Digital Commons Network^™

Design, Synthesis, Characterization And Anti-Cancer Effects Evaluation Of Interchain Cysteine Linked Antibody Drug Conjugates, Ke Li

Doctoral Dissertations

"Antibody drug conjugates (ADCs) are emerging therapeutic products specially designed for the treatment of cancers. Potent cytotoxic agents are linked to antibodies via linkers. Antibody drug conjugates, which take advantage of both antibodies and cytotoxic agents, showed high selectivity towards cancer cells. Cytotoxic agents are delivered to the cancer cells selectively and kill them from inside while leaving low or non-toxicity towards normal cells. Antibody drug conjugates are actually heterogeneous mixtures. The major heterogeneities mainly lie in the drug to antibody ratio (DAR) and drug linking positions, both of which potentially affect the therapeutic index of ADCs. In this research, …

Learning Human Anatomy Using Ara Mobile Application, Samia Loucif, Murad Al-Rajab, Reem Salem, Abdullah Hesham, Doaa Mahely, Mhd Alaa Ajlouni

All Works

© 2019 University of Bahrain. All rights reserved. Smartphones with mobile applications have become part of everyday life, as they transformed the ways people manage their tasks. Many fields and sectors are using mobile applications to facilitate their services. Education is an important field that can utilize the various features of mobile applications to assist students and educators. Students are learning several subjects and concepts in schools, including biology. With traditional teaching methods, students may face difficulties in grasping knowledge about human anatomy. This can affect the teaching effectiveness, students' learning process, their engagement in class, and their academic performance. …

Bootstrapping The Empirical Distribution Of A Stationary Process With Change-Point, Farid El Ktaibi, B. Gail Ivanoff

All Works

© 2019, Institute of Mathematical Statistics. All rights reserved. When detecting a change-point in the marginal distribution of a stationary time series, bootstrap techniques are required to determine critical values for the tests when the pre-change distribution is unknown. In this paper, we propose a sequential moving block bootstrap and demonstrate its validity under a converging alternative. Furthermore, we demonstrate that power is still achieved by the bootstrap under a non-converging alternative. We follow the approach taken by Peligrad in [14], and avoid assumptions of mixing, association or near epoch dependence. These results are applied to a linear process and …

Intensive Pre-Processing Of Kdd Cup 99 For Network Intrusion Classification Using Machine Learning Techniques, Ibrahim M. Obeidat, Nabhan Hamadneh, Mouhammd Alkasassbeh, Mohammad Almseidin, Mazen Ibrahim Alzubi

All Works

© 2019, International Association of Online Engineering. Network security engineers work to keep services available all the time by handling intruder attacks. Intrusion Detection System (IDS) is one of the obtainable mechanism that used to sense and classify any abnormal actions. Therefore, the IDS must be always up to date with the latest intruder attacks signatures to preserve confidentiality, integrity and availability of the services. The speed of the IDS is very important issue as well learning the new attacks. This research work illustrates how the Knowledge Discovery and Data Mining (or Knowledge Discovery in Databases) KDD dataset is very …

Effective Evaluation Of The Non-Technical Skills In The Computing Discipline, Maurice Danaher, Kevin Schoepp, Ashley Ater Kranov

All Works

© 2019, Journal of Information Technology Eucation Research. Aim/Purpose Assessing non-technical skills is very difficult and current approaches typically assess the skills separately. There is a need for better quality assessment of these skills at undergraduate and postgraduate levels. Background A method has been developed for the computing discipline that assesses all six non-technical skills prescribed by ABET (Accreditation Board for Engineering and Technology), the accreditation board for engineering and technology. It has been shown to be a valid and reliable method for undergraduate students Methodology The method is based upon performance-based assessment where a team of students discuss and …

Everything-As-A-Thing For Abstracting The Internet-Of-Things, Zakaria Maamar, Noura Faci, Mohamed Sellami, Emir Ugljanin, Ejub Kajan

