The Role Of Atypical Protein Kinase C In Colorectal Cancer Cells Carcinogenesis, S M Anisul Islam

USF Tampa Graduate Theses and Dissertations

Colorectal cancer (CRC) is the third most common malignancy and the fourth most common cause of cancer-related death worldwide. CRC is a life-threatening disease due to therapy-resistant cancerous cells. The exact mechanisms of cell growth, survival, metastasis and inter & intracellular signaling pathways involved in CRC are still a significant challenge. Moreover, the treatment of metastatic CRC considered palliative for many years aimed for an improved life, with little hope of a cure, highlighting the need for developing novel targeted therapy for CRC. Hence, investigating new molecular mechanism(s) that lead to colorectal carcinogenesis may give insight into the therapeutic target. …

Single-Molecule Real-Time Transcript Sequencing Identified Flowering Regulatory Genes In Crocus Sativus, Xiaodong Qian, Youping Sun, Guifen Zhou, Yumei Yuan, Jing Li, Huilian Huang, Limin Xu, Liqin Li

Plants, Soils, and Climate Faculty Publications

Background: Saffron crocus (Crocus sativus) is a valuable spice with medicinal uses in gynaecopathia and nervous system diseases. Identify flowering regulatory genes plays a vital role in increasing flower numbers, thereby resulting in high saffron yield.

Results: Two full length transcriptome gene sets of flowering and non-flowering saffron crocus were established separately using the single-molecule real-time (SMRT) sequencing method. A total of sixteen SMRT cells generated 22.85 GB data and 75,351 full-length saffron crocus unigenes on the PacBio RS II panel and further obtained 79,028 SSRs, 72,603 lncRNAs and 25,400 alternative splicing (AS) events. Using an Illumina RNA-seq platform, …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Untapped Potential Of Gorgonian Octocorals For Detecting Environmental Change In Biscayne National Park, Florida, Usa, Selena A. Kupfner Johnson

USF Tampa Graduate Theses and Dissertations

One consequence of dramatic stony-coral loss has been recognition that gorgonian octocorals (Anthozoa: Octocorallia) have emerged among the dominant reef fauna. However, gorgonians are notoriously difficult to field-identify and consequently have been underrepresented in most monitoring efforts resulting in a lack of long-term data. The rich diversity of habitats, close proximity to the urban center of Miami, and connectivity to other areas of Florida have made Biscayne National Park an active location for reef research since its establishment in 1968. As such, a plethora of data (e.g., museum specimen and species abundance data) has been collected and stored in archives …

Amyloid Protein Aggregation And Associated Toxicity, Chamani A. Niyangoda

USF Tampa Graduate Theses and Dissertations

Amyloidosis is a group of diseases in which amyloid fibrils accumulate and deposit into plaques and intracellular inclusions which lead to disruption of the tissue architecture and function. Most of the amyloid diseases are incurable due to a lack of understanding of the amyloid formation, as well as associated toxicity. My research work is focused on three different aspects of amyloid aggregation.

The aim of the first project is to investigate the potential use of deep-blue autofluorescence (dbAF) as an intrinsic optical probe to study amyloid self-assembly. This novel fluorescence signal is excited at the long wavelength edge of the …

Self-Assembly Of 2d And 3d Metallo-Supramolecules With Increasing Complexity, Bo Song

USF Tampa Graduate Theses and Dissertations

Synthetic organic chemistry played a crucial role in the construction of molecules through the formation and dissociation of covalent bonds. However, the laborious synthetic procedures as well as the low yield after multiple steps have restricted the pursuit of complicated giant molecules with high efficiency. Being complementary to organic synthesis, self-assembly provided an alternative route to achieving the giant architectures using weak non-covalent interactions in high efficiency, which is in analog to natural systems such as DNA, peptide, and protein. Among the various interactions, coordination has shown unique advantages in terms of directionality, reversibility and strength. Serving as a bottom-up …

Deviation Between Projected And Observed Precipitation Trends Greater With Altitude, T. R. Murphy, M. E. Hanley, J. S. Ellis, P. H. Lunt

School of Geography, Earth and Environmental Sciences

No abstract provided.

