Digital Commons Network^™

Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin

University of the Pacific Theses and Dissertations

Structure based computational peptide design methods have gained significant interest in recent years with the availability of structural insights of protein-protein interactions obtained from the crystal structures. Most of these approaches design new peptide ligands by connecting the crucial amino acid residues from the protein interface and are generally not based on any predicted receptor-ligand interaction. In this work, a peptide design method based on the Knob-Socket model was used to identify the specific ligand residues packing into the receptor interface. This method enables rational peptide ligand design by predicting amino acid residues that will fit best at the binding …

Factors Underlying High School Mathematics Teachers' Perceptions Of Challenging Math Tasks, Mariya Anne Sullivan

University of the Pacific Theses and Dissertations

In this confirmatory factor analysis, factors previously identified to explain the variability in Middle School Mathematics Teachers’ perception of the Common Core State Standards of Mathematics were considered as factors hypothesized to effect high school math teachers’ perceptions of challenging math tasks (CMTs). The factor of student characterization (i.e., disposition, academic preparation, and student behavior) was additionally considered as a factor hypothesized to explain teachers’ perceptions of CMTs, as well as site-based variables (i.e., curriculum, assessment and evaluation, professional development, and collaboration). In addition, teachers’ understanding of the importance of the mathematical practice standards and teacher familiarity with enacting CMTs …

Structural Characterization Of Black Widow Spider Dragline Silk Proteins Crp1 And Crp4, Mikayla Shanafelt

University of the Pacific Theses and Dissertations

Spider dragline silk is a biomaterial with outstanding material properties, possessing high-tensile strength and toughness. In nature, dragline silk serves a central role during spider locomotion and web construction. Today, scientists are racing to elucidate the molecular machinery governing silk extrusion, attempting to translate this knowledge into a mimicry process in the laboratory to create synthetic fibers for a wide range of different applications. During extrusion, it has been established that biochemical and mechanical forces govern spidroin folding, aggregation, and assembly. In black widow spiders, at least 7 different proteins have been identified as constituents of dragline silk fibers. These …

Faculty Adaptation To Emerging Instructional Technologies In Higher Education, Marilyn Murrillo

University of the Pacific Theses and Dissertations

This study examined how and why faculty adopt podcasting as an instructional technology tool in their teaching. Podcasting is an instructional technology tool being used for teaching and learning in higher education. Faculty may record lectures with audio, video, and/or PowerPoint slides to instruct students on class material. Students may access podcasts at their convenience through various devices, including mobile devices and computers. Research has shown that students who use podcasts to study for tests tend to perform more successfully on tests. This study was a qualitative multiple case study of seven California community college faculty using podcasting as an …

An Autoethnographic Study: An Identity Lost And A Passage Discovered, Simone Shonte Martinez

University of the Pacific Theses and Dissertations

The professional careers of teachers with a chronic illness can sometimes be devastating. This study addresses the insufficient understanding of the identity crisis a teacher goes through when one is suddenly diagnosed with a chronic illness. While researching different types of theories, identity theory best fit this topic and my interest. Within identity theory, there are four perspectives to view identity. The four perspectives are Nature, Institution, Discourse, and Affinity identities. In order to understand identity, one must understand how identity is formed. Chronic illness identity is a change from all other identities that have been constructed. This study uses …

Fliposomes With A Ph-Sensitive Conformational Switch For Anticancer Drug Delivery Against Triple Negative Breast Cancer, Yifan Lu

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death in the US and worldwide, accounting for 16% of deaths worldwide in 2015. Of more than 100 types of cancers affecting humans, breast cancer is the most common cancer among women and is the second leading cause of death in women. Triple negative breast cancer (TNBC) is a subtype of breast carcinomas defined by the lack of the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2 /neu). The prognosis and survival of TNBC patients remains the poor due to the lack of effective targeted therapy. …

Intrapulmonary Inoculation Of Multicellular Tumor Spheroids To Construct An Orthotopic Lung Cancer Xenograft Model That Mimics Four Clinical Stages Of Non-Small Cell Lung Cancer, Yingbo Huang

