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2019

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My News, Georgia Southern University Nov 2019

My News, Georgia Southern University

My News (2014-2020)

  • Communication Arts welcomes back alumni for 50+1 anniversary celebration
  • Jiann-Ping Hsu College of Public Health presents Grand Rounds
  • Georgia Southern improves health in Coastal Georgia through new partnership
  • Bring food donations. Get your parking fines waived.
  • Books Donation Drive to help raise funds for Staff Scholarship program
  • Tony Award-winning musical, 'The Color Purple,' to inspire audiences at Performing Arts Center this Friday
  • Future Eagles can apply for free in November
  • Georgia Southern celebrates first-generation college students, faculty, staff
  • Hanner Fieldhouse to host this week's athletics events


Systems And Methods For Treating Dilute Wastewater, Daniel H. Yeh, George H. Dick, Robert A. Bair, Onur Y. Ozcan, Jorge Luis Calabria Nov 2019

Systems And Methods For Treating Dilute Wastewater, Daniel H. Yeh, George H. Dick, Robert A. Bair, Onur Y. Ozcan, Jorge Luis Calabria

USF Patents

In one embodiment, a dilute wastewater treatment system includes a separation subsystem configured to receive dilute wastewater and separate it into a product stream containing a low concentration of organic material and a reject stream containing a high concentration of organic material, and a conversion subsystem configured to receive the reject stream from the separation subsystem and anaerobically treat the reject stream to break down the organic material and separate it from water within the reject stream.


Plasmonic Stimulation Of Electrically Excitable Biological Cells, Parveen Bazard, Robert Dana Frisina, Joseph Paul Walton, Venkat Rama Bhethanabotla Nov 2019

Plasmonic Stimulation Of Electrically Excitable Biological Cells, Parveen Bazard, Robert Dana Frisina, Joseph Paul Walton, Venkat Rama Bhethanabotla

USF Patents

A novel method to stimulate electrically active biological cells using visible wavelength light and metallic nanoparticles possessing plasmonic properties is presented herein. Using this technology, prosthetic devices such as cochlear and retinal implants and cardiac pacemakers can be developed to have superior properties as compared to the currently utilized electrical stimulation designs. These properties include improved spatial resolution; less or non-invasive devices; and higher fidelity of transduction. An additional advantage of using visible light wavelengths is the avoidance of unwanted heating of surrounding tissue that occurs with infrared stimulation.


Evaluation Of Drought-Resistant Plants For Beneficial Insect Attraction, Benjamin Gluck Nov 2019

Evaluation Of Drought-Resistant Plants For Beneficial Insect Attraction, Benjamin Gluck

Master's Theses

Beneficial insects, such as natural enemies and pollinators, provide billions of dollars of ecological services to agricultural operations. However, as the climate changes, Connecticut is projected to have longer periods of drought. This could negatively impact the availability of flowering plants, and the beneficial insects who rely on their floral resources.


This research focuses on the diversity of insect visitors to five species of drought-resistant plants at the Plant Science Research and Educational facility. Over the two-year study the visitation frequency of pollinators and beneficial insects on the plants was observed, insect samples were collected for further identification. Agastache foeniculum …


Predation Of The Mexican Deer Mouse (Peromyscus Mexicanus) By Long-Tailed Weasel (Mustela Frenata) In Laguna Bélgica Educational Park, Ocozocoautla De Espinosa, Chiapas, O. Iván Martínez Vaca-León, Elizabeth Arellano, Xavier López-Medellín Nov 2019

Predation Of The Mexican Deer Mouse (Peromyscus Mexicanus) By Long-Tailed Weasel (Mustela Frenata) In Laguna Bélgica Educational Park, Ocozocoautla De Espinosa, Chiapas, O. Iván Martínez Vaca-León, Elizabeth Arellano, Xavier López-Medellín

Western North American Naturalist

The long-tailed weasel (Mustela frenata) is a generalist predator that feeds mainly on rodents and rab­bits. However, predation on Peromyscus rodents has been reported mostly at the genus level and records are scarce. In April 2018, we made a field trip to Laguna Bélgica Educational Park, Chiapas, to capture, handle, and study mam­malian wildlife species. We set 15 Sherman traps 5 m apart on a 70-m linear transect for one night. One male M. frenata was captured along with a dead Mexican deer mouse (Peromyscus mexicanus) in the same trap. The rodent had incision marks on …