Pathological Comparisons Of The Hippocampal Changes In The Transient And Permanent Middle Cerebral Artery Occlusion Rat Models, Fawad Ali Shah, Tao Li, Lina Tariq Al Kury, Alam Zeb, Shehla Khatoon, Gongping Liu, Xifei Yang, Fang Liu, Huo Yao, Arif Ullah Khan, Phil Ok Koh, Yuhua Jiang, Shupeng Li

All Works

© Copyright © 2019 Shah, Li, Kury, Zeb, Khatoon, Liu, Yang, Liu, Yao, Khan, Koh, Jiang and Li. Ischemic strokes are categorized by permanent or transient obstruction of blood flow, which impedes delivery of oxygen and essential nutrients to brain. In the last decade, the therapeutic window for tPA has increased from 3 to 5–6 h, and a new technique, involving the mechanical removal of the clot (endovascular thrombectomy) to allow reperfusion of the injured area, is being used more often. This last therapeutic approach can be done until 24 h after stroke onset. Due to this fact, more acute …

Exploration Of Muscle Loss And Metabolic State During Prolonged Critical Illness: Implications For Intervention?, Liesl Wandrag, Stephen J. Brett, Gary S. Frost, Vasiliki Bountziouka, Mary Hickson

School of Health Professions

No abstract provided.

The De Haan Family, James C. Schaap

The Voice

No abstract provided.

Bringing What's Out There Home, James C. Schaap

The Voice

No abstract provided.

True To The Task, Sarah Moss

The Voice

No abstract provided.

A Bit Of Restoration, Sarah Moss

The Voice

No abstract provided.

Athletic Teams Reach Scholarly Milestone, Mike Byker

The Voice

No abstract provided.

Dordt Choir Sings In Dordrecht, Lydia Marcus

The Voice

No abstract provided.

Adopted For Life, Kate Henreckson

The Voice

No abstract provided.

Glial Regulators Of Ionic Homeostasis Shape Neuronal Output In C. Elegans, Christina K. Johnson

Open Access Dissertations

The ability to sense touch is fundamentally important for interacting with and understanding the world around us. Touch plays a major role in many pathologies in which injury or inflammation leads to abnormal responses to touch, such as allodynia and mechanical hyperalgesia. Despite its crucial roles in physiology and pathology, the mechanisms by which we sense touch are the least understood of all the senses. Mammals sense touch through mechanosensors embedded in the skin, which are either free nerve endings or cooperative complexes formed by nerve endings and associated glia and epithelial cells. Work on Merkel cell-neurite complexes has demonstrated …

Family Perspectives On Newborn Screening For X-Linked Adrenoleukodystrophy In California, Katharina Schwan, Janey Youngblom, Kara Weisiger, Jessica Kianmahd, Rebecca Waggoner, Joanna H. Fanos

Institute on Disability

X-linked adrenoleukodystrophy (ALD) is caused by gene variants in the ABCD1 gene, resulting in a varied clinical spectrum. Males with ALD present with symptoms ranging from isolated adrenal insufficiency and slowly progressive myelopathy to severe cerebral demyelination. Females who are heterozygous for ALD typically develop milder symptoms by late adulthood. Treatment for adrenal insufficiency associated with ALD exists in the form of cortisol, and cerebral ALD may be treated with stem cell transplantation. Currently, there is no treatment for myelopathy. Since 2013, at least 14 states have added ALD to their newborn screening (NBS) panel, including California in 2016. We …

We Are...Marshall, November 13, 2019, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Psychological Stress And Cellular Aging In Cancer: A Meta-Analysis, Joanna Kruk, Basil Aboul-Enein, Joshua Bernstein, Magdalena Gronostaj

Health & Wellness Department Faculty Publications and Research

Background. Epidemiological evidence continues to accumulate on the effect of psychosocial and behavioral factors in relation to cancer risk, progression, and mortality. Material and Methods. This article presents the current evidence on the relationship between psychological stress and the risk of cancer and cellular aging process. Ten databases were searched to identify publications up to September 2019. References from retrieved articles were also reviewed. We included nine review papers and 26 cohort or case-control studies based on inclusion/exclusion criteria. Results. Results of previously published review articles did not show consistent evidence for the association between cancer risk …

Intermountain Biological Engineering Conference A Success | College Of Engineering, Utah State University

College of Engineering News

Intermountain Biological Engineering Conference at USU on Nov. 9 was tremendous success. About 150 people were in attendance.

