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2019

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Articles 29821 - 29850 of 29874

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Let’S Make It Simple: Understanding Nutrition In The Management Of Obesity And Diabetes Through Visual Displays, Rosalie Magramo Del Valle Jan 2019

Let’S Make It Simple: Understanding Nutrition In The Management Of Obesity And Diabetes Through Visual Displays, Rosalie Magramo Del Valle

Electronic Theses and Dissertations 2010 - 2019

In only 3 decades, obesity has evolved to a leading cause of morbidity and premature mortality in the United States (US) and worldwide (Kotsis et al., 2018). The rise in the prevalence of obesity has been accompanied by a rise in the prevalence of diabetes and nearly 90% of newly diagnosed patients were overweight (Rossouw, 2015). Most guidelines recommend promoting weight loss among overweight or obese individuals by reducing energy intake together with a healthy eating pattern that focuses on a diet composed of whole or unprocessed foods combined with physical activity and ongoing support (Forouhi et al., 2018). Research …

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Knowledge And Practice Among Housekeeping Staff On Methods Of Bio-Medical Waste (Bmw) Management, Nanda Kumar Paniyadi Mr, Asha P. Shetty Dr, Alice Minj Ms, Edavathra Jennie Varghese Ms Jan 2019

Knowledge And Practice Among Housekeeping Staff On Methods Of Bio-Medical Waste (Bmw) Management, Nanda Kumar Paniyadi Mr, Asha P. Shetty Dr, Alice Minj Ms, Edavathra Jennie Varghese Ms

Manipal Journal of Nursing and Health Sciences

Waste is any substance that is not useful. Bio-medical waste (BMW) is any kind of waste containing infectious material. Inappropriate and inadequate handling of health care waste has serious public health issues and significant influence on environment. Objective: Objective of the study is to find out the relation between knowledge and practice regarding the method of BMW disposal. Methodology: A descriptive study design with non-probability convenient sampling technique was used to collect the data from 65 housekeeping staff of AIIMS, Bhubaneswar after obtaining administrative approval from the authorities. Structured knowledge questionnaire on BMW disposal and observational checklist for the practice …

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Community Breast Screening “Treasure Your Chest”, Lovely Joji Jan 2019

Community Breast Screening “Treasure Your Chest”, Lovely Joji

Electronic Theses and Dissertations 2010 - 2019

Background: Cancer is the second leading cause of death in United States (CDC, 2019). It has a huge impact on our society. In 2019, an estimated 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive breast cancer (U.S. Breast Cancer Statistics, 2019). About 41,760 women in the U.S. are expected to die in 2019 from breast cancer. Early diagnosis of the disease can reduce the mortality significantly and promote quality of life. Screening mammography has shown to reduce mortality from breast cancer in women 40-70years …

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Improving Hgba1c And Overall Insulin Resistance For Patients With Type Ii Diabetes: Evaluating The Effectiveness Of A Whole-Food, Plant-Based Diet, Jennifer Seegott Jan 2019

Improving Hgba1c And Overall Insulin Resistance For Patients With Type Ii Diabetes: Evaluating The Effectiveness Of A Whole-Food, Plant-Based Diet, Jennifer Seegott

Electronic Theses and Dissertations 2010 - 2019

The purpose of this Doctor of Nursing Practice (DNP), quality improvement project was to assist participants in the management of their type 2 diabetes through the use an evidencebased Whole-Food, Plant-Based (WFPB) diet approach. The project described the effectiveness of individual WFPB instruction and counseling. Following recruitment, the participant attended weekly dietary counseling sessions focused on incorporating a WFPB diet over a 6-week period. The participant completed the 16-item food intake questionnaire (16-FIQ) pre- and post-dietary counseling along with HgbA1c measurements during the project period. Post dietary counseling resulted in an increase in the participant’s HgbA1c from 8.1% to 8.9%, …

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Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng Jan 2019

Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng

Peninsula Medical School

More individuals are requesting medical assistance for gender uncertainty or dysphoria and provision of adult NHS gender identity services (GIS) is changing. Despite minimal medical input to polarised debates, several issues are potentially concerning: reports of poor care; rapid rises in referrals of children and young people to GIS; public conflation of biological sex with socially influenced gender roles; and extensive uncertainty in the evidence base to guide practice. Medical practice should happen within robust human rights frameworks where individual patients always have their concerns heard. Generalists, with expertise in whole-person care, handling uncertainty and complexity, have a key role …

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Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira Jan 2019

Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira

Peninsula Medical School

No abstract provided.

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Diverse Sources Of Aeolian Sediment Revealed In An Arid Landscape In Southeastern Iran Using A Modified Bayesian Un-Mixing Model, Hamid Gholami, Kordestani M Dolat, Junran Li, Matt W. Telfer, Aboalhasan Fathabadi Jan 2019

Diverse Sources Of Aeolian Sediment Revealed In An Arid Landscape In Southeastern Iran Using A Modified Bayesian Un-Mixing Model, Hamid Gholami, Kordestani M Dolat, Junran Li, Matt W. Telfer, Aboalhasan Fathabadi

School of Geography, Earth and Environmental Sciences

No abstract provided.

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Fathers At Work: Challenges And Stereotypes Facing Fathers With Caregiving Responsibilities In Employment, Jasmine Kelland Jan 2019

Fathers At Work: Challenges And Stereotypes Facing Fathers With Caregiving Responsibilities In Employment, Jasmine Kelland

Plymouth Business School Theses

This study explores how caregiving fathers are perceived in contemporary employment to establish if this contributes to an understanding of the dominance of fathers in the role of ‘breadwinner’. Much existing research in this area is based in the US, largely utilising students as participants, and has limited applicability to contemporary UK fatherhood. This study employs a mixed methods design underpinned by a social constructivist standpoint, with managers and working parents as participants. Understanding regarding the perceptions of caregiving fathers is sought through exploring how such fathers are rated when they apply for work utilising online vignettes, vignette based focus …

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Foraging Performance, Prosociality, And Kin Presence Do Not Predict Lifetime Reproductive Success In Batek Hunter-Gatherers, Thomas S. Kraft, Vivek V. Venkataraman, Ivan Tacey, Nathaniel J. Dominy, Kirk M. Endicott Jan 2019

Foraging Performance, Prosociality, And Kin Presence Do Not Predict Lifetime Reproductive Success In Batek Hunter-Gatherers, Thomas S. Kraft, Vivek V. Venkataraman, Ivan Tacey, Nathaniel J. Dominy, Kirk M. Endicott

School of Law, Humanities and Social Sciences

No abstract provided.

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Transmural Unipolar Electrogram Change Occurs Within 7s At The Left Atrial Posterior Wall During Pulmonary Vein Isolation, Dr Tomlinson, M Myles, Kn Stevens, A Streeter Jan 2019

Transmural Unipolar Electrogram Change Occurs Within 7s At The Left Atrial Posterior Wall During Pulmonary Vein Isolation, Dr Tomlinson, M Myles, Kn Stevens, A Streeter

Peninsula Medical School

No abstract provided.

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Challenging Robot Morality: An Ethical Debate On Humanoid Companions, Dataveillance, And Algorithms, Eugenia Stamboliev Jan 2019

Challenging Robot Morality: An Ethical Debate On Humanoid Companions, Dataveillance, And Algorithms, Eugenia Stamboliev

School of Art, Design and Architecture Theses

In this thesis, I reflect on ethical, moral, and agenthood debates around social and humanoid robots in two ways. I focus on how the technological agency of social robots is understood in ethical canons by shifting from moral concerns in Robot Ethics to data-related ethical concerns in Media and Surveillance Studies. I then move to wider debates on morality, agenthood, and agencies in Machine and Computer Ethics research, so as to highlight that social robots, other robots, machines, and algorithmic structures are often moralised but not understood ethically. In that vein, I distinguish between these two terms to point to …

