Digital Commons Network^™

Clinicopathological And Prognostic Significance Of Androgen Receptor Overexpression In Colorectal Cancer: Experience From Al-Madinah Al-Munawarah, Saudi Arabia, Abdulkader M. Albasri, Mohammed A. Elkablawy

Saudi Medical Journal

Objectives: To examine the androgen receptor (AR) status in colorectal cancer (CRC) patients by the immunohistochemical method and to correlate the findings with all available clinicopathological parameters of prognostic significance. Methods: Archival tumor samples were studied using immunohistochemistry for AR expression in 324 patients with CRC. Patients were diagnosed at the Pathology Department at a tertiary care Hospital, Al-Madinah Al-Munawarah, Saudi Arabia, between January 2006 and December 2017. Results: There is a complete lack of AR expression in normal colonic mucosa; however, AR was expressed in 16 cases (40%) of colorectal adenoma. In CRC, AR expression was high in 118 …

Aspirin May Interact With Cells’ Dna Modifications To Alter Breast Cancer Outcomes

Saudi Medical Journal

No abstract provided.

Research Symposium 2019 - Health Disparities: Community Engagement, The University Of Texas Rio Grande Valley. School Of Medicine

School of Medicine Publications

With the theme of “Health Disparities: Community Engagement,” this symposium aims to showcase the work done by researchers here in the Valley and beyond toward improving the health and well-being of the communities they serve and society as a whole.

Hydrodynamic And Total Dissolved Solids Model Of The Tigris River Using Ce-Qual-W2, Muhanned D. Al-Murib, Scott Wells

Civil and Environmental Engineering Faculty Publications and Presentations

The headwaters of the Tigris River basin in Iraq is controlled by Turkey due to a series of dams constructed over the last few decades. Since Total Dissolved Solids (TDS) in the Tigris River within Baghdad and downstream cities can reach 1000 mg/L exceeding both drinking water and irrigation guidelines, a hydrodynamic and water quality model, CE-QUAL-W2, of the river was developed to understand how changes in flow affect TDS downstream. A model of 880 km of the Tigris River from Mosul Dam to Kut Barrage including Tharthar Lake was constructed for 2009. Model development was challenging due to a …

Editorial Introduction: Circuits Of Art And Communication In The Twenty-First Century, Jonathan W. Marshall

Sound Scripts

A founding editor of Sound Scripts, Jonathan W. Marshall, introduces the essays that follow in volume six of the journal, taking the reader through a tour of informatic exchanges, truths and falsehoods.

Addressing Climate Change Scepticism Through The Sonic Arts, Cissi Tsang

Sound Scripts

This paper discusses the continued denial of climate change despite overwhelming scientific evidence and agreement, through viewing climate change as a “hyperobject”—that is, a concept of such massive temporal and spatial dimensions that it defies traditional understanding. One of the challenges of the scientific community is to combat such scepticism through new ways of framing information, and the sonic arts offers an alternative presentation of truth through its ability to create emotional and narrative rapport, and also humanise esoteric information. This paper will focus on various methods of communicating climate change data aurally—such as sonification of data, and ecoacoustic methods …

What About Us? Vicarious Trauma In Our “Systems”, Suzanne Spencer

Graduate Student Dissertations, Theses, Capstones, and Portfolios

This narrative design investigates the phenomenon of vicarious trauma in a teacher’s system. Vicarious trauma is a silent phenomenon that can occur through the secondary witnessing of the traumatic experiences of others. This narrative design will describe how and what teachers experience through chronic and cumulative exposure to the adverse childhood experiences of their students. This research will narrate the lived experience of a teacher with vicarious trauma and the impact of vicarious trauma on a teacher’s belief system.

Unraveling The Functional Role Of The Orphan Solute Carrier, Slc22a24 In The Transport Of Steroid Conjugates Through Metabolomic And Genome-Wide Association Studies, Sook Wah Yee, Adrian Stecula, Huan-Chieh Chien, Ling Zou, Elena V Feofanova, Marjolein Van Borselen, Kit Wun Kathy Cheung, Noha A Yousri, Karsten Suhre, Jason M Kinchen, Eric Boerwinkle, Roshanak Irannejad, Bing Yu, Kathleen M Giacomini

Faculty, Staff and Student Publications

Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value

Academic Department Indicators, 2018-2019, Uno Office Of Instituional Effectiveness

Academic Department Indicators

The audience is the Academic Planning Council (APC), college and department heads, and faculty. The purpose is to report instructional productivity measures useful for making comparisons and observing trends. Selected departmental information in this report is submitted annually to the Delaware Study, a National Study of Instructional Costs and Productivity.

