Digital Commons Network^™

Towards The Discovery Of Oligonucleotide Cross-Linking Agents, Bhaskar Halami

Dissertations, Master's Theses and Master's Reports

Oligonucleotide cross-linking agents are expected to become a new class of antisense drugs. They function by first hybridizing with a complementary mRNA and then form a covalent bond to permanently link the mRNA to the oligonucleotide agent. Because of covalent cross-linking, this new class of antisense drugs are expected to have much higher potency than existing ones.

Some oligonucleotide cross-linking agents have appeared in the literature, but they have various drawbacks, which include slow cross-linking rate and reversible cross-linking. To address these problems, we designed a series of new cross-linking oligonucleotides with a range of different reactivities. These oligonucleotides were …

Emotional Affect In Mathematics, Eric Marshall

Dissertations, Master's Theses and Master's Reports

Research indicates that a myriad of possibilities exist for why students perform poorly in mathematics and also suggests strategies that could help students be more proficient in mathematics. The possible factors that hinder performance in mathematics include perception of abilities, motivation and relevance, resilience in challenges, mathematics anxiety, and sense of belonging. These factors all have the underlying feature of emotional affect that hinder mathematical performance and are related to students’ emotions. Therefore, increasing emotional affect and forming methods for working through the emotions related to mathematics may help all students do better in mathematics as a whole. This requires …

Electro-Optic Antenna Elements For Passive Phased Array Radar, Evan Gawron

Dissertations, Master's Theses and Master's Reports

Passive phased antenna arrays are utilized in military and civilian radar systems to determine the received signal origination. Phased array placement for optimal reception is challenging due to the required supporting electronic hardware and the associated coaxial cabling that typically accompanies each antenna channel. Low noise amplifiers and frequency conversion hardware add size and complexity, limiting possible positions for phased array placement. Eliminating required phased array electronic subcomponents without sacrificing function would allow placement onto smaller agile platforms, such as unmanned systems and rapid deployment networks. Electro-optic (EO) antenna elements utilize an optical waveguide embedded between the antenna and ground …

Performance Improvement Of A Single Cylinder, Air-Cooled, Spark-Ignited Engine Utilizing 1-D Cycle Simulation, Chun Wang

Dissertations, Master's Theses and Master's Reports

This study is about using a 1-D cycle simulation program (GT-Power) for improving the power of a multi-purpose engine to further extend its use.

A Smart Implantable Bone Fixation Plate Providing Actuation And Load Monitoring For Orthopedic Fracture Healing, Brad Nelson

Dissertations, Master's Theses and Master's Reports

Fracture non-union occurs in roughly 5-10% of all fracture cases, and current interventions are both time-consuming and costly. There is therefore significant incentive to develop new tools to improve fracture healing outcomes. Several studies have shown that low-magnitude, high-frequency (LMHF) mechanical loading can promote faster healing and reduce the risk of refracture in critical-size long bone fractures. This is typically done using whole-body vibration, which may result in undesirable systemic effects on the rest of the body. This work discusses an implantable piezoelectric fixation plate that can both apply LMHF loading directly to the fracture site using flexible scheduling and …

Application Of Agent-Based Modeling To Complex Systems, Robert J. Zupko Ii

Dissertations, Master's Theses and Master's Reports

This dissertation examines the application of agent-based modeling (ABM) to complex systems with the intent of developing a means of overcoming limitations present in existing tools. This is done though the development of two ABMs intended to address complex systems present in the fields of sustainability studies and chemistry.

After introductory information, Chapters 2 - 4 of this dissertation address the limitations of tools intended to project the environmental, economic, and social impacts of woody biomass based biofuels. Chapter 2 begins by discussing the limitations in tools to study timber harvest decision making and its impact upon the landscape, and …

Interactive Sonification Strategies For The Motion And Emotion Of Dance Performances, Steven Landry

Dissertations, Master's Theses and Master's Reports

The Immersive Interactive SOnification Platform, or iISoP for short, is a research platform for the creation of novel multimedia art, as well as exploratory research in the fields of sonification, affective computing, and gesture-based user interfaces. The goal of the iISoP’s dancer sonification system is to “sonify the motion and emotion” of a dance performance via musical auditory display. An additional goal of this dissertation is to develop and evaluate musical strategies for adding layer of emotional mappings to data sonification. The result of the series of dancer sonification design exercises led to the development of a novel musical sonification …

