Digital Commons Network^™

A Race Against Time: Deciphering Evolution And Describing New Species Of Threatened Tropical Stick Insects (Phasmatodea), Michael F. Whiting

Journal of Undergraduate Research

Funding was received in 2016 to support mentored research into the phylogeny and evolution of stick insects. Specific goals include providing students with scientific design experience, field-based research experience, collections-based experience, molecular lab experience, bioinformatics experience, and experience in presentation at national meetings and publication in peer reviewed journals. One particular focus was to describe new stick insect species, but it became clear very quickly that the phylogeny portion of this work was essential before any new species could be described, so we concentrated our efforts on stick insect phylogeny. The following is a brief summary of accomplishments.

Byu Undergraduates Solving The Genetic Causes Of Alzheimer’S Disease, John Kauwe

Journal of Undergraduate Research

Successful enrollment in and completion of graduate programs requires a constellation of skills. Students must be prepared to plan and execute experiments, present their findings both verbally and in manuscript form and interact effectively with senior scientists in the field of their choice. In this MEG I will mentor three undergraduate students (Sheradyn Hamilton, Kristen Cockriel, and Moroni Chalita) as they develop skills in study design, data analysis, manuscript preparation, presentation and networking while identifying genetic factors that protect individuals from Alzheimer’s disease.

T Cell Immunotherapy Of Infection Disease And Cancer, Scott Weber

Journal of Undergraduate Research

This project was focused on improving the immune response to infectious disease and cancer. We have engineered T cell receptors with 1000-fold increase in affinity and will characterize their value as diagnostics and therapeutics. In addition, we examined changes in T cell function due to the co-receptor CD5. We also examined how T cell responses to infection are dependent upon metabolic and epigenetic regulation.

Rage And Sage: Therapeutic Modalities For Copd, Paul Reynolds

Journal of Undergraduate Research

Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important at BYU. We have been successful in conducting pilot studies that reveal possible roles for SAGEs in ameliorating mechanisms of lung inflammation induced by and cigarette smoke (CS). Despite improvement in personal air quality during the past few decades, the rationale for studying mechanisms leading to adverse health effects remains important. This MEG award specifically provided opportunities for students to conduct meaningful research that led to the observation that alveolar epithelial cells and bronchiolar epithelial cells experience elevated …

Genesis And Geochemical Characteristics Of Coalbed Methane From Taiyuan Formation In Sijiazhuang Mine Field Of Yangquan Mining Area, Yu Zhenfeng, Hao Chunsheng, Yang Changyong, Yao Jinbao, Wang Wei, Ji Changjiang

Coal Geology & Exploration

In order to study the geochemical characteristics and the genesis of CBM of Sijiazhuang mine field in Yangquan mining area, the in-site desorption test of coal core samples from the main gas-producing seams(seams 8, 9 and 15) from Permo-Carboniferous Taiyuan Formation was carried out systematically, gas samples were collected to conduct component and carbon isotope analysis. The results indicated that the gas content of seam 8 was higher than that of seam 9, on the plan the gas content of seam 15 was uneven, in some parts there was almost no gas. During the whole desorption, the gas component content …

"If They Don't Tell You, The Hair Will": Hair Narrative In Contemporary Women's Writing, Darina Pugacheva

LSU Doctoral Dissertations

The history of colonial and racial oppression made hair stories and testimonials fundamental to understanding hair as a unifying element particular for women of African descent in the post-slavery era. Seen as such, their hair narrations provide the first-person perspective of their life experiences while at the same time inviting a critical investigation of colonial and racial oppression. Contemporary women writers develop these types of narrations into a special language of hair that helps them tell a story that is not apparent or straightforward. This literary device that uses hair to uncover deeper social and political issues is bound up …

Method Of Forming Microparticles For Use In Cell Seeding, Sutapa Barua, Chase Herman

Chemical and Biochemical Engineering Faculty Research & Creative Works

The present invention is directed to methods for forming microparticles useful for cell seeding and for conjugating protein to the surface of the microparticles. The method comprises co-injecting an organic solution of PLGA or other polymer with an aqueous solution into a flow focusing tube.

