Digital Commons Network^™

Normal And Pathological Tau Uptake Mediated By M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes, Viktoriya Morozova, Leah S. Cohen, Ali El-Hadi Makki, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Alejandra D. Alonso

Publications and Research

The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing neurodegeneration. Here, we show that HEK293 cells and neurons in culture uptake extracellular normal and pathological Tau. Muscarinic receptor antagonists atropine and pirenzepine block 80% this uptake. CHO cells do not express these receptors therefore cannot uptake tau, unless transfected with M1 and/or M3 receptor. These results strongly suggest that muscarinic receptors mediate this process. Uptake of normal tau in neurons enhances neuronal …

Microfluidic Systems For Cancer Diagnostics, Mohamed Sharafeldin

Doctoral Dissertations

Cancer is the second leading cause of death in noncommunicable diseases coming right after cardiovascular diseases. Early diagnosis is a key for improving survival expectancy and treatment outcomes as cancer in early stage is more responsive to treatment. Currently, center of diseases control and prevention (CDC) recommend regular screening for cervical, breast and colorectal cancers. Although other screening procedures are available for prostate, pancreatic, thyroid and ovarian cancer, they did not prove to be effective in reducing mortality rates of these cancers. Adaption of prostate specific antigen (PSA) screening test for prostate cancer has not been related to improved survival …

Nitric Oxide Is Involved In Heavy Ion-Induced Non-Targeted Effects In Human Fibroblasts, Megumi Hada, Premkumar B. Saganti, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human fibroblast irradiated under confluent culture conditions were best fit by non-linear models motivated by a non-targeted effect (NTE). Our results suggested that the simple exchanges in normal human fibroblasts have an important NTE contribution at low particle fluence. Nitric oxide (NO) has been reported as a candidate for intercellular signaling for NTE in many studies. In order to estimate the …

Montana Kaimin, September 4, 2019, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Risk Of Predation: A Critical Force Driving Habitat Quality Perception And Foraging Behavior Of Granivorous Birds In A Nigerian Forest Reserve, Umarfarooq A. Abdulwahab, Samuel Temidayo Osinubi, Jacinta Abalaka

Ecology Center Publications

Background: Understanding the factors that influence the foraging behavior and perception of habitat quality by animals has long been the focus in ecology. Due to the direct effect resource acquisition has on an individual’s fitness and species’ survival, predation risk is considered widely to be a major driver of foraging decision. The objectives of this study were to investigate how predation risk is perceived by granivorous bird species with respect to different habitat and microhabitat types, time of day and food types in Amurum Forest Reserve, Nigeria, with a view to direct future conservation planning.

Methods: For 3 months, we …

The Use Of Ice For Pain Associated With Chest Tube Removal, Jenny L. Sauls

Dissertations

The purpose of this experimental study was to ascertain whether the application of ice would decrease pain before, during, and after chest tube removal (CTR) in adults who have undergone cardiothoracic surgery.

Drones As A Tool To Monitor Human Impacts And Vegetation Changes In Parks And Protected Areas, Francisco Javier Ancin-Murguzur, Lorena Munoz, Christopher Monz, Vera H. Hausner

Environment and Society Faculty Publications

Increased visitation to protected areas could have adverse impacts on the conservation values in the protected areas, and therefore effective visitor monitoring methods are needed to meet the complex management challenges that arise. Collecting data on human impacts is highly time consuming, thus requiring more effective tools that allow for high-quality and long-term measurements. In this study, we show how unmanned aerial vehicles (i.e. UAV or drones) could be used to monitor tourism impacts in protected areas. Tourism has boomed in national parks in Norway in recent years, such as in Jotunheimen National Park for which this study applies. We …

Function And Transcriptional Regulation Of Bovine Torc2 Gene In Adipocytes: Roles Of C/Ebpγ, Xbp1, Insm1 And Znf263, Rajwali Khan, Sayed Haidar Abbas Raza, Zainaguli Junjvlieke, Wang Xiaoyu, Matthew D. Garcia, Ibrahim Elsaeid Elnour, Wang Hongbao, Zan Linsen

Animal, Dairy, and Veterinary Science Faculty Publications

The TORC2 gene is a member of the transducer of the regulated cyclic adenosine monophosphate (cAMP) response element binding protein gene family, which plays a key role in metabolism and adipogenesis. In the present study, we confirmed the role of TORC2 in bovine preadipocyte proliferation through cell cycle staining flow cytometry, cell counting assay, 5-ethynyl-20 -deoxyuridine staining (EdU), and mRNA and protein expression analysis of proliferation-related marker genes. In addition, Oil red O staining analysis, immunofluorescence of adiponectin, mRNA and protein level expression of lipid related marker genes confirmed the role of TORC2 in the regulation of bovine adipocyte differentiation. …