University of the Pacific Theses and Dissertations

Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development and progression of lung cancer as seen …

Blubber Transcriptome And Proteome Responses To Repeated Adrenocorticotropic Hormone Administration In A Marine Mammal, Jared Deyarmin

University of the Pacific Theses and Dissertations

Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction and immunity. This can be especially deleterious for capital breeding carnivores, such as marine mammals, which rely on lipid stores accrued during intensive foraging to sustain prolonged periods of fasting associated with reproduction. Therefore, chronic stress may cause a decrease in fitness in these animals, leading to population declines and potentially detrimental shifts in food web dynamics as a result. However, the impacts and indicators of chronic stress in animals are currently poorly understood. To identify downstream mediators of repeated stress responses in marine mammals, adrenocorticotropic hormone …

The Effects Of Design Thinking On Students' Career Self-Efficacy In Career Guidance Courses, Zhongmiao Sun

University of the Pacific Theses and Dissertations

The present study focuses on integrating design thinking into career guidance courses to test whether students’ career self-efficacy is increased by comparing the experiment group (by using design thinking method) and the general group (by using traditional teacher-centered method). The basic theoretic framework is Bandura’s self-efficacy theory (Bandura, 1977). Students will achieve career self-efficacy after experiencing repeatedly success (Bandura, 1977) in the career activities through design thinking method. Then students will have more confidence to make more appropriate career choices in their employment environment.

This study used AMOS and path analysis to analyze a just-identified model. The model included five …

A Trio Of Sigma Factors Control Hormogonium Development In Nostoc Punctiforme, Alfonso Gonzalez Jr.

University of the Pacific Theses and Dissertations

Cyanobacteria are prokaryotes capable of oxygenic photosynthesis, and for many species, nitrogen fixation, giving cyanobacteria an important role in global carbon and nitrogen cycles. Furthermore, multicellular filamentous cyanobacteria are developmentally complex, capable of differentiation into different cell types, including cells capable of nitrogen fixation and cells for motility, making them an ideal platform for studying development, as well as for practical use in biotechnology. Understanding how developmental programmes are activated require an understanding of the role of alternative sigma factors, which are required for transcriptional activation in bacteria. In order to investigate the gene regulatory network and to determine the …

How A Small Business Negotiates Digital Inclusion Of People With Disabilities: A Case Study, Belo Miguel Cipriani

University of the Pacific Theses and Dissertations

Technology has provided more people access products and services, yet some individuals who would benefit the most from digital access to resources are frequently excluded from participation. One group that is largely neglected is the disability community. Despite federal regulations intended to ensure that people with physical/mental disabilities are included in public digital platforms, organizations continuously design websites, applications, and interfaces without people with disabilities in mind. This is particularly the case with small businesses, which are most commonly reported as having inaccessible digital platforms.

Digital inclusion attempts to ensure equity in digital properties by providing a model to operationalize …

Approaches To The Search Of Platinum Anticancer Agents: Derivatizing Current Drugs And Incorporating Hdac Inhibition, Chao Feng

University of the Pacific Theses and Dissertations

Platinum-based anticancer drugs, such as cisplatin, carboplatin, and oxaliplatin, have been approved for clinical use worldwide for decades. Despite their enormous success, their widespread application is hindered by either cross-resistance or toxic side effects, including nephrotoxicity and neurotoxicity. The need to overcome these drawbacks has stimulated the search for new platinum-based drugs.

This dissertation will start with the accidental discovery of cisplatin, followed by an introduction of other platinum-based anticancer agents, including the action mechanism, general structures, and development history. Picoplatin is a newer generation of platinum-based anticancer agent. The bulky 2-methylpyridine as a non-leaving group on picoplatin could reduce …

The Effects Of The Flipped Classroom Model On Students' Learning In A College English Class In Shanghai, China, Xiaoying Wei

University of the Pacific Theses and Dissertations

For many decades, college English teaching in China has been teacher-centered, mainly focusing on the enhancement of students’ four basic English language skills of listening, speaking, reading and writing, with little attention paid to the cultivation of students’ higher order thinking skills (Tang, 2016; Wang, Xu, & Zhou, 2016). The teacher-centered teaching approach has led to the problem that after having learned English for many years, students cannot speak English fluently (Dai, 2001). There has been a call for promoting the student-centered teaching model in China (NACFLT, 2000). One relatively new approach to support student-centered active learning is flipped instruction …