A Six Week Therapeutic Ballet Intervention Improved Gait And Inhibitory Control In Children With Cerebral Palsy—A Pilot Study, Kimberley D. Lakes, Kelli Sharp, Marybeth Grant-Beuttler, Ross Neville, Fadia Haddad, Rachel Sunico, Daniel Ho, Melinda Schneider, Sofia Sawitz, Janine Paulsen, Kim Caputo, Kim D. Lu, Afshin Aminian, Citlali López-Ortiz, Shlomit Radom-Aizik

Physical Therapy Faculty Articles and Research

Children with cerebral palsy (CP) have motor impairments that make it challenging for them to participate in standard physical activity (PA) interventions. There is a need to evaluate adapted PA interventions for this population. Dance can promote coordination, posture, muscle strength, motor learning, and executive functioning. This pilot study evaluated the feasibility and the effects of a new therapeutic ballet intervention specifically designed for children with CP.

Methods: Eight children with CP (9–14 y/o; 75% female) participated in a 6-week therapeutic ballet intervention. Outcomes were measured in multiple domains, including body composition (DXA), muscle strength (hand-grip dynamometer), habitual physical …

Hourly Precipitation Climatology Of The Southeast United States, Vincent Brown

LSU Doctoral Dissertations

Precipitation changes are one of the most important potential outcomes of a warming climate because of how essential it is to society and ecosystems. Sub-daily precipitation time series provide more information on precipitation characteristics, particularly frequency, intensity, and duration compared to daily data. In a series of four peer-reviewed manuscripts, this research investigates sub-daily precipitation characteristics from a climatological perspective. The first study introduces a climatology of hourly precipitation for four first-order weather stations across Louisiana, explores possible changes in the hourly precipitation distribution, and links winter Gulf of Mexico sea surface temperatures to the frequency of hours with precipitation. …

Near Infrared Gumbos And Nanogumbos For Biomedical Applications, Mi Chen

LSU Doctoral Dissertations

Recent advances in development of nanomaterials have provided great opportunities for cancer research. In this dissertation, nanoGUMBOS derived from a group of uniform materials based on organic salts (GUMBOS) were investigated for several biomedical applications including chemotherapy, photothermal therapy (PTT), and drug delivery. GUMBOS are solid-phase organic salts consisting of bulky cations and anions. Similar to ionic liquids, GUMBOS display highly tunable properties with counter-ions variation, but with a defined melting point range of 25–250 °C. Nanomaterials derived from GUMBOS, i.e. nanoGUMBOS, display enhanced properties at the nanoscale level. This dissertation focuses on development of near infrared IR780 nanoGUMBOS for …

Reflection Learning With Neural Network Ensemble, Mars Gao

Purdue Undergraduate Research Conference

For the current architecture of neural networks, it usually requires a high training cost in time and computation. From our perspective, the current methods in deep learn- ing might not be optimal in architecture and it fails to have an effective learning strategy. To solve these problems, in this paper, we would like to introduce the Collaborative Neural Network Group (CNNG). CNNG is a series of neural networks that work collaboratively to handle different tasks separately in the same learning system. It is evolved from a single neural network by our designed algorithm — Reflection. In this way, based on …

Changes In Microglial Morphology Following An Acute Stressor In Male And Female Rats, Houston Meminger, Jadebrielle Bennesh, Mikayla Voglewede, Amy L. Brewster Phd, Susan Sangha Phd

Purdue Undergraduate Research Conference

Changes in microglial morphology following an acute stressor in male and female rats Houston Meminger1*, Jadebrielle Bennesh1*, Mikayla Voglewede 1Department of Psychological Sciences, Purdue University *Contributed equally Post-traumatic stress disorder (PTSD) is characterized by generalized fear responses to previously non-aversive stimuli following exposure to a traumatic event. Despite incidence rates for traumatic events being nearly equal between the sexes, women are twice as likely to develop PTSD. To explore these sex differences, we are examining how microglia in the prefrontal cortex respond to stress in both male and female Long Evans rats. Specifically, male and female rats were exposed to …

Understanding The Transcarboxylation Reaction Performed By Acetyl Coa Carboxylase, Ana Pascual-Garrigos

Purdue Undergraduate Research Conference

Malonyl-CoA is a molecule involved in a variety of important reactions and it is biologically important as it is required for fatty acid synthesis. This compound is also highly reactive making it and the enzymes that use it difficult to study. As a result, in order to learn mechanistic information, more stable analogs of malonyl-CoA were made in order to mimic the size, shape and acidity of the thioester and carboxylate groups. Throughout the semester, some malonyl-CoA analogs were synthesized and bacterial inhibition growth assays were performed with Escherichia Coli, Bacillus cereus, and Micrococcus luteus. However, the inhibition predicted was …