Examining Aspen Expansion From Before And After Prescribed Burning In A Native Fescue Grassland Through Geospatial Techniques, Christopher Anderson

Dissertations, Master's Theses and Master's Reports

Native fescue (Fescue spp.) grasslands of the Intermountain West have become increasingly scarce due to the advent of modern agriculture, the loss of Indigenous people’s land management practices, modern wildfire management and the extirpation of bison (Bison bison bison). Native grassland is a biodiversity hot-spot, is significant for carbon sequestration, and essential to many species of flora and fauna that occur in the ecosystem. Our study site, on the Rocky Mountain Front in Waterton Lakes National Park, Alberta Canada, consists of 30 discrete aspen stands (Populous tremuloides) which are encroaching on this declining shortgrass fescue …

Application Of A Distributed Hydrologic Model For The Analysis Of Land Use Change In Kedougou, Senegal, Francisco Perez

Dissertations, Master's Theses and Master's Reports

West Africa has experienced extensive land use/land cover (LULC) change since the Sahel drought of the 1970s and 80s. Demographic changes, rapid urbanization, and other anthropogenic impacts on land cover in West Africa have potentially altered hydrological regimes. This work was undertaken while I served as a Peace Corps Volunteer in the Kedougou region of Senegal, an area that has experienced significant and rapid infrastructural improvements and urbanization since the early 2000s. The Gambia River flows near Kedougou, where flooding is an extensive problem, making access and livelihood practices difficult during the rainy season. Changes in climate and land use …

Characterizing Freshwater Phytoplankton Dynamics With Electro-Optical Remote Sensing, Michael Sayers

Dissertations, Master's Theses and Master's Reports

Freshwater lakes are an important component contributing to ecosystem health and biodiversity on local, regional, and global scales. And while lakes only represent <5% of the global surface area, they are often very productive systems which contribute significantly to carbon cycling dynamics and freshwater fish production on a number of spatial scales. Due to the remote location and sheer size of some of these lakes it has proven difficult to adequately document changes in water quality. Significant challenges exist to adequately monitor water quality, and in particular phytoplankton dynamics, over large spatial and temporal scales using traditional in situ methods. Satellite electro-optical remote sensing offers a potential tool to provide better characterization of phytoplankton dynamics for a variety of freshwater systems. This work resulted in an approach to quantify global summer phytoplankton abundance using a newly developed remote sensing derived chlorophyll-a product. This product was also used in conjunction with a newly created carbon fixation model to assess global freshwater phytoplankton production which provided new insights into the role freshwater systems play in the …

The Archaeology Of The Postindustrial: Spatial Data Infrastructures For Studying The Past In The Present, Daniel Trepal

Dissertations, Master's Theses and Master's Reports

Postindustrial urban landscapes are large-scale, complex manifestations of the past in the present in the form of industrial ruins and archaeological sites, decaying infrastructure, and adaptive reuse; ongoing processes of postindustrial redevelopment often conspire to conceal the toxic consequences of long-term industrial activity. Understanding these phenomena is an essential step in building a sustainable future; despite this, the study of the postindustrial is still new, and requires interdisciplinary connections that remain either unexplored or underexplored. Archaeologists have begun to turn their attention to the modern industrial era and beyond. This focus carries the potential to deliver new understandings of the …

Formative Interests And Pathways To Natural Resources Careers Among Racial And Ethnic Minorities, Laura Burmann

Dissertations, Master's Theses and Master's Reports

Land use, values, and ethics vary across cultures; however, those making natural resource (NR) management decisions are often not representative of the diversity of people who live on the land. Diversifying the workforce is a step towards ensuring management decisions and policies are inclusive of all peoples; however, few people from minority groups are pursuing degrees related to NR management. The purpose of this study is to assess factors affecting the decisions to pursue careers in NR fields among historically underrepresented groups of people, with an emphasis on the role that youth environmental education (EE) programs play in creating career …

Assessing Soil Compaction Following A Winter Timber Harvest In The Western Upper Peninsula Of Michigan, Rafia Rahman

