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Clinical, Cytogenetic, And Molecular Findings In Two Cases Of Variant T(8;21) Acute Myeloid Leukemia (Aml)., Lindsay Wilde, Jillian Cooper, Zi-Xuan Wang, Jinglan Liu

Department of Medical Oncology Faculty Papers

t(8;21)(q22;q22) is present in ~5–10% of patients with de novo acute myeloid leukemia (AML) and is associated with a better overall prognosis. Variants of the t(8;21) have been described in the literature, however, their clinical and prognostic significance has not been well-characterized. Molecular profiling of these cases has not previously been reported but may be useful in better defining the prognosis of this subset of patients. We present two cases of variant t(8;21) AML including clinical, cytogenetic, and molecular data.

Polymer-Grafted Nanoparticle Membranes With Unusual Gas Separation Properties, Sanat K. Kumar

Amgen Seminar Series in Chemical Engineering

Polymer membranes are employed in several critical sustainability applications involving the separation of gas mixtures based on size differences. In spite of their widespread use, important performance challenges remain outstanding - the need to dramatically affect the transport of a desired mixture component and improving mechanical resilience relative to the current state-of-the-art. Here, we develop novel membranes based on polymer-grafted nanoparticles (GNPs) which possess controllable, spatially inhomogeneous gas transport behavior. We show that smaller gases are transported more uniformly than larger solutes in the polymer layer of pure GNPs; these larger gases preferentially move through the interstices between the NPs. …

A Community-Based Survey To Assess Knowledge, Attitudes, Beliefs And Practices Regarding Herpes Zoster In An Urban Setting, Nour A. Baalbaki, Joseph P. Fava, Melanie Ng, Ezinwanne Okorafor, Asad Nawaz, Wesley Chiu, Abdulbaset Salim, Raymond Cha, Paul E. Kilgore

Department of Pharmacy Practice

Introduction: In the USA, nearly one in three people will experience herpes zoster (HZ) in their lifetime. Underserved communities may be at even higher risk due to several factors, including access to healthcare, education, and co-morbid conditions. The purpose of this study was to investigate current knowledge, attitudes, beliefs and practices (KABP) relative to HZ and HZ vaccines in a large urban city.

Methods: A cross-sectional KABP survey was conducted via in-person interview among 381 participants aged ≥ 50 years in Detroit, MI, USA, from June to August 2018. Survey results were stratified into two groups [< 60 and ≥ 60 years of age (YO)] for comparison.

Results: Of the …

Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher

College of Science & Mathematics Departmental Research

Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the formation of mucocutaneous lesions (cold sores), but asymptomatic reactivation accompanied by viral shedding is more frequent and allows virus spread to new hosts. HSV-1 DNA has been detected in many oral tissues. In particular, HSV-1 can be found in periodontal lesions and several studies associated its presence with more severe periodontitis pathologies. Since gingival fibroblasts may become exposed to salivary …

Program For The Stage Production The Complete History Of Ursinus College [Abridged], Domenick Scudera

Theater Production Programs

This twelve-page program details the Theater Department of Ursinus College’s production of The Complete History of Ursinus College [Abridged], held October 3rd through October 6th, 2019 in Lenfest Theater. It includes information about the director, cast, and production of this special sesquicentennial show.

Day Funded By Nih To Study Neural Coding Of Spatial Hearing, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

First Monday- Cardozo Professors Preview The Supreme Court Term, Benjamin N. Cardozo School Of Law

Cardozo News 2019

No abstract provided.

Group Assignments & Teamwork, Rebecca Roten

Teamwork: An Open Access Practical Guide - Archive

Lecture/discussion on teamwork, challenges, roles, and planning, and activity (Jeopardy)

Vista: October 3, 2019, University Of San Diego

USD Vista (1965-)

No abstract provided.