Atm Deficiency Accelerates Dna Damage, Telomere Erosion, And Premature T Cell Aging In Hiv-Infected Individuals On Antiretroviral Therapy, Juan Zhao, Lam Ngoc Nguyen, Lam Nhat Nguyen, Xindi Dang, Dechao Cao, Sushant Khanal, Madison Schank, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zheng D. Morrison, Xiao Y. Wu, Zhengke Li, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao Nov 2019

Atm Deficiency Accelerates Dna Damage, Telomere Erosion, And Premature T Cell Aging In Hiv-Infected Individuals On Antiretroviral Therapy, Juan Zhao, Lam Ngoc Nguyen, Lam Nhat Nguyen, Xindi Dang, Dechao Cao, Sushant Khanal, Madison Schank, Bal Krishna Chand Thakuri, Stella C. Ogbu, Zheng D. Morrison, Xiao Y. Wu, Zhengke Li, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in individuals on combined antiretroviral therapy (cART) with undetectable viremia. In this study, we investigated T cell homeostasis and telomeric DNA damage and repair machineries in cART-controlled HIV patients at risk for inflammaging. We found a significant depletion of CD4 T cells, which was inversely correlated with the cell apoptosis in virus-suppressed HIV subjects compared to age-matched healthy subjects (HS). In addition, HIV CD4 T cells were prone to DNA damage that extended to chromosome ends—telomeres, leading to accelerated telomere erosion—a hallmark …


Streambed Flux Measurement Informed By Distributed Temperature Sensing Leads To A Significantly Different Characterization Of Groundwater Discharge, Troy E. Gilmore, Mason Johnson, Jesse T. Korus, Aaron R. Mittelstet, Marty A. Briggs, Vitaly A. Zlotnik, Sydney Corcoran Nov 2019

Streambed Flux Measurement Informed By Distributed Temperature Sensing Leads To A Significantly Different Characterization Of Groundwater Discharge, Troy E. Gilmore, Mason Johnson, Jesse T. Korus, Aaron R. Mittelstet, Marty A. Briggs, Vitaly A. Zlotnik, Sydney Corcoran

Conservation and Survey Division: Faculty and Staff Publications

Groundwater discharge though streambeds is often focused toward discrete zones, indicating that preliminary reconnaissance may be useful for capturing the full spectrum of groundwater discharge rates using point-scale quantitative methods. However, many direct-contact reconnaissance techniques can be time-consuming, and remote sensing (e.g., thermal infrared) typically does not penetrate the water column to locate submerged seepages. In this study, we tested whether dozens of groundwater discharge measurements made at “uninformed” (i.e., selected without knowledge on high-resolution temperature variations at the streambed) point locations along a reach would yield significantly dierent Darcy-based groundwater discharge rates when compared with “informed” measurements, focused at …


Executive Committee - Agenda, 11/05/2019, Academic Senate Nov 2019

Executive Committee - Agenda, 11/05/2019, Academic Senate

Academic Senate Agendas

No abstract provided.


The Prospector, November 5, 2019, Utep Student Publications Nov 2019

The Prospector, November 5, 2019, Utep Student Publications

The Prospector

Headline: The Basketball Issue


Making Decision Adaptive To Price Uncertainty And Risk Preference: A New Decision-Making Model For Forest Management, Fan Zhang Nov 2019

Making Decision Adaptive To Price Uncertainty And Risk Preference: A New Decision-Making Model For Forest Management, Fan Zhang

LSU Doctoral Dissertations

While the forest grows, the price of timber fluctuates. Price uncertainty plays a key role in forestry due to the extended rotation length of growing trees. Like double sides of the same coin, risk preference and uncertainties should be considered together. This is because risk preference represents people’s attitude toward that uncertainty when making management decisions. Risk preference is especially an important issue for forest management because forests are exposed to substantial uncertainties during their long growing period. However, most existing relevant studies either simply overlook the risk preference issue or fail to consider it together with a practical forest …


Using Poultry Litter Ash As A Fertilizer Source For Bermudagrass (Cynodon Dactylon) Establishment And Loblolly Pine (Pinus Taeda) Plantation, Crystal L. Vance Nov 2019

Using Poultry Litter Ash As A Fertilizer Source For Bermudagrass (Cynodon Dactylon) Establishment And Loblolly Pine (Pinus Taeda) Plantation, Crystal L. Vance