Volume 57, Number 14: November 13, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

November 13th, 2019, Csusb

Coyote Chronicle (1984-)

Inside This Issue

• Lack of on-campus student engagement Pg. 4
• Concerns over campus parking Pg. 6-7
• Our first "Women Writers Unite" Pg. 11

New Plant Club Officers Planning A Diverse Set Of Activities, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Impact Of A Web-Based Instructional Module Of Alzheimer’S Disease Within Seven Content Knowledge Domains, Joyce Haynie

Dissertations

Abstract

Alzheimer’s Disease (AD) has been classified as the most common form of dementia. Primary health care providers are usually the first clinicians to whom individuals present with symptoms of dementia. By 2050, it is expected that as many as 13.8 million Americans will be living with AD, and millions more will be placed in the challenging role of providing care for these individuals. However, studies continue to show that dementia is often underdiagnosed and under detected. The purpose of the study was to systematically inquire about the impact of AD education on level of knowledge about AD among primary …

Residential Household Yard Care Practices Along Urban-Exurban Gradients In Six Climatically-Diverse U.S. Metropolitan Areas, Dexter H. Locke, Colin Polsky, J. Morgan Grove, Peter M. Groffman, Kristen C. Nelson, Kelli L. Larson, Jeannine Cavender-Bares, James B. Heffernan, Rinku Roy Chowdhury, Sarah E. Hobbie, Neil D. Bettez, Sharon J. Hall, Christopher Neill, Laura Ogden, Jarlath O'Neil-Dunne

Publications and Research

Residential land is expanding in the United States, and lawn now covers more area than the country’s leading irrigated crop by area. Given that lawns are widespread across diverse climatic regions and there is rising concern about the environmental impacts associated with their management, there is a clear need to understand the geographic variation, drivers, and outcomes of common yard care practices. We hypothesized that 1) income, age, and the number of neighbors known by name will be positively associated with the odds of having irrigated, fertilized, or applied pesticides in the last year, 2) irrigation, fertilization, and pesticide application …

Faculty Recognized At Endowed Chairs And Professorships Reception, Allison Taylor

Browse All News

No abstract provided.

The Firre Locus Produces A Trans-Acting Rna Molecule That Functions In Hematopoiesis., Jordan P Lewandowski, James C Lee, Taeyoung Hwang, Hongjae Sunwoo, Jill M Goldstein, Abigail F Groff, Nydia P Chang, William Mallard, Adam Williams, Jorge Henao-Meija, Richard A Flavell, Jeannie T Lee, Chiara Gerhardinger, Amy J Wagers, John L Rinn

Faculty Research 2019

RNA has been classically known to play central roles in biology, including maintaining telomeres, protein synthesis, and in sex chromosome compensation. While thousands of long noncoding RNAs (lncRNAs) have been identified, attributing RNA-based roles to lncRNA loci requires assessing whether phenotype(s) could be due to DNA regulatory elements, transcription, or the lncRNA. Here, we use the conserved X chromosome lncRNA locus Firre, as a model to discriminate between DNA- and RNA-mediated effects in vivo. We demonstrate that (i) Firre mutant mice have cell-specific hematopoietic phenotypes, and (ii) upon exposure to lipopolysaccharide, mice overexpressing Firre exhibit increased levels of pro-inflammatory cytokines …

Heart Hormones That Affect Development Of Diabetes, Hypertension Differ In African Americans And Whites, Staff

Browse All News

No abstract provided.