Dissertations, Master's Theses and Master's Reports

Harvesting during winter is encouraged as a best management practice to protect soil during logging operations. The western Upper Peninsula of Michigan typically experiences early and persistent snowfall, which insulates the forest floor and prevents soils from freezing. The objective of this study is to assess the effects of slash volume, snow depth, overstory treatment, and machine traffic intensity on soil bulk density following a winter harvest of a northern hardwood forest on cobbly silt-loam soils. The harvest was conducted at the Ford Forest in Alberta, Michigan using cut-to-length harvest systems (i.e. harvester and forwarder) during which the soil remained …

Novel Computational Methods For Eigenvalue Problems, Ruihao Huang

Dissertations, Master's Theses and Master's Reports

This dissertation focuses on novel computational method for eigenvalue problems. In Chapter 1, preliminaries of functional analysis related to eigenvalue problems are presented. Some classical methods for matrix eigenvalue problems are discussed. Several PDE eigenvalue problems are covered. The chapter is concluded with a summary of the contributions. In Chapter 2, a novel recursive contour integral method (RIM) for matrix eigenvalue problem is proposed. This method can effectively find all eigenvalues in a region on the complex plane with no a priori spectrum information. Regions that contain eigenvalues are subdivided and tested recursively until the size of region reaches specified …

Using Short-Term Professional Development To Increase Science Teacher Confidence For Integrating The Ngss Engineering Standards, Janet Lalonde

Dissertations, Master's Theses and Master's Reports

Teacher professional development has long been acknowledged as a useful tool to improve instructional methods and to increase the likelihood of successful implementation of new standards. The duration of the training is often identified as a factor that determines how successful professional development experiences can be, with the best options taking place over several days and for more than 40 hours. However, with serious limitations in time, funding, and substitute teachers, districts must often consider offering short-term professional development instead.

This case study followed a professional development experience of seven high school science teachers as they spent a day learning …

Design And Development Of Personal Protective Equipment Products To Reduce The Impacts Of Machete Injuries For Indigenous Ngäbe Subsistence Farmers In Bocas Del Toro, Panama, Micah Koller

Dissertations, Master's Theses and Master's Reports

Design and development of personal protective equipment products for workers using machetes (MPPE) is considered in the specific context of indigenous Ngäbe subsistence farmers in a small, rural community in Bocas del Toro, Panama where the author spent two years as a Peace Corps volunteer from 2017-2019. People in this community regularly suffer significant health and economic impacts due to accidents with machetes, which are essential tools in their farm work and daily lives. The history, criticisms, and recent frameworks related to product design and development in resource-poor markets is examined, and specific details of the problem of machete injuries …

The Origin Of An Archean Batholith In Michigan’S Upper Peninsula, Brandi Petryk

Dissertations, Master's Theses and Master's Reports

The Southern Complex is part of the Archean Superior Province in the Upper Peninsula of Michigan and includes a batholithic sized body of Archean high-K megacrystic granitoid rocks informally called the Bell Creek granite. U-Pb zircon ages of the granitoid from previous studies suggest an emplacement age of ~2.6 Ga (Tinkham, 1997). Based on those ages the Bell Creek granite formed around the Archean-Proterozoic transition. This transition is a crucial time period in Earth’s history for crustal growth because of the onset of subduction and increased sedimentary environments at the end of the Archean (Taylor and McLennan, 1995). In this …

Online Learning Of The Spatial-Temporal Channel Variation In Underwater Acoustic Communication Networks, Wensheng Sun

Dissertations, Master's Theses and Master's Reports

Influenced by environmental conditions, underwater acoustic (UWA) communication channels exhibit spatial and temporal variations, posing significant challenges for UWA networking and applications. This dissertation develops statistical signal processing approaches to model and predict variations of the channel and relevant environmental factors. Firstly, extensive field experiments are conducted in the Great Lakes region. Three types of the freshwater river/lake acoustic channels are characterized in the aspects of statistical channel variations and sound propagation loss, including stationary, mobile and under-ice acoustic channels. Statistical data analysis shows that relative to oceanic channels, freshwater river/lake channels have larger temporal coherence, higher correlation among densely …

Paleomagnetic Investigation Of Igneous Rocks Deformed By The Keweenaw Fault In The Northwestern Keweenaw Peninsula., Daniel Trekas

