Digital Commons Network^™

Agriculture, Ecosystems & Environment, William A. Arigiroff, Donald R. Zak, Rima A. Upchurch, Sydney O. Salley, A. Stuart Grandy

Faculty Publications

Fine root litter is a primary source of soil organic matter (SOM), which is a globally important pool of C that is responsive to climate change. We previously established that ~20 years of experimental nitrogen (N) deposition has slowed fine root decay and increased the storage of soil carbon (C; +18%) across a widespread northern hardwood forest ecosystem. However, the microbial mechanisms that have directly slowed fine root decay are unknown. Here, we show that experimental N deposition has decreased the relative abundance of Agaricales fungi (−31%) and increased that of partially ligninolytic Actinobacteria (+24%) on decaying fine roots. Moreover, …

How A Psychopathic Serial Killer Becomes An American Favorite: An Analysis Of Dexter Morgan, Joanna Dunn

Augsburg Honors Review

In a society where the selling of serial killers' personal items is a profitable business and killers are the focus of many facets of entertainment such as biopics, crime novels, films, and the television network TruTV it is not surprising that a series about a killer debuting in 2006 would be the highest rated premiere of its home network Showtime, or that its viewership would increase by 84% between the pilot and season one finale. The series Dexter does, after all, follow the everyday routine of a serial killer, even giving the audience a glimpse into his innermost thoughts. However, …

The Catch-22 Irony Of Child Labor And The Urgency For State Intervention, Ka Yee Lau

Augsburg Honors Review

Child labor (CL) has been found to enhance substantially the poorest households' chances for short-term survival. CL could also - it has been argued - facilitate CWs' socialization and development of moral values and survival skills. This article aims to demonstrate that these short-term benefits are considerably outweighed by the corresponding long-term detrimental repercussions on CWs' health, education, and earning potential in adulthood. While the poorest households might strategically employ CL as a last resort to ensure their short-term survival, it is CL per se that maintains these families in extreme poverty through the impediment to CWs' human capital accumulation, …

Off With Their Heads! How China's Controversial Human Head-Transplant Procedure Exceeds The Parameters Of International Ethical Standards In Human Experimentation, Deena Agamy

Georgia Journal of International & Comparative Law

No abstract provided.

Parameter Estimation For The Power Generalized Weibull Distribution Based On One- And Two-Stage Ranked Set Sampling Designs, Sabry M. A., Muhammed H. Z., Nabih A., Shaaban M.

Journal of Statistics Applications & Probability

Parameter estimation Based on Double Ranked Set Sampling (DRSS) designs was recently developed by Sabry et al., (2019) and shows high efficiency and precision of the likelihood estimators when applied to the two-parameter Weibull distribution. In this paper the likelihood function of the General Double Ranked Set Sampling (GDRSS) design discussed by Taconeli & Cabral (2019) is derived and the two double ranked set sampling designs DRSS and GDRSS are compared along with the usual Ranked Set Sampling (RSS) and Extreme Ranked Set Sampling (ERSS) designs for the estimation of the parameters of the Power Generalized Weibull (PGW) distribution which …

Genetic Risk For Childhood Posttraumatic Stress Disorder, Breanne A. Danzi

Open Access Dissertations

Posttraumatic stress disorder (PTSD) is highly prevalent in children exposed to disasters. Yet, there are several widely discrepant diagnostic models of PTSD (DSM-IV, DSM-5, DSM-5 Preschool, and ICD-11); evidence suggests that these models may diagnose different groups of children (Danzi & La Greca, 2016, 2017; La Greca, Danzi, & Chan, 2017). Genetic biomarkers have been identified as a promising diagnostic tool for identifying risk for PTSD (National Research Action Plan, 2013). A large number of studies have investigated candidate genes in adult samples, but this research has not been extended to children. This project investigated genetic risk for PTSD in …

Biophysical Characterization Approaches To Aid The Selection Of Protein Formulations By Predicting Their Physical Stability During Long-Term Storage, Hristo Svilenov, Gerhard Winter

Biological and Pharmaceutical Complex Fluids III: Protein Self-Assembly, Rheology and Interfacial Properties

The formulation of therapeutic proteins is a critical process which aims at finding the most suitable conditions that impede protein degradation during long-term storage. One degradation path of high interest is the non-native aggregation¹. The latter can be greatly suppressed by the selection of suitable solution conditions². Over the years, various biophysical techniques have been explored as tools to quickly select the most promising formulations for long-term storage.