LSU Doctoral Dissertations

Lower solubility of P in poultry litter ash (PLA) than conventional phosphorus (P) fertilizers such as triple superphosphate (TSP) may reduce P losses in drainage and runoff; however, lower P solubility may reduce its efficacy as a P source. A laboratory experiment was conducted to examine the effect of acidity on P release and the effect of different combustion temperatures on P solubility as a prerequisite to the following studies. The first research objective was to determine the effect of soil pH on the efficiency of PLA relative to TSP for establishment of common bermudagrass (Cynodon dactylon L.) and …


Effectiveness Of The E-Nursus Children Intervention In The Training Of Nursing Students, Cristina Álvarez-García, Carmen Álvarez-Nieto, Janet Kelsey, Rachel Carter, Sebastián Sanz-Martos, Isabel M. López-Medina Nov 2019

Effectiveness Of The E-Nursus Children Intervention In The Training Of Nursing Students, Cristina Álvarez-García, Carmen Álvarez-Nieto, Janet Kelsey, Rachel Carter, Sebastián Sanz-Martos, Isabel M. López-Medina

School of Nursing and Midwifery

The paediatric population is the most vulnerable to exposure to environmental risk factors. Institutions of higher education have to equip nursing students with the attitudes, knowledge, and skills to respond to this using blended learning. The aim of this study was to evaluate the effect of e-NurSus Children intervention on student nurses’ attitudes, knowledge, and skills. A quasi-experimental study of time series was designed using pre and post educational intervention evaluation in 2018. The participants were nursing students (N = 267) from Spain (n = 110) and the United Kingdom (n = 157). Three instruments were used: the Sustainability Attitudes …


Remedy, Michael Cyr Nov 2019

Remedy, Michael Cyr

Akesis

In keeping with this issues’ theme this piece is meant to highlight the subtle places terminal illness hides biologically, socially and spiritually and how and where it is expressed, sometimes despite the best efforts of the patient or caregivers. This piece also makes effort to convey the importance of humanity in medicine and highlight loving connection as an important part of the arsenal we use against sickness.


Targeting The Oncogenic Myc Pathway By Miniproteins: Understanding Mechanism Of Action, Mark J. Demma Nov 2019

Targeting The Oncogenic Myc Pathway By Miniproteins: Understanding Mechanism Of Action, Mark J. Demma

Open Access Dissertations

The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions of genes and activate transcription. No MYC specific inhibitors are currently in clinical trials. Here, we show two distinct recombinant mini proteins act as Myc inhibitors and have cellular activity. The first mini protein is Omomyc, a well characterized Myc inhibitor that has been ectopically expressed in cells. Recombinant Omomyc is cell penetrant, reduces cell proliferation of tumor cells in a MYC dependent manner and reduces the expression of MYC …


About The Life Cycle Of Black Vulture (Milvus Migrans) In Fergana Valley, M. Xoliqov Candidate Of Biological Sciences, Y. Axmedova Master Student Nov 2019

About The Life Cycle Of Black Vulture (Milvus Migrans) In Fergana Valley, M. Xoliqov Candidate Of Biological Sciences, Y. Axmedova Master Student

Scientific journal of the Fergana State University

The article described the life cycle of Milvus migrans in the Fergana valley. On the basis of literary data and personal observation some information such as knowing their couples, their occurrence, building nests are given.


Morphogenetic And Biogeochemical Features Of The Medicinal Capparis Spinosa, M. Isag‘Aliyev, Candidate Of Biological Sciences Associate Professor, M. Obidov Base Doctoral Student., R. Matholiqov Master Student Nov 2019

Morphogenetic And Biogeochemical Features Of The Medicinal Capparis Spinosa, M. Isag‘Aliyev, Candidate Of Biological Sciences Associate Professor, M. Obidov Base Doctoral Student., R. Matholiqov Master Student

Scientific journal of the Fergana State University

The article studies the morphogenetic features, the composition of macro- and microelements, the coefficient of biological absorption in medicinal Capparis spinosa in light serozems, and also proved the high demand of macro elements of phosphorus, and microelements of zinc.