All Works

Copyright © 2018 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved This paper discusses Everything-as-a-Thing (*aaT) as a novel way for abstracting the Internet-of-Things (IoT) applications. Compared to other forms of abstraction like Everything-as-a-Service (*aaS) and Everything-as-a-Resource (*aaR), *aaT puts emphasis on living things, on top of non-living things, that populate these applications. On the one hand, living things take over roles that are defined in terms of rights and duties. On the other hand, non-living things offer capabilities that are defined in terms of functional and non-functional properties. Interactions that occur between living and non-living things …

Using Homing, Synchronizing And Distinguishing Input Sequences For The Analysis Of Reversible Finite State Machines, Martin Lukac, Michitaka Kameyama, Marek A. Perkowski, Pawel Kerntopf

Electrical and Computer Engineering Faculty Publications and Presentations

A digital device is called reversible if it realizes a reversible mapping, i.e., the one for which there exist a unique inverse. The field of reversible computing is devoted to studying all aspects of using and designing reversible devices. During last 15 years this field has been developing very intensively due to its applications in quantum computing, nanotechnology and reducing power consumption of digital devices. We present an analysis of the Reversible Finite State Machines (RFSM) with respect to three well known sequences used in the testability analysis of the classical Finite State Machines (FSM). The homing, distinguishing and synchronizing …

Aggregation Of Residential Water Heaters For Peak Shifting And Frequency Response Services, Thomas Leighton Clarke, Tylor Slay, Robert B. Bass, Conrad Eustis

Electrical and Computer Engineering Faculty Publications and Presentations

The increased penetration of renewable energy resources poses challenges for grid stability. The stochastic generation of solar and wind power cannot be controlled to follow load. And, the transition away from synchronous generators is reducing the capacity to arrest and recover from frequency disturbances. Smart electric water heaters provide utilities with an appliance that can be remotely controlled and serve as a form of energy storage. They have very fast response times and make up a large amount of residential energy consumption, making them useful for load peak shifting as well as other ancillary grid services. As smart appliances become …

The Public Trust Doctrine, Outer Space, And The Global Commons: Time To Call Home Et, Hope M. Babcock

Georgetown Law Faculty Publications and Other Works

Space exploration is heating up. Governments and private interests are on a fast track to develop technologies to send people and equipment to celestial bodies, like the moon and asteroids, to extract their untapped resources. Near-space is rapidly filling up with public and private satellites, causing electromagnetic interference problems and dangerous space debris from collisions and earlier launches. The absence of a global management system for the private commercial development of outer space resources will allow these near space problems to be exported further into the galaxy. Moreover, without a governing authority or rules controlling entry or limiting despoliation, outer …

The Genie Is Out Of The De-Extinction Bottle: A Problem In Risk Regulation And Regulatory Gaps, Hope M. Babcock

Georgetown Law Faculty Publications and Other Works

Once the province of horror films and fantasy, the idea of recreating extinct life forms is poised to move from science fiction to laboratories and from there to the world at large. While “de-extinction is not something that will take place tomorrow . . . scientists are making major advancements, and eventual success appears inevitable.” Spurred on by the burgeoning field of genetic engineering, it was only a matter of time before scientists turned their attention to recreating extinct life forms, either for the thrill of it or in atonement for the human role in the extinction process.

But science …

The New Frontier For Labor In Trade Agreements, Alvaro Santos

Georgetown Law Faculty Publications and Other Works

In the spring of 2015, I took my students of international trade law to visit the World Trade Organization (WTO) in Geneva. It was a two-day trip, organized around lectures and discussions with staff from different divisions of the organization, the Advisory Centre of WTO Law and the permanent missions of two countries. None of my students had been there before, and even though I had taught international trade law for several years, it was also my first time visiting the headquarters of the organization. We were excited and curious. The building looked big and majestic. The back side opened …

Post-Crisis Economic And Social Policy: Some Thoughts On Structural Reforms 2.0., Philomila Tsoukala