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Space-Time Experience In The Meta-Environment: A Cybersemiotic Analysis, Claudia Ferreira Jacques De Moraes Cardoso Jan 2019

Space-Time Experience In The Meta-Environment: A Cybersemiotic Analysis, Claudia Ferreira Jacques De Moraes Cardoso

School of Art, Design and Architecture Theses

Space-time Experience in the Meta-environment: A Cybersemiotic Analysis Written from the perspective of a reflective technoetic art practitioner, this thesis investigates Human-Computer Interactions in interactive hybrid environments and their influences on mediated consciousness. It argues that practices established during the advent of computer graphic interfaces have limited the interactive potential of such environments. It examines interactive processes among user, information, and interface; proposes a closer look at representational paradigms of space and time; suggests potentially illuminating parallels with complex adaptive systems; and explores their theoretical and practical co-implications. Influenced by Marcel Duchamp’s conceptual-interactive art experiments, Brazil’s syncretic Tropicalismo movement, and …

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Artistic Modulation Of Consciousness By Bioelectromagnetic Stimulation, Luis Miguel Almeida Ferreira Girao Jan 2019

Artistic Modulation Of Consciousness By Bioelectromagnetic Stimulation, Luis Miguel Almeida Ferreira Girao

School of Art, Design and Architecture Theses

The thesis demonstrates why the application of bioelectromagnetic stimulation as a medium of artistic expression allows for the production of new and unprecedented realisations of integrative art. Furthermore, the modulation of consciousness in human beings relating with such realisations is argued to be the core of a new practice of research resulting from the technological confluence of Philosophy, Art and Science. The Brunelleschi Experiment is examined in order to establish the assumption that one of the fundamental characteristics of Art is to impact consciousness of those interacting with its forms. The aspects of disembodiment of the previously referred experiment, instrumental …

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Application Of Musical Computing To Creating A Dynamic Reconfigurable Multilayered Chamber Orchestra Composition, Alexis Kirke Jan 2019

Application Of Musical Computing To Creating A Dynamic Reconfigurable Multilayered Chamber Orchestra Composition, Alexis Kirke

School of Art, Design and Architecture

With increasing virtualization and the recognition that today’s virtual computers are faster than hardware computers of 10 years ago, modes of computation are now limited only by the imagination. Pulsed Melodic Affective Processing (PMAP) is an unconventional computation protocol that makes affective computation more human-friendly by making it audible. Data sounds like the emotion it carries. PMAP has been demonstrated in nonmusical applications, e.g. quantum computer entanglement and stock market trading. This article presents a musical application and demonstration of PMAP: a dynamic reconfigurable score for acoustic orchestral performance, in which the orchestra acts as a PMAP half-adder to add …

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Antifouling Paint Particles In Intertidal Estuarine Sediments From Southwest England And Their Ingestion By The Harbour Ragworm, Hediste Diversicolor, Christina Muller-Karanassos, Andrew Turner, William Arundel, Tom Vance, Penelope K. Lindeque, Matthew Cole Jan 2019

Antifouling Paint Particles In Intertidal Estuarine Sediments From Southwest England And Their Ingestion By The Harbour Ragworm, Hediste Diversicolor, Christina Muller-Karanassos, Andrew Turner, William Arundel, Tom Vance, Penelope K. Lindeque, Matthew Cole

School of Geography, Earth and Environmental Sciences

© 2019 Antifouling paint particles (APPs) of between 500 μm and >2 mm in diameter have been identified in silty, intertidal estuarine sediments through a combination of microscopy and x-ray fluorescence spectrometry. APPs were heterogeneously distributed, with maximal concentrations of 430 particles L −1 (0.2 g L −1 ) near to a facility where boats are regularly maintained and 400 particles L −1 (4.2 g L −1 ) at a location where old boats had been abandoned, with the majority of particles encountered in the finest size fraction retrieved. APPs contained variable concentrations of Cu, Zn, Sn and Pb, with …