Geoenergetic Features Of Lanthanoids And Radioactive Elements In Irrigated Soils, A. Turdaliyev Doctor Of Biological Sciences, K. Asqarov Teacher, N. Xodjibolayeva Teacher Nov 2019

Geoenergetic Features Of Lanthanoids And Radioactive Elements In Irrigated Soils, A. Turdaliyev Doctor Of Biological Sciences, K. Asqarov Teacher, N. Xodjibolayeva Teacher

Scientific journal of the Fergana State University

The paper studies the geoenergetic features of the lanthanides and radioactive elements in the genetic horizons of irrigated meadow saz soils of Central Fergana. moreover, the number of these elements was determined depending on their geoenergetic features in the soil profile, and the geochemical Clark spectra of these elements were developed.


Translated Works In Latin In The Translation Centers Of Medieval Spain (Part I: Books On Exact Sciences), O. V. Mahmudov Doctor Of Philosophy (Phd). Nov 2019

Translated Works In Latin In The Translation Centers Of Medieval Spain (Part I: Books On Exact Sciences), O. V. Mahmudov Doctor Of Philosophy (Phd).

Scientific journal of the Fergana State University

The article provides information about translations into Latin of about 60 works of scientists of antiquity and the medieval East, made in the translation centers of Spain. It analyzes and classifies the information collected from the scientific literature on the history of translations in Spain in the XII–XIII centuries.


Understanding Factors Related To Undergraduate Student Decision-Making About A Complex Socio-Scientific Issue: Mountain Lion Management, Ashley Alred, Jenny Dauer Nov 2019

Understanding Factors Related To Undergraduate Student Decision-Making About A Complex Socio-Scientific Issue: Mountain Lion Management, Ashley Alred, Jenny Dauer

School of Natural Resources: Faculty Publications

We outline an instructional strategy for supporting students’ science literacy skills using a structured decision-making tool in an interdisciplinary undergraduate course. Instructional tools support basing complex socioscientific issues decisions on a reasoned analysis of tradeoffs among multiple conflicting values rather than heuristics, such as social norms. We explored the factors related to students’ decision-making about mountain lion management by examining if students’ value orientations, identity, or knowledge predicted their management decisions before, during, and after engaging in structured decision-making where they performed a tradeoffs analysis. We found that student decision-making may align more closely to students’ value orientations and identity …


The Fallacy Of Enzymatic Hydrolysis For The Determination Of Bioactive Curcumin In Plasma Samples As An Indication Of Bioavailability: A Comparative Study, Sidney J. Stohs, C. Y. O. Chen, Harry G. Preuss, Sidhartha D. Ray, Luke R. Bucci, Jin Ji, Kevin J. Ruff Nov 2019

The Fallacy Of Enzymatic Hydrolysis For The Determination Of Bioactive Curcumin In Plasma Samples As An Indication Of Bioavailability: A Comparative Study, Sidney J. Stohs, C. Y. O. Chen, Harry G. Preuss, Sidhartha D. Ray, Luke R. Bucci, Jin Ji, Kevin J. Ruff

Touro Scholarly Works

Background

Numerous health benefits have been demonstrated for curcumin which is extracted from turmeric (Curcuma longa L). However, due to its poor absorption in the free form in the gastrointestinal tract and rapid biotransformation, various formulations have been developed to enhance its bioavailability. Previous studies indicate that the free form of curcumin is more bioactive than its conjugated counterparts in target tissues. Most curcumin pharmacokinetics studies in humans designed to assess its absorption and bioavailability have measured and reported total (free plus conjugated) curcumin, but not free, bioactive curcumin in the plasma because enzymatic hydrolysis was employed prior to …


A Conversation With Mariana Wolfner, Newly Inducted Member Of The National Academy Of Sciences, Willie J. Swanson, Geoffrey D. Findlay Nov 2019

A Conversation With Mariana Wolfner, Newly Inducted Member Of The National Academy Of Sciences, Willie J. Swanson, Geoffrey D. Findlay

Biology Department Faculty Scholarship

Molecular Reproduction and Development is delighted to announce that editorial board member Mariana F. Wolfner has been elected to the National Academy of Sciences. Here, Dr Wolfner is interviewed by two of her former postdocs. She discusses her path to studying reproduction and her career as a researcher and mentor.


F. Ludwig Diehn Concert Series: Blue Heron, Blue Heron, Scott Metcalfe (Director), Owen Mcintosh, Jason Jason Mcstoots, Stefan Reed, Sumner Thompson, Margot Rood, Martin Near, Paul Guttry, Steven Hrycelak Nov 2019

F. Ludwig Diehn Concert Series: Blue Heron, Blue Heron, Scott Metcalfe (Director), Owen Mcintosh, Jason Jason Mcstoots, Stefan Reed, Sumner Thompson, Margot Rood, Martin Near, Paul Guttry, Steven Hrycelak

Guest Performances

No abstract provided.