Georgetown Law Faculty Publications and Other Works

Managing the euro crisis has been a process of institutional transformation for the EU. The European Semester has emerged as a powerful tool for economic policy coordination between the Member States. Beyond the new enforcement tools that the Semester affords the Commission and Council in case of non-compliance with country-specific recommendations, the management of the crisis has given the Commission experience in structural reforms. The Commission now regularly uses this experience in formulating its yearly country-specific recommendations to Member States. Far from a stalwart of untethered neoliberalism, the Commission has been fashioning itself as the manager with a human face, …

Shared Collection Development, Digitization, And Owned Digital Collections, Michelle M. Wu

Georgetown Law Faculty Publications and Other Works

While library models already exist for sharing physical materials and joint licensing, this paper envisions an aspect of future collections involving a national digital collection owned, not licensed, by libraries. Collaborative collection development, digitization, and digital object management of owned collections can benefit societies in multiple ways, from expanding access to users otherwise unable to reach these materials, to preserving content even when disaster strikes, to reducing duplication of effort and expense in collection or digitization. This article will explore both the benefits of and the challenges to this type of collaboration.

Revisiting Controlled Digital Lending Post-Redigi, Michelle M. Wu

Georgetown Law Faculty Publications and Other Works

Now that the Second Circuit has ruled on the ReDigi appeal, some libraries and users may be curious to see how the decision factors into controlled digital lending (CDL) efforts. To understand the interest and the implications, we first need to establish the basic contours of copyright, fair use, CDL, and ReDigi.

Supply Chain Infrastructure Restoration Calculator Software Tool -- Developer Guide And User Manual, Akhilesh Ojha, Bhanu Kanwar, Suzanna Long, Thomas G. Shoberg, Steven Corns

Engineering Management and Systems Engineering Faculty Research & Creative Works

This report describes a software tool that calculates costs associated with the reconstruction of supply chain interdependent critical infrastructure in the advent of a catastrophic failure by either outside forces (extreme events) or internal forces (fatigue). This tool fills a gap between search and recover strategies of the Federal Emergency Management Agency (or FEMA) and construction techniques under full recovery. In addition to overall construction costs, the tool calculates reconstruction needs in terms of personnel and their required support. From these estimates, total costs (or the cost of each element to be restored) can be calculated. Estimates are based upon …

Analysis Of Wcag 2.0 Data Accessibility Success Criterion Of E-Government Websites, Mohamed Basel Al Mourad, Mohammed Hussein, Faouzi Kamoun, Zelal Wattar

All Works

© 2019, International University of Sarajevo. An accessible website enables the access to information and interaction for many people with disabilities so these people can contribute more effectively in the society. Today, most governments are enforcing their websites to follow the www consortium (w3c)'s Web Content Accessibility Guidelines (WCAG 2.0). This paper investigates the WCAG 2.0 success criterions that make a website accessible and explores the most violated WCAG 2.0 success criterions by the developers of e-Government websites.

Assessment And Hardening Of Iot Development Boards, Omar Alfandi, Musaab Hasan, Zayed Balbahaith

All Works

© IFIP International Federation for Information Processing 2019. Internet of Things (IoT) products became recently an essential part of any home in conjunction with the great advancements in internet speeds and services. The invention of IoT based devices became an easy task that could be performed through the widely available IoT development boards. Raspberry Pi is considered one of the advanced development boards that have high hardware capabilities with a reasonable price. Unfortunately, the security aspect of such products is overlooked by the developers, revealing a huge amount of threats that result in invading the privacy and the security of …

Trapping Aco Applied To Mri Of The Heart, Shannon Lloyd Birchell

UNF Graduate Theses and Dissertations

The research presented here supports the ongoing need for automatic heart volume calculation through the identification of the left and right ventricles in MRI images. The need for automated heart volume calculation stems from the amount of time it takes to manually processes MRI images and required esoteric skill set. There are several methods for region detection such as Deep Neural Networks, Support Vector Machines and Ant Colony Optimization. In this research Ant Colony Optimization (ACO) will be the method of choice due to its efficiency and flexibility. There are many types of ACO algorithms using a variety of heuristics …

