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Autonomic Response In Autism Spectrum Disorder: Relationship To Social And Cognitive Functioning, Michelle A Patriquin, Elizabeth M Hartwig, Bruce H Friedman, Stephen W Porges, Angela Scarpa

Staff and Researcher Publications

Individuals with autism spectrum disorder (ASD) may exhibit chronic autonomic nervous system (ANS) hyperarousal (e.g., lower respiratory sinus arrhythmia and higher heart rate) compared to their typically developing peers, reflecting a chronic biological threat response. The sustained nature of this cardiac threat suggests tonic nervous system perception of threat in safe contexts. Herein, the cardiac literature in adult and child populations with ASD is reviewed and placed within a continuum of functioning in order to inform the relationship between cardiac response and functioning in ASD. Findings from this review support the relationship between chronic autonomic hyperarousal and emotional and behavioral …

Contents, Saint Mary's College Of California

Academic Catalog

No abstract provided.

The Schools, Saint Mary's College Of California

Academic Catalog

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Complete Catalog, Saint Mary's College Of California

Academic Catalog

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Student Life, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Academic Requirements, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Allied Health Science, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Anthropology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

English And Mfa In Creative Writing, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Environmental And Earth Science Programs, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Integral Program, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Kinesiology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Pre-Professional Curricula, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Psychology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Sociology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Theology & Religious Studies, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Women's And Gender Studies, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Undergraduate Faculty, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Using An Elicited Orienting Response And Respondent Conditioning To Increase Eye Contact In Response To A Name Call In Children With Autism, Nicole Adriaenssens

Theses and Dissertations

One of the earliest and most noticeable characteristics of children with Autism Spectrum Disorder (ASD) is impaired eye contact. Difficulty with making eye contact presents concerns for children regarding academic, social, and safety skills—for instance, failing to respond to a teacher calling a child’s name to give instructions, looking at a peer during play, or orienting toward an adult speaker warning the child of a risky situation. Currently published research on increasing responding to name with eye contact has primarily involved separate and combined procedures such as physical prompting, visual prompting, differential reinforcement, and overcorrection. The current study evaluated the …

Investigating Factors Affecting Venture Growth Intention For Women Entrepreneurs, Beth Johanna Gitlin

Theses and Dissertations

During the past several years the number of women-owned firms increased by 45% from 2007-2016, a rate five times faster than the national average. However, their overall venture growth is far below the national average. The benefits of studying the internal and external context in which this phenomenon has occurred will help us to understand what types of interventions may contribute to enhancing venture growth intention for women entrepreneurs. In light of the scant research linking factors such as self-confidence, access to role models, perceived family support and risk-taking to venture growth intention for women entrepreneurs, this study examines a …

Metastable-State Photoacid: A Comprehensive Theoretical Study Of The Photoreaction, Reverse Reaction, Thermal Isomerization, And Td-Dft Absorption In Solvent, Arwa Wasel Hamed Alharbi

Theses and Dissertations

The main objective of the research is to investigate the fundamentals of novel metastable-state photoacids. These photoacids can reversibly produce a large concentration of protons while undergoing photo-irradiation. This change in proton concentration can induce and catalyze chemical reactions, biological functions, and material properties that do not occur in the dark. (IMAGE) Scheme 1. Energy diagram of the photoreaction. (The red route is the forward photoreaction; the blue route is the reverse reaction; and the process that involves the proton dissociation of the photoacid in the dark is the green route; "t-" means trans- and "c-" means cis-). Scheme 1 …

Gene Expression Studies For Analyzing Effects Of Space Radiation In Tissues, Amatulshakoor Mohammed Farooqui

Theses and Dissertations

Human exploration beyond the earth's orbit poses many risks for the crew on these missions. One of the major health risks is exposure to space radiation environment beyond the earth’s magnetic field. The space environment exposes astronauts to high levels of ionizing radiation such as galactic cosmic rays. The radiations can have acute and delayed effects on the human body. The primary response to tissue injury is increased oxidative stress and inflammation. The overall objective of this study was to analyze the effects of ionizing radiation in heart tissue by quantifying its impact on the expression of genes that correlate …

