Digital Commons Network^™

Health Disparities Among Sickle Cell Disease Patients: A Grounded Theory Model, Raha Forooz Sabet

Open Access Dissertations

Sickle cell disease (SCD) is the most commonly diagnosed genetic blood disorder in the United States. Although SCD can occur in other ethnic groups, in the U.S. it primarily affects individuals who are Black, and, as such, has come to be conceptualized as a “racialized” disease. This inherited disease causes chronic and acute pain episodes, resulting in frequent hospitalizations. Alarmingly, SCD patients are at disproportionate risk for early mortality during the transition period between pediatric and adult care. Hypotheses exist to explain this occurrence, but the contextual and individual-level factors underlying it are not well understood. Therefore, in this grounded …

Sepsis-Induced Dessemination Intravascular Coagulation, Hussainatu Bah

Nursing Student Class Projects (Formerly MSN)

Abstract

This poster focused on Sepsis-Induced DIC, life-threatening complications causing severe coagulopathy that if not recognize and treated early, can lead to multi-organ failure, death, and morbidity. Many patients who come to the hospital for some sort of infection are already at risk for Sepsis-Induced DIC and moreover, surgeries can increase the risk of Sepsis-Induced DIC. It is now understood that the prevention of Sepsis-Induced DIC largely depends on early detection, treatment, and prevention. Advanced Practice Registered Nurses (APRN) need to be well educated on this topic to be effective providers. Five research-based articles with other supporting sources were reviewed …

Ieds And Urban Clearance Variables In Mosul: Defining Complex Environments, Mark Wilkinson Ph.D.

The Journal of Conventional Weapons Destruction

More than any other post-conflict environment in Iraq, the complexity of west Mosul and its improvised explosive device (IED) threat challenges our fundamental perceptions and definitions of mine action. From here, 400 km (248.5 mi) north of Baghdad in the al-Maedan District on the west side of the Tigris River, ISIS ran its caliphate and made its ill-fated last stand against attacking Iraqi Security Forces (ISF).

The Journal Of Conventional Weapons Destruction Issue 23.2 (2019), Cisr Journal

The Journal of Conventional Weapons Destruction

The Middle East: An Editorial by Jordan's HRH Prince Mired R.Z. Al-Hussein | IEDs: 'Complex' vs. Simple Clearance in Fallujah and Mosul | Iraq: A Photo Essay by Sean Sutton | Lebanon: Impact of Landmines and ERW on food Security

Development Of Novel Zika And Anthrax Viral Nanoparticle Vaccines, Elizabeth Henderson

KGI Theses and Dissertations

Vaccines protect against numerous infectious diseases and prevent millions of deaths annually, but there are still many infectious diseases for which no licensed vaccine exists. Developing a new vaccine requires balancing safety and efficacy, and viral nanoparticle (VNP) vaccines possess both of these characteristics. The work herein demonstrates how tobacco mosaic virus (TMV) nanoparticles can serve as a platform to create candidate vaccines for Zika virus (ZIKV) and anthrax. In the first study, a ZIKV-specific epitope was genetically fused to TMV to create a safe and inexpensive vaccine that proved highly immunogenic in mice and led to the discovery of …

Hannah Arendt’S “Political Beings” As A Representation Of Political Existentialism For Humans Existing In The World, Rendi Lustanto, Ganang Dwi Kartika

International Review of Humanities Studies

Discussions in politics often focus on a broad range of political systems or political movements. This focus leads to the efforts to direct the public to the conversation of "Politics" in the sense of a system and it overlooks the fact that politics is built on the crystallization of ideas from individuals who interpret the condition of togetherness in the world. The interpretation is very important because it is the starting point for political discourse to grow and develop, which is often referred to as individual’s "political" struggle. The struggle involves a conversation between me and myself which is later …

Uncovering Secrets Of Bone Marrow Cells And How They Differentiate, Jeff Hansen

Browse All News

No abstract provided.