This Instructional Productivity information corresponds to the UNO state- and tuition-funded budget. The Supplemental Information at the end of the document provides counts and statistics for campus-wide programs embedded in most colleges. Only Dual Enrollment instruction is excluded from the productivity report since it is a fee-based instructional program for …

Pubfair: A Framework For Sustainable, Distributed, Open Science Publishing Services, Tony Ross-Hellauer, Benedikt Fecher, Kathleen Shearer, Eloy Rodrigues

Copyright, Fair Use, Scholarly Communication, etc.

Over the last thirty years, digitally-networked technologies have disrupted traditional media, turning business models on their head and changing the conditions for the creation, packaging and distribution of content. Yet, scholarly communication still looks remarkably as it did in the pre-digital age. The primary unit of dissemination remains the research article (or book in some disciplines), and today’s articles still bear a remarkable resemblance to those that populated the pages of Oldenburg’s Philosophical Transactions 350 years ago. In an age of such disruptive innovation, it is striking how little digital technologies have impacted scholarly publishing; and this is also somewhat …

An Open-Source, Automated Home-Cage Sipper Device For Monitoring Liquid Ingestive Behavior In Rodents, Elizabeth Godynyuk, Maya N Bluitt, Jessica R Tooley, Alexxai V Kravitz, Meaghan C Creed

Open Access Publications

Measuring ingestive behavior of liquids in rodents is commonly used in studies of reward, metabolism, and circadian biology. Common approaches for measuring liquid intake in real time include computer-tethered lickometers or video-based systems. Additionally, liquids can be measured or weighed to determine the amount consumed without real-time sensing. Here, we built a photobeam-based sipper device that has the following advantages over traditional methods: (1) it is battery powered and fits in vivarium caging to allow home-cage measurements; (2) it quantifies the intake of two different liquids simultaneously for preference studies; (3) it is low cost and easily constructed, enabling high-throughput …

Tyk2 Promotes Malignant Peripheral Nerve Sheath Tumor Progression Through Inhibition Of Cell Death, Wenjing Qin, Abigail Godec, Xiaochun Zhang, Cuige Zhu, Jieya Shao, Yu Tao, Xianzhang Bu, Angela C Hirbe

Open Access Publications

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise most commonly in the setting of the Neurofibromatosis Type 1 (NF1) cancer predisposition syndrome. Despite aggressive multimodality therapy, outcomes are dismal and most patients die within 5 years of diagnosis. Prior genomic studies in our laboratory identified tyrosine kinase 2 (TYK2) as a frequently mutated gene in MPNST. Herein, we explored the function of TYK2 in MPNST pathogenesis.

METHODS: Immunohistochemistry was utilized to examine expression of TYK2 in MPNSTs and other sarcomas. To establish a role for TYK2 in MPNST pathogenesis, murine and human TYK2 knockdown and knockout …

Relation Between Central Venous, Peripheral Venous And Arterial Lactate Levels In Patients With Sepsis In The Emergency Department, Dimitrios Velissaris, Vasileios Karamouzos, Nikolaos Dimitrios Pantzaris, Ourania Kyriakopoulou, Charalampos Gogos, Menelaos Karanikolas

Open Access Publications

Background: Sepsis and multi-organ failure remain a major clinical problem with high morbidity and mortality worldwide. Lactate measurement remains part of the initial assessment and management of patients with sepsis. Although arterial blood is most commonly used for lactate measurement, there is increasing use of peripheral venous lactate for initial assessment and for monitoring of response to treatment in patients with sepsis. The aim of this study was to evaluate the relation between lactate levels measured from central line, peripheral vein and arterial line in patients treated for sepsis in the emergency department (ED).