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How Data Science Can Advance Mental Health Research, Tc Russ, E Woelbert, Kas Davis, Jd Hafferty, Et Al Jan 2019

How Data Science Can Advance Mental Health Research, Tc Russ, E Woelbert, Kas Davis, Jd Hafferty, Et Al

Peninsula Medical School

Accessibility of powerful computers and availability of so-called big data from a variety of sources means that data science approaches are becoming pervasive. However, their application in mental health research is often considered to be at an earlier stage than in other areas despite the complexity of mental health and illness making such a sophisticated approach particularly suitable. In this Perspective, we discuss current and potential applications of data science in mental health research using the UK Clinical Research Collaboration classification: underpinning research; aetiology; detection and diagnosis; treatment development; treatment evaluation; disease management; and health services research. We demonstrate that …

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Endo-Β-1,3-Glucanase (Gh16 Family) From Trichoderma Harzianum Participates In Cell Wall Biogenesis But Is Not Essential For Antagonism Against Plant Pathogens, Marcela Suriani Ribeiro, Renato Graciano De Paula, Aline Raquel Voltan, Raphaela Georg De Castro, Cláudia Batista Carraro, Leandro José De Assis, Andrei Stecca Steindorff, Gustavo Henrique Goldman, Roberto Nascimento Silva, Cirano José Ulhoa, Valdirene Neves Monteiro Jan 2019

Endo-Β-1,3-Glucanase (Gh16 Family) From Trichoderma Harzianum Participates In Cell Wall Biogenesis But Is Not Essential For Antagonism Against Plant Pathogens, Marcela Suriani Ribeiro, Renato Graciano De Paula, Aline Raquel Voltan, Raphaela Georg De Castro, Cláudia Batista Carraro, Leandro José De Assis, Andrei Stecca Steindorff, Gustavo Henrique Goldman, Roberto Nascimento Silva, Cirano José Ulhoa, Valdirene Neves Monteiro

Peninsula Medical School

Trichoderma species are known for their ability to produce lytic enzymes, such as exoglucanases, endoglucanases, chitinases, and proteases, which play important roles in cell wall degradation of phytopathogens. β-glucanases play crucial roles in the morphogenetic-morphological process during the development and differentiation processes in Trichoderma species, which have β-glucans as the primary components of their cell walls. Despite the importance of glucanases in the mycoparasitism of Trichoderma spp., only a few functional analysis studies have been conducted on glucanases. In the present study, we used a functional genomics approach to investigate the functional role of the gluc31 gene, which encodes an …

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Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang Jan 2019

Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang

Peninsula Medical School

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both …

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Neurological Effects Of Glucocerebrosidase Gene Mutations, S. Mullin, D. Hughes, A. Mehta, A. H.V. Schapira Jan 2019

Neurological Effects Of Glucocerebrosidase Gene Mutations, S. Mullin, D. Hughes, A. Mehta, A. H.V. Schapira

Peninsula Medical School

No abstract provided.

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Mitochondrial Integrity In Neurodegeneration, Katrina Cowan, Oleg Anichtchik, Shouqing Luo Jan 2019

Mitochondrial Integrity In Neurodegeneration, Katrina Cowan, Oleg Anichtchik, Shouqing Luo

Peninsula Medical School

No abstract provided.

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Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo Jan 2019

Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo

Peninsula Medical School

No abstract provided.