Energy Harvesting For Micromobility Systems, Alex Kattamis, Zachary Lochner, Nov 2019

Energy Harvesting For Micromobility Systems, Alex Kattamis, Zachary Lochner,

Energy Harvesting from Infrastructure and Ocean Systems (EHIOS)

No Abstract.


Fathers' Experiences With Their Premature Infants Or Unhealthy Neonates, Lisa Cummings Nov 2019

Fathers' Experiences With Their Premature Infants Or Unhealthy Neonates, Lisa Cummings

Dissertations

Author: Lisa Cummings PhD RN

Fathers’ Experiences with Their Premature Infants or Unhealthy Neonates

Purpose and Background/Significance: Fifteen million babies worldwide are born prematurely each year, impacting a multitude of fathers. The importance of an early close father-infant relationship has been identified as central for the development of the child. Fathers influence on a child’s emotional and cognitive development and their physical well-being and health. Many times, the Neonatal Intensive Care Unit (NICU) is the initial contact environment between a father and his premature infant. Studies have shown that the NICU can be a stressful environment for parents, producing emotional …


Use Of Neural Networks To Identify Safety Prevention Priorities In Agro-Manufacturing Operations Within Commercial Grain Elevators, Fatemeh Davoudi Kakhki, Steven A. Freeman, Gretchen A. Mosher Nov 2019

Use Of Neural Networks To Identify Safety Prevention Priorities In Agro-Manufacturing Operations Within Commercial Grain Elevators, Fatemeh Davoudi Kakhki, Steven A. Freeman, Gretchen A. Mosher

General Engineering

The grain handling industry plays a significant role in U.S. agriculture by storing, distributing, and processing a variety of agricultural commodities. Commercial grain elevators are hazardous agro-manufacturing work environments where workers are prone to severe injuries, due to the nature of the activities and workplace. Safety incidents in agro-manufacturing operations generally arise from a combination of factors, rather than a single cause, therefore, research on occupational incidents must look deeper into identifying the underlying causes, through the application of advanced analyses methods. In occupational safety, it is possible to estimate and predict probability of safety risks through developing artificial neural …


An Efficient Viologen-Based Electron Donor To Nitrogenase, Artavazd Badalyan, Zhi-Yong Yang, Bo Hu, Jian Luo, Maowei Hu, T. Leo Liu, Lance C. Seefeldt Nov 2019

An Efficient Viologen-Based Electron Donor To Nitrogenase, Artavazd Badalyan, Zhi-Yong Yang, Bo Hu, Jian Luo, Maowei Hu, T. Leo Liu, Lance C. Seefeldt

Chemistry and Biochemistry Faculty Publications

Nitrogenase catalyzes the reduction of N2 to NH3, supporting all biological nitrogen fixation. Electron donors to this enzyme are ferredoxin or flavodoxin (in vivo) and sodium dithionite (in vitro). Features of these electron donors put a limit on spectrophotometric studies and electrocatalytic applications of nitrogenase. Although it is common to use methyl viologen as an electron donor for many low-potential oxidoreductases, decreased nitrogenase activity is observed with an increasing concentration of methyl viologen, limiting its utility under many circumstances. In this work, we suggest that this concentration-dependent decrease in activity can be explained …


Sign And Speech Share Partially Overlapping Conceptual Representations, Samuel Evans, Cathy J. Price, Jörn Diedrichsen, Eva Gutierrez-Sigut, Mairéad Macsweeney Nov 2019

Sign And Speech Share Partially Overlapping Conceptual Representations, Samuel Evans, Cathy J. Price, Jörn Diedrichsen, Eva Gutierrez-Sigut, Mairéad Macsweeney

Brain and Mind Institute Researchers' Publications

© 2019 The Author(s) Conceptual knowledge is fundamental to human cognition. Yet, the extent to which it is influenced by language is unclear. Studies of semantic processing show that similar neural patterns are evoked by the same concepts presented in different modalities (e.g., spoken words and pictures or text) [1–3]. This suggests that conceptual representations are “modality independent.” However, an alternative possibility is that the similarity reflects retrieval of common spoken language representations. Indeed, in hearing spoken language users, text and spoken language are co-dependent [4, 5], and pictures are encoded via visual and verbal routes [6]. A parallel approach …