The Effects Of Clipping On The Biomass Production Of Native Warm Season Grasses On Reclaimed Abandoned Coal Mine Soils, James A K Daniel

Electronic Theses & Dissertations

THE EFFECTS OF CLIPPING ON THE BIOMASS PRODUCTION OF NATIVE

WARM SEASON GRASSES ON RECLAIMED

ABANDONED COAL MINE SOILS

James A K Daniel

Strip mining leaves behind highly disrupted plant and soil communities. Mined land reclamation returns the land back to a natural or economically usable state, however, reclamation cannot completely restore the soils to their original state. Subsequently, normal frequencies of management practices may not be as effective as in undisturbed soils. Understanding how the severity of soil disturbance affects plant production is important for habitat rehabilitation and determining effective management techniques to be implemented following reclamation. This project …

Volume 56, Number 50: July 31, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Identifying Important Parameters In The Inflammatory Process With A Mathematical Model Of Immune Cell Influx And Macrophage Polarization, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca A. Segal, Angela M. Reynolds

Department of Math & Statistics Faculty Publications

In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype or to an anti-inflammatory M2 phenotype, as well as existing on a spectrum between these two extremes. Dysfunction of this phenotypic switch can result in a population imbalance that leads to chronic wounds or disease due to unresolved inflammation. Therapeutic interventions that target macrophages have therefore been proposed and implemented in diseases that feature chronic inflammation such as diabetes mellitus and atherosclerosis. We have developed a model for the sequential influx of immune cells in the peritoneal cavity in response to a bacterial stimulus that includes macrophage …

Phosphonate-Directed Catalytic Asymmetric Hydroboration: Synthesis Of Functionalized Chiral Secondary And Tertiary Boronic Esters And Mechanistic Insights, Suman Chakrabarty

Department of Chemistry: Dissertations, Theses, and Student Research

Over the past 30 years, catalytic asymmetric hydroboration (CAHB) of alkenes has emerged as a leading methodology to access chiral primary and secondary boronic esters. However, it wasn’t until 2015 that directed-CAHB was for the first time shown to efficiently access chiral tertiary boronic esters. The latter are excellent precursors to synthetically challenging structural motifs such as chiral tertiary alcohols, carbinamines and all-carbon quaternary stereocenters via stereospecific C-B bond substitutions. This dissertation focuses on phosphonate-directed CAHB of diverse alkene substrates, including challenging stereodefined trisubstituted alkenes, to efficiently access multifunctional chiral secondary and tertiary boronic esters. Mechanistic insights obtained via deuterium …

Plasticity In The Human Gut Microbiome Defies Evolutionary Constraints, Andres Gomez, Ashok Kumar Sharma, Elizabeth K. Mallott, Klara J. Petrzelkova, Carolyn A. Jost Robinson, Carl J. Yeoman, Franck Carbonero, Barbora Pafco, Jessica M. Rothman, Alexander Ulanov, Klara Vickova, Katherine R. Amato, Stephanie L. Schnorr, Nathaniel J. Dominy, David Modry, Angelique Todd, Manolito Torralba, Karen E. Nelson, Michael B. Burns, Ran Blekhman, Melissa Remis, Rebecca M. Stumpf, Brenda A. Wilson, H. Rex Gaskins, Paul A. Garber, Bryan A. White, Steven R. Leigh

Anthropology Faculty Research

The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host. However, the comparative models used to date have mainly included a limited set of closely related primates. To further understand the forces that shape the primate gut microbiome, with reference to human populations, we expanded the comparative analysis of variation among gut microbiome compositions and their primate hosts, including 9 different primate species and 4 human groups characterized by a diverse set of subsistence patterns (n = 448 samples). The results …

Differences In Falls And Recovery From A Slip Based On An Individual's Lower Extremity Corrective Response, Samuel J. Wilson, Paul T. Donahue, Charles C. Williams, Christopher M. Hill, Jeffrey D. Simpson, Dwight E. Waddell, Jeremy P. Loenneke, Harish Chander, Chip Wade, John C. Garner

Faculty Publications

Background: Slips and falls account for high rates of injury and mortality in multiple populations. The corrective responses during the slip perturbation have been well documented. However, when a fall results from a slip, it is unclear which of these responses were inadequate.

Objective: The purpose of this study was to examine differences in lower extremity corrective responses of the slip recovery response between individuals who fall and those who recover.

Methodology: Sixty-four participants completed this study (32 males & 32 females). Participant’s gait kinematics and kinetics were collected during normal gait (NG) and an unexpected slip …

Nuclear Magnetic Resonance Solution Structure And Functional Behavior Of The Human Proton Channel, Monika Bayrhuber, Innokentiy Maslennikov, Witek Kwiatkowski, Alexander Sobol, Christoph Wierschem, Cédric Eichmann, Lukas Frey, Roland Riek

Pharmacy Faculty Articles and Research

The human voltage-gated proton channel [Hv1⁽¹⁾ or VSDO⁽²⁾] plays an important role in the human innate immune system. Its structure differs considerably from those of other cation channels. It is built solely of a voltage-sensing domain and thus lacks the central pore domain, which is essential for other cation channels. Here, we determined the solution structure of an N- and C-terminally truncated human Hv1 (Δ-Hv1) in the resting state by nuclear magnetic resonance (NMR) spectroscopy. Δ-Hv1 comprises the typical voltage-sensing antiparallel four-helix bundle (S1–S4) preceded by an amphipathic helix (S0). The solution structure corresponds to an intermediate …