Eocene Terrestrial Mammals From Central Georgia, Parker D. Rhinehart, Alfred J. Mead, Dennis Parmley

Georgia Journal of Science

Descriptions of fossils of Eocene terrestrial mammals from the southeastern United States are rare, and particularly so in the Eocene sediments of Georgia. Here we describe a small collection of fossilized teeth and tooth fragments representing four mammalian taxa. The fossils were recovered by surface collecting overburden sediments and screen washing in situ Clinchfield Formation sediments exposed in an inactive kaolin mine, Hardie Mine, in Wilkinson County, Georgia. The Clinchfield Formation has been described as a Late Eocene coastal unit with abundant gastropods, bivalves, sharks, and rays. This is the first detailed description of terrestrial mammals from this unit. Although …

A Systematic Review And Analysis Of Racial Differences In Treatment For Depression, Elli D. R. Parisi

DePaul Discoveries

Mental health affects a large proportion of the population across the world. Though many mental health studies exist, they are inconsistent in methodology, conceptualization of terms, and populations studied; as a result, many studies are incomparable with each other. Further, there is arguably too few studies that focus on marginalized or underrepresented populations. The current study aims to address some of this gap in knowledge. The differences in the way depression is diagnosed and treated in various racial and ethnic groups were identified, and the findings of previous studies were analyzed to help improve the way mental health, and specifically …

Sex-Specific Personalities In The Purple Marsh Crab, Jillian Sterman, Jessica Barton, Panagiota Delmedico, Samantha Sweeney

DePaul Discoveries

Animals are considered to possess personalities when individuals differ in behavior, and these differences are consistent between situations. Several studies have identified personalities in diverse groups but less is known about personality variation between the sexes. In this study, we examined variation in two key personality traits (boldness, activity) in female and male purple marsh crabs (Sesarma reticulatum) using a semi-field approach. Specifically, we measured boldness and activity on two consecutive days using the same behavioral assays during each time point. Consistency (personality) was determined using Kendall’s coefficient of concordance based on Spearman correlation coefficients for each behavior. …

Behavioral Responses To Gold Nanoparticle Exposure And H2o2-Induced Oxidative Stress In Caenorhabditis Elegans, Rachel Pride, Ashley Wagner

DePaul Discoveries

Gold nanoparticles (AuNPs) have been utilized in many biomedical disciplines, most notably cancer therapy and drug delivery. Recent research suggests that with specific peptide manipulation, AuNPs can deliver drugs across the blood-brain barrier (BBB), allowing for treatment of neurodegeneration and other neurological afflictions. Neurodegeneration has been shown to be caused by oxidative stress. The present experiment aimed to assess the effects of AuNPs on C. elegans behavior that had undergone H₂O₂-induced oxidative stress. It was predicted that worms exposed to both H₂O₂ and AuNPs would have higher survival, mechanosensation, and thrashing rates than …

Effects Of Reduced Ph On Health Biomarkers Of The Seagrass Cymodocea Nodosa, Regan A. Mcenaney

DePaul Discoveries

Ocean acidification is a growing problem that may affect many marine organisms in the future. Within 100 years the pH of the ocean is predicted to decrease to 7.8, from the current ocean pH of around 8.1. Using phenolic acid levels as a stress indicator as well as respiration and chlorophyll content as a measure of health, the effect of lowering pH was tested on the seagrass, Cymodocea nodosa, in a controlled environment. Plant samples, water, and soil were taken from the Bay of Cádiz, Spain, and placed in aquaria in a temperature-controlled room. One control group was left …

On The Composistion Of Cymodocea Nodosa Root Exudate Under Artificial Blue, Green And Natural Light Conditions, Armand Martin, Ben Manriquez, Christian Pompa, Aaron Saper, Kyle A. Grice, Jason Bystriansky