The Grizzly, October 3, 2019, Kevin Leon, Kim Corona, Emina Takahashi, Madison Rodak, Jen Joseph, Jake Supran, Gabriela Howell

Ursinus College Grizzly Newspaper, 1978 to Present

New Play Inspired by Ursinus' History • Dr. Shuru Helps Launch Latinx Book Club • Life as an International Student at Ursinus • Librarian Creates New Myrin Escape Room • Opinions: Slouching Towards Paradise: A Bolder "Bachelor"?; Students Should Have a Say in Colleges' Endowment Investments • Volleyball Looks to get Back on Track • Field Hockey Extends Win Streak to Five Games

Daily Eastern News: October 03, 2019, Eastern Illinois University

October

No abstract provided.

Optothermal Microbubble Assisted Manufacturing Of Nanogap-Rich Structures For Active Chemical Sensing, Farzia Karim, Erick S. Vasquez, Yvonne Sun, Chenglong Zhao

Chemical and Materials Engineering Faculty Publications

Guiding analytes to the sensing area is an indispensable step in a sensing system. Most of the sensing systems apply a passive sensing method, which waits for the analytes to diffuse towards the sensor. However, passive sensing methods limit the detection of analytes to a picomolar range on micro/nanosensors for a practical time scale. Therefore, active sensing methods need to be used to improve the detection limit in which the analytes are forced to concentrate on the sensors. In this article, we have demonstrated the manufacturing of nanogap-rich structures for active chemical sensing. Nanogap-rich structures are manufactured from metallic nanoparticles …

Plant Cell-Derived Growth Factors For Ex Vivo Mass Production Of Red Blood Cells, Xiaoting Wang

Student Theses and Dissertations

Generation of red blood cells from hematopoietic stem cells (HSCs) used for blood transfusion represents one of the focus in regenerative medicine. Erythropoietic growth factors (eGFs), including stem cell factor (SCF), erythropoietin (EPO) and interleukin 3 (IL-3) are vital for proliferation and differentiation of HSCs into mature red blood cells (RBCs) ex vivo. However, massive production of RBCs requires significant quantity and high quality of eGFs, making manufacturing at large scale cost prohibitive. Plant cell culture is proposed to be a promising bioproduction platform for growth factors based on the advantages of, fast growing, no risk of human pathogen, and …

Egestion Versus Excretion: A Meta-Analysis Examining Nutrient Release Rates And Ratios Across Freshwater Fauna, Halvor Halvorson, Carla Atkinson

Faculty Publications

In aquatic settings, animals directly affect ecosystem functions through excretion of dissolved nutrients. However, the comparative role of egestion as an animal-mediated nutrient flux remains understudied. We conducted a literature survey and meta-analysis to directly compare nitrogen (N), phosphorus (P), and N:P of egestion compared to excretion rates and ratios across freshwater animals. Synthesizing 215 datasets across 47 animal species (all primary consumers or omnivores), we show that the total N and P egestion rates exceed inorganic N and P excretion rates but not total N and P excretion rates, and that proportions of P egested compared to excreted depend …

Optimizing Hydroxyproline-O-Glycan Engineering In Tobacco Transient Protein Expression: Fish Il-22 And Enhanced Green Fluorescent Protein (Egfp), Cristofer Calvo

Student Theses and Dissertations

Despite the advantages of plant-produced recombinant proteins, the most important bottleneck that limits the commercialization is the low protein yields. Plants have a unique type of O-glycosylation that has potential to enhance the stability and solubility of recombinant proteins. Specifically, target gene sequences are fused with a sequence to code for hydroxyproline-O-glycosylated peptide (HypGP) tags. We targeted the expression of a very unstable rainbow trout interleukin 22 (rtIL-22) and a readily-monitored enhanced green fluorescent protein (EGFP). The HypGP-tagged rIL-22 accumulation in planta was significantly enhanced over the untagged protein and showed increase stability. Changes in gene expression of the marker …

Katie Rothas, Katie Rothas 2014

All oral histories

Ms. Rothas is a member of IWU's Class of 2014. She made this recording during Homecoming on October 3, 2019.