Let It Rest: Sleep And Health As Positive Correlates Of Forgiveness Of Others And Self-Forgiveness, Loren Toussaint, Andrew J. Gall, Alyssa Cheadle, David R. Williams

Faculty Publications

Objective: The present study examined forgiveness of others, self-forgiveness, sleep, and health in a nationally representative sample of United States adults. It was hypothesised that sleep would mediate the associations of forgiveness of others and self-forgiveness with health.

Design: A nationally representative survey of 1,423 United States adults.

Main Outcome Measures: Measures included forgiveness of others, self-forgiveness, sleep quantity, sleep quality, psychological distress, life satisfaction, and self-rated physical health.

Results: Forgiveness of others (β = .20, p < .001) and self-forgiveness (β = .11, p < .01) were associated with sleep and forgiveness of others (β = .24, p < .001) and self-forgiveness (β = .27, p < .001) were associated with health. Sleep was associated with health (β = .45, p < .001) and also acted as a mediator of the associations of forgiveness of others (β = .09, p < .01) and self-forgiveness (β = .05, p < .01) with health.

Conclusions: Forgiveness of others and self-forgiveness may attenuate emotions such as anger, regret, and rumination and provide …

Effects Of A High Protein Diet And Liver Disease In An In Silico Model Of Human Ammonia Metabolism, Jeddidiah W.D. Griffin, Patrick C. Bradshaw

ETSU Faculty Works

BACKGROUND: After proteolysis, the majority of released amino acids from dietary protein are transported to the liver for gluconeogenesis or to peripheral tissues where they are used for protein synthesis and eventually catabolized, producing ammonia as a byproduct. High ammonia levels in the brain are a major contributor to the decreased neural function that occurs in several pathological conditions such as hepatic encephalopathy when liver urea cycle function is compromised. Therefore, it is important to gain a deeper understanding of human ammonia metabolism. The objective of this study was to predict changes in blood ammonia levels resulting from alterations in …

Detection And Remodeling Of Toxic Amyloid Aggregates By Novel Conjugated Polyelectrolytes, Adeline Marianne Fanni

Biomedical Engineering ETDs

The abnormal misfolding and aggregation of intrinsically disordered proteins into ordered fibrillar amyloid aggregates is recognized as a common pathological event in neurodegenerative disorders (ND) such as Alzheimer’s and Parkinson’s diseases. The key role of fibrillar and pre-fibrillar aggregates in ND makes them ideal biomarkers to better understand disease progression but also for early disease detection and therapeutic intervention. The work described herein was conducted to gain a better understanding of amyloid interaction to lipid membrane and its role in peptide toxicity. This research was also focused on evaluating the fluorescent probe, oligomeric p-phenylene ethynylene (OPE), as an amyloid …

Unit Produksi Dan Jasa Sebagai Edupreneurship, Desy Anggreani, Sudarmiatin Sudarmiatin, Suharto Suharto

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study focuses on identifying internal and external factors from Crystal Guava Production and Service Unit of SMK 2 Batu. Therefore, strategies for the development of Production Units as edupreneurship can be obtained, namely vehicles for practicing work and entrepreneurship for students by doing creative and innovative efforts, the use of technology at the time of the guava crystal production process and its marketing implementation. Based on the internal factor analysis of the UPJ in SMK 2 Batu at 1.19 and the external factor analysis of 1.15 which is then analyzed using the SWOT matrix at the coordinate point (1.19:1.15) …

Comparison Of Forward And Reverse Wingate Anaerobic Tests: A Brief Technical Note, Joseph Berning, Trish Gail Sevene, Mark Debeliso, Carole Carson, Chad Harris, Mike Climstein, Kent Jason Adams

Kinesiology Faculty Publications and Presentations

BACKGROUND: The Wingate anaerobic test (WAT) is traditionally performed in the forward pedaling direction on a cycle ergometer. However, reverse (backward) pedaling during a WAT test may be a novel way to convey meaningful information related to performance and rehabilitation. This study compared peak power measurements between 30-second forward pedaling WAT (FWAT) with a 30-second reverse pedaling WAT (RWAT). METHODS: 10 male and 10 female participants (age 27.6 ± 7.31 yrs, mass 74.9 ± 21.3 kg and height 172.6 ± 10.9 cm) volunteered to participate. Participants performed one FWAT and one RWAT at 7.5% of body mass on a specially …