Feed Efficiency And Carcass Metrics In Growing Cattle, David N. Kelly, Craig Murphy, Roy D. Sleator, Michelle M. Judge, Stephen B. Conroy, Donagh P. Berry Nov 2019

Feed Efficiency And Carcass Metrics In Growing Cattle, David N. Kelly, Craig Murphy, Roy D. Sleator, Michelle M. Judge, Stephen B. Conroy, Donagh P. Berry

Department of Biological Sciences Publications

Some definitions of feed efficiency such as residual energy intake (REI) and residual gain (RG) may not truly reflect production efficiency. The energy sinks used in the derivation of the traits include metabolic live-weight; producers finishing cattle for slaughter are, however, paid on the basis of carcass weight, as opposed to live-weight. The objective of the present study was to explore alternative definitions of REI and RG which are more reflective of production efficiency, and quantify their relationship with performance, ultrasound, and carcass traits across multiple breeds and sexes of cattle. Feed intake and live-weight records were available on 5,172 …


Aniseed 2019: 4d Exploration Of Genetic Data For An Extended Range Of Tunicates, J. Dardaillon, D. Dauga, P. Simion, E. Faure, T. A. Onuma, M. B. Debiasse, A. Louis, K. R. Nitta, M. Naville, L. Besnardeau, W. Reeves, K. Wang, M. Fagotto, M. Guéroult-Bellone, S. Fujiwara, R. Dumollard, M. Veeman, J.-N. Volff, H. Roest Crollius, E. Douzery, J. F. Ryan, Bradley Justin Davidson , '91, H. Nishida, C. Dantec, P. Lemaire Nov 2019

Aniseed 2019: 4d Exploration Of Genetic Data For An Extended Range Of Tunicates, J. Dardaillon, D. Dauga, P. Simion, E. Faure, T. A. Onuma, M. B. Debiasse, A. Louis, K. R. Nitta, M. Naville, L. Besnardeau, W. Reeves, K. Wang, M. Fagotto, M. Guéroult-Bellone, S. Fujiwara, R. Dumollard, M. Veeman, J.-N. Volff, H. Roest Crollius, E. Douzery, J. F. Ryan, Bradley Justin Davidson , '91, H. Nishida, C. Dantec, P. Lemaire

Biology Faculty Works

ANISEED (https://www.aniseed.cnrs.fr) is the main model organism database for the worldwide community of scientists working on tunicates, the vertebrate sister-group. Information provided for each species includes functionally-annotated gene and transcript models with orthology relationships within tunicates, and with echinoderms, cephalochordates and vertebrates. Beyond genes the system describes other genetic elements, including repeated elements and cis-regulatory modules. Gene expression profiles for several thousand genes are formalized in both wild-type and experimentally-manipulated conditions, using formal anatomical ontologies. These data can be explored through three complementary types of browsers, each offering a different view-point. A developmental browser summarizes the information in a gene- …


The Total Syntheses Of Jbir-94 And Two Synthetic Analogs And Their Cytotoxicities Against A549 (Ccl-185) Human Small Lung Cancer Cells, Cathy L. Mangum, Mica B. Munford, Alyssa Sam, Sandra K. Young, Jeremy T. Beales, Yagya Prasad Subedi, Chad D. Mangum, Tanner J. Allen, Miranda S. Liddell, Andrew I. Merrell, Diana I. Saavedra, Becky L. Williams, Nicole Evans, Joseph L. Beales, Mike A. Christiansen Nov 2019

The Total Syntheses Of Jbir-94 And Two Synthetic Analogs And Their Cytotoxicities Against A549 (Ccl-185) Human Small Lung Cancer Cells, Cathy L. Mangum, Mica B. Munford, Alyssa Sam, Sandra K. Young, Jeremy T. Beales, Yagya Prasad Subedi, Chad D. Mangum, Tanner J. Allen, Miranda S. Liddell, Andrew I. Merrell, Diana I. Saavedra, Becky L. Williams, Nicole Evans, Joseph L. Beales, Mike A. Christiansen

Chemistry and Biochemistry Faculty Publications

We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectual. We accordingly opted for the lengthier approach of acylating each amine individually, which gratuitously prevailed and also aligns with separate literature precedent. Moreover, we here share our analysis of these target compounds’ cytotoxicities and IC50 values against A549 (CCL-185) human …