Htlv-1 Viral Oncogene Hbz Drives Bone Destruction In Adult T Cell Leukemia, Jingyu Xiang, Daniel A Rauch, Devra D Huey, Amanda R Panfil, Xiaogang Cheng, Alison K Esser, Xinming Su, John C Harding, Yalin Xu, Gregory C Fox, Francesca Fontana, Takayuki Kobayashi, Junyi Su, Hemalatha Sundaramoorthi, Wing Hing Wong, Yizhen Jia, Thomas J Rosol, Deborah J Veis, Patrick L Green, Stefan Niewiesk, Lee Ratner, Katherine N Weilbaecher

Open Access Publications

Osteolytic bone lesions and hypercalcemia are common, serious complications in adult T cell leukemia/lymphoma (ATL), an aggressive T cell malignancy associated with human T cell leukemia virus type 1 (HTLV-1) infection. The HTLV-1 viral oncogene HBZ has been implicated in ATL tumorigenesis and bone loss. In this study, we evaluated the role of HBZ on ATL-associated bone destruction using HTLV-1 infection and disease progression mouse models. Humanized mice infected with HTLV-1 developed lymphoproliferative disease and continuous, progressive osteolytic bone lesions. HTLV-1 lacking HBZ displayed only modest delays to lymphoproliferative disease but significantly decreased disease-associated bone loss compared with HTLV-1-infected mice. …

Irak4 Mediates Colitis-Induced Tumorigenesis And Chemoresistance In Colorectal Cancer, Qiong Li, Yali Chen, Daoxiang Zhang, Julie Grossman, Lin Li, Namrata Khurana, Hongmei Jiang, Patrick M Grierson, John Herndon, David G Denardo, Grant A Challen, Jingxia Liu, Marianna B Ruzinova, Ryan C Fields, Kian-Huat Lim

Open Access Publications

Aberrant activation of the NF-κB transcription factors underlies chemoresistance in various cancer types, including colorectal cancer (CRC). Targeting the activating mechanisms, particularly with inhibitors to the upstream IκB kinase (IKK) complex, is a promising strategy to augment the effect of chemotherapy. However, clinical success has been limited, largely because of low specificity and toxicities of tested compounds. In solid cancers, the IKKs are driven predominantly by the Toll-like receptor (TLR)/IL-1 receptor family members, which signal through the IL-1 receptor-associated kinases (IRAKs), with isoform 4 (IRAK4) being the most critical. The pathogenic role and therapeutic value of IRAK4 in CRC have …

Sr9009 Administered For One Day After Myocardial Ischemia-Reperfusion Prevents Heart Failure In Mice By Targeting The Cardiac Inflammasome, Cristine J Reitz, Faisal J Alibhai, Tarak N Khatua, Mina Rasouli, Byram W Bridle, Thomas P Burris, Tami A Martino

Open Access Publications

Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac inflammation that leads to infarct expansion and heart failure (HF). We previously showed that the circadian mechanism is a critical regulator of reperfusion injury. However, whether pharmacological targeting using circadian medicine limits reperfusion injury and protects against HF is unknown. Here, we show that short-term targeting of the circadian driver REV-ERB with SR9009 benefits long-term cardiac repair post-myocardial ischemia reperfusion in mice. Gain and loss of function studies demonstrate specificity of targeting REV-ERB in mice. Treatment for just one day abates the cardiac NLRP3 inflammasome, decreasing immunocyte recruitment, and thereby …

Nextgen Advises "Trying To Manage", Douglass Steinhauff, Joel Henrique Ellwanger, Monika Lewinska, Edmond Sanganyado, Yongsheng Ji, Buddini Iroshika Karawdeniya, Naike Bochatay, Eric Britt Moore, Aminata Coulibaly, Shaima Ibrahim, Déna Skye Jansen, Joshua I. James, David M. Cole, Anna Lipkin, Beth Mckinnon Adamowicz, Science Management Associates, Shervin Fatehi, Maria Helena Holmstrom, Rosa Li