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Teasing Apart The Impact Of Illness And Iq On Functional Neuroimaging Findings In Schizophrenia, S Graham, Tm Oh, V Manning, J Jiang, Ib Yeh, S Kang, Pj Mckenna Jan 2019

Teasing Apart The Impact Of Illness And Iq On Functional Neuroimaging Findings In Schizophrenia, S Graham, Tm Oh, V Manning, J Jiang, Ib Yeh, S Kang, Pj Mckenna

Peninsula Medical School

Schizophrenia is a major psychiatric disorder associated with cognitive impairment. Functional brain imaging (fMRI) studies of schizophrenia patients reveal a complex pattern of brain differences in the prefrontal cortex. Both decreased (hypofrontality) and increased (hyperfrontality) activity have been reported in patients – inconsistencies that this paper argues could be explained by differences in IQ between patients and healthy controls. This study demonstrates a novel method to tease apart IQ and schizophrenia effects on brain activity. Twelve schizophrenia patients were matched to twelve healthy controls matched to patients’ estimated (premorbid) IQ before their illness, and twelve healthy controls matched to patients’ …

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Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey Jan 2019

Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey

Peninsula Medical School

Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others’ data indicates that this practice risks excluding ‘Goldilocks’ effects in which a biological variable falls within a range between ‘too much’ and ‘too little’ with a region between where its function is ‘just right’; a concept captured by the Swedish term ‘Lagom’. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical phenomena of the Goldilocks/Lagom form including …

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Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin Jan 2019

Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin

Peninsula Medical School

Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied …

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Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson Jan 2019

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …

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Food Choice By A Free-Ranging Antillean Manatee (Trichechus Manatus Manatus) In Tabasco, Mexico, Daniel Gonzalez-Socoloske, David Olivera-Gomez Jan 2019

Food Choice By A Free-Ranging Antillean Manatee (Trichechus Manatus Manatus) In Tabasco, Mexico, Daniel Gonzalez-Socoloske, David Olivera-Gomez

Faculty Publications

Understanding foraging ecology is an important element of effective conservation strategies. While West Indian manatees (Trichechus manatus) have been documented to consume a wide variety of vascular plants and algae, little is known about the diet of the Endangered Antillean subspecies (T. m. manatus) at freshwater sites such as the wetlands of Tabasco, the largest manatee habitat in Mexico. Here we present the results of a study of wild manatee diet in a freshwater site in Mexico. Controlled food choice experiments were conducted on a wild adult manatee during the dry seasons of 2011 and 2012. …

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Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek Jan 2019

Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek

Faculty Publications

No abstract provided.

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Parenting Adolescents In Today’S World, Alina M. Baltazar Jan 2019

Parenting Adolescents In Today’S World, Alina M. Baltazar

Faculty Publications

No abstract provided.

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Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin Jan 2019

Developing A Rational Peptide Ligand Design Method Using Cd13 As A Prototype Target Receptor, Md Zahir Uddin

University of the Pacific Theses and Dissertations

Structure based computational peptide design methods have gained significant interest in recent years with the availability of structural insights of protein-protein interactions obtained from the crystal structures. Most of these approaches design new peptide ligands by connecting the crucial amino acid residues from the protein interface and are generally not based on any predicted receptor-ligand interaction. In this work, a peptide design method based on the Knob-Socket model was used to identify the specific ligand residues packing into the receptor interface. This method enables rational peptide ligand design by predicting amino acid residues that will fit best at the binding …

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Structural Characterization Of Black Widow Spider Dragline Silk Proteins Crp1 And Crp4, Mikayla Shanafelt Jan 2019

Structural Characterization Of Black Widow Spider Dragline Silk Proteins Crp1 And Crp4, Mikayla Shanafelt

University of the Pacific Theses and Dissertations

Spider dragline silk is a biomaterial with outstanding material properties, possessing high-tensile strength and toughness. In nature, dragline silk serves a central role during spider locomotion and web construction. Today, scientists are racing to elucidate the molecular machinery governing silk extrusion, attempting to translate this knowledge into a mimicry process in the laboratory to create synthetic fibers for a wide range of different applications. During extrusion, it has been established that biochemical and mechanical forces govern spidroin folding, aggregation, and assembly. In black widow spiders, at least 7 different proteins have been identified as constituents of dragline silk fibers. These …

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