Digital Commons Network^™

Aspergillus Fumigatushigh Osmolarity Glycerol Mitogen Activated Protein Kinases Saka And Mpkc Physically Interact During Osmotic And Cell Wall Stresses, Adriana Oliveira Manfiolli, Eliciane Cevolani Mattos, Leandro José De Assis, Lilian Pereira Silva, Mevlüt Ulas, Neil Andrew Brown, Rafael Silva-Rocha, Özgür Bayram, Gustavo H. Goldman

Peninsula Medical School

Aspergillus fumigatus, a saprophytic filamentous fungus, is a serious opportunistic pathogen of mammals and it is the primary causal agent of invasive aspergillosis (IA). Mitogen activated protein Kinases (MAPKs) are important components involved in diverse cellular processes in eukaryotes. A. fumigatus MpkC and SakA, the homologs of the Saccharomyces cerevisiae Hog1 are important to adaptations to oxidative and osmotic stresses, heat shock, cell wall damage, macrophage recognition, and full virulence. We performed protein pull-down experiments aiming to identify interaction partners of SakA and MpkC by mass spectrometry analysis. In presence of osmotic stress with sorbitol, 118, and 213 proteins were …

Foundations Of Offshore Wind Turbines: A Review, Xiaoni Wu, Yu Hu, Ye Li, Jian Yang, Lei Duan, Tongguang Wang, Thomas Adcock, Zhiyu Jiang, Zhen Gao, Zhiliang Lin, Alistair Borthwick, Shijun Liao

School of Engineering, Computing and Mathematics

No abstract provided.

An Evaluation Of The Fishing For Litter (Ffl) Scheme In The Uk In Terms Of Attitudes, Behavior, Barriers And Opportunities, Kayleigh J. Wyles, Sabine Pahl, Lauren Carroll, Richard C. Thompson

School of Psychology

No abstract provided.

Social Prescribing: Where Is The Evidence? Commissioned Editorial, Kerryn Husk, Julian Elston, Felix Gradinger, Lynne Callaghan, Sheena Asthana

Peninsula Medical School

Social prescribing is the topic of the moment. Many national organisations and individuals from policy, practice, and academia (such as NHS England, the RCGP, the Mayor of London, and National Institute for Health Research) are rightly advocating social prescriptions as an important way to expand the options available for GPs and other community-based practitioners to provide individualised care for people’s physical and mental health through social interventions. No robust figures exist but it is thought that around 20% of patients consult their GP for primarily social issues, given this and the driving forces of an ageing population, increased complex health …

A Proactive Malicious Software Identification Approach For Digital Forensic Examiners, Muhammad Ali, Stavros Shiaeles, Nathan Clarke, Dimitrios Kontogeorgis

School of Engineering, Computing and Mathematics

No abstract provided.

Fungi In Aquatic Ecosystems, Hans Peter Grossart, Den Wyngaert S Van, Maiko Kagami, Christian Wurzbacher, Michael Cunliffe, Keilor Rojas-Jimenez

School of Biological and Marine Sciences

No abstract provided.

Differential Immunity As A Factor Influencing Mussel Hybrid Zone Structure, Deryk Tolman, Hannah L. Wood, David O.F. Skibinski, Manuela Truebano

School of Biological and Marine Sciences

No abstract provided.

Variation In Growth And Defence Traits Among Plant Populations At Different Elevations: Implications For Adaptation To Climate Change, James Buckley, Alex Widmer, Mark C. Mescher, Moraes Cm De

School of Biological and Marine Sciences

Alpine plants occurring at high elevation are vulnerable to ongoing climate change, yet relatively little is known about the potential for high-elevation species to adapt to changing environmental conditions. In particular, the extent to which high-elevation plants will be able to resist predicted increases in the intensity of biotic interactions, such as herbivory, remains unclear. Species distributed across broad elevational ranges provide an opportunity to investigate evolutionary mechanisms and traits involved in adaptation to varying abiotic and biotic environments. This study focused on the perennial alpine plant Arabis alpina and combined field surveys and climate chamber experiments to test for …

Progression Of Hearing Loss In Neurofibromatosis Type 2 According To Genetic Severity, C. Oliver Hanemann, Beatrice Emmanouil, Rory Houston, Anne May, James D. Ramsden, Dorothy Halliday, Allyson Parry, Samuel Mackeith

Peninsula Medical School

No abstract provided.

Trends In Phenotype In The English Paediatric Neurofibromatosis Type 2 Cohort Stratified By Genetic Severity, Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D. Gareth Evans, Allyson Parry, Patrick Axon, Juliette Gair, Carolyn Smyth, Shazia K. Afridi, Rupert Obholzer, Vanessa Everett, Nicola Jarvis, Kirsty Henshaw, C. Oliver Hanemann, Wendy Howard, Anne May, Carolyn Redman, Rohini Rattihalli, Helen Tomkins

Peninsula Medical School

No abstract provided.