Metastable-State Photoacids And Polymers With High Photoacidity, Thaaer Khalil

Theses and Dissertations

In recent years, metastable-state photoacids (mPAH) have been utilized to control various chemical processes using visible light and have found many applications in materials, energy, and biomedical areas. An introduction of metastable state photoacid is given in Chapter 1. In chapter 2, to clearly understand the relationship between the structures and the physicochemical properties of mPAHs, a series of mPAHs were designed and synthesized. The reversibility, stability, reverse reaction rate, and photoreaction of the mPAHs were studied in detail using UV/VIS spectroscopy. The results demonstrated that the electron-withdrawing groups on the electron-accepting moiety enhance the overall photoreaction and stability of …

Controlling Co Dose From Corm-Loaded Electrospun Scaffolds With Diffusion-Based Modeling And Experimental Assessment Of Endothelial Cell Response, Kenyatta S. Washington

Theses and Dissertations

Cardiovascular disease (CVD) accounts for one in every five deaths in the United States alone due to occlusion in small diameter (< 6 mm) vessels. The current treatment options includes bypass grafting; however, more than 30 percent of patients do not have viable saphenous veins for autologous grafting [1]. Therefore, tissue engineering is being considered as an alternative approach. The overall goals of this project were to develop a tissue engineered vascular graft with the incorporation of carbon monoxide releasing molecules (CORMs) and to determine the impacts of carbon monoxide (CO) on endothelial cells (ECs) with the goal of promoting a functional endothelium within the graft. This was accomplished through two complementary studies: investigating the impacts of CO-loaded electrospun scaffolds on ECs for cardiovascular applications and diffusion-based modeling of drug delivery of gasotransmitters from tissue engineered scaffolds. In the first study, we extended the maximum in vitro incubation time to permit better cellular attachment and proliferation with a newly-synthesized, more hydrophobic CORM (DK3) and established the impact of CORMs on EC viability and function (e.g. reactive oxygen species (ROS) products, and ROS levels). We further investigated toxicity and biocompatibility of a newly synthesized CORM (DK4) loaded within PCL thin films and nanoparticles. We concluded that the DK4 and other compounds are not toxic at doses ranging from 0 – 50 μg/mL to the ECs both within nanoparticles that can be internalized within cells. We also conducted an in vivo pilot study to determine graft biocompatibility and preliminary results showed that CORM implants maintain mechanical integrity, support blood flow, and do not show toxicity for up to six weeks. In the second study, we validated a computational model and analyzed the output of CO delivery to better understand and control local dose. For CO release, this model is necessary because of the limitations with real-time experimental analysis and the need to better understand the dose available to the cells. We demonstrated that the validated model can be used to predict drug availability to cells for a variety of scaffolds and drug molecules. Our simulated results suggest that only a fraction of the initial concentration of gasotransmitters released from fibers that enters the interstitial fluid in vivo, or culture media in vitro, will be available to cells. We also demonstrated that fiber orientation and fiber diameter are important for drug delivery, but fiber density provides even more important information. The more contact area within the fiber scaffolds is equivalent to experimental conditions with more cell attachment and spreading. These parameters are not only important for traditional tissue engineering, but also for drug delivery. Overall, these results demonstrate the feasibility of making a tissue engineered vascular graft with the incorporation of CORMs and validating he importance of computational modeling of diffusion-based transport of CO. Future work will involve performing surface modifications to enhance cell attachment and proliferation, using the developed computational model to better predict dose available to cells, and experimentally determining impact of CO dose on ECs.