Ritualisation Du Langage Et Métaphores Naturelles : Paradigmes Ou Écueils Pour Construire Un Discours Propre Au Sud ?, Cécile Chapon

Artl@s Bulletin

L'article envisage les conditions de possibilité d'une méthodologie propre à l'espace littéraire et artistique du Sud, à partir du cas particulier de la Caraïbe et de la double perspective du langage et de l'espace déjà élaborée dans la langue de Caliban. Les discours théoriques ou critiques qui partent de la Caraïbe créent souvent des images-concepts tantôt à partir d'un modèle linguistique hybride, tantôt à partir d'un modèle élémentaire ou géographique. L'article tâche de dégager la portée et les limites de ce double paradigme, de ritualisation du langage d'une part, et de métaphore naturelle d'autre part, pour construire un discours propre …

True Injustice: Cultures Of Violence And Stories Of Resistance In The New True Crime, Marcos A. Hernandez

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Identification Of Mined Areas That May Contribute To Water Quality Degradation At Hobet Coal Mine, West Virginia, Brian P. Murphy

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

The Effects Of Citric Acid On Ph And Nutrient Uptake In Wheatgrass (Triticum Aestivum), Cristina Tusei

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Diversity And Abundance Of Soil Microbes Differ Along A Forest-Pasture Transect, Hannah Suli, Ashley Schumann, Cleo Bickley, Jasmine Rodriguez

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Responses Of Bouteloua Eriopoda And Soil Stability To Precipitation Extremes In Chihuahuan Desert Grassland, Laura Kay Sadorf

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Evaluating The Effect Of Time Of Day On Singing Behavior In Anna’S Hummingbirds, Adrian D. Macedo, Maxine R. Mota

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Graduate Student Perspectives On Scale And Hierarchy In Ecology, Carolyn Delevich, Adrian Macedo, Claire Nasr, Adrian Bouissou, Sabrina Horrack, Johnny Roche, Joseph Saler, Stacie Nunes, Vladimir Bonilla, Matthew Reilly, Wesley Hull

IdeaFest: Interdisciplinary Journal of Creative Works and Research from Cal Poly Humboldt

No abstract provided.

Welfare Reform & The Devaluation Of Women's Work, Anna Kerregan

DePaul Journal for Social Justice

No abstract provided.

Application Of Active And Edible Films Of Sodium Caseinate To Extend The Shelf-Life Of Argentine Pategrás Cheese, Brenda S. Álvarez, Natalia Damiani, Marina Czerner, Josefa F. Martucci, Liesel B. Gende

Journal of Applied Packaging Research

Argentine Pategrás cheese is one of the most popular types of cheese in Argentina. The main spoilage causes in these products are microbiological contamination and lipid rancidity. Semi-hard cheeses are usually covered with a paraffin wax that favors its preservation. When pieces are stored, cutting faces must be protected to prevent desiccation and contamination. Active biodegradable films are an alternative to the traditional materials, in particular, casein-based edible films are attractive for food applications. In the present work, active films of sodium caseinate with oregano (Origanum vulgare) and laurel (Laurus nobilis) essential oils were produced for …

Chemical Epitope Targeting: Review Of A Novel Screening Technology, Qurrat Ul-Ain, Rene Kandler, Dylan Gillespie, Arundhati Nag

Scholarly Undergraduate Research Journal at Clark (SURJ)

Chemical Epitope Targeting is a novel technology developed for designing peptide ligands with high affinity and specificity against specific regions of a protein that may be inaccessible to small molecules or antibodies. In this review, we summarize the key steps and significant applications of this technology. Operating on the same principles as antibody-antigen interactions, this technique involves chemically synthesizing the region of interest on the protein, called the epitope, as a polypeptide with a biotin detection tag and a strategically placed alkyne or azide presenting amino acid. The constructed epitope is screened against a comprehensive linear or cyclic One Bead …

Coming Out Experiences Of Lgb Latinos/As, Camilo Posada Rodriguez

Scholarly Undergraduate Research Journal at Clark (SURJ)

The coming out process is a fundamental part in the lives of LGB individuals. Research suggests that there are factors that might make coming out detrimental to the mental health of an individual. This study aims to better understand the coming out experiences of LGB Latinos/as and the possible relations to cultural values such as religion, familismo, and conservative points of view. Participants were 9 self-identified Latino/a lesbian, gay, or bisexual adults currently living in the U.S. recruited through public and online advertisements. The author engaged in thematic analysis to identify relevant patterns about the participants’ coming out experiences. …

Unh Researchers Study 2017 Puerto Rico Hurricane To Understand Impact On New England, Lori Tyler Gula

Media Relations

No abstract provided.