Methods: This prospective study enrolled 31 …

Dhx33 Interacts With Ap-2Β To Regulate Bcl-2 Gene Expression And Promote Cancer Cell Survival, Jiuling Wang, Weimin Feng, Zhen Yuan, Jason D. Weber, Yandong Zhang

Open Access Publications

The RNA helicase DHX33 has been found to be overexpressed in human cancers, where it promotes cancer development. Previous reports have shown that DHX33 deficiency caused cancer cell apoptosis, but the underlying mechanism remains unknown. In this study, we discovered that DHX33 regulates Bcl-2 family protein expression. In multiple human cancer cell lines, DHX33 was found to stimulate the transcription of

Omnipresence Of Inflammasome Activities In Inflammatory Bone Diseases, Yael Alippe, Gabriel Mbalaviele

Open Access Publications

The inflammasomes are intracellular protein complexes that are assembled in response to a variety of perturbations including infections and injuries. Failure of the inflammasomes to rapidly clear the insults or restore tissue homeostasis can result in chronic inflammation. Recurring inflammation is also provoked by mutations that cause the constitutive assembly of the components of these protein platforms. Evidence suggests that chronic inflammation is a shared mechanism in bone loss associated with aging, dysregulated metabolism, autoinflammatory, and autoimmune diseases. Mechanistically, inflammatory mediators promote bone resorption while suppressing bone formation, an imbalance which over time leads to bone loss and increased fracture …

Four-Jointed Knock-Out Delays Renal Failure In An Adpkd Model With Kidney Injury, Chiara Formica, Hester Happé, Kimberley Am Veraar, Andrea Vortkamp, Marion Scharpfenecker, Helen Mcneill, Dorien Jm Peters

Open Access Publications

Autosomal Dominant Polycystic Kidney Disease is characterised by the development of fluid-filled cysts in the kidneys which lead to end-stage renal disease (ESRD). In the majority of cases, the disease is caused by a mutation in the Pkd1 gene. In a previous study, we demonstrated that renal injury can accelerate cyst formation in Pkd1 knock-out (KO) mice. In that study, we found that after injury four-jointed (Fjx1), an upstream regulator of planar cell polarity and the Hippo pathway, was aberrantly expressed in Pkd1 KO mice compared to WT. Therefore, we hypothesised a role for Fjx1 in injury/repair and cyst formation. …

Structural Properties And Cellular Expression Of Afrlea6, A Group 6 Late Embryogenesis Abundant Protein From Embryos Of Artemia Franciscana, Blase M. Leblanc, Mike T. Le, Brett Janis, Michael Menze, Steven C. Hand

Faculty and Staff Scholarship

Late embryogenesis abundant (LEA) proteins are intrinsically disordered proteins (IDPs) commonly found in anhydrobiotic organisms and are frequently correlated with desiccation tolerance. Herein we report new findings on AfrLEA6, a novel Group 6 LEA protein from embryos of Artemia franciscana. Assessment of secondary structure in aqueous and dried states with circular dichroism (CD) reveals 89% random coil in the aqueous state, thus supporting classification of AfrLEA6 as an IDP. Removal of water from the protein by drying or exposure to trifluoroethanol (a chemical de-solvating agent) promotes a large gain in secondary structure of AfrLEA6, predominated by α-helix and exhibiting minimal …

Isolation Of Caldatribacterium (Op9) And Investigation Of Its Potential Interactions With A Novel, Co-Cultivated Thermodesulfobacterium Species, Toshio Alvarado

Electronic Theses, Projects, and Dissertations

Atribacteria (OP9), candidate phylum with no representatives in pure culture, is found in various anaerobic environments worldwide. “Caldatribacterium”, a lineage within Atribacteria that is predicted to be a strictly anaerobic sugar fermenter based on cultivation-independent genomic analyses, is currently being maintained in lab enrichment cultures with fucose as its sole growth substrate. Metagenomics and 16S rRNA gene tag sequencing indicated that the fucose culture was a co-culture of “Caldatribacterium” and an uncultivated member of the genus Thermodesulfobacterium. Due to failed attempts to isolate “Caldatribacterium” by dilution-to-extinction and plating, it was hypothesized that “Caldatribacterium” is dependent in some way on the …

Using Single-Cell Sorting, Fish And 13c-Labeling To Cultivate And Assess Carbon Substrate Utilization Of ‘Aigarchaeota’ And Other Novel Thermophiles, Damon Kurtis Mosier