Representation Of Women Leaders In Business Magazines: 2010-2018, Kia Ja'shona Cooper

UNF Graduate Theses and Dissertations

This framing analysis focuses on the portrayal of women leaders in popular business magazines. Framing theory was used to examine how women leaders were portrayed in Forbes, Fortune, Entrepreneur, and Bloomberg Businessweek magazines from 2010-2018. The study identified three key frames, which include the minority frame, asset and fixer frame, and the work-life balance frame. Further findings from the study suggested that the portrayals of women have changed following the women's movement in the 1970's and that women are indeed beneficial to organizations in senior-level positions, although there is still a low percentage of women in these roles.

A Method Of Evaluation Of High-Performance Computing Batch Schedulers, Jeremy Stephen Futral

UNF Graduate Theses and Dissertations

According to Sterling et al., a batch scheduler, also called workload management, is an application or set of services that provide a method to monitor and manage the flow of work through the system [Sterling01]. The purpose of this research was to develop a method to assess the execution speed of workloads that are submitted to a batch scheduler. While previous research exists, this research is different in that more complex jobs were devised that fully exercised the scheduler with established benchmarks. This research is important because the reduction of latency even if it is miniscule can lead to massive …

The Operational And Safety Effects Of Heavy Duty Vehicles Platooning, Ahmed Alzahrani

UNF Graduate Theses and Dissertations

Abstract

Although researchers have studied the effects of platooning, most of the work done so far has focused on fuel consumption. There are a few studies that have targeted the impact of platooning on the highway operations and safety. This thesis focuses on the impact of heavy-duty vehicles (HDVs) platooning on highway characteristics. Specifically, this study aims at evaluating the effects of platooning of HDVs on capacity, safety, and CO₂ emissions.

This study is based on a hypothetical model that was created using the VISSIM software. VISSIM is a powerful simulation software designed to mimic the field traffic flow …

A Topic Modeling Approach For Code Clone Detection, Mohammed Salman Khan

UNF Graduate Theses and Dissertations

In this thesis work, the potential benefits of Latent Dirichlet Allocation (LDA) as a technique for code clone detection has been described. The objective is to propose a language-independent, effective, and scalable approach for identifying similar code fragments in relatively large software systems. The main assumption is that the latent topic structure of software artifacts gives an indication of the presence of code clones. It can be hypothesized that artifacts with similar topic distributions contain duplicated code fragments and to prove this hypothesis, an experimental investigation using multiple datasets from various application domains were conducted. In addition, CloneTM, an LDA-based …

Modeling Context-Adaptive Energy-Aware Security In Mobile Devices, Preeti Singh

UNF Graduate Theses and Dissertations

As increasing functionality in mobile devices leads to rapid battery drain, energy management has gained increasing importance. However, differences in user’s usage contexts and patterns can be leveraged for saving energy. On the other hand, the increasing sensitivity of users’ data, coupled with the need to ensure security in an energy-aware manner, demands careful analyses of trade-offs between energy and security. The research described in this thesis addresses this challenge by 1)modeling the problem of context-adaptive energy-aware security as a combinatorial optimization problem (Context-Sec); 2) proving that the decision version of this problem is NP-Complete, via a reduction from a …

On Learning And Visualizing Lexicographic Preference Trees, Ahmed S. Moussa

UNF Graduate Theses and Dissertations

Preferences are very important in research fields such as decision making, recommendersystemsandmarketing. The focus of this thesis is on preferences over combinatorial domains, which are domains of objects configured with categorical attributes. For example, the domain of cars includes car objects that are constructed withvaluesforattributes, such as ‘make’, ‘year’, ‘model’, ‘color’, ‘body type’ and ‘transmission’.Different values can instantiate an attribute. For instance, values for attribute ‘make’canbeHonda, Toyota, Tesla or BMW, and attribute ‘transmission’ can haveautomaticormanual. To this end,thisthesis studiesproblemsonpreference visualization and learning for lexicographic preference trees, graphical preference models that often are compact over complex domains of objects built of …