In this talk, we share the experience in our lab how some of these techniques can be integrated into protein formulation studies. We discuss the application of differential …

Conference Program, Samiul Amin, Saad Khan, Srinivasa Raghavan

Colloidal, Macromolecular and Biological Gels II

No abstract provided.

Expanding Instream Flows To Protect Ecosystems In Overallocated River Basins, Belize Lane, David E. Rosenberg

All In-stream Flows Material

Utahns are expressing a rapidly growing interest in protecting and enhancing instream flows for outdoor recreation and environmental benefits (Endter-Wada et al. 2015). However, many Utah rivers are already over-allocated for agricultural, municipal, hydropower and other water uses, making it difficult to procure additional water for instream flows. ‘Use it or lose it’ western water law and mentality encourages Utahns to use water rather than return it to rivers and ecosystems.

The Chemistry And Biology Of Cyclophostin, The Cyclipostins And Related Compounds, Christopher Spilling

Chemistry & Biochemistry Faculty Works

Cyclophostin, the cyclipostins and the salinipostins are structurally related cyclic enolphosphate natural products. This mini review describes their isolation, synthesis and biological activities. In addition, the synthesis and biological activities of monocyclic enolphosphate and mono and bicyclic enolphosphonate analogs are presented.

Photosynthetic Response Of Pentagramma Triangularis To Summer Desiccation, Brandon R. Grinovich, Stephen D. Davis

Featured Research

Ferns are thought to have been some of the first vascular plants to develop, perhaps on the order of 390 million years ago. Since then, ferns have speciated and developed innovative methods of survival especially in relation to water stress. Research conducted in 2016 by Helen Holmlund showed that eight California fern species fell into four primary classes of survival strategies, one of those being resurrection. Pentagramma triangularis is one of the resurrection-type ferns and is endemic to the western coast of the United States. As P. triangularis desiccates during the summer it enacts a physiological response by which it …

Functional Dna Methylation Signatures For Autism Spectrum Disorder Genomic Risk Loci: 16p11.2 Deletions And Chd8 Variants, M. T. Siu, D. T. Butcher, A. L. Turinsky, C. Cytrynbaum, D. J. Stavropoulos, S. Walker, O. Caluseriu, M. Carter

Paediatrics Publications

Background: Autism spectrum disorder (ASD) is a common and etiologically heterogeneous neurodevelopmental disorder. Although many genetic causes have been identified (> 200 ASD-risk genes), no single gene variant accounts for > 1% of all ASD cases. A role for epigenetic mechanisms in ASD etiology is supported by the fact that many ASD-risk genes function as epigenetic regulators and evidence that epigenetic dysregulation can interrupt normal brain development. Gene-specific DNAm profiles have been shown to assist in the interpretation of variants of unknown significance. Therefore, we investigated the epigenome in patients with ASD or two of the most common genomic variants conferring …

An Exploration Of Colorectal Cancer Incidence Rates In North Dakota, Usa, Via Structural Equation Modeling, Gary G. Schwartz, Marilyn G. Klug, Bradley C. Rundquist

Geography & Geographic Information Science Faculty Publications

Purpose The state of North Dakota has one of the highest incidence rates for colorectal cancer in the USA. Its high incidence rate, coupled with a large variation in incidence rates among counties within the state, makes North Dakota a “natural laboratory” in which to investigate environmental clues to colorectal cancer. We conducted a hypothesis-generating study to explore potential determinants of colorectal cancer in North Dakota.

Methods We obtained county-specific incidence rates for North Dakota’s 53 counties from the statewide cancer registry and corresponding data on county demographic, agricultural, and geophysical features from population-based sources. Candidate demographic/agricultural variables included median …

An Index To Better Estimate Tropical Cyclone Intensity Change In The Western North Pacific, Woojeong Lee, Sung-Hun Kim, Pao-Shin Chu, Il-Ju Moon, Alexander Soloviev

Marine & Environmental Sciences Faculty Articles

A revised predictor called the net energy gain rate (NGR) is suggested by considering wind dependent drag coefficient based on the existing maximum potential intensity theory. A series of wind speed dependent NGR, known as NGR‐w, is calculated based on pre‐tropical cyclone (TC) averaged ocean temperatures from the surface down to 120 m (at 10‐m intervals) to include the TC‐induced vertical mixing for 13 years (2004–2016) in the western North Pacific. It turns out that the NGR50‐w (NGR‐w based on temperature averaged over top 50 m) has the highest correlation with 24‐h TC intensity …