Dialogue During Team Problem Solving Using Visual Representation Boundary Objects: A Case Study, Julie Marie Webb

University of the Pacific Theses and Dissertations

Organizations benefit from the knowledge held by individual members as well as knowledge that is shared among those members. In order for knowledge to co-develop between members, and to spread, organizations must provide opportunities for members to collaborate. Organizational teams sometimes require assistance with interpersonal communication, establishing consensus, and sharing knowledge when collaborating. Group facilitators can offer guidance and intervene when teams need support. In addition, teams can find support through the use of visual representation boundary objects (VRBOs) to build trust, improve communication, increase cooperation, and share ideas. This study explores how knowledge is shared between team members and …

I3: Isomerization Of Isomer Ions, Krisztián Gabor Torma

University of the Pacific Theses and Dissertations

Photoelectron Photoion Coincidence (PEPICO) spectroscopy is a robust tool for elucidating complex unimolecular dissociation mechanisms and for determining thermochemical and kinetic data of gas-phase ion dissociations with high accuracy. In this work, the dissociative photoionization of two sets of isomeric systems were analyzed with PEPICO: 1) C7H7+ ions of toluene (Tol) and 1,3,5-cycloheptatriene (CHT), and 2) two butyl alcohol isomers, 1-butanol and isobutanol. Threshold dissociative photoionization data on these four molecules of interest were collected on the imaging PEPICO apparatus at the VUV beamline of the Swiss Light Source. Data analysis was aided by ab initio calculations and Rice-Ramsperger-Kassel-Marcus (RRKM) …

How Cultural Impact On Knowledge Sharing Contributes To Organizational Performance: Using The Fsqca Approach, O Oyemomi, Shaofeng Liu, Irina Neaga, Huilan Chen, Franklin Nakpodia

Plymouth Business School

© 2018 Elsevier Inc. Knowledge sharing is crucial for attaining a competitive edge in organizations. Knowledge and performance motivate organizations to launch new innovative products and services to sustain market advantages among competitors. Many factors have been shown to be determinants for supporting organizational performance growth, one of which is organizational culture. The objective of this paper is to analyze the organizational culture that supports knowledge sharing activities for organizational performance, innovation and strategy. This paper uses a sample of 107 cases to examine the empirical data. The results demonstrate the role of organizational culture with an innovative strategy in …

China's Organization And Governance Of Innovation – A Policy Foresight Perspective, Peijie Wang, Fan Li

Plymouth Business School

No abstract provided.

Operational Risk And Reputation In Financial Institutions: Does Media Tone Make A Difference?, A Barakat, S Ashby, P Fenn, C Bryce

Plymouth Business School

Operational risk announcements are unexpected adverse media news that potentially harm the reputation of financial institutions. This paper examines the equity-based and debt-based reputational effects of financial sentiment tones in operational risk announcements and shows how such reputational effects are moderated by alternative sources of public information. Our analysis reveals that the net negative tone and litigious tone have adverse reputational effects, and the uncertainty tone mitigates the adverse reputational impact. Additionally, alternative, simultaneous sources of information neutralize the reputational effects of textual tones. First, third-party information about the event (i.e. regulatory announcements and final settlements) dissolves the favorable (adverse) …

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …

How Data Science Can Advance Mental Health Research, Tc Russ, E Woelbert, Kas Davis, Jd Hafferty, Et Al

Peninsula Medical School

Accessibility of powerful computers and availability of so-called big data from a variety of sources means that data science approaches are becoming pervasive. However, their application in mental health research is often considered to be at an earlier stage than in other areas despite the complexity of mental health and illness making such a sophisticated approach particularly suitable. In this Perspective, we discuss current and potential applications of data science in mental health research using the UK Clinical Research Collaboration classification: underpinning research; aetiology; detection and diagnosis; treatment development; treatment evaluation; disease management; and health services research. We demonstrate that …