Brain Injury Case Managers' Experience Of Mental Capacity And The Uk's Mental Capacity Act: Supporting Decision Making, M Holloway, A Norman, J Dean

School of Psychology

No abstract provided.

163 Development Of Clinical And Patient-Reported Quality Metrics For Multiple Sclerosis: A Uk Pilot Study Report, G Giovannoni, S White, N Mistry, S Calhoun, C Young, M Coutts, M Roberts, P Anderson, R Bernstein, J Hobart

Peninsula Medical School

BackgroundQuality standards (QS) for people with multiple sclerosis (PwMS) are suboptimal, ambiguous and restricted to certain patient subgroups and care pathways.AimDevelop and pilot MS metrics measuring service provision quality to identify areas for improvement.MethodsA multidisciplinary Working Group developed clinician and patient-reported metrics and standardised data collection forms through an iterative process.ResultsMetrics covered: referral; diagnosis; treatment; annual review; general management; education. Pilot (n=76) showed: 31% of PwMS were referred to MS specialist within 4 weeks of suspected/confirmed demyelination; 28% and 56% had uncomplicated MS confirmed and were offered specialist MS nurse appointment, respectively, within 4 weeks of specialist referral; 75% of …

Changes In The Biochemical And Nutrient Composition Of Seafood Due To Ocean Acidification And Warming, A. J. Lemasson, J. M. Hall-Spencer, V. Kuri, A. M. Knights

School of Biological and Marine Sciences

Ocean acidification and warming may threaten future seafood production, safety and quality by negatively impacting the fitness of marine species. Identifying changes in nutritional quality, as well as species most at risk, is crucial if societies are to secure food production. Here, changes in the biochemical composition and nutritional properties of the commercially valuable oysters, Magallana gigas and Ostrea edulis, were evaluated following a 12-week exposure to six ocean acidification and warming scenarios that were designed to reflect the temperature (+3 °C above ambient) and atmospheric pCO ₂ conditions (increase of 350–600 ppm) predicted for the mid-to end-of-century. Results suggest …

Big Data Analytics And Organizational Culture As Complements To Swift Trust And Collaborative Performance In The Humanitarian Supply Chain, R Dubey, A Gunasekaran, Sj Childe, D Roubaud, Wamba S Fosso, M Giannakis, C Foropon

Plymouth Business School

No abstract provided.

China's Organization And Governance Of Innovation – A Policy Foresight Perspective, Peijie Wang, Fan Li

Plymouth Business School

No abstract provided.

Internal And External Determinants Of Export Performance: Insights From Algeria, My Haddoud, W Nowinski, P Jones, R Newbery

Plymouth Business School

The internationalization of small and medium‐sized enterprises (SMEs) has been the focus of numerous studies. However, while the attention has thus far been on SMEs operating in developed countries, firms evolving in a developing context, including Africa, have been largely neglected. To address this, and drawing on a dual resources‐based and network‐based view, this study simultaneously investigates the importance of internal and external resources for firms’ export performance and regularity in the context of North African SMEs. Using a sample of Algerian exporters, the study reveals the superiority of discrete resources for boosting export performance and export regularity. These findings …

Hemen Mazumdar: The Last Romantic, Caterina Corni, Nirmalya Kumar

Research Collection Lee Kong Chian School Of Business

Hemendranath Mazumdar, popularly referred to as Hemen Mazumdar, was born 1894 in Gachihata village of Mymensingh district, which is currently part of Bangladesh. Coming from a relatively wealthy landowning family, at the age of sixteen, Hemen dropped out of school and ran away to Calcutta to pursue his passion for painting. He enrolled at the Government College of Art in 1911, but left in 1912 for another institution, Jubilee Art Academy. By 1915, he left Jubilee Art Academy to start earning his living through portrait painting. Abanindranath Tagore’s coterie had banished any artist following the western academic approach. In response, …

Evaluating Local, National, Regional And International Interventions In Northern Uganda Using A Human Security Approach, Davis Kawooya

Theses

Since gaining independence from Britain in 1962, Uganda has been beset by conflicts, the worst of which took place between the Ugandan government and the Lord’s Resistance Army in northern Uganda (1988-2006), causing a massive humanitarian crisis. The central argument of the thesis is that the government’s programmes in response would have been more successful if they had been people-centred, directly responsive to the suffering of the people, rather than centralised in the hands of a small Kampala-based elite, which controlled access to funding and political power, without transparency or accountability. This research uses human security as an umbrella concept …

Patient Involvement In Healthcare Projects: A Mixed Method Study On The Perspectives Of Project Staff In Western Australian (Wa) Public Hospitals And Health Services, Melanie Wright

Theses

Background: the benefits of patient involvement in clinical care and research is well described in the literature; but there is little evidence to suggest that involving patients in the planning and delivery of healthcare projects is beneficial to the outcomes of the project.