Switching Dynamics And Conductance Quantization Of Aloe Polysaccharides-Based Device, Z. X. Lim, I. A. Tayeb, Z. A.A. Hamid, M. F. Ain, A. M. Hashim, J. M. Abdullah, F. Zhao, K. Y. Cheong

Electrical and Computer Engineering Faculty Research & Creative Works

The switching behaviors of polysaccharides-based resistive random-access memories change substantially depending on the electrical inputs. Here, the switching dynamics of the device are presented by varying the applied current compliance (CC) and voltage sweeping rate (ν). The results show that the device resistance in the low-resistance state (RLRS) can be modulated over five orders of magnitude by varying (CC) and ν in the typical current-voltage measurements. The (RLRS) modulation is attributed to the variable tunneling gap between the filament tip and the top electrode (TE). Conductance quantization is observed once a single-atomic contact with resistance ≤12.9kΩ is formed. Depending on …

The Role Of T-Cell Protein Tyrosine Phosphatase In Epithelial Carcinogenesis, Liza D. Morales, Anna K. Archbold, Serena Olivarez, Thomas J. Slaga, John Digiovanni, Dae Joon Kim

School of Medicine Publications

T-cell protein tyrosine phosphatase (TC-PTP, encoded by PTPN2) is a non-receptor PTP that is mostly highly expressed in hematopoietic tissues. TC-PTP modulates a variety of physiological functions including cell cycle progression, cell survival and proliferation, and hematopoiesis through tyrosine dephosphorylation of its target substrates, such as EGFR, JAK1, JAK3, STAT1, and STAT3. Studies with whole or tissue-specific loss of TC-PTP function transgenic mice have shown that TC-PTP has crucial roles in the regulation of the immune response, insulin signaling, and oncogenic signaling. More recently, generation of epidermal-specific TC-PTP-deficient mice for use in multistage skin carcinogenesis bioassays demonstrated that TC-PTP …

Not All Surveillance Data Are Created Equal—A Multi‐Method Dynamic Occupancy Approach To Determine Rabies Elimination From Wildlife, Amy J. Davis, Jordona D. Kirby, Richard B. Chipman, Kathleen M. Nelson, Tatiana Xifara, Colleen T. Webb, Ryan Wallace, Amy T. Gilbert, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

1. A necessary component of elimination programmes for wildlife disease is effective surveillance. The ability to distinguish between disease freedom and non‐detection can mean the difference between a successful elimination campaign and new epizootics. Understanding the contribution of different surveillance methods helps to optimize and better allocate effort and develop more effective surveillance programmes.

2. We evaluated the probability of rabies virus elimination (disease freedom) in an enzootic area with active management using dynamic occupancy modelling of 10 years of raccoon rabies virus (RABV) surveillance data (2006–2015) collected from three states in the eastern United States. We estimated detection probability …

Transmission Dynamics Of Toxoplasma Gondii In Arctic Foxes (Vulpes Lagopus): A Long-Term Mark-Recapture Serologic Study At Karrak Lake, Nunavut, Canada, Emilie Bouchard, Stacey A. Elmore, Ray T. Alisauskas, Gustaf Samelius, Alvin A. Gajadhar, Keaton Schmidt, Sasha Ross, Emily J. Jenkins

United States Department of Agriculture Wildlife Services: Staff Publications

Transmission dynamics of Toxoplasma gondii, a parasite of importance for wildlife and human health, are enigmatic in the Arctic tundra, where free-ranging wild and domestic felid definitive hosts are absent and rarely observed, respectively. Through a multiyear mark-recapture study (2011– 17), serosurveillance was conducted to investigate transmission of T. gondii in Arctic foxes (Vulpes lagopus) in the Karrak Lake region, Nunavut, Canada. Sera from adult foxes and fox pups were tested for antibodies to T. gondii by using serologic methods, including the indirect fluorescent antibody test, direct agglutination test, and modified agglutination test. The overall seroprevalence was 39% in adults …

Genetic Risk Score In Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus, Andres Gelrud

All Publications

Introduction: Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.

Methods: We used 60 T2DM single …