The Effectiveness Of Geographic Information System Training For Surveillance Officers In Sukabumi District, Martya Makful

ASEAN Journal of Community Engagement

Surveillance is the systematic, continuous collection, processing, analysis and interpretation of data and the dissemination of information to units in need to be able to take action. In the field of health, human resources (HR) in an organization is very important role. Because the quality of health services to the public is determined by the human resources working in it. With the number of reports and cases of outbreaks in Sukabumi district, it is necessary a system of information and recording of data that muktahir. The purpose of this research is to know the effectiveness of training of geographic information …

Acceleration Of Starts Up Business In Agriculture Through Improvement Of Production, Financial And Marketing System, Alfu Laila, Lutfy Ditya Cahyanti, Use Etica, Niken Trisnaningrum

ASEAN Journal of Community Engagement

Due to decrease unemployment graduates, University of Darussalam Gontor-Indonesia provided the requirement through strengthening entrepreneurship development program for starts up business in Agricultural sector. The aims of the program are 1) improvement of production; 2) building financial system and 3) expanding network both of domestic and aboard market. To achieve the objectives, this program created four strategic levels which were 1) assessment; 2) training; 3) mentoring; and 4) evaluation. This program applied to 8 starts up business including in sub sectors of horticulture production, aquaculture, livestock and agro-industrial. The program resulted increasing on crop production, improvement of feasibility business analysis …

The Cultural Evolution Of Local Islamic Values On The Muludan Tradition In Cirebon: A Memetics Perspective, Eko Wijayanto, Siti Rohmah Soekarba

International Review of Humanities Studies

The Muludan is a tradition conducted by the Royal family in Cirebon Sultanate on the third month of the Islamic calendar (Rabi' al-awwal) to mark the celebration of the prophet Muhammad's birthday. Thousands of people from some places participate in this tradition. This paper is aimed to elaborate the cultural evolution theory (memetics) introduced by Richard Dawkings which is used to interpret the Muludan tradition as a meme. The role of the agent will be considered as a vector, not an actor. In the meantime, the Muludan can be defined not only as a religious ritual but also as a …

Validation Of A Death Assay For Angiostrongylus Cantonensis Larvae (L3) Using Propidium Iodide In A Rat Model (Rattus Norvegicus), Susan I. Jarvi, John Jacob, Robert T. Sugihara, Israel L. Leinbach, Ina H. Klasner, Lisa M. Kaluna, Kirsten A. Snook, M. Kathleen Howe, Steven H. Jacquier, Ingo Lange, Abigail L. Atkinson, Ashley R. Deane, Chris N. Niebuhr, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Angiostrongylus cantonensis is a pathogenic nematode and the cause of neuroangiostrongyliasis, an eosinophilic meningitis more commonly known as rat lungworm disease. Transmission is thought to be primarily due to ingestion of infective third stage larvae (L3) in gastropods, on produce, or in contaminated water. The gold standard to determine the effects of physical and chemical treatments on the infectivity of A. cantonensis L3 larvae is to infect rodents with treated L3 larvae and monitor for infection, but animal studies are laborious and expensive and also raise ethical concerns. This study demonstrates propidium iodide (PI) to be a reliable marker of …

Modified Substrate Specificity Of A Methyltransferase Domain By Protein Insertion Into An Adenylation Domain Of The Bassianolide Synthetase, Fuchao Xu, Russell Butler, Kyle M. May, Megi Rexhepaj, Dayu Yu, Jiachen Zi, Yi Chen, Yonghong Liang, Jia Zeng, Joan Hevel, Jixun Zhan

Chemistry and Biochemistry Faculty Presentations

Background: Creating designer molecules using a combination of select domains from polyketide synthases and/or nonribosomal peptide synthetases (NRPS) continues to be a synthetic goal. However, an incomplete understanding of how protein-protein interactions and dynamics affect each of the domain functions stands as a major obstacle in the field. Of particular interest is understanding the basis for a class of methyltransferase domains (MT) that are found embedded within the adenylation domain (A) of fungal NRPS systems instead of in an end-to-end architecture.

Results: The MT domain from bassianolide synthetase (BSLS) was removed and the truncated enzyme BSLS-ΔMT was recombinantly expressed. The …

Inquiry-Based Learning: An Attempt To Enhance Students’ Speaking Performance, Riwayati Yanu Fatkhriyah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aimed to investigate how the Inquiry-Based Learning strategy can improve the speaking skills of the students. This collaborative classroom action research was conducted in two cycles. The result of this study revealed the average speaking met the first criterion of success. Considering to the result of the questionnaire toward the students’ attitude after joining the implementation of the teaching strategy, most of the students had good respond to the implementation of IBL.