Effects Of Invasive Species On Post-Fire Ceanothus Spinosus Seedling Establishment, Nina Duchild, Frank W. Ewers, Stephen D. Davis

Featured Research

This study compared seedling establishment of the native chaparral species Ceanothus spinosus in two different burn sites at Pepperdine University following the Woolsey Fire of November 2018. One site was a low-density fuel site, and experienced a “cool burn,” and the other site was a high-density fuel site and experienced a “hot burn.” In the low-density fuel site, fire type-conversion had occurred, resulting in a dominance of exotic species. The high-density fuel site was populated by many native fire-following species and chaparral shrubs, exemplifying pristine post-fire conditions. Initially, I hypothesized that seedling success in the cool burn site would be …

Seedling And Resprout Survival Of Three Chaparral Species Following Woolsey Wildfire, Karagan L. Smith, Stephen D. Davis

Featured Research

Fire is a common natural disaster that effects Southern California. Combined with recent chronic drought, there has been an increase in the damage and frequency of these fires in recent years. Three chaparral species are common to the Pepperdine campus: Malosma laurina, Ceanothus spinosus, and Ceanothus megacarpus. The survival of these native species is essential because they are indicators for the changes that are occurring in our local ecosystem and provide further implications of how our ecosystem responds to natural disaster. Seedling recruitment and resprouting are mechanisms these chaparral species use to reestablish postfire. Postfire data have been recorded …

The Impact Of The Woolsey Fire On The Fungus Botryosphaeria Dothidea, Juan Arguijo

Featured Research

Southern California suffered a six-year drought in 2012 through 2018 during which the laurel sumac, Malosma laurina, experienced water stress and the fungus Botryosphaeria dothidea began to kill this plant, causing a massive dieback of this keystone chaparral species in the Santa Monica Mountains. Botryosphaeria is an opportunistic endophytic fungus that invades the xylem of woody type plants and waits till the plant starts to experience stress to proliferate. In November of 2018, the Woolsey fire burned up to 96,000 acres of vegetation. I ran tests at two sites on the Pepperdine University campus, the Baxter Ridge Site which …

Post-Fire Soil Microbiome Recovery And Respiration In A Chaparral Ecosystem, Mari R. Irving, Stephen D. Davis

Featured Research

This study characterizes post-fire recovery of microbial and fungal populations adjacent to three keystone chaparral plant species affected by varying burn intensities via systematic measurement of soil respiration. The CO₂ released from soil surrounding Ceanothus spinosus, Heteromeles arbutifolia and Malasma laurina affected by mild, severe or no heat during the Woolsey Fire of November 2018 were monitored and used as an indicator of microbial, fungal, and root activity. We hypothesized that soil which experienced less intense heat would exhibit higher rates of respiration based on preliminary data taken in March 2019. However, the opposite was observed from May through …

Nih Grant Will Examine Fertility Preservation Counseling For Women With Cystic Fibrosis, Staff

Browse All News

No abstract provided.

Some Environmental And Biological Determinants Of Coral Richness, Resilience And Reef Building In Galápagos (Ecuador), Bernhard Riegl, Matthew Johnston, Peter W. Glynn, Inti Keith, Fernando Rivera, Mariana Vera-Zambrano, Stuart Banks, Joshua Feingold, Peter J. Glynn

Marine & Environmental Sciences Faculty Articles

Throughout the Galápagos, differences in coral reef development and coral population dynamics were evaluated by monitoring populations from 2000–2019, and environmental parameters (sea temperatures, pH, NO₃⁻, PO₄³⁻) from 2015–19. The chief goal was to explain apparent coral community differences between the northern (Darwin and Wolf) and southern (Sta. Cruz, Fernandina, San Cristóbal, Española, Isabela) islands. Site coral species richness was highest at Darwin and Wolf. In the three most common coral taxa, a declining North (N)-South (S) trend in colony sizes existed for Porites lobata and Pocillopora spp., but not for Pavona spp. …

Antimicrobial Analogues Of Gramicidin S, Juan R. Del Valle, Lindsey Shaw

USF Patents

Disclosed herein are N-aminated variants of Gramicidin S and methods of using the same for treating infections in a subject.

Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju

USF Patents

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

γ-Aa-Peptide Stat3/Dna Inhibitors And Methods Of Use, Said M. Sebti, Jianfeng Cai

USF Patents

STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been recognized as a promising target for cancer therapy. Although a number of inhibitors of STAT3-STAT3 dimerization have been reported, molecular ligands that prevent interactions between STAT3 and DNA are very rare. The γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library was used, and identified γ-AApeptides that can selectively inhibit STAT3/DNA interaction and suppress the expression levels of STAT3 target genes in intact cells. The results not only validate γ-AApeptides as novel inhibitors of STAT3 signaling pathway, but also demonstrate that in addition …

University Funds Six Undergraduate Projects For Summer Research, Shea Stewart

University of Mississippi News

Projects explore topics from hearing loss to nutritional education

Bitter Taste Receptors For Asthma Therapeutics., Ajay P. Nayak, Sushrut D. Shah, James V. Michael, Deepak A. Deshpande

Center for Translational Medicine Faculty Papers

Clinical management of asthma and chronic obstructive pulmonary disease (COPD) has primarily relied on the use of beta 2 adrenergic receptor agonists (bronchodilators) and corticosteroids, and more recently, monoclonal antibody therapies (biologics) targeting specific cytokines and their functions. Although these approaches provide relief from exacerbations, questions remain on their long-term efficacy and safety. Furthermore, current therapeutics do not address progressive airway remodeling (AR), a key pathological feature of severe obstructive lung disease. Strikingly, agonists of the bitter taste receptors (TAS2Rs) deliver robust bronchodilation, curtail allergen-induced inflammatory responses in the airways and regulate airway smooth muscle (ASM) cell proliferation and mitigate …

The Use Of Celebrity And Non-Celebrity Examples To Reduce Stigma In University Students, Tyrus Mccartney

Seton Hall University Dissertations and Theses (ETDs)

Although effective treatments have been developed for various mental illnesses, many individuals who need psychological help do not seek it because of stigma. Interventions have been developed to reduce stigma, with the hope of increasing access to mental healthcare. Vicarious contact with individuals who have mental illness can reduce both public and internal stigma. Furthermore, celebrity examples have been used to reduce stigma. The present study compared celebrity examples and non-celebrity examples across a stigma-reduction intervention, as well as a control group, to determine the most effective ways to present first-person narrative vignettes for reducing both public and internal stigma. …

Are We Getting Better In Using Nitrogen?: Variations In Nitrogen Use Efficiency Of Two Cereal Crops Across The United States, Chaoqun Lu, Jien Zhang, Peiyu Cao, Jerry L. Hatfield

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Spatial variation and temporal trajectory of crop nitrogen use efficiency (NUE) have important implications for nitrogen management and environmental conservation. Previous studies have examined cross‐nation divergences in crop NUE but often overlooked its spatial heterogeneity and cross‐crop differences at subnational scales. We examined the relationship between state‐level NUE and nitrogen fertilizer use for two major fertilizer‐consuming crops, corn and winter wheat, which account for over half of national N fertilizer use in the United States. Since 1970, as N fertilizer use rates have changed, the responses of crop yield and NUE have exhibited large temporal and spatial variations. It is …

Climate Change, Snow Mold And The Bromus Tectorum Invasion: Mixed Evidence For Release From Cold Weather Pathogens, Danielle M. Smull, Nicole Pendleton, Andrew R. Kleinhesselink, Peter B. Adler

Ecology Center Publications

Climate change is reducing the depth and duration of winter snowpack, leading to dramatic changes in the soil environment with potentially important ecological consequences. Previous experiments in the Intermountain West of North America indicated that loss of snowpack increases survival and population growth rates of the invasive annual grass Bromus tectorum; however, the underlying mechanism is unknown. We hypothesized that reduced snowpack might promote B. tectorum population growth by decreasing damage from snow molds, a group of subnivean fungal pathogens. To test this hypothesis, we conducted greenhouse and field experiments to investigate the interaction between early snowmelt and either …

Locomotor Patterns Change Over Time During Walking On An Uneven Surface, Jenny A. Kent, Joel H. Sommerfeld, Mukul Mukherjee, Kota Z. Takahashi, Nicholas Stergiou

Journal Articles

During walking, uneven surfaces impose new demands for controlling balance and forward progression at each step. It is unknown to what extent walking may be refined given an amount of stride-to-stride unpredictability at the distal level. Here, we explored the effects of an uneven terrain surface on whole-body locomotor dynamics immediately following exposure and after a familiarization period. Eleven young, unimpaired adults walked for 12 min on flat and uneven terrain treadmills. The whole-body center of mass excursion range (COM_exc) and peak velocity (COM_vel), step length and width were estimated. On first exposure to uneven terrain, …

School Deans, Department Chairpersons, And Program Directors 2019-2020, Saint Mary's College Of California

Chairs and Program Directors lists

No abstract provided.