DePaul Discoveries

Seagrasses are identified as a sentinel species: a good indicator of overall marine ecosystem health and function. At the rhizome, they are known to interact with marine bacteria by exchanging energy in the form of glucose and free amino acids secreted through root exudate in exchange for microbe-fixated nitrogen that can be utilized for plant growth. To analyze potential outcomes of possible future changes in light availability, an experiment was designed to collect and analyze the root exudate of Cymodocea nodosa under three light conditions (standard fluorescent light, blue LED, and green LED light). After 72 hours of treatment, the …

Comparing Carapa Guianensis Seed Production In 3 Amazonian Forests, Carmen Valencia

DePaul Discoveries

This paper is the first part of a project that has the purpose of creating models that help us better understand variation in seed production in Carapa guianensis, a species in the mahogany family. The goal of this paper is to visualize seed production patterns to inform species management. When this study is completed, it will aid local communities harvesting Carapa in projecting revenue from the oil produced from the seeds. Carapa is a masting species, which means it has an intermittent synchronous production of large seed crops. The major suspected causes of variation in seed production are resource …

A Playful Life Cycle Assessment Of The Environmental Impact Of Children's Toys, Madeline R. Robertson, Christie Klimas

DePaul Discoveries

Toys aid in children’s progression through developmental stages, yet toy production has an environmental impact. This study is the first comparative life cycle assessment of three children’s toys. A life cycle assessment quantifies the impact of an item in comparable impact categories (i.e. global warming potential in kg CO2 equivalents). In this study, we use open LCA to compare toy impact from production to use. The results indicate that the plastic polybutylene carried the highest impact in terms of global warming potential for our predominantly plastic toy. The addition of a battery to the plush dog increased the toy’s eutrophication …

A Life Cycle Assessment Of Jewelry, Jessica Fernandez, Christie Klimas

DePaul Discoveries

Jewelry is unique in that it is not a necessity, yet it holds sentimental and material value to the owner. Jewelry sales in the US have increased throughout time, meaning the demand for gold has almost always been increasing, as well. With more than half of the gold mined going towards the production of jewelry, it is the product with the highest demand of the resource. However, mining for the metals to produce a piece of jewelry, specifically gold, has negative consequences on both the environment and the people working in or living near mines. This study is a life …

Muscle Activation Via Mri: Comparison Of Techniques, Logan Thorneloe, Neal Bangerter

Journal of Undergraduate Research

Muscle functional magnetic resonance imaging (mfMRI) is a proven concept to non-invasively identify muscle activation1. Noninvasively identifying muscle activation can be used to diagnose metabolic muscle disease, identify and pinpoint muscular dysfunction, observe muscle deterioration in aging individuals, and help researchers better understand the biological foundation of musclechemistry2. Current proven methods of mfMRI include analyzing pre- and post-exercise T2-weighted images, T2 maps, and sodium images of muscle; however, there is considerable debate around the best of these techniques1-4. We tested these three imaging techniques to determine which has the greatest post-exercise shift in signal intensity.

Relating Spatial Patterns Of Stream Metabolism To Distributions Of Juveniles Salmonids At The River Network Scale, Matthew J. Kaylor, Seth M. White, W. Carl Saunders, Dana R. Warren

Watershed Sciences Faculty Publications

Understanding the factors that drive spatial patterns in stream ecosystem processes and the distribution of aquatic biota is important to effective management of these systems and the conservation of biota at the network scale. In this study, we conducted field surveys throughout an extensive river network in NE Oregon that supports diminishing populations of wild salmonids. We collected data on physical habitat, nutrient concentrations, biofilm standing stocks, stream metabolism (gross primary production [GPP] and ecosystem respiration [ER]), and ESA‐listed juvenile salmonid density from approximately 50 sites across two sub‐basins. Our goals were to (1) to evaluate network patterns in these …

Nepal Ambient Monitoring And Source Testing Experiment (Namaste): Emissions Of Particulate Matter And Sulfur Dioxide From Vehicles And Brick Kilns And Their Impacts On Air Quality In The Kathmandu Valley, Nepal, Min Zhong, Eri Saikawa, Alexander Avramov, Chen Chen, Boya Sun, Wenlu Ye, William C. Keene, Robert J. Yokelson, Thilina Jayarathne, Elizabeth A. Stone, Maheswar Rupakheti, Arnico K. Panday