Purpose: this study explores the perspectives of staff who were specifically employed to lead and manage healthcare projects in Western Australian (WA) public hospitals and health services, regarding patient involvement in their projects and the perceived benefits and barriers of this involvement.

Study design: the study was designed using a sequential mixed method approach in three phases …

Youth Who Serve: Mandatory School Service Experience And Consequent Civic Responsibility, Cho See Chong

Theses

Two phenomena are of interest in this study. One is youth service, in particular, the acts of volunteering by young adults. The second concerns the learning of service, with specific reference to mandatory school service. The aim of the study is to explore to what extent and in what ways young people believe that their sense of civic responsibility and propensity to serve was influenced by their experience of service at school. To achieve this aim, a qualitative study was conducted on a group of post-school youth in Singapore who had participated in mandatory community service while at school, and …

St Thomas Aquinas On Affectivity: A Way Forward For Seminary Formation, Bernard Gordon

Theses

St Thomas Aquinas on Affectivity: A Way Forward for Seminary Formation, is a theological argument that St Thomas’ teaching can be applied to the affective formation of men preparing to be Catholic priests. St Thomas’ teaching provides a very helpful understanding of affective maturity and its integral importance for a truly Christian and priestly life in the service of others. It flows from a theological anthropology that recognizes proper affective growth as an integral part of human life and interpersonal relationships. Affective maturity is an essential attribute for the seminarian to acquire because he is preparing to be a priest …

Towards An Aristotelian Theory Of Care: A Comparison Of Neo-Aristotelian Virtue Ethics With Feminist Ethics Of Care, And The Fundaments Of A Virtue Ethical Theory Of Care, Steven Steyl

Theses

The intersection between virtue and care ethics is underexplored in contemporary moral philosophy. This thesis approaches care ethics from a neo-Aristotelian virtue ethical perspective, comparing the two frameworks and drawing on recent work on care to develop a theory thereof. It is split into seven substantive chapters serving three major argumentative purposes, namely the establishment of significant intertheoretical agreement, the compilation and analysis of extant and new distinctions between the two theories, and the synthesis of care ethical insights with neo-Aristotelianism to generate a virtue ethical theory of care. In the first two chapters, I outline virtue ethics and care …

Hearing And Understanding: Vernacular Liturgical Reform At Holy Trinity Abbey New Norcia 1963-1970, Christopher Kan

Theses

The first fruit of the Second Vatican Council (1962-65) was Sacrosanctum Concilium – the Constitution on the Sacred Liturgy. Within eight years of its promulgation Roman Catholic worship across the world was transformed, as the language and practice of the rites of the Church underwent significant change. One of the most noticeable changes was the relaxation of the requirement for the Church’s liturgy to be celebrated in Latin and instead be in the local language of the people, the vernacular.

Case studies of the implementation of the post-conciliar reform, as advocated by the Council, are infrequent, especially in the context …

Being On Track: A Phenomenological Study Of The Lived Experience Of Staff Development Nurses’ Transition From A Ward-Based Role To The Role Of Staff Development Nurse In A Hospital In Western Australia, Penny Keogh

Theses

Continuing education is widely accepted as a means to remain competent in nursing and knowledgeable about the numerous changes in health care and the health care environments in which nurses work. The ward-based staff development nurse (SDN) role is considered a vital support for clinical staff (Armstrong & Laschinger, 2006; Conway & Elwin, 2007), with the role responsible for organising orientation and continuing education for nursing staff in their respective area of specialty. There is a dearth of research on the lived experience of the hospital-based SDN, most of whom have no formal training or preparation for their role. Newly …

Trading Regularity And Fund Performance, Jeffrey Busse, Lin Tong, Qing Tong, Zhe Zhang

Research Collection Lee Kong Chian School Of Business

We construct a new measure of trading regularity, capturing the extent to which investors trade on a regular basis. Institutional investors that regularly trade outperform those that trade less regularly. The performance of funds that regularly trade persists for at least a year. Among those who trade most regularly, larger funds perform relatively worse, because they incur higher transaction costs associated with their larger trades. Institutions that regularly trade generate superior performance, in part, by behaving as contrarians and by trading more aggressively on information. By contrast, we find no relation between trading regularity and performance among index funds.