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Peer mentors can provide crucial support to young scientists by asking questions to facilitate further reflection, assuring mentees that they are not alone, and suggesting potential next steps. We asked our readers to act as peer mentors to “Trying to Manage,” the anonymous student who posed the question above. Follow NextGen Voices on Twitter with hashtag #NextGenSci. Read previous NextGen Voices survey results at https://science.sciencemag.org/collection/nextgen-voices. —Jennifer Sills

Human Sperm Motility, Viability, And Morphology Decreased After Cryopreservation, Ninik Darsini, Berliana Hamidah, Seso Sulijaya Suyono, Faisal Yusuf Ashari, R Haryanto Aswin, Rina Yudiwati

Folia Medica Indonesiana

The aim of this study was to analyze human sperm motility, viability, and morphology before and after cryopreservation. This true laboratory experimental study had pre and post randomized one group design. The study was conducted at the Embryology, Andrology, and Genetics Laboratory, Department of Medical Biology, Faculty of Medicine, Universitas Airlangga from August to November 2017. The eighteen samples of fresh semen were collected from male volunteers who agreed and signed the informed consent of the study. Samples were analyzed their motility, viability, and morphology before and after cryopreservation. Results of this study indicated differentiation between motility before and after …

Effect Of Combination Soy Bean Oil And Oleic Acid To Characteristic, Penetration, Physical Stability Of Nanostructure Lipid Carrier Resveratrol, Widji Soeratri, Rohmawati Hidayah, Noorma Rosita

Folia Medica Indonesiana

Resveratrol is an antioxidant that can be used as anti-aging. Topical use has several problems because solubility in water is low and unstable to light. This study aimed to evaluate the effect of the combination of soy bean oil and oleic acid liquid lipids on the characteristics, penetration, and stability of resveratrol nanostructured lipid carriers (NLC). Nanostructured lipid carriers (NLC) were made with high shear homogeneous technique. To determine the characterization of NLC, diffraction scanning calorimetry, X-ray diffraction, and Fourier transforms infrared spectrophotometry were used. Examination of the morphological form was carried out with a transmission electron microscope. The particle …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Comparison Of The Effectiveness Of Tomato (Lycopersicum Commune) And Red Melon (Cucumis Melo L.) Juice In Increasing Vaginal Wall Thickness Of Menopausal Rats Model, Yhenti Widjayanti, Arief Widya Prasetya

Folia Medica Indonesiana

Menopausal period is the period of permanent cessation of menstruation due to reduced or lost ovarian activity. One of the effects of decline estrogen levels during menopause is atropic vulvovaginitis. Consumption of phytoestrogens can reduce menopausal symptoms. Phytoestrogen is found in vegetables and fruits such as tomatoes and red melon. The objective of this study was to compare the effectiveness of red melon juice and tomato on the increase of vaginal wall thickness in menopausal rats. This study revealed an alternative of phytoestrogen sources that is more effective to reduce menopausal symptoms, especially those related to vaginal atrophy to improve …

Acceleration Of Bone Fracture Healing Through The Use Of Natural Bovine Hydroxyapatite Implant On Bone Defect Animal Model, Junaidi Khotib, Cantika Sc Lasandara, Samirah Samirah, Aniek S Budiatin

Folia Medica Indonesiana

Bone is an important organ for supports the body that stores reserve of calcium, phosphorus, and other minerals. In fracture conditions where bleeding, soft tissue edema, nerve damage, and blood vessels around the bone damage happen, they can cause the mobilization of these minerals in the surrounding tissue. One of the efforts made in the treatment of these fractures is reconnection, in which it works by filling of bone defect with a matrix and administration of anti-infection. Biomaterial filling in defective bone is thought to accelerate the healing process of bone fracture and prevent osteomyelitis. For this reason, this study …

Leaf And Petiole Extract Of Centella Asiatica Are Potential For Antifertility And Antimicrobial Material, Susie Amilah, Sukarjati Sukarjati, Diaz P Rachmatin, Masruroh Masruroh

