in New Mexico.

A Blind Comparative Study Of Focused Wave Interactions With A Fixed Fpso-Like Structure (Ccp-Wsi Blind Test Series 1), Ej Ransley, S Yan, S Brown, T Mai, D Graham, Q Ma, P-H Musiedlak, Ap Engsig-Karup, C Eskilsson, Q Li, J Wang, Z Xie, V Sriram, T Stoesser, Y Zhuang, Q Li, D Wan, G Chen, H Chen, L Qian, Z Ma, C Mingham, D Causon, I Gatin, H Jasak, V Vukcevic, S Downie, P Higuera, E Buldakov, Q Chen

School of Engineering, Computing and Mathematics

No abstract provided.

A Personalized And Platform-Independent Behavior Control System For Social Robots In Therapy: Development And Applications, T Belpaeme

School of Engineering, Computing and Mathematics

Social robots have been proven beneficial in different types of healthcare interventions. An ongoing trend is to develop (semi-)autonomous socially assistive robotic systems in healthcare context to improve the level of autonomy and reduce human workload. This paper presents a behavior control system for social robots in therapies with a focus on personalization and platform-independence. This system architecture provides the robot an ability to behave as a personable character, which behaviors are adapted to user profiles and responses during the human-robot interaction. Robot behaviors are designed at abstract levels and can be transferred to different social robot platforms. We adopt …

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …

Dealing With The Effects Of Ocean Acidification On Coral Reefs In The Indian Ocean And Asia, Vicky W.Y. Lam, Suchana Chavanich, Salpie Djoundourian, Sam Dupont, Françoise Gaill, Guillaume Holzer, Kirsten Isensee, Stephen Katua, Frank Mars, Marc Metian, Jason M. Hall-Spencer

School of Biological and Marine Sciences

© 2019 Elsevier B.V. Shallow coral reefs provide food, income, well-being and coastal protection to countries around the Indian Ocean and Asia. These reefs are under threat due to many anthropogenic stressors including pollution, sedimentation, overfishing, sea surface warming and habitat destruction. Ocean acidification interacts with these factors to exacerbate stress on coral reefs. Effective solutions in tackling the impact of ocean acidification require a thorough understanding of the current adaptive capacity of each nation to deal with the consequences. Here, we aim to help the decision-making process for policy makers in dealing with these future challenges at the regional …

Can Ecosystem Functioning Be Maintained Despite Climate-Driven Shifts In Species Composition? Insights From Novel Marine Forests, A Pessarrodona, A Foggo, D Smale

School of Biological and Marine Sciences

No abstract provided.

Internal Lee Waves And Baroclinic Bores Over A Tropical Seamount Shark ‘Hot-Spot’, P. J. Hosegood, W. A.M. Nimmo-Smith, R. Proud, K. Adams, A. S. Brierley

School of Biological and Marine Sciences

Oceanographic observations were made with a subsurface oceanographic mooring over the summit and flanks of two neighbouring seamounts in the tropical Indian Ocean to identify processes that may be responsible for the aggregation of silvertip sharks (Carcharhinus albimarginatus) in the deep water drop-off surrounding the summits. The seamounts, which are in the Chagos Archipelago in the British Indian Ocean Territories, are narrow in horizontal extent (<10 km), have steeply sloping (>15°) sides that rise from depths of > 600 m, and flat summits at a depth of 70 m. They are subjected to forcing at subinertial, basin-scales and local scales that include a mixed tidal …