Dissertations, Master's Theses and Master's Reports

One of the most prominent structural features associated with the ~1.1 Ga Midcontinent Rift (MCR) system is the >350 km long Keweenaw Fault that bisects the Keweenaw Peninsula, separating the MCR-related Portage Lake Volcanics (PLV) and the younger Jacobsville Sandstone (JS). The fault trend is NE-NNE over most of its length, but changes to an easterly direction along the shore of Bête Grise Bay near the end of the peninsula. Conventionally, the Keweenaw Fault has been considered to be a continuous reverse (dip-slip) fault formed by inversion of an original rift-bounding normal fault during the Grenville Orogeny. However, recent mapping …

Lithium-Ion Battery Degradation Evaluation Through Bayesian Network Method For Residential Energy Storage Systems, Khalid Khan

Dissertations, Master's Theses and Master's Reports

Batteries continue to infiltrate in innovative applications with the technological advancements led by Li-ion chemistry in the past decade. Residential energy storage is one such example, made possible by increasing efficiency and decreasing the cost of solar PV. Residential energy storage, charged by rooftop solar PV is tied to the grid, provides household loads. This multi-operation role has a significant effect on battery degradation. These contributing factors especially solar irradiation and weather conditions are highly variable and can only be explained with probabilistic analysis. However, the effect of such external factors on battery degradation is approached in recent literature with …

Magnetic Characterization Of Iron Formations From Drill Cores Near Iron Mountain, Michigan, Adren Rigdon

Dissertations, Master's Theses and Master's Reports

The magnetic properties of the ~1.88 Ga Vulcan Iron Formation and Felch Formation were investigated from samples taken from three drill cores through the Felch Trough, north of Iron Mountain, MI. The conducted analyses included measurements of natural remanent magnetization, magnetic hysteresis, first order reversal curves, magnetic anisotropy, scanning electron microscopy, and electron dispersive spectroscopy. The data is compared to the results of a previous magnetic characterization study conducted on surface outcrop samples on two members of the Vulcan formation, the Curry and Traders members, near Iron Mountain, MI. Two distinct members of the Vulcan Formation were identified in the …

Keweenaw Fault Geometry And Slip Kinematics - Bête Grise Bay, Keweenaw Peninsula, Michigan, Colin Tyrrell

Dissertations, Master's Theses and Master's Reports

The Keweenaw Fault (KF) has been interpreted as a rift-bounding normal fault along the southern margin of the Midcontinent Rift System; later inverted into a reverse fault by a tectonic compression event. The fault trends NNE to NE for most of its trace but curves clockwise to ESE along the Bête Grise Bay area in Michigan’s Keweenaw Peninsula. U.S. Geological Survey maps depict the KF along Bête Grise Bay as a continuous thrust that follows a sinuous contact between Portage Lake Volcanics (PLV) and Jacobsville Sandstone (JS). New fieldwork reveals a left-stepping en echelon system of ESE-trending faults connected by …

3d Printing In Low Resource Healthcare Settings: Analysis Of Potential Implementations, Alenna Beroza

Dissertations, Master's Theses and Master's Reports

3D printing has gained significant momentum in the past ten years, and its unique advantages make it especially ideal for use in low resource healthcare settings, where many designs have already been successfully implemented. Yet, little has been studied on how 3D printing can be sustainably and functionally implemented in low resource healthcare systems as a manufacturing practice. In this report, three business models are proposed for this implementation: In-House Operator, Independent Operator, and Print Farm. These models were then tested over four months in Kisumu county, Kenya, at two workshops and seven public hospitals. I worked with local medical …

Spatial And Temporal Distribution Of Hydrothermal Minerals And Sources Of Hydrothermal Fluids Inferred From Light Stable Isotopes, Keweenaw Peninsula Native Copper District, Michigan, Thomas Bodden

Dissertations, Master's Theses and Master's Reports

Hydrothermal native copper deposits are hosted by Mesoproterozoic Midcontinent Rift-filling volcanic and sedimentary rocks in Michigan’s Keweenaw Peninsula. The genesis of the native copper deposits has been a point of interest since their discovery. Native copper and associated mineral assemblages vary temporally and spatially. A refined mineral paragenesis is presented and used as the basis to spatially compare mineral assemblages as it is essential that spatial comparison involve only minerals that are temporally/genetically, related to each other. The main-stage minerals associated with precipitation of native copper are spatially zoned. The higher-grade zones correspond to the area of native copper deposits …