Folia Medica Indonesiana

Ethanol extract of leaves and petiole of pegagan (Centella asiatica) is potential as antimicrobial and antifertility. This study was to investigate whether ethanol extracts of leaf and petiole of Centella asiatica has potential as an antimicrobial and can decrease sperm quality and spermatogenic cells of mice. This was a randomized controlled study using Centella asiatica plant from which we made ethanol extract. The extract of the leaves and petiole of Centella asiatica was subjected to antimicrobial test using the bacteria S. aureus, S. epidermidis, and A. aerogenes. Then the observation was done after a 24-hour-old bacterial cultures by measuring the …

The Influence Of Psychocurative On Cortisol Level, Anxiety, And Quality Of Life In Advanced Stage Cervical Cancer Patients, Soetrisno Soetrisno, Sri Mulyani, Hafi Nurinasari, Hafi Nurinasari, Erindra Budi

Folia Medica Indonesiana

Every year, there are 500.000 new cases and more than 250.000 deaths caused by cervical cancerworldwide. Cervical cancer patients faced physical and psychological problems several times that it activate stress mechanism such as hypothalamus-pituitary-adrenal (HPA) axis. These recurrent activations caused HPA axis disruption and adverse clinical effects. Several symptoms of endocrine stress response are the change of circadian cortisol rhythm. Cortisol is known as a stress hormone that involves an organism's response to stress and anxiety that influence the quality of life. This research aims to analyze the differences among serum cortisol level, anxiety, and quality of life in cervical …

Evaluation Of Ki-67, Apoptosis, And Hyaluronic Acid In Grading Retinoblastoma, Hendrian D Soebagjo, Nurwasis Nurwasis, Ugresone Y Bintoro, Sutiman B Soemitro

Folia Medica Indonesiana

Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular weight has the property of angiogenesis, inflammation, and suppresses apoptosis. This study occupied the samples of 35 paraffin block from poorly and well differentiated retinoblastoma tissue and 8 normal retinal block which have been collected for 4 years from 2010-2013 at Dr. Soetomo Hospital, Surabaya, Indonesia. Afterwards, the paraffin blocks were immunohistochemically examined for HA staining, expression of cell proliferation (Ki-67), and cell apoptosis to determine intratumoral aggressiveness of …

Design Of Hydroxyapatite/Magnetite (Hap/Fe3o4) Based Composites Reinforced With Zno And Mgo For Biomedical Applications, D. Katundi, E. Bayraktar, F. Gatamorta, I. Miskioglu

Michigan Tech Publications, Part 1

Hydroxyapatite (HAP-- Ca 10(PO4 )6 (OH)2 ) is a biocompatible and bioactive material that is widely used for biomedical applications, especially in bone replacements. It has good load carrying capacity; however, it lacks antibacterial property. New bio-composites based on bovine hydroxyapatite doped with, magnetite iron oxide (HAP/ Fe3 O4 ) matrix reinforced with ZnO and MgO nanoparticles are proposed for biomedical applications that provide improved antibacterial activity with potential to be used in magnetic therapy. Microwave sintering was used to manufacture the composites. The microstructure evolution in these composites were studied by Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy …

Policy Interventions For The Development Of The Blue Economy In Bangladesh, Pierre Failler, M Gulam Hussain, Khurshed Alam, Ahmad Al Karim

Journal of Ocean and Coastal Economics

Between 2012 and 2014, disputes over maritime boundary with Myanmar and India were favorably settled for Bangladesh, resulting in the expansion of its territorial waters of more than 30% and the country received entitlement to 118,813 km² in the Bay of Bengal. This achievement offers a wide range of new economic opportunities for jobs & growth around marine and coastal sectors such as marine fisheries, marine aquaculture, tourism, exploitation of natural resources, trade and energy. This created new opportunities to exploited the untapped potential of these waters. The challenge will be to develop smart and sustainable solutions to meet …