Electronic Theses, Projects, and Dissertations

‘Aigarchaeota’, a deeply branching lineage in the domain Archaea with no cultivated representatives, includes both thermophilic and hyperthermophilic microorganisms that reside in terrestrial and marine geothermal environments. The ‘Aigarchaeota’ consists of at least nine proposed genus-level groups that have been confirmed via 16S rRNA sequencing, with ‘Aigarchaeota’ Group 1 (AigG1) being the focus of this study. Based on cultivation-independent genomic data available from several AigG1 members in Great Boiling Spring (GBS), NV, and Yellowstone National Park, 22 different types of growth media were designed and tested for their ability to support growth of AigG1. One of these cultures, G1-10, was …

Occurrence And Potential Sources Of Cd, Cu, And Pb In Reach 6 Of The Santa Ana River, May Mamari

Electronic Theses, Projects, and Dissertations

The Santa Ana River (SAR) is the largest river in Southern California. The flow of the SAR begins in the San Bernardino Mountains and discharges into the Pacific Ocean at Huntington Beach. The SAR contains one of the most essential and rare biodiversity hotspots on earth. In order to protect the wildlife, and suit population demands, the SAR must meet the Clean Water Act (CWA) regulations. The SAR Reach 6 is the uppermost segment of the river, and is currently listed under the CWA 303(d) List for impaired water due to contamination of cadmium, copper, and lead from an unknown …

Etiology And Clinical Patterns Of Uveitis At Three Ophthalmic Clinics In Tajikistan, Sayyora Yuldasheva, Saidbeg Satorov, Shekhratdzon Satorov, Vyacheslav Dushenkov

Publications and Research

A prospective observational study was conducted at three ophthalmic clinics to assess the clinical patterns and etiology of uveitis in the Central Asia Republic of Tajikistan. All patients underwent physical and ophthalmologic examinations. Extensive efforts were made to determine the etiology of uveitis, including workups for Behçet's Disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome. All patients were tested for the presence of HLA-B27. Presence and/or history of tuberculosis and syphilis were ruled out. HSV, CMV, Chlamydia trachomatis and HIV antibody titers were determined by ELISA. Uveitis was diagnosed in 51 patient ages 14 to 60 were with women accounted for 60.8%. …

Anthropology's Science Wars : Insights From A New Survey, Mark Horowitz, William Yaworsky, Kenneth Kickham

Anthropology Faculty Publications

In recent decades the field of anthropology has been characterized as sharply divided between proscience and antiscience factions. The aim of this study is to empirically evaluate that characterization. We survey anthropologists in graduate programs in the United States regarding their views of science and advocacy, moral and epistemic relativism, and the merits of evolutionary biological explanations. We examine anthropologists’ views in concert with their varying appraisals of major controversies in the discipline (Chagnon/Tierney, Mead/Freeman, and Menchú/Stoll). We find that disciplinary specialization and especially gender and political orientation are significant predictors of anthropologists’ views. We interpret our findings through the …

The Water/Energy Nexus: Climate, Consumption And Ecosystem Services, Hildegaard D. Link

Dissertations, Theses, and Capstone Projects

Water and energy are drivers of living systems. This work provides an assessment of the Water Energy Nexus in the United States, comparing the well-watered north-east and the arid west. Electric grid systems are most stressed on hot summer afternoons. Grid stress can lead to cascading failures of electricity, water and wastewater treatment systems. (Zimmerman, 2017) Water for power generation and/or water supply depend on ecosystem services. The ecosystem services and resource trade-offs embedded in provision of a watt of power and an ounce of potable water, however, have yet to be comprehensively enumerated nor have the cost relationships been …

Investigating The Feasibility Of Advanced Law Enforcement Resilience Training (A.L.E.R.T.): An Innovated And Practical Intervention To Enhance Police Mindfulness And Resilience, Stephanie B. Stern

Dissertations, Theses, and Capstone Projects

Policing is thought to be one of the most stressful occupations. Without effective strategies to cope with chronic work-related stress, police are vulnerable to developing mental and physical health problems. The police literature and research highlights the need for proactive, evidence-based interventions to help police maintain their resilience throughout their careers. The current study sought to bridge a gap between police literature, research and practice by developing and testing the feasibility of using the Advanced Law Enforcement Resilience Training (A.L.E.R.T.) mobile app to help police learn and practice mindfulness skills after engaging in a brief in-person training. Using a pre-test, …

What Are The Long-Term Survival And Complication Rates Of Complete-Arch Fixed Implant Rehabilitation In Edentulous Patients?, K Ali, Ej Kay

Peninsula Dental School

Cohort selection The study cohort was selected through screening of electronic records of all patients rehabilitated with interforaminal implants and implant-supported fixed complete dental prostheses (IFCDPs) over an 11-year period at the Tufts University School of Dental Medicine. Evaluation was based on medical and dental history; clinical oral examination of hard and soft tissues; and radiographic examination during a single visit.

Eating Disorder Pathology Among Individuals Living With Food Insecurity: A Replication Study, Carolyn Becker, Keesha M. Middlemass, Francesca Gomez, Andrea Martinez-Abrego

Psychology Faculty Research

Eating disorders (EDs) are stereotypically associated with thin, White, affluent women and girls. One result of the ED stereotype has been a relative dearth of ED research with marginalized communities. The aim of the present study was to replicate recent findings showing an association between severity of food insecurity (FI) and increased ED pathology. Participants included 891 clients at an urban food bank. Results replicated previous research with participants in the most severe FI group reporting significantly higher levels of ED pathology, dietary restraint, anxiety, and depression. Findings provide further evidence that the thin, White, affluent, female ED stereotype offers …

Sustainable Solutions, Georgia Southern University

Sustainable Solutions Newsletter (2016-2021)

• Director's Message
• Happenings
• Upcoming in Fall 2019
• Campus Engagement
• Campus in the Spotlight
• Conferences
• Environmental News
• Green Tip

Storm-Induced Predator-Prey Decoupling Promotes Springtime Accumulation Of North Atlantic Phytoplankton, Francoise Morison, Elizabeth Harvey, Gayantonia Franzè, Susanne Menden-Deuer

Graduate School of Oceanography Faculty Publications

We examined the response of North Atlantic plankton population dynamics to rapid re-stratification of surface waters following a deep mixing event during spring. Over the 4-day occupation of a station, we measured phytoplankton growth and grazer/virus-induced mortality rates in dilution assays conducted across a range of light intensities. Rates were estimated from changes in chlorophyll a and the abundance of three phytoplankton groups identified by flow cytometry. Initially, biological and physical water column properties were homogeneous down to >200 m, followed by rapid shoaling of the mixed layer to 20–30 m. Initial in situ chlorophyll a concentration was 0.4 μ …

Nitrogen (N) Dynamics In A Post-Fire Landscape: A Search For The Missing N Source, Cory C. Cleveland

University Grant Program Reports

Throughout the intermountain western U.S., both the number and extent of highintensity wildfires are increasing (Westerling et al. 2006; Westerling 2016; Abatzaglou & Williams 2017). In Montana alone, wildfires consumed more than 1 million acres in 2017, and these trends are projected to continue (USDA 2017). High-intensity fire not only consumes vegetation, but also depletes much of the nutrient capital needed for recovering forests to regenerate. The majority of temperate forests are most strongly limited by nitrogen (N) availability (LeBauer & Treseder 2008), meaning that even when undisturbed, tree growth is often suppressed by insufficient quantities of N. During fire, …

Arkansas Wheat Cultivar Performance Tests 2018-2019, R. E. Mason, R. G. Miller, D. E. Moon, J. P. Kelley

Arkansas Agricultural Experiment Station Research Series

Wheat cultivar performance tests are conducted each year in Ark- ansas by the University of Arkansas System Division of Agriculture’s Arkansas Agricultural Experiment Station, Department of Crop, Soil and Environmental Sciences. The tests provide information to companies developing cultivars and marketing seed within the state and aid the Arkansas Cooperative Extension Service in formulating cultivar recommendations for small-grain producers. The tests are conducted at the Northeast Research and Extension Center at Keiser, the Vegetable Substation near Kibler, the Lon Mann Cotton Research Station near Marianna, the Newport Extension Center near Newport, the Rohwer Research Station near Rohwer, the Pine Tree …