Fabrication Of Core–Shell Cofe2o4@Hap Nanoparticles: A Novel Magnetic Platform For Biomedical Applications, D. Karthickraja, S. Karthi, G. A. Kumar, Gamage Chamath Dannangoda, Karen S. Martirosyan, E. L. Girija

Physics & Astronomy Faculty Publications

Core–shell CoFe2O4@HAp magnetic nanoparticles were successfully prepared by a simple two-step hydrothermal process, and their physicochemical and magnetic properties were studied. X-ray diffraction and Fourier transform infrared spectroscopy of the as-synthesized samples reveal that the nanoparticles are composed of both phases (HAp@CoFe2O4). The core–shell formation was confirmed by TEM and from the magnetization studies using a vibrating sample magnetometer (VSM), and the ferromagnetic nature of the synthesized core–shell nanoparticles at room temperature was confirmed by saturation magnetization (Ms) and coercivity values of 9.04 emu g−1 and 0.1 T, respectively. It has been observed that heat treatment enhanced the …

Sojourner Students' Adjustment: Do They Need To Lower Their Normative Achievement Goal Orientation To Remain Confident And Survive, Lailatul Faizah, Tjut Rifameutia

Makara Human Behavior Studies in Asia

Adjustment is very important for college students, especially for sojourner students. Even though sojourner students initially had high academic self-efficacy, it does not necessarily help them to survive their new academic learning environment. This study argues that normative achievement goal orientation moderates the relationship between academic self-efficacy and academic adjustment among sojourner students. To test the hypothesis, data was collected from 296 first-year sojourner students from 16 public universities in Indonesia and analyzed using Hayes moderator analysis. The results showed that normative achievement goal orientation negatively moderated the relationship between academic self-efficacy and academic adjustment (β = −0.09, SE = …

Undergraduate Students' Intelligence Profiles According To The Tes Intelligensi Kolektif Indonesia Tinggi (Tiki-T): A Cluster Analysis Based On The Rasch Model Person Ability, Whisnu Yudiana, Hery Susanto, Airin Triwahyuni

Makara Human Behavior Studies in Asia

This research aims to identify undergraduate students’ intelligence profiles using a two-stage cluster analysis based on the person’s ability of the Rasch model to examine the effect of the clusters on academic performance. A total of 1443 undergraduate students from nine academic disciplines at Universitas Padjadjaran in Bandung, Indonesia, participated in the study, completing 11 subtests of the Tes Intelligensi Kolektip Indonesia Tinggi (TIKI-T). A hierarchical cluster analysis approach using Ward’s linkage method and squared Euclidean distance was conducted, followed by a nonhierarchical k-means cluster analysis using simple Euclidean distance as the similarity measure to examine two-, three-, four-, and …

Spatiotemporal Analysis In Monitoring Landscape Dynamic Patterns In Tropical Peat Ecosystem (Study In Tebing Tinggi Island, Riau, Indonesia), Dheny Sampurno

Journal of Environmental Science and Sustainable Development

The increasing deforestation rate in the tropical peat landscape is impacting the sustainability of the peat ecosystem. Previous studies have monitored the deforestation on tropical forest using Landsat imagery. The analysis of forest landscape dynamics is crucial in understanding the functions of the sustainable ecosystem and to support sustainable development goals. The government controls the peat ecosystem function (PEF) based on the Indonesian Government Regulation No. 71/2014. However, a booming sago industry has resulted in smallholders establishing farms and expanding into the peatland. In this study, we conducted a spatiotemporal analysis of land use/cover changes based on a series of …

Fractionation Of Iron (Fe) And Manganese (Mn) In The Horizons Of A Forest Soils, Agroforestry, And Dryland Agriculture, Parjono Parjono, Syaiful Anwar, Kukuh Murtilaksono, Lilik Indriyati

Journal of Environmental Science and Sustainable Development

One of the main problems with acidic soils is the availability of soil nutrients. In such soils, iron (Fe) and manganese (Mn) ions are highly present. This study evaluated the Fe and Mn fractions in the soil profiles of forests used for agroforestry and dryland agriculture in the upper Ciliwung watershed. The watershed is a zone of high rainfall washing. The evaluation was based on the results of analysis of soil samples taken at four soil horizons (Ao or Ap, A1 or A2, B1, and B2) for each type of land use. Research was conducted by survey and laboratory analysis. …