Chemistry and Biochemistry Faculty Publications

Air pollution is one of the most pressing environmental issues in the Kathmandu Valley, where the capital city of Nepal is located. We estimated emissions from two of the major source types in the valley (vehicles and brick kilns) and analyzed the corresponding impacts on regional air quality. First, we estimated the on-road vehicle emissions in the valley using the International Vehicle Emissions (IVE) model with local emissions factors and the latest available data for vehicle registration. We also identified the locations of the brick kilns in the Kathmandu Valley and developed an emissions inventory for these kilns using emissions …

English As A Foreign Language (Efl) In Captivity: The Case Of Iranian Prisoners Of War In The Iraq-Iran War, Abbas Emam

Journal of Prison Education and Reentry (2014-2023)

During the Persian Gulf War of Iraq-Iran (1980-1988), thousands of Iranians were taken captive by Iraqi troops. These prisoners of war (POWs) had to find ways to enrich and fill their time in prison camps. Learning English was one such activity. This study was carried out to appraise the motivations of the Iranian POWs for learning English, and to understand more about their textbooks, their classroom environment, the teaching methods and techniques employed, the skills emphasized, the teaching aids improvised, the types of exercises mobilized, as well as the test-taking techniques adopted. A relevant corpus of 21 memoirs and 7 …

Molecular Recognition Of M1-Linked Ubiquitin Chains By Native And Phosphorylated Uban Domains, Lina Herhaus, Henry Van Den Bedem, Sean Teng, Innokentiy Maslennikov, Soichi Wakatsuki, Ivan Dikic, Simin Rahighi

Pharmacy Faculty Articles and Research

Although the Ub-binding domain in ABIN proteins and NEMO (UBAN) is highly conserved, UBAN-containing proteins exhibit different Ub-binding properties, resulting in their diverse biological roles. Post-translational modifications further control UBAN domain specificity for poly-Ub chains. However, precisely, how the UBAN domain structurally confers such functional diversity remains poorly understood. Here we report crystal structures of ABIN-1 alone and in complex with one or two M1-linked di-Ub chains. ABIN-1 UBAN forms a homo-dimer that provides two symmetrical Ub-binding sites on either side of the coiled-coil structure. Moreover, crystal structures of ABIN1 UBAN in complex with di-Ub chains reveal a concentration-dependency of …

Field Trial Of A Probiotic Bacteria To Protect Bats From White-Nose Syndrome, Joseph R. Hoyt, Kate E. Langwing, Paul White

KIP Articles

Tools for reducing wildlife disease impacts are needed to conserve biodiversity. White-nose syndrome (WNS), caused by the fungus Pseudogymnoascus destructans, has caused widespread declines in North American bat populations and threatens several species with extinction. Few tools exist for managers to reduce WNS impacts. We tested the efficacy of a probiotic bacterium, Pseudomonas fluorescens, to reduce impacts of WNS in two simultaneous experiments with caged and free-flying Myotis lucifugus bats at a mine in Wisconsin, USA. In the cage experiment there was no difference in survival between control and P. fluorescens-treated bats. However, body mass, not infection intensity, predicted mortality, …

Gwu Alumna’S Research Could Save Thousands Of Lives, Office Of University Communications

Gardner-Webb NewsCenter Archive

In her classes at Gardner-Webb University, Kaylan Kelsey explored her interests in chemistry, discovering the properties of matter and chemical reactions. After graduating in 2018 with a major in chemistry and minor in mathematics, Kelsey is using her research skills to improve early detection of ovarian cancer, a disease that kills over 13,000 women a year. “I am fortunate to be in a research group I am passionate about, and one that resonates highly with me,” observed Kelsey, a native of Warner Robins, Ga.

Feasibility Of Generating Synthetic Ct From T1-Weighted Mri Using A Linear Mixed-Effects Regression Model, Anant Pandey, S. A. Yoganathan, Beibei Guo, Rui Zhang

Faculty Publications

Generation of synthetic computed tomography (sCT) for magnetic resonance imaging (MRI)-only radiotherapy is emerging as a promising direction because it can eliminate the registration error and simplify clinical workflow. The goal of this study was to generate accurate sCT from standard T1-weighted MRI for brain patients. CT and MRI data of twelve patients with brain tumors were retrospectively collected. Linear mixed-effects regression models were fitted between CT and T1-weighted MRI intensities for different segments in the brain. The whole brain sCTs were generated by combining predicted segments together. Mean absolute error (MAE) between real CTs and sCTs across all patients …