Testing The Use Of Vegetation Indices As Indicators Of Pre-Eruptive Volcanic Unrest At Kilauea Volcano, Hawaii, Quelyn Bekkering

Dissertations, Master's Theses and Master's Reports

Satellite remote sensing has become an integral part of pre-eruptive and long-term volcano monitoring due to its low cost, spatial and temporal coverage, and time-series analysis capabilities. Pre-eruptive unrest at volcanoes can include increased fluxes of heat and volcanic gases, which can be manifested either directly (e.g., the appearance of thermal anomalies or fumaroles) or indirectly (e.g., through impacts on vegetation health and extent). We are evaluating the use of novel, high spatial and temporal resolution data from the Planet Labs cubesat constellation to monitor changes in vegetation related to volcanic unrest. We present results from a study of key …

Physics And Applications Of Exceptional Points, Qi Zhong

Dissertations, Master's Theses and Master's Reports

Exceptional points (EPs) are singularities that arise in non-Hermitian physics. Crossing EPs is believed to be related with phase transitions between parity-time-(PT-)symmetric phase and broken PT phase. Owing to their peculiar topology, EPs can remotely induce observable effects when encircled by closed trajectories in the parameter space. In this dissertation, first of all, we investigate the extreme dynamics of non-Hermitian systems near higher order EPs constructed using the bosonic algebra method. The strong power oscillations for certain initial conditions can occur as a result of the peculiar eigenspace geometry and its dimensionality collapse near these singularities. And in the PT …

Crack Pattern Simulation Of Pressurized Borosilicate Glass Tube Under Pellet Impact Using Ale Method, Omkar Bhumkar

Dissertations, Master's Theses and Master's Reports

Transformer bushings are a common target for sniper attacks to cause power failure in large areas. Given the size, internal pressure and brittle nature of transformer bushing, pellet impact causes damage to surrounding components due to broken bushing pieces. To mitigate this, a project was initiated by United States Burau of Reclaimation to develop a safety mechanism. Finite Element Analysis is proposed to optimize and reduce cost of the design.

A simplified Finite Element model is created which consists of 0.22 caliber lead pellet impacting Pyrex 7740 borosilicate glass tube. Previous studies on the effect of the mesh pattern, size …

Assessing The Spatial And Temporal Variability Of The Detroit River And Harmful Algal Blooms In Western Lake Erie, Angela W. Yu

Dissertations, Master's Theses and Master's Reports

Despite efforts to reduce the occurrence of harmful algal blooms (HABs) in western Lake Erie, blooms recur annually due to agricultural runoff, storms with high winds and heavy rains, and weak lake circulation patterns. The influence from river inputs on the spatial and temporal characteristics of HABs remains relatively unknown. The Detroit River, which contributes about 80% of the basin's total inflow can have a large influence on the spatial and temporal distribution of the bloom. To understand this, optically classified imagery, in situ water measurements, and meteorological and river discharge observations were compiled and synthesized to examine the spatiotemporal …

Fortune And Failure - Gold And Silver Smelting In The Colorado Rockies 1861 To 1900, Andrew Mueller

Dissertations, Master's Theses and Master's Reports

This dissertation is a study of small-scale smelting in Colorado during the nineteenth century. Many small smelting enterprises were established throughout the mountains of the state from the mid-1860s to the mid-1880s. The smelters helped to revitalize a flagging mining industry by fostering its growth and, consequently, the development of the state before being outcompeted by larger smelting establishments developing in the growing cities on the Front Range. However, the life of these smelters was brief, and the majority failed within a few years. The role of these smelters in Colorado’s history has been largely overlooked but provide a rich …

Ecophysiological Responses Of Tropical Woody Species To Ambient And Elevated Temperatures, Kelsey R. Carter

Dissertations, Master's Theses and Master's Reports

Tropical forests cycle one third of Earth’s carbon, yet we are still unsure how tropical vegetation will respond to climate warming. Tropical biomes experience a smaller temperature margin compared to other systems, possibly making them less capable of thermal adjustments. In addition, thermal responses of vegetation have been identified as one of the areas of greatest uncertainty for global carbon models. This dissertation works to quantify tropical forest photosynthetic responses to temperature as well as assessing physiological thermal acclimation of four tropical species. In Chapter, 2 we conducted a meta-analysis to investigate global tropical photosynthetic responses to temperature. We presented …