Operational Effectiveness Of Connected Vehicle Smartphone Technology On A Signalized Corridor, Festo Mjogolo

UNF Graduate Theses and Dissertations

Over the last decade, extensive research efforts have been placed on performance evaluation and the benefits of innovative CV applications. Findings indicate that CV technology can effectively mitigate the safety, mobility, and environmental challenges experienced on transportation networks. Most of research evaluated CV technology through simulation studies. However, a field study provides a more ideal method of assessing CV technology effectiveness. Therefore, a field study to obtain the actual effectiveness of CV technology was warranted, to validate previous findings, and to add to the body of knowledge surrounding this topic. This thesis presents both a field study and simulation evaluation …

Active Analytics: Suggesting Navigational Links To Users Based On Temporal Analytics Data, Jacob Koza

UNF Graduate Theses and Dissertations

Front-end developers are tasked with keeping websites up-to-date while optimizing user experiences and interactions. Tools and systems have been developed to give these individuals granular analytic insight into who, with what, and how users are interacting with their sites. These systems maintain a historical record of user interactions that can be leveraged for design decisions. Developing a framework to aggregate those historical usage records and using it to anticipate user interactions on a webpage could automate the task of optimizing web pages. In this research a system called Active Analytics was created that takes Google Analytics historical usage data and …

Testing Coulwave For Use In Modeling Cross-Shore Sand Transport And Beach Profile Evolution, Patrick Michael Cooper

UNF Graduate Theses and Dissertations

Realistic, reliable, and effective modeling of cross-shore sediment transport is not present in the current literature. Building that model requires the accurate recreation of breaking wave processes in the nearshore. To develop that first step for an as-yet-to-be-designed model, multiple phase-resolving wave transformation algorithms are reviewed for in-depth investigation. The COULWAVE model is selected for robust testing. Testing of the COULWAVE model shows that, although capable of recreating realistic results, it does not adequately describe major wave characteristics in the surf zone, across a wide range of conditions, to warrant use in a future cross-shore sediment transport model.

Development, Validation, And Utilization, Of A Long-Term Nearshore Synthetic Wave Record, Sergio A. Pena

UNF Graduate Theses and Dissertations

The need for a consistent and accurate production of long-term nearshore wave record is discussed. With multiple decades of offshore hindcasts and long, continuous data sets available, it is possible to create a nearshore synthetic wave record. The Brevard County coastline offers an area with a high quality 62-year long offshore hindcast, as well as an 11-year long and nearly continuous high-resolution nearshore wave record to compare with model performance. This thesis presents the steps in the development and performance of the synthetic nearshore wave record produced. A novel approach was used to compare, validate and calibrate this type of …

Investigating The Effects Of Rainfall On Traffic Operations On Florida Freeways, Lucia Andrew

UNF Graduate Theses and Dissertations

Rainfall affects the performance of traffic operations and endangers safety. A common and conventional method (rain gauges) for rainfall measurements mostly provide precipitation records in hourly and 15-minute intervals. However, reliability, continuity, and wide area coverage pose challenges with this data collection method. There is also a greater likelihood for data misrepresentation in areas where short duration rainfall is predominant, i.e., reported values may not reflect the actual equivalent rainfall intensity during subintervals over the entire reporting period. With recent weather and climate patterns increasing in severity, there is a need for a more effective and reliable way of measuring …

Hedonic Coalition Formation For Task Allocation With Heterogeneous Robots, Emily Czarnecki

UNF Graduate Theses and Dissertations

Tasks in the real world are complex in nature and often require multiple robots to collaborate in order to be accomplished. However, multiple robots with the same set of sensors working together might not be the optimal solution. In many cases a task might require different sensory inputs and outputs. However, allocating a large variety of sensors on each robot is not a cost-effective solution. As such, robots with different attributes must be considered. In this thesis we study the coalition formation problem for task allocation with multiple heterogeneous (equipped with a different set of sensors) robots. The proposed solution …