Beyond The Blue: Cyanotype's Qualities Of Light, Time, And Space, Alexus Jungles

All College Thesis Program, 2016-2019

No abstract provided.

Geriatric Hepatology: The Hepatic Diseases Of The Elderly And Liver Transplant, Shima Ghavimi, Hamed Azimi, Neel Patel, Oleg Shulik

Internal Medicine

Introduction: With the aging US population, chronic liver diseases are becoming more commonly diagnosed in the geriatric population. Advanced age leads to changes in liver blood flow, volume, morphology and normal physiology. This predisposes elderly patients to develop certain chronic liver diseases. Also, the clinical course and management differ in an older patient when compared to a younger patient. Some causes of chronic liver disease in the geriatric population include Hepatitis A, B, C, Non-Alcoholic Fatty liver disease, prolonged alcohol use and inflammation. Many chronic liver diseases are characterized by a slow, indolent course of progression with non-specific symptoms and …

Mining Biosynthetic Gene Clusters In Virgibacillus Genomes, Ghofran Othoum, Salim Bougouffa, Ameerah Bokhari, Feras F Lafi, Takashi Gojobori, Heribert Hirt, Ivan Mijakovic, Vladimir B Bajic, Magbubah Essack

Open Access Publications

BACKGROUND: Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug-resistant bacteria that have become a global health threat. Genera of the phylum Firmicutes are frequently identified as sources of such metabolites, but the biosynthetic potential of its Virgibacillus genus is not known. Here, we used comparative genomic analysis to determine whether Virgibacillus strains isolated from the Red Sea mangrove mud in Rabigh Harbor Lagoon, Saudi Arabia, may be an attractive source of such novel antimicrobial agents.

RESULTS: …

Lecture Series Bring Cas Faculty Research Into The Spotlight, Haley Herfurth

Browse All News

No abstract provided.

Permafrost Hydrology Drives The Assimilation Of Old Carbon By Stream Food Webs In The Arctic, Jonathan A. O’Donnell, Michael P. Carey, Joshua C. Koch, Xiaomei Xu, Brett A. Poulin, Jennifer Walker, Christian E. Zimmerman

United States National Park Service: Publications

Permafrost thaw in the Arctic is mobilizing old carbon (C) from soils to aquatic ecosystems and the atmosphere. Little is known, however, about the assimilation of old C by aquatic food webs in Arctic watersheds. Here, we used C isotopes (d13C, D14C) to quantify C assimilation by biota across 12 streams in arctic Alaska. Streams spanned watersheds with varying permafrost hydrology, from ice-poor bedrock to ice-rich loess (that is, yedoma). We measured isotopic content of (1) C sources including dissolved organic C (DOC), dissolved inorganic C (DIC), and soil C, and (2) stream biota, including benthic biofilm and macroinvertebrates, and …

2019-20 Killeen Chair Lecture Series To Feature Martha Nussbaum, St. Norbert College

Press Releases 2019

No abstract provided.

Sensitive Detection And Analysis Of Neoantigen-Specific T Cell Populations From Tumors And Blood., Songming Peng, Jesse M Zaretsky, Alphonsus H C Ng, William Chour, Michael T Bethune, Jongchan Choi, Alice Hsu, Elizabeth Holman, Xiaozhe Ding, Katherine Guo, Jungwoo Kim, Alexander M Xu, John E Heath, Won Jun Noh, Jing Zhou, Yapeng Su, Yue Lu, Jami Mclaughlin, Donghui Cheng, Owen N Witte, David Baltimore, Antoni Ribas, James R Heath

Articles, Abstracts, and Reports

Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation of neoantigen-specific CD8+ T cells from small samples of patient tumor or blood. The method relies on magnetic nanoparticles that present neoantigen-loaded major histocompatibility complex (MHC) tetramers at high avidity by barcoded DNA linkers. The magnetic particles provide a convenient handle to isolate the desired cell populations, and the barcoded DNA enables multiplexed analysis. The method exhibits superior recovery of antigen-specific T cell populations relative to literature approaches. We applied …

Ionizing Radiation Resistant Coatings, Julie P. Harmon

USF Patents

A mixture of a lacquer and carbon nanotubes that form a cross-linked network to convert excitation energy into non-chemistry inducing energy in a cured lacquer.

Unh Researchers Study Puerto Rico Hurricane To Understand Impact Of New England Storms On Watersheds, Lori Wright

UNH